Conserved Protein Domain Family
RR_TM4-6

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pfam06459: RR_TM4-6 
Ryanodine Receptor TM 4-6
This region covers TM regions 4-6 of the ryanodine receptor 1 family.
Statistics
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PSSM-Id: 336413
View PSSM: pfam06459
Aligned: 51 rows
Threshold Bit Score: 186.79
Threshold Setting Gi: 313236461
Created: 26-Mar-2017
Updated: 23-May-2017
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q5RGQ4       4240 NMPDPTQFGIHGDvlEAEKAEISEMVVS--AD-----------MVQmt-gaGGGEKLETDVIMDlln-pavKKEGK---- 4300 zebrafish
Q7PMK5       4459 LMRGPAQEE-EEPi------pEAEPSLRalPP-----------LP----------LEEPPGTVQafgldisKEENGqyrm 4510 Anopheles gam...
Q17EB5       4471 LMRGSTQEE-EEVi------vEVEPSLRalPP-----------LP----------TEEPPSTVQafgldisKEENGqyrv 4522 yellow fever ...
XP_018669433 4358 pTHERIQHSVENl-sDSGTDDTGQDQTK---------------------------GDKEDFISDvfgmdikKSKELikav 4409 vase tunicate
XP_015833833 4441 LMRGPI-----EEpaVLEIKEEEEKVGL--SR-----------VLP-----ALPSSEEQNTQMQafglditKEDNGqykm 4497 red flour beetle
XP_012544766 4485 LMRGPQ---VEEPp--pEPTEEEKIGPRhlPA-----------LPP--------ADDTGQMQVSafglditKEDNGqiqv 4540 domestic silk...
XP_016661950 4471 LMSGTQSEET-----TVEVVEEKSGSFRmlPA-----------LPS--------SGMDEPPSTLtdgnnmrKNSGS---- 4522 pea aphid
XP_002032982 3172 LMRGPAPEQEEEPv------vEEETFGRalPP-----------LP----------LEEPPGTVQafgldinKEENGmykv 3224 Drosophila se...
XP_011482910 4290 gilEPTLDEVMEGpsGVNR-----------LRkysasflcpteLSEigqmaALTSPREVDALSDifg-lklKKEGGqyrl 4357 Japanese medaka
XP_011601311 4203 giLEPTLDEVTGGp-SGDQLRKYSCSLTlqEE-----------TSGirqaeGVTSTRDMDGLSNvfg-lkvKKEGScyrl 4269 torafugu
Q5RGQ4       4301 --HGAEPGLGDVCEILTETs-aPVEKKKSQ--------KVAAEKPESEP-EKa------------------------DTE 4344 zebrafish
Q7PMK5       4511 apHESPalsp-------------------------sssIEETGESSPEDg---------------------------AAE 4538 Anopheles gam...
Q17EB5       4523 qpHESPalsp-------------------------sssVEETGESSPEDg---------------------------AGE 4550 yellow fever ...
XP_018669433 4410 vhTKPEAGFGDFTVDEAADtfsli----------asdyESGINTPRTSKiKKrrkllrkgkqigqtasttstilsslENS 4479 vase tunicate
XP_015833833 4498 aaHESP------------TtsqPSSAEGEGettpeedgEHPETETMEAPlSLs------------------------DLL 4541 red flour beetle
XP_012544766 4541 kpHESPttst-------------------------pssGEEADASLDEGlEHs------------------------Ee- 4570 domestic silk...
XP_016661950 4523 --PDSKhlks-------------------------nsvGDDKDETSAENhEKe------------------------DGV 4551 pea aphid
XP_002032982 3225 vvHESPan----------------------------ssMEEGGESSPEDgAAa------------------------SGE 3252 Drosophila se...
XP_011482910 4358 vsKDLSASLTDLFQTASRTtvtTEIFEQHHsv----frEQVDTDETAKDgNMi------------------------QLK 4409 Japanese medaka
XP_011601311 4270 iaKDLTDSLTDLFTTTSGRvkaAEVPEKHQett--hiyKEEQTEEKGTDrKgidiek----------------------- 4324 torafugu
Q5RGQ4       4345 NQEKED--KTkeeap----------eepaaEKPAP--KVKRGSSKDEspAFMASFFA-------GLEVYKTKMLNYLARN 4403 zebrafish
Q7PMK5       4539 LTGEGVppGEqmtlvdllggeaakraaqerTEAQKaqEATLASIEAEskKASTETKEpaavhqiDFSKYTKKCVSYLARN 4618 Anopheles gam...
Q17EB5       4551 LSAEAAstEPpmtlvdllggeaakraaqerSEAQKaqEATLANIEAEqkKASAETKEpaavtqiDFSKYTKKAVSFLARN 4630 yellow fever ...
XP_018669433 4480 STSEQRlsNLksamsfders-gednispwyTCMKEcgRPARYKHEEKteDRNAMYLD-------TWNAFCMGTMGLFARN 4551 vase tunicate
XP_015833833 4542 GGEQAKraAQekvea----------qaaqqAVMQAieSESKQPVVTEpsAVSQ---I-------NFGAYSHRAVSFLARN 4601 red flour beetle
XP_012544766 4571 --------QRppslidllggeqakkqalerIEAQAaqQAAMSAIEAEskKAVQGPASssalsqvDLSQYTRRAVSFLARN 4642 domestic silk...
XP_016661950 4552 DGS-----EQqasfvdllvgesarkdsiagPEVLAqqQAVMAAVEAEikQKNS-VENpsafstiDINAYTHRALSFLARN 4625 pea aphid
XP_002032982 3253 LVE-GEphQEpisivdllggeaakkaaqerQEAQKaqEAAMASIEAEakKSSSAPQEtpavhqiDFSQYTHRAVSFLARN 3331 Drosophila se...
XP_011482910 4410 HTEneks--------------------enmKPETNltNKGCSNKSKDshGQHFALWE-------TISSQNKSLLSFFARN 4462 Japanese medaka
XP_011601311 4325 -------------------------kseviMMEPKwrAKSHPQKSEEpeNQQSALWG-------IISTHNKSMLNYFARN 4372 torafugu
Q5RGQ4       4404 FYNLRFLALFVAFAINFILLFYKVTGd-FDDEEEE---------------------------------EGSwggeeeeaD 4449 zebrafish
Q7PMK5       4619 FYNLKYVALVLAFCINFMLLFYKVTTlgDDEDGEGgsgeslmglgsglgsg-lgiletgsgggeggsgDGE--------G 4689 Anopheles gam...
Q17EB5       4631 FYNLKYVALVLAFGINFMLLFYKVTTlgDDEASEGsgddmmelasglgsglaeavleggsgdggsgdgGDE--------G 4702 yellow fever ...
XP_018669433 4552 FYKFKILALGLTFCINFILLFYKwhs---------------------------------------innDLK--------V 4584 vase tunicate
XP_015833833 4602 FYNLKYVALVLAFCINFMLLFYRVSTlgDDAEGSGskgipdileg--------------saegsgagsGES--------G 4659 red flour beetle
XP_012544766 4643 FYNLKYVALVLAFCINFVLLFYKVSTldGEKAEGSgigdiiagsg--------------sgqgsgsgdGSG--------- 4699 domestic silk...
XP_016661950 4626 FYNLKYVALVLAFCINFILLFYKVTTlaDDLSDDGdvkefalgsag-----------isnddmddsnsTEI--------A 4686 pea aphid
XP_002032982 3332 FYNLKYVALVLAFSINFMLLFYKVTSftEEADSSAeeelilgsgsgggad----itgsgfggsgdggsGDS--------E 3399 Drosophila se...
XP_011482910 4463 FYTMRFVALFVTFAINFILLFYKVASmpASKGEEVritsvd---------------------redldsVIE--------- 4512 Japanese medaka
XP_011601311 4373 YYNMRVLALFVTFAINFILLFYKVASspTAHVEGKettpps---------------------rqesysAGD--------E 4423 torafugu
Q5RGQ4       4450 EDEGGMEY----FILQESTGYMAPTLTFLAVLHTVISLLCVFGYYCLKVPLVV 4498 zebrafish
Q7PMK5       4690 EEEDPPEK----VHVDEDFFYMEHVLRIAAILHSLVSLCMLIAYYHLKVPLAI 4738 Anopheles gambiae str. PEST
Q17EB5       4703 DGEDPLEK----VEVDEDFFYMEHVMRVAALMHSLVSLCMLIAYYHLKVPLAI 4751 yellow fever mosquito
XP_018669433 4585 DSESSEDEveesLILEDTSKYMEPTLRAFSIIHFILSFSMLVSYYGLKVPLVI 4637 vase tunicate
XP_015833833 4660 EDDDPPEL----VHVDEDFYYMAHVMRLAAILHSVVSLAMLIAYYNLKVPLAI 4708 red flour beetle
XP_012544766 4700 EEDDALEV----VHIDEDFFYMEHVIKVAAVLHSIVSLAILIGYYHLKVPLAI 4748 domestic silkworm
XP_016661950 4687 DDEGVLEL----VHVNEDFFYMAHVMRLAALLHSLASLAMLIAYYHLKVPLAI 4735 pea aphid
XP_002032982 3400 MEDEIPEL----VHVDEDFFYMEHVLRIAACLHSLVSLAMLIAYYHLKVPLAI 3448 Drosophila sechellia
XP_011482910 4513 EDSRGRDY----FVLEESSGWMEPSLHLLAFAHTVISFCCIIGYYYLKVPLLI 4561 Japanese medaka
XP_011601311 4424 DEEDGTVY----FVLEESSGYMESSLHFLAVVHTIISFFCIIGYYCLKVPLVI 4472 torafugu
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