Conserved Protein Domain Family
DUF927

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pfam06048: DUF927 
Domain of unknown function (DUF927)
Family of bacterial proteins of unknown function. The C-terminal half of this family contains a P-loop motif. The N-terminal domain appears to have a unique fold, which contains three Helices and two strands. Structural analyses show that helicases containing this domain form a hexameric ring with a positively charged central pore threading a single DNA strand through suggestive of a replicative function for this helicase.
Statistics
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PSSM-Id: 336282
View PSSM: pfam06048
Aligned: 23 rows
Threshold Bit Score: 261.849
Threshold Setting Gi: 74531901
Created: 26-Mar-2017
Updated: 23-May-2017
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q01TT1       148 FSLD-----VDGTYECKVRRDLlggtaidtvLVAHAPLLISGRLEDI--E---TGTQALQIH-WRRPDGWH-ERTVDRAV 215  Candidatus Sol...
Q4K6S5       413 FRLT-----PEGVFYAGDDGEAr---------pVCSPLEIIARTRDE--K---GHNWGLLVE-FDDPDGAK-KRWNIPAR 471  Pseudomonas pr...
Q63YV7       369 FVVD-----DKGVWFHGFNNQGdpl----ppHWVSTRIDVIAETRNE--M---NSEWGYLLE-FTDRDGIL-KRWAVPAG 432  Burkholderia p...
Q5HK55        13 rykS-----KKGWYKDKPPKEKggm---pteVEIAGPIVIENKFIDP--K---TNTEKVIIT-----DEDQ-KEIVESSD 73   Staphylococcus...
Q5HK67        11 FKLK-----PSGWYKTIPPKKDggt---efeIMLSGPIAFTDRFIDP--A---TRKEKVFLS-----DLNN-IELVEKAS 71   Staphylococcus...
Q8TPL3         9 YEKN-----------------EegkteekpiVLAQRPVYITSKFKNFdkNvtlKEKEFLGIE-IHSKNGKIeELVVTPED 70   Methanosarcina...
Q8TNP8       114 FNLYpfrvsKNGIEVLNNNKDIed-----ydVISETPIVISATGVNL--D---DETFLYQCT-YRNVIGDYnTKWVLPSD 182  Methanosarcina...
WP_049753803 360 FRVS-----ENGIEMINYKTGIp-------qLICRTPILISNRLKSL--D---SYDEKIEITfYRD------KKWHRVTE 416  Alkaliphilus o...
WP_011784096   3 YQLR-----DSGLYCYSSEEWQ----------RVGGWIEVVARTRLSn-K---KHGHGALLQ-WKNMDNVL-LREVVYAR 61   Gammaproteobac...
WP_012330781 363 YAMN-----SGGLTVEVIKGRGeart--eetIWCAAPFEVIGRARDP--Q---GQGWARWLR-WRDPDGRR-HEYAVPDA 428  Methylobacteri...
Q01TT1       216 AL----DSRRIIELAGEGFPvFSNNA-----AGLTKYLEAVeaanySRLPRAHVSSHLGWQgrNGEHGFLAGRSLISGSG 286  Candidatus Sol...
Q4K6S5       472 TMtgdfGKDVLGPLVDMGLRlAGSRSgrnarNDLQSYLGGF-----DSAQRARLVTRLGWH----GNAFLLPEQQIGSHE 542  Pseudomonas pr...
Q63YV7       433 LFag-dGTELRRMLLDMGVK-LGVTQia--rTQIANYVQMA-----QPDERVRCVPRVGWH----HGAFVLPDRVIGTGK 499  Burkholderia p...
Q5HK55        74 IL----TTQKLPSLMKYGFSiNEKYT-----KDLGYALQQMr----NQLPISYLYEGVGILe-TPFGPIVSLSEIYTTKE 139  Staphylococcus...
Q5HK67        72 IL----TALQLPSLIEYGFTiNEKHI-----RDLGFVLQQMr----STTPLSTIYSGVGMLh-TLLGPLISLDQPYFSNE 137  Staphylococcus...
Q8TPL3        71 IFt--kGKKGLGGLYNKKLLhFEDKE-----KDLAKFFVSFydlneDILKESVFADKNGWN--ADFTQFVFGNRVYFEGG 141  Methanosarcina...
Q8TNP8       183 ILss-----dIKKLANLGLHiNSNDS-----KYLLTYFKKMvk-yvRWMPKEYTALRTGWK--KDCAIFIIGNNSYSADG 249  Methanosarcina...
WP_049753803 417 QRsvifQARTIIKLADVGVTvTSENA-----KFLVKFLEKLeaenfDMIQTLQSVDQLGWH----NDNFLPGREGE---- 483  Alkaliphilus o...
WP_011784096  62 NLngdnARQIRELLVDTGYP-LEPGNis--wTRLQRYLLEEm----AKAPPATTVDRSGWH----GPIFATSSWTAGQAD 130  Gammaproteobac...
WP_012330781 429 ALhg-dAGALAAELASRGLT-VSRNGr----GHLCDYLNQV-----RVSARVTVVPRTGWHvvGDQQVFVLPDQVLGQPT 497  Methylobacteri...
Q01TT1       287 EViQTQqkldMNSGVIppgavafrgltpgdeqiVDGWHARGSHDEWCR-AAHLVRDRPRVMAGL---YGALVPPLL---A 359  Candidatus Sol...
Q4K6S5       543 EH-LHF----YEAGAQ-----------------LPPISEAGSLEQWQQqIGALCVGNHRLAFVV---SVAFAGPLL---N 594  Pseudomonas pr...
Q63YV7       500 EA-LIY----QADTPI-----------------QSQFKERGTLDDWQReVAAYCVGNSRLLFCV---ATAFAGPLL---H 551  Burkholderia p...
Q5HK55       140 FDnKSPsdaiCDNAYD--------------------LTPKGTFDNWFNmYLKEVKGSLLLELAVvfgISALVTSFLkhkH 199  Staphylococcus...
Q5HK67       138 ITnSTSi--iCDNKYD--------------------LIPKGNLSEWLQmYKEEVHGNLSLELDVlfgVSSLVTAFLkyhN 195  Staphylococcus...
Q8TPL3       142 FKdIHI----PEKFKNd---------------vTKGISSKGDIKEFERlTQKLFNTKAYRHLSY----IAILSLVL---R 195  Methanosarcina...
Q8TNP8       250 KRdIIP----IDEVMG------------------EMYTQKGNRDEWIKiIAPMLDYDITRIKCY----SVVAAMIL---K 300  Methanosarcina...
WP_049753803 484 ---LVIdvdtNERKWI------------------NAYRKIGTLDSWIKyMKDF-RHNTIFRFIL---ASSFAAPLL---K 535  Alkaliphilus o...
WP_011784096 131 EQhHFV----GQLSTS------------------PLLQESGSLQDWQNqVGKLCGGNPLAILSV---GVALAAPLL---K 182  Gammaproteobac...
WP_012330781 498 NEtVVL----VGAAAA-------------------PYSARGTLDGWRRgVGQLSAGHGRLVLAI---ATALAGSLV---H 548  Methylobacteri...
Q01TT1       360 ILRCPNFIMDWAHRTSVGKTTTLRLAASVWGNPNedavdTILRSWDSTQVYIERAASIISGLPLILDETKRVKDPGl-VA 438  Candidatus Sol...
Q4K6S5       595 LLGHESGGFHFYGDSSGGKTTHLQVAASVYGGPR------LVRSWRSTDNALESIAAAHSDGLLVLDEIGMCDARI--IG 666  Pseudomonas pr...
Q63YV7       552 FSGLQSGGFHLLGTTSKGKSTGGVIAASVFGSPD------YVRSWKATDNALEAVATQHSDALLILDEIGQVEPRL--VG 623  Burkholderia p...
Q5HK55       200 ETEFAGIIFSFTGQSSTGKSTAASLAVSVAGNPTkg-neTLFRNWNATRNALEGYLSNNFGIPIVFDELSSATFRD--TT 276  Staphylococcus...
Q5HK67       196 NVEFSGTIFSFTGQSSTGKSTAAMLAASVAGNPTkg-teNLFRSWNATRNALEGYLSGNYGVPIVLDELSAATFHD--TT 272  Staphylococcus...
Q8TPL3       196 IIGAESILINIYSQTTVGKTLICRLVMSQYGFAPekgnnGLVHAAAGSKSGFESLLYGYNDRPVYFDESKSEDKEEknSA 275  Methanosarcina...
Q8TNP8       301 IIDAPSFILHQYFESSGSKTLTTKIALSLIGNPE-----LLCRSANSTDIGIEQTAIQNTDVVLAFDETTRNPQ----FR 371  Methanosarcina...
WP_049753803 536 LLNHRIFFVHNWGDSRSGKTAALKAALTVWGNPE-----ELMTSFNATNVGLERLACFFNDLPLGIDERQVAGGKQeyIE 610  Alkaliphilus o...
WP_011784096 183 HAELENGAFHLVGNSSTGKTTLLQVAASVCGAPT------FVRNWVATANGLAAVAAEHNDMLLALDEIGLARPED--VD 254  Gammaproteobac...
WP_012330781 549 LVGGEGGGLNLYGQSSKGKTTTLRAAASVWGRGSad--pGFIRSWRATANAQEATAAIVTDTLLCLDEIGVAEGRD--AA 624  Methylobacteri...
Q01TT1       439 KI-MYEVANGQGRGRGNVRSTAylRTWRT 466  Candidatus Solibacter usitatus Ellin6076
Q4K6S5       667 ET-VYMLGNGTGKARANDRGQAg-RQVQE 693  Pseudomonas protegens Pf-5
Q63YV7       624 DV-IYMLANESGKARASRSGSA--KPvlt 649  Burkholderia pseudomallei
Q5HK55       277 GL-LYSITEGQGRQRSNVHGEV--KTPKN 302  Staphylococcus epidermidis RP62A
Q5HK67       273 GL-LYSFAEGQGRQRANINGDV--KTPKN 298  Staphylococcus epidermidis RP62A
Q8TPL3       276 GLsIYDIVNGLSRILSNQDNTV--KNSRD 302  Methanosarcina acetivorans
Q8TNP8       372 QN-VYNLVNGVSRNRGTIKNNEv-RAANV 398  Methanosarcina acetivorans
WP_049753803 611 TL-VYMLAMGYSKVRGAKTGGL--QSQKS 636  Alkaliphilus oremlandii
WP_011784096 255 VA-TYHIMTGASKLRANISGDL--AEQTH 280  Gammaproteobacteria
WP_012330781 625 AA-VYQLASGVGKGRAARDGHI--RSPMT 650  Methylobacterium sp. 4-46
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