5CVD


Conserved Protein Domain Family
Methyltransf_PK

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pfam05891: Methyltransf_PK 
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AdoMet dependent proline di-methyltransferase
This protein is expressed in the tail neuron PVT and in uterine cells in C. elegans [worm-base]. In Saccharomyces cerevisiae this is AdoMet dependent proline di-methyltransferase. This enzyme catalyzes the di-methylation of ribosomal proteins Rpl12 and Rps25 at N-terminal proline residues. The methyltransferases described here specifically recognize the N-terminal X-Pro-Lys sequence motif, and they may account for nearly all previously described eukaryotic protein N-terminal methylation reactions. A number of other yeast and human proteins also share the recognition motif and may be similarly modified. As with other methyltransferases, this family carries the characteristic GxGxG motif.
Statistics
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Aligned: 8 rows
Threshold Bit Score: 321.629
Threshold Setting Gi: 28922558
Created: 5-May-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5CVD_A    28 DEKQFYSKAKTYWKQIPPTVDGMLGGY----G---HISSIDINSSRKFLQRFLREg----pNKTGTSCALDCGAGIGRIT 96  human
O13748     2 DPEKFYSDAIDYWNGVQPTVDGMLGGL----Gt-gRIPQTDVVGSRTFLNRLNYRi-----GKIENLVAADCGAGIGRVT 71  Schizosaccharomyces...
EAA31785  18 DASISKEHGLAYWESVSADENGMLGGIptfaGf-aNTSKIDLQGSRNFLAKFGIGsk---pGLRRCKRILEGGAGVGRIT 93  Neurospora crassa O...
Q5PP70    31 KKTQWYRDGVSYWEGVEASVDGVLGGY----G---HVNDADIIGSEVFLKTLLQErlvnnvGANQHLVALDCGSGIGRIT 103 thale cress
Q10CT5    61 KREEWYSKAIAYWQGVEASTEGVLGGY----G---CVNDVDVKGSDAFLRPLLAErf---gAARRHLVALDCGSGIGRVT 130 Japanese rice
Q8R2U4     8 DEKQFYSKAKTYWKQIPPTVDGMLGGY----G---HISNIDLNSSRKFLQRFLREg----pNKTGTSCALDCGAGIGRIT 76  house mouse
Q9N4D9    11 NGEDVYEKAEEYWSRASQDVNGMLGGF----E---ALHAPDISASKRFIEGLKKKn-----lFGYFDYALDCGAGIGRVT 78  Caenorhabditis elegans
P38340     6 DSHIKYEDAIDYWTDVDATVDGVLGGY----GegtVVPTMDVLGSNNFLRKLKSRml---pQENNVKYAVDIGAGIGRVS 78  Saccharomyces cerev...
5CVD_A    97 KRLLLPLF-----------REVDMVDITEDFLVQAKTYLGee------gkRVRNYFCCGLQDFTPE----PDSYDVIWIQ 155 human
O13748    72 ENVLLKIA-----------SHVDLVEPVENFISTAKKQLAt---------KPCSFINVGLQNWTPE----KNRYGLIWNQ 127 Schizosaccharomyces...
EAA31785  94 EGLLTDLLvvdeneggkgpGKVDVVEPIAKFTAKLQgk-----------kGVGKVYVMGLEEWVPEvgegENKYDLVWTQ 162 Neurospora crassa O...
Q5PP70   104 KNLLIRYF-----------NEVDLLEPVAQFLDAARENLAsags---ethKATNFFCVPLQEFTPA----AGRYDVIWVQ 165 thale cress
Q10CT5   131 KNFLLRHF-----------NEVDLVEPVSHFLEAAQENLTecmevgedthKAANFYCVPLQDFTPD----EGRYDVIWIQ 195 Japanese rice
Q8R2U4    77 KRLLLPLF-----------RVVDMVDVTEDFLAKAKTYLGee------gkRVRNYFCCGLQDFSPE----PGSYDVIWIQ 135 house mouse
Q9N4D9    79 KHLLMPFF-----------SKVDMEDVVEELITKSDQYIGkh-------pRIGDKFVEGLQTFAPP----ERRYDLIWIQ 136 Caenorhabditis elegans
P38340    79 KTMLHKHA-----------AKIDLVEPVKPFIEQMHVELAelk----dkgQIGQIYEVGMQDWTPD----AGKYWLIWCQ 139 Saccharomyces cerev...
5CVD_A   156 WVIGHLTDQHLAEFLRRCKGSLRPNGIIVIKDNMAQEGv-ILDDVDSSVCRDLDVVRRIICSAGLSLLAEERQENLPD-- 232 human
O13748   128 WCLSHLTDEDLIAYLSRCCEAIQEKGVICVKENVSSFEd-TFDPIDSSVTRCEQSLKSLFKKANLVVVAETLQHGFPE-- 204 Schizosaccharomyces...
EAA31785 163 WCVGHLTDEQLVAYLQRCKSALAEDGLIVIKENTTVLGndEFDKEDSSVTRGEATFQKVFQKAGLKVVKAEFQKGFPQtr 242 Neurospora crassa O...
Q5PP70   166 WCIGHLTDNDFVSFFNRAKGYLKPGGFFVVKENLAKNGf-VLDKEDHSITRSDPYFKQLFRQCGLHLYRTKDQKGLPQ-- 242 thale cress
Q10CT5   196 WCIGQLPDDDFISFFNRAKIGLKPNGFFVLKENIARNGf-VLDKEDNSITRSDAYFKELFKKCGLYIHSIKDQSDLPK-- 272 Japanese rice
Q8R2U4   136 WVIGHLTDQHLAEFLRRCKRGLRPNGIIVIKDNMAQEGv-ILDDVDSSVCRDLEVVRRIIRTAGLSLLAEERQENLPD-- 212 house mouse
Q9N4D9   137 WVSGHLVDEDLVDFFKRCAKGLKPGGCIVLKDNVTNHEkrLFDDDDHSWTRTEPELLKAFADSQLDMVSKALQTGFPK-- 214 Caenorhabditis elegans
P38340   140 WCVGHLPDAELVAFLKRCIVGLQPNGTIVVKENNTPTDtdDFDETDSSVTRSDAKFRQIFEEAGLKLIASERQRGLPR-- 217 Saccharomyces cerev...
5CVD_A   233 --EIYHVYSFALR 243 human
O13748   205 --ELFPVKMYALV 215 Schizosaccharomyces pombe 972h-
EAA31785 243 tmKLLPVRMYALK 255 Neurospora crassa OR74A
Q5PP70   243 --ELFAVKMYALT 253 thale cress
Q10CT5   273 --ELFAVKMYALV 283 Japanese rice
Q8R2U4   213 --EIYHVYSFALR 223 house mouse
Q9N4D9   215 --EIYPVKMYALK 225 Caenorhabditis elegans
P38340   218 --ELYPVRMYALK 228 Saccharomyces cerevisiae S288C
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