6DFL


Conserved Protein Domain Family
Kdo

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pfam06293: Kdo 
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Lipopolysaccharide kinase (Kdo/WaaP) family
These lipopolysaccharide kinases are related to protein kinases pfam00069. This family includes waaP (rfaP) gene product is required for the addition of phosphate to O-4 of the first heptose residue of the lipopolysaccharide (LPS) inner core region. It has previously been shown that WaaP is necessary for resistance to hydrophobic and polycationic antimicrobials in E. coli and that it is required for virulence in invasive strains of S. enterica.
Statistics
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PSSM-Id: 399356
View PSSM: pfam06293
Aligned: 11 rows
Threshold Bit Score: 221.474
Threshold Setting Gi: 23821766
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6DFL_A  21 AVEALQGKVYRELEGRRTLRTEVDGR-----GYFVKIHRGIGWGEIAKNLLTAK-LPVLGARQEWQAIRRLHEAGVATXT 94  Pseudomonas aeruginosa
Q7MPR5  30 QYWQAQNKVVGSATGRGTTWFVQLPKi---tAALRHYRRGGLFGKLVKDHYWFRsWSATRSFAEFHLLKQLREAGVNVPR 106 Vibrio vulnificus YJ016
Q329M7  23 EVKTLQGEVFRELETRRTLRFEMAGK-----SYFLKWHRGTTLKEIIKNLLSLR-MPVLGADREWNAIHRLRDVGVDTMY 96  Shigella dysenteriae ...
Q9HUF8  23 ALWALQLDAVDEPNTERGGWSSVYRLd----LGDSAYYLKRQSNHLTRS-LRHP-LGEPTFAREFRNIERYRALGIPALQ 96  Pseudomonas aeruginosa
Q9HW24  19 QWLQVPGSWVEEPNERRGGASGVQRVy---tGDGRLLYRKQQTGHVYRD-WQRP-FGYPTAMRERDALRAFESLGIRVPR 93  Pseudomonas aeruginosa
P27294  12 HWWATEGDWVEEPNYRRNGMSGVQCVe----RNGKKLYVKRMTHHLFHS-VRYP-FGRPTIVREVAVIKELERAGVIVPK 85  Escherichia coli K-12
Q9CLD5  29 SFWKKQARILGSAQGRGVTWFLQTKDlfgvnAALKHYYRGGLWGKINRDYYRFStLSNARSFAEFSLLKQLHEAGLAVPK 108 Pasteurella multocida...
O86224  29 EFWQKQERVIGSAKGRGITYFLQTEDwfgvnCALRHYYRGGLWGKLNKDRYRFSaLETTRSFAEFHLLQRLYEAGLPVPK 108 Haemophilus influenza...
Q9PBJ1  40 AWWGGRAHAVSEG-GRGSAWFVEASFg---nAVLRQYRRGGMIAMLNRDRYFWCgGHRTRSVLEFRLMRELISRGLPVPT 115 Xylella fastidiosa 9a5c
Q8PBX3  40 QRWGDRARPVDEG-GRGGAWFVDAPFg---hSVLRQYRRGGMAARVSRDQYLWKgAGRTRSFAEFRLMRELLKRKLPVPR 115 Xanthomonas campestri...
Q8E8I7  33 DFWREKSAVVGSSKGRYTTWFVAFEHs---hWVLRHYWRGGMMEKFSKDAYFYTgLENTRAMGELRLLDALYREQFAVPK 109 Shewanella oneidensis
6DFL_A  95 AVAYGERGSDPAr-QHSFIVTEELAPTVDLEVFSQDwrerpppPRLKRALVEAVARXVGDXHRAGVNHRDCYICHFLLHT 173 Pseudomonas aeruginosa
Q7MPR5 107 PIAAYAMRKGLF--YQADLLSERIANAQDLVTILQK-------HSLNAELYQKIGVEIAKMHRVGVNHTDLNIHNILIDA 177 Vibrio vulnificus YJ016
Q329M7  97 GVAFGEKGMNPLt-RTSFIITEDLTPTISLEDYCADwatnppdVRVKRMLIKRVATMVRDMHAAGINHRDCYICHFLLHL 175 Shigella dysenteriae ...
Q9HUF8  97 AAFFAQQAVGGE--RQAILLTRALDGWQDLDTWLASwhd--laEERRRAILRAVGRLARQLHAAGQMHGCFYPKHVFLRE 172 Pseudomonas aeruginosa
Q9HW24  94 LVYSGCRKVDGQ--WQALLVTEALEGFSSLDECYARgdqdrwgEAKHQRILQQIGATIARMNLAHWQHGCLYPKHIFVRV 171 Pseudomonas aeruginosa
P27294  86 IVFGEAVKIEGE--WRALLVTEDMAGFISIADWYAQhavspysDEVRQAMLKAVALAFKKMHSINRQHGCCYVRHIYVKT 163 Escherichia coli K-12
Q9CLD5 109 PLGACVEKVAFGf-YRADLLTEKIEHAQDLTVYLQQ-------GKLTEQDWHKVGQLIHQLHSLQVCHTDLNAHNILVQQ 180 Pasteurella multocida...
O86224 109 PIAARIQKGKLGicYQADILTEKIENAQDLTALLQT-------QTLPKETWMQIGRLIRKLHDLQICHTDLNAHNILLQQ 181 Haemophilus influenza...
Q9PBJ1 116 PLAACYVRYGVQ--YRAAILMERLEGVSSLAMCVR--------GNSKETHWEQIGRMISRFHREGLDHADLNAHNILLDQ 185 Xylella fastidiosa 9a5c
Q8PBX3 116 PLAACYLREGLG--YRAALLMERLENVRSLADHAQ--------VAGRGAPWEDTGRLIARFHRAGLDHADLNAHNILFDA 185 Xanthomonas campestri...
Q8E8I7 110 PIAANIVRDGLF--YRADIIIERVDGAEDLVAKLTK-------GTMTQAQWHALGATIAQFHRRGVYHADLNAKNILWQP 180 Shewanella oneidensis
6DFL_A 174 DKpvsaddfRLSVIDLHRAQTRDatPKRWRNKDLAALYFSAL-------DIGLTRRDKLRFLRTY 231 Pseudomonas aeruginosa
Q7MPR5 178 QE-------TIWIIDFDKCYPQA--GDGWKQENLDRLKRSFNker-vkrSIHWHDKDFQALLTGY 232 Vibrio vulnificus YJ016
Q329M7 176 PFsgkeeelKISVIDLHRAQLRTrvPRRWRDKDLIGLYFSSM-------NIGLTQRDIWRFMKVY 233 Shigella dysenteriae Sd197
Q9HUF8 173 GAdg---vfEACLIDLEKTRPIWf-GRRDQVKDLEPMLRR---------APDWSEADVHEFISAY 224 Pseudomonas aeruginosa
Q9HW24 172 Ege----aiEVALIDLEKSRRRLt-VNKASQHDLKQLKR----------RSSWTGAQWQAFIYGY 221 Pseudomonas aeruginosa
P27294 164 EGn-----aEAGFLDLEKSRRRLr-RDKAINHDFRQLEKY---------LEPIPKADWEQVKAYY 213 Escherichia coli K-12
Q9CLD5 181 RDdg----rKFWLIDFDKCAHQL--GERWKSENLNRLHRSFMkev-trmKIQFSEQDWQALLAGY 238 Pasteurella multocida subsp. multoci...
O86224 182 TEqg----qKCWLLDFDKCGEKS--ADFWKVQNLNRLKRSFEkev-grmNIQFTEQNWADLTSAY 239 Haemophilus influenzae Rd KW20
Q9PBJ1 186 AG-------QCWLIDFDRGALRIp-ATKWRERNLARLLRSLLkir-gerSVDAVYRDFERLRRAY 241 Xylella fastidiosa 9a5c
Q8PBX3 186 GG-------HGWLIDFDRGVLRIp-ATRWRERNLARLHRSLLklr-gnrTREDVDKDYERLHRAY 241 Xanthomonas campestris pv. campestri...
Q8E8I7 181 QQtds-aqeRFYLIDFDRGELKTp-NAKWQKANLDRLLRSFNkeqgkqpTLAFTPANWAALLEGY 243 Shewanella oneidensis
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