Conserved Protein Domain Family
Kdo

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pfam06293: Kdo 
Lipopolysaccharide kinase (Kdo/WaaP) family
These lipopolysaccharide kinases are related to protein kinases pfam00069. This family includes waaP (rfaP) gene product is required for the addition of phosphate to O-4 of the first heptose residue of the lipopolysaccharide (LPS) inner core region. It has previously been shown that WaaP is necessary for resistance to hydrophobic and polycationic antimicrobials in E. coli and that it is required for virulence in invasive strains of S. enterica.
Statistics
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PSSM-Id: 283861
View PSSM: pfam06293
Aligned: 11 rows
Threshold Bit Score: 224.945
Threshold Setting Gi: 23821766
Created: 26-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q329M7  22 EEVKTLQGEVFRELETRRTLRFEMAGK-----SYFLKWHRGTTLKEIIKNLLSLR-MPVLGADREWNAIHRLRDVGVDTM 95  Shigella dysenteriae ...
Q7MPR5  29 PQYWQAQNKVVGSATGRGTTWFVQLPKi---tAALRHYRRGGLFGKLVKDHYWFRsWSATRSFAEFHLLKQLREAGVNVP 105 Vibrio vulnificus YJ016
Q9HUF7  20 eAVEALQGKVYRELEGRRTLRTEVDGR-----GYFVKIHRGIGWGEIAKNLLTAK-LPVLGARQEWQAIRRLHEAGVATM 93  Pseudomonas aeruginos...
Q9HUF8  22 DALWALQLDAVDEPNTERGGWSSVYRLd----LGDSAYYLKRQSNHLTRS-LRHP-LGEPTFAREFRNIERYRALGIPAL 95  Pseudomonas aeruginosa
Q9HW24  18 DQWLQVPGSWVEEPNERRGGASGVQRVy---tGDGRLLYRKQQTGHVYRD-WQRP-FGYPTAMRERDALRAFESLGIRVP 92  Pseudomonas aeruginosa
P27294  11 NHWWATEGDWVEEPNYRRNGMSGVQCVe----RNGKKLYVKRMTHHLFHS-VRYP-FGRPTIVREVAVIKELERAGVIVP 84  Escherichia coli K-12
Q9CLD5  28 SSFWKKQARILGSAQGRGVTWFLQTKDlfgvnAALKHYYRGGLWGKINRDYYRFStLSNARSFAEFSLLKQLHEAGLAVP 107 Pasteurella multocida...
O86224  28 AEFWQKQERVIGSAKGRGITYFLQTEDwfgvnCALRHYYRGGLWGKLNKDRYRFSaLETTRSFAEFHLLQRLYEAGLPVP 107 Haemophilus influenza...
Q9PBJ1  39 PAWWGGRAHAVSEG-GRGSAWFVEASFg---nAVLRQYRRGGMIAMLNRDRYFWCgGHRTRSVLEFRLMRELISRGLPVP 114 Xylella fastidiosa 9a5c
Q8PBX3  39 pQRWGDRARPVDEG-GRGGAWFVDAPFg---hSVLRQYRRGGMAARVSRDQYLWKgAGRTRSFAEFRLMRELLKRKLPVP 114 Xanthomonas campestri...
Q8E8I7  32 VDFWREKSAVVGSSKGRYTTWFVAFEHs---hWVLRHYWRGGMMEKFSKDAYFYTgLENTRAMGELRLLDALYREQFAVP 108 Shewanella oneidensis
Q329M7  96 YGVAFGEKGMNPLt-RTSFIITEDLTPTISLEDYCADwatnppdVRVKRMLIKRVATMVRDMHAAGINHRDCYICHFLLH 174 Shigella dysenteriae ...
Q7MPR5 106 RPIAAYAMRKGLF--YQADLLSERIANAQDLVTILQK-------HSLNAELYQKIGVEIAKMHRVGVNHTDLNIHNILID 176 Vibrio vulnificus YJ016
Q9HUF7  94 TAVAYGERGSDPAr-QHSFIVTEELAPTVDLEVFSQDwrerpppPRLKRALVEAVARMVGDMHRAGVNHRDCYICHFLLH 172 Pseudomonas aeruginos...
Q9HUF8  96 QAAFFAQQAVGGE--RQAILLTRALDGWQDLDTWLASwhd--laEERRRAILRAVGRLARQLHAAGQMHGCFYPKHVFLR 171 Pseudomonas aeruginosa
Q9HW24  93 RLVYSGCRKVDGQ--WQALLVTEALEGFSSLDECYARgdqdrwgEAKHQRILQQIGATIARMNLAHWQHGCLYPKHIFVR 170 Pseudomonas aeruginosa
P27294  85 KIVFGEAVKIEGE--WRALLVTEDMAGFISIADWYAQhavspysDEVRQAMLKAVALAFKKMHSINRQHGCCYVRHIYVK 162 Escherichia coli K-12
Q9CLD5 108 KPLGACVEKVAFGf-YRADLLTEKIEHAQDLTVYLQQ-------GKLTEQDWHKVGQLIHQLHSLQVCHTDLNAHNILVQ 179 Pasteurella multocida...
O86224 108 KPIAARIQKGKLGicYQADILTEKIENAQDLTALLQT-------QTLPKETWMQIGRLIRKLHDLQICHTDLNAHNILLQ 180 Haemophilus influenza...
Q9PBJ1 115 TPLAACYVRYGVQ--YRAAILMERLEGVSSLAMCVR--------GNSKETHWEQIGRMISRFHREGLDHADLNAHNILLD 184 Xylella fastidiosa 9a5c
Q8PBX3 115 RPLAACYLREGLG--YRAALLMERLENVRSLADHAQ--------VAGRGAPWEDTGRLIARFHRAGLDHADLNAHNILFD 184 Xanthomonas campestri...
Q8E8I7 109 KPIAANIVRDGLF--YRADIIIERVDGAEDLVAKLTK-------GTMTQAQWHALGATIAQFHRRGVYHADLNAKNILWQ 179 Shewanella oneidensis
Q329M7 175 LPFsgkeeelKISVIDLHRAQLRTrvPRRWRDKDLIGLYFSSM-------NIGLTQRDIWRFMKVY 233 Shigella dysenteriae Sd197
Q7MPR5 177 AQE-------TIWIIDFDKCYPQA--GDGWKQENLDRLKRSFNker-vkrSIHWHDKDFQALLTGY 232 Vibrio vulnificus YJ016
Q9HUF7 173 TDKpvsaddfRLSVIDLHRAQTRDatPKRWRNKDLAALYFSAL-------DIGLTRRDKLRFLRTY 231 Pseudomonas aeruginosa PAO1
Q9HUF8 172 EGAdg---vfEACLIDLEKTRPIWf-GRRDQVKDLEPMLRR---------APDWSEADVHEFISAY 224 Pseudomonas aeruginosa
Q9HW24 171 VEge----aiEVALIDLEKSRRRLt-VNKASQHDLKQLKR----------RSSWTGAQWQAFIYGY 221 Pseudomonas aeruginosa
P27294 163 TEGn-----aEAGFLDLEKSRRRLr-RDKAINHDFRQLEKY---------LEPIPKADWEQVKAYY 213 Escherichia coli K-12
Q9CLD5 180 QRDdg----rKFWLIDFDKCAHQL--GERWKSENLNRLHRSFMkev-trmKIQFSEQDWQALLAGY 238 Pasteurella multocida subsp. multoc...
O86224 181 QTEqg----qKCWLLDFDKCGEKS--ADFWKVQNLNRLKRSFEkev-grmNIQFTEQNWADLTSAY 239 Haemophilus influenzae Rd KW20
Q9PBJ1 185 QAG-------QCWLIDFDRGALRIp-ATKWRERNLARLLRSLLkir-gerSVDAVYRDFERLRRAY 241 Xylella fastidiosa 9a5c
Q8PBX3 185 AGG-------HGWLIDFDRGVLRIp-ATRWRERNLARLHRSLLklr-gnrTREDVDKDYERLHRAY 241 Xanthomonas campestris pv. campestr...
Q8E8I7 180 PQQtds-aqeRFYLIDFDRGELKTp-NAKWQKANLDRLLRSFNkeqgkqpTLAFTPANWAALLEGY 243 Shewanella oneidensis
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