3EBQ


Conserved Protein Domain Family
Peptidase_C97

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pfam05903: Peptidase_C97 
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PPPDE putative peptidase domain
The PPPDE superfamily (after Permuted Papain fold Peptidases of DsRNA viruses and Eukaryotes), consists of predicted thiol peptidases with a circularly permuted papain-like fold. The inference of the likely DUB function of the PPPDE superfamily proteins is based on the fusions of the catalytic domain to Ub-binding PUG (PUB)/UBA domains and a novel alpha-helical Ub-associated domain (the PUL domain, after PLAP, Ufd3p and Lub1p).
Statistics
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PSSM-Id: 336235
View PSSM: pfam05903
Aligned: 31 rows
Threshold Bit Score: 81.9607
Threshold Setting Gi: 56755846
Created: 24-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3EBQ_A          9 YPVKLYVYDLS---KGLARRL-------------SPIMLGKQLEGI--WHTSIVVHKD-EFFFg----------sGGIS- 58   human
O56042       1040 HSYATISYDYVlpkTGGNRRVlcfagvgdpnpynLP--TGDKNVGIgsYMVEFDIIGL-DKDTgvkvmrpvpwkqCGYTe 1116 Rice ragged s...
Q8LN31          2 KEVVLHVYDVTnsdSEKTNNTilqi------nriFKDRIG--LGGI--FHSAVQVYGEeEWSFgfc------engSGVF- 64   Japanese rice
Q9SZZ4          2 AEVVLHIYDVTnsgSEKTNNTivqi------nrfFKDGIG--LGGI--FHSAIQVYGNdEWSYgyc------eqgTGVF- 64   thale cress
Q7SF35         22 TEILINVYDLL---PPGRISS-------------TLWFLG--T-SL--LHSGVVINGR-EYAYgght----hrgkTGVY- 74   Neurospora cr...
Q8X1T0          1 MKVYINVYDLMpdsPVNK----------------LAWTLGL---GI--YHTGLVLEGK-EYAFgahe----ipgsTGVF- 53   Schizosacchar...
O49393         17 VPVYLNVYDLTpmnV-------------------YGYWLGI---GI--YHSGLEVHGV-EYGYgahe-----kssSGIF- 65   thale cress
Q6NQ19         18 VPVYLNVYDLTpinG-------------------YAYWLGL---GI--YHSGVEVHGV-EYGFgahd-----hstTGIF- 66   thale cress
Q8LA90         15 VPVYLNVYDLTpinG-------------------YAYWLGL---GV--YHSGVEVHGI-EYAYgahe-----ypsTGIF- 63   thale cress
XP_001347354   44 NMVYLNIYDLDsvsKVVNTVA-------------RSVGAGA-------FHAGVEVYGY-EYSFgyim-----dgeTGVT- 96   Plasmodium fa...
3EBQ_A         59 -----------------SCPPGGt----LLG-PPDSVV-----DVGSTEVTEEIFLEYLSSLGESlFRGEAYNLFEHNCN 111  human
O56042       1117 eqvwsiyktlgkeyrkvELKPYTvedawRVIaKSSHKRvlsdkAIISTPISYERQRAIEYMLSS---HGFDYNLVLNNCQ 1193 Rice ragged s...
Q8LN31         65 -----------------SCPIGK-----NPMyTYRECI-----VLGETECSIATVNRILRELSRE-WPGHSYDLLSRNCN 116  Japanese rice
Q9SZZ4         65 -----------------SCPSGK-----NPMyTYREKI-----VLGKTDCTIFMVNQILRELSRE-WPGHTYDLLSKNCN 116  thale cress
Q7SF35         75 -----------------WTAPRTe----PPGgTFRCEL-----LHGFTLATPAEIDAIIREASEE-FLGTAYNLLTKNCN 127  Neurospora cr...
Q8X1T0         54 -----------------ATMPRPp----LEGcRWRCSI-----ALPNCTLPKPDVDRILIRLSQE-FTGLSYSLLERNCN 106  Schizosacchar...
O49393         66 -----------------EVEPKK-----CPGfTFRKSI-----LVGETEMKAKEVRSFMEKLSEE-YQGNKYHLITRNCN 117  thale cress
Q6NQ19         67 -----------------EVEPKQ-----CPGfTFRKSI-----LIGRTDLDPENVRVFMEKLAEE-YSGNSYHLITKNCN 118  thale cress
Q8LA90         64 -----------------EGEPKQ-----CEGfTFRKSI-----LIGKTDLGPLEVRATMEQLADN-YKGSSYNLITKNCN 115  thale cress
XP_001347354   97 -----------------KTNARY-----HPYhVYRETI-----PMGKTPLTKEEVDLLVEVMKLQ-WIGDTYDILSRNCL 148  Plasmodium fa...
3EBQ_A        112 TFSNEVAQFLTGRKIPSYITDLPSEVLSTPFgqalRPLLD 151  human
O56042       1194 DFTRGLFDYARGGPVPDFIENDVRIAMIHSTsr---hfAE 1230 Rice ragged stunt virus (isolate Thailand)
Q8LN31        117 HFCDVLCERLAVPKLPGWVNRFANAGDTAVVvaenTAVKF 156  Japanese rice
Q9SZZ4        117 HFCDVLCDRLGVPKIPGWVNRFAHAGDTALEvagnTAMRV 156  thale cress
Q7SF35        128 HFTSHLCQKLTGLPGPAWLNRAASIGV---AlpcmVPKDW 164  Neurospora crassa
Q8X1T0        107 HFTNAAAIELTGSPIPSFLNRISRIGLAFPTi---TNALL 143  Schizosaccharomyces pombe 972h-
O49393        118 HFCNHVSLKLTHKSIPSWVNRLARLGF---LcncvLPACL 154  thale cress
Q6NQ19        119 HFCNDVCVQLTRRSIPSWVNRLARFGL---FcncvLPAEL 155  thale cress
Q8LA90        116 HFCDETCIKLTGNPIPSWVNRLARIGF---McncvLPATI 152  thale cress
XP_001347354  149 NYADYFCNLLDVGGIPEWVMSLQKKVT---WvksnINIAa 185  Plasmodium falciparum 3D7
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