Conserved Protein Domain Family
Kdo

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pfam06293: Kdo 
Lipopolysaccharide kinase (Kdo/WaaP) family
These lipopolysaccharide kinases are related to protein kinases pfam00069. This family includes waaP (rfaP) gene product is required for the addition of phosphate to O-4 of the first heptose residue of the lipopolysaccharide (LPS) inner core region. It has previously been shown that WaaP is necessary for resistance to hydrophobic and polycationic antimicrobials in E. coli and that it is required for virulence in invasive strains of S. enterica.
Statistics
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PSSM-Id: 283861
View PSSM: pfam06293
Aligned: 11 rows
Threshold Bit Score: 224.945
Threshold Setting Gi: 23821766
Created: 26-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123561131  22 EEVKTLQGEVFRELETRRTLRFEMAGK-----SYFLKWHRGTTLKEIIKNLLSLR-MPVLGADREWNAIHRLRDVGVDTM 95
gi 39931328   29 PQYWQAQNKVVGSATGRGTTWFVQLPKi---tAALRHYRRGGLFGKLVKDHYWFRsWSATRSFAEFHLLKQLREAGVNVP 105
gi 81539625   20 eAVEALQGKVYRELEGRRTLRTEVDGR-----GYFVKIHRGIGWGEIAKNLLTAK-LPVLGARQEWQAIRRLHEAGVATM 93
gi 81539626   22 DALWALQLDAVDEPNTERGGWSSVYRLd----LGDSAYYLKRQSNHLTRS-LRHP-LGEPTFAREFRNIERYRALGIPAL 95
gi 81539928   18 DQWLQVPGSWVEEPNERRGGASGVQRVy---tGDGRLLYRKQQTGHVYRD-WQRP-FGYPTAMRERDALRAFESLGIRVP 92
gi 2507050    11 NHWWATEGDWVEEPNYRRNGMSGVQCVe----RNGKKLYVKRMTHHLFHS-VRYP-FGRPTIVREVAVIKELERAGVIVP 84
gi 20138719   28 SSFWKKQARILGSAQGRGVTWFLQTKDlfgvnAALKHYYRGGLWGKINRDYYRFStLSNARSFAEFSLLKQLHEAGLAVP 107
gi 6831714    28 AEFWQKQERVIGSAKGRGITYFLQTEDwfgvnCALRHYYRGGLWGKLNKDRYRFSaLETTRSFAEFHLLQRLYEAGLPVP 107
gi 119364601  39 PAWWGGRAHAVSEG-GRGSAWFVEASFg---nAVLRQYRRGGMIAMLNRDRYFWCgGHRTRSVLEFRLMRELISRGLPVP 114
gi 23821766   39 pQRWGDRARPVDEG-GRGGAWFVDAPFg---hSVLRQYRRGGMAARVSRDQYLWKgAGRTRSFAEFRLMRELLKRKLPVP 114
gi 81458295   32 VDFWREKSAVVGSSKGRYTTWFVAFEHs---hWVLRHYWRGGMMEKFSKDAYFYTgLENTRAMGELRLLDALYREQFAVP 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123561131  96 YGVAFGEKGMNPLt-RTSFIITEDLTPTISLEDYCADwatnppdVRVKRMLIKRVATMVRDMHAAGINHRDCYICHFLLH 174
gi 39931328  106 RPIAAYAMRKGLF--YQADLLSERIANAQDLVTILQK-------HSLNAELYQKIGVEIAKMHRVGVNHTDLNIHNILID 176
gi 81539625   94 TAVAYGERGSDPAr-QHSFIVTEELAPTVDLEVFSQDwrerpppPRLKRALVEAVARMVGDMHRAGVNHRDCYICHFLLH 172
gi 81539626   96 QAAFFAQQAVGGE--RQAILLTRALDGWQDLDTWLASwhd--laEERRRAILRAVGRLARQLHAAGQMHGCFYPKHVFLR 171
gi 81539928   93 RLVYSGCRKVDGQ--WQALLVTEALEGFSSLDECYARgdqdrwgEAKHQRILQQIGATIARMNLAHWQHGCLYPKHIFVR 170
gi 2507050    85 KIVFGEAVKIEGE--WRALLVTEDMAGFISIADWYAQhavspysDEVRQAMLKAVALAFKKMHSINRQHGCCYVRHIYVK 162
gi 20138719  108 KPLGACVEKVAFGf-YRADLLTEKIEHAQDLTVYLQQ-------GKLTEQDWHKVGQLIHQLHSLQVCHTDLNAHNILVQ 179
gi 6831714   108 KPIAARIQKGKLGicYQADILTEKIENAQDLTALLQT-------QTLPKETWMQIGRLIRKLHDLQICHTDLNAHNILLQ 180
gi 119364601 115 TPLAACYVRYGVQ--YRAAILMERLEGVSSLAMCVR--------GNSKETHWEQIGRMISRFHREGLDHADLNAHNILLD 184
gi 23821766  115 RPLAACYLREGLG--YRAALLMERLENVRSLADHAQ--------VAGRGAPWEDTGRLIARFHRAGLDHADLNAHNILFD 184
gi 81458295  109 KPIAANIVRDGLF--YRADIIIERVDGAEDLVAKLTK-------GTMTQAQWHALGATIAQFHRRGVYHADLNAKNILWQ 179
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 123561131 175 LPFsgkeeelKISVIDLHRAQLRTrvPRRWRDKDLIGLYFSSM-------NIGLTQRDIWRFMKVY 233
gi 39931328  177 AQE-------TIWIIDFDKCYPQA--GDGWKQENLDRLKRSFNker-vkrSIHWHDKDFQALLTGY 232
gi 81539625  173 TDKpvsaddfRLSVIDLHRAQTRDatPKRWRNKDLAALYFSAL-------DIGLTRRDKLRFLRTY 231
gi 81539626  172 EGAdg---vfEACLIDLEKTRPIWf-GRRDQVKDLEPMLRR---------APDWSEADVHEFISAY 224
gi 81539928  171 VEge----aiEVALIDLEKSRRRLt-VNKASQHDLKQLKR----------RSSWTGAQWQAFIYGY 221
gi 2507050   163 TEGn-----aEAGFLDLEKSRRRLr-RDKAINHDFRQLEKY---------LEPIPKADWEQVKAYY 213
gi 20138719  180 QRDdg----rKFWLIDFDKCAHQL--GERWKSENLNRLHRSFMkev-trmKIQFSEQDWQALLAGY 238
gi 6831714   181 QTEqg----qKCWLLDFDKCGEKS--ADFWKVQNLNRLKRSFEkev-grmNIQFTEQNWADLTSAY 239
gi 119364601 185 QAG-------QCWLIDFDRGALRIp-ATKWRERNLARLLRSLLkir-gerSVDAVYRDFERLRRAY 241
gi 23821766  185 AGG-------HGWLIDFDRGVLRIp-ATRWRERNLARLHRSLLklr-gnrTREDVDKDYERLHRAY 241
gi 81458295  180 PQQtds-aqeRFYLIDFDRGELKTp-NAKWQKANLDRLLRSFNkeqgkqpTLAFTPANWAALLEGY 243
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