Conserved Protein Domain Family
Terminase_GpA

?
pfam05876: Terminase_GpA 
Phage terminase large subunit (GpA)
This family consists of several phage terminase large subunit proteins as well as related sequences from several bacterial species. The DNA packaging enzyme of bacteriophage lambda, terminase, is a heteromultimer composed of a small subunit, gpNu1, and a large subunit, gpA, products of the Nu1 and A genes, respectively. Terminase is involved in the site-specific binding and cutting of the DNA in the initial stages of packaging. It is now known that gpA is actively involved in late stages of packaging, including DNA translocation, and that this enzyme contains separate functional domains for its early and late packaging activities.
Statistics
?
PSSM-Id: 310457
View PSSM: pfam05876
Aligned: 27 rows
Threshold Bit Score: 527.26
Threshold Setting Gi: 123589895
Created: 19-Jul-2016
Updated: 4-Aug-2016
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Q141S6        37 H-LSNQ--GGGYVGRW-------HHEKAPYLVGPMETLTRLD-YLTTVVVGPGQSGKTE-IAQNWLLKSVANDPADMLWY 104 Paraburkholderi...
Q5FNH9        44 I-LDNR--GGGFVGRW-------SHDEAPYLVGPMEALTEQQ-YLTTAVVGPARSGKTT-IGQNWLLQSVDVDPADFLVY 111 Gluconobacter o...
Q3IVP6        47 aerhmrvpvqGNWVPF-------DRAVTPYTVEPADMTQSRR-FKAVVFLGPSQSGKSQ-MMQSVSAHAVTCAPGPVQVI 117 Rhodobacter sph...
Q8ZQH1        36 M-FVPR--GANTAVPW-------DDTLTPYMNEAINTLSKRE-YDAVIFAGPARTGKTLgLIDGWIVYGIVCDPADMLVV 104 Salmonella ente...
Q8ZQ96        46 M-RVPR--DAGNSVAW-------ESTLTPYVVEAMNCLSSRS-YDAVVFVAPARTGKTLgLIDGWISYNIVCDPSDMLVV 114 Salmonella ente...
Q9PFZ8        41 Y-RKIArgSGAEPGQW-------RTDRHPPLREIMNCLSDHTpVQQVSFMKSGQIGATE-IGINWVCYVIDRGIDSMIVT 111 Xylella fastidiosa
ABQ68552       8 I-IRPK--ASLTVSQWaiehlgyDPETLPWQMEIMDALGDPE-VAEVGLMGPAQAGKSE-IGLAWLGWSIEHDPAGFMIC 82  Sphingomonas wi...
WP_012091779  33 VrLPAD--VSAMRGPI---------RLYPFQRGMADAMSDSK-IERITVVKSARIGYTT-LLVGLLGSHVVNEPAPVLFV 99  Ochrobactrum an...
WP_012006464  39 Y-LPKE--SSYQEGRW---------ETMPFQVAIMNAMGSDD-IREVNLIKSARVGYSK-MLLAVVAYFIQHKQRNGLLW 104 Serratia protea...
WP_012206486  41 L-LAGE--SSHQKGGW-------VA--WPFQIGILDFMSDDR-IEELAVKKSKRVGYSK-MITAFVCYNIAHRRRKQALW 106 Delftia acidovo...
Q141S6       105 MQTDPGLESYVKSRINPMIDSHPEMAMRLGS----RPIDDSLHFKRFD--GMRVEFLSAAPNNVINKSAPRIVADEVDAY 178 Paraburkholderi...
Q5FNH9       112 AQTDDVIESYVKREIAPMIDAHPSMKEKLGT----RPVDNSLKFKRFR--SMWIEFLAAAYNNLINKSAPRIIMTEIDAY 185 Gluconobacter o...
Q3IVP6       118 HMTKTDADAWVEEKLDPTILNSPALRERLGT----GRDDSTFSRKRFK--GMRLTIGYPVPNQLSSRSQRLVMLTDYDHM 191 Rhodobacter sph...
Q8ZQH1       105 QMTETKAREHSKTRLARTFHHSPEVRKRLSP----SRNDNNVHDKMFRd-GSFLKIGWPSITVFSSSDYKRVALTDYDRF 179 Salmonella ente...
Q8ZQ96       115 QMTQDKAQEHSKRRLAKMFRHSPAIARRLSP----HRNDNNVHDKTFRd-GSFLKIGWPSINVFSSSDFKCVALTDYDRF 189 Salmonella ente...
Q9PFZ8       112 QPVKDLARTWTVAKFDPGVLDMPPLLNKLTT--------NNTFEKQYPg-GTLFVKWANSSSQLRQITACYAFLDEIDEY 182 Xylella fastidiosa
ABQ68552      83 QPSKVLTQDFVVRRVAPMIKSTSALRGQLLs----EVGADNMFLKQFR--AMLLTSIWPTAENFRARPVPRGWVDDYDAI 156 Sphingomonas wi...
WP_012091779 100 LPTEDDCRTFVVSNVEPTFEASPCLANALASdk-gSEKRNTLLSRRFPg-GSLKVIAAKAPRNLRAHNARILIMDETDGM 177 Ochrobactrum an...
WP_012006464 105 QPTDGDAENFMKSHVEPTIRDVPSLL-AMAPwygkKHRDNTLSMKRFSngRGFWCLGGKAAKNYREKSVDYVGYDELAAF 183 Serratia protea...
WP_012206486 107 QPTDDDRDSFVKTEIEPLLDSKDGVPSVIAArkqgSRVEETIKYKPFRd-SVLHLLGGKAARAYRRITVAVAILDEWTAF 185 Delftia acidovo...
Q141S6       179 DKAL--------GDVKTLLDVRRQTFQRQSMLLAMSHPDRARglvp-----------drdwSEGIMAMYGDSDRR-IWYW 238 Paraburkholderi...
Q5FNH9       186 PANL--------GDAYALASIRRETFGQESMVLAESHPDAALgsdp------------skwTNGIMKLYRDSDRR-IWWW 244 Gluconobacter o...
Q3IVP6       192 PQKLgpkd-speGSPFGMALQRIRTFMSRGCVLAETSPAFPVdpnadwaphaghphmlppaTAGLVPIYNEGTRG-RWYW 269 Rhodobacter sph...
Q8ZQH1       180 PENIdg-----eGDGFSLASKRTTTFMSAGMTLAESSPGREItdvkwrrs----spheappTTGILSLYNRGDRR-RWYW 249 Salmonella ente...
Q8ZQ96       190 PEDVdg-----eGDAFSLASKRTTTFMSLGMTLVESSPGREItdtrwkps----spheappTTGILSLYNRGDRR-RWYW 259 Salmonella ente...
Q9PFZ8       183 PRNLnn-----qGTADQQIAARIMSHGERGKIYRACTPTVAG-------------------GSAIEASFLDGDQR-HYHI 237 Xylella fastidiosa
ABQ68552     157 DANIeg-----kGSAVSLMDDRAATFEGRDTKFISSSPADEK-------------------GGKIEAFVKGGTHE-RLMP 211 Sphingomonas wi...
WP_012091779 178 --EMtk-----eGSPIPIAERRTMSF-PDRKIIIGSTPIYED-------------------SSHVLSAYERSDKR-IYEV 229 Ochrobactrum an...
WP_012006464 184 DEDVek-----eGSPTFLGDKRIEGS-VWPKSIRGSTPKIRG-------------------ICQIERAASESGHLmRFHV 238 Serratia protea...
WP_012206486 186 DQTIggskdksaGSPGTLAKGRLEGA-PYPKFIGGSTPGIKG-------------------LCHVSRACEDSDDEvDYLI 245 Delftia acidovo...
Q141S6       239 PCPHCGAWSSpvpiAArYMA------LHYdekqT----LDEIERNTRLICPVNGCLIEDRERRAmn-vAafr--spfGG- 304 Paraburkholderi...
Q5FNH9       245 PCPHCNGFSSpnptASvPMT------LHWnadaP----LDEIRDSAALLCPHCGTLIEDKWRRAmn-rD--------GI- 304 Gluconobacter o...
Q3IVP6       270 ECPDCGDLFE----PR-FDR------LHYdadlD----PGAAGEQAMMECPHCGTLIAHRHKVGlnraAle----grGG- 329 Rhodobacter sph...
Q8ZQH1       250 PCPHCGDWFQpameNM----------VGYrdnpD----LMAASEAARIQCPHCRALIQPEQKRGln-nR--------GV- 305 Salmonella ente...
Q8ZQ96       260 PCPHCGEYFQpsmaNM----------TGYrhiaD----PMEASEAARIQCPHCHKLTEPQQKREln-nR--------GV- 315 Salmonella ente...
Q9PFZ8       238 HCPHCGSEQI----LD-LEH---------------------LQPDGTFACAVNGCIIQEHHKNT----Ilk----erGTg 283 Xylella fastidiosa
ABQ68552     212 PCPHCEERIE----ID-LRRd-----LRF----DdsgsADLAEQTAHVVCSKNGCIIEPHHKRT----MidamarlpGRg 273 Sphingomonas wi...
WP_012091779 230 PCPECGDFHE----IE-WKD------IHW----P----EG-EPEKAHWACPGCGSVVEERYKGS----Mva-----aGR- 279 Ochrobactrum an...
WP_012006464 239 KCPHCDEEQF----LK-FGDretpygFKW----E----SG-KPKTVFYLCEHNACVIRQQELNFs-----------gAR- 292 Serratia protea...
WP_012206486 246 ECPRCEAEHP----LT-WGGkevmhgFKW----E----AG-KPETVRHMCPHCRESISQAEYLP----Ggwp---ltGA- 303 Delftia acidovo...
Q141S6       305 ----WIGDGQeisqdg------ivtgeLVARKSAGFWIVGAMSPFi-lGGIGGLARAKVKAEreLEVSGEDMALRQVTVK 373 Paraburkholderi...
Q5FNH9       305 ----WVGRGQdisqdg------evsgdLVASTTAGFWITGLMSPFi-iGGMGSLAYDMVKAQrdFETTGDDKDLRAVTVK 373 Gluconobacter o...
Q3IVP6       330 ----WLHEGRhieangrralvriddpdIRRTPIASYSLNGAAAAF---ASWEELVQRYETERrrFEALGDDTDFARVHYT 402 Rhodobacter sph...
Q8ZQH1       306 ----WLKEGQfinkdg------eisgeARRSRIASFWMEGPAAAY---QTWQQLVYKLLTAEeeYERTGSEETLKAVINT 372 Salmonella ente...
Q8ZQ96       316 ----WLREGQhidrdg------nitgeARRSRIASFWMEGPAAAY---QTWAQLVYKLLTAEeeYERTGSEETLKAVINT 382 Salmonella ente...
Q9PFZ8       284 gtafWHPHNP-----------------SAPPDHRSYYLWAAYAPLglgLSWKQIADKWAEA------KRDPSKLPGFTNL 340 Xylella fastidiosa
ABQ68552     274 ----FVVTNL-----------------DAGRRRRTFSADGLLC-F---RSWGRLARQWREAQieWETLQSEAGLVGFFNG 328 Sphingomonas wi...
WP_012091779 280 ----WRITAP------------------EVKGHAGFRINSLVSPLe-nAAWGILAKEFLAA------KDDPALLQTFINL 330 Ochrobactrum an...
WP_012006464 293 ----YICENTglytsdglrwfestgqeVDPPESVSFHIWTAYSSF---TTWAQIVKDFRKT------KGDPGKLKTFTNT 359 Serratia protea...
WP_012206486 304 ----WVCRRSgrrfgadriwrtadgtpCRPPRTLGVHLWAAYSPQ---RTWASIVDEFEKAHr-ALQEGDAGPMTSFTNE 375 Delftia acidovo...
Q141S6       374 QLGFPYaAT--RgVG---SI-DANVLAERADsE-LKLGVVPEGVRFLVTGVDCQ-LA--HFEWLTRGFGIDGESWVIDKG 443 Paraburkholderi...
Q5FNH9       374 RWGLPYqPP--RaAG---SL-DSQAIANRAEpG-LRLGFVPEGVRFLTAAVDVQ-AN--RFEFMVRGWGVDGESWIIDYQ 443 Gluconobacter o...
Q3IVP6       403 DIGVPYrRP--E-AEeegAL-TAAQIREHMR-S-QERRVAPAWTRFVTVSIDVQ-GN--RFEVLVMAWGAQGERMPIDRF 473 Rhodobacter sph...
Q8ZQH1       373 DWGLPY-LP--RiSLd--QR-KAETLIARAE-K-LPPRRVPDGVRFLVATVDVQgGKkrRFVVQVVGYGSHGERWIVDRF 444 Salmonella ente...
Q8ZQ96       383 DWGLPY-QS--RrSLe--AR-SGDALMARAE-D-VSKRTVSDGVRFIVATVDVQgGKkrRFVVQVVGYGAYGERWIIDRY 454 Salmonella ente...
Q9PFZ8       341 ILGLPF-QG--E-RD---AR-NAHEVATLAEpG-VYRGLVPRGGLVLAAGVDLA-HD--RAEVHLIATGRGQRRYIVDYA 408 Xylella fastidiosa
ABQ68552     329 KAGYNY-RSilS-GE---PPiEIKTLAARRR-KgWKLGTVPAGVKVIVITVDVQ-AN--RFECAAVGYGDGLECWVIDRW 399 Sphingomonas wi...
WP_012091779 331 VLGQGW-RE--S-GE---EM-DDSELASRVE-A-ISLDMLPESVLALTAGVDTQ-RD--RLEVTIIGWTRDGEAMILDHK 397 Ochrobactrum an...
WP_012006464 360 TLGETW-AE--EvGE---RP-LPETLVELAE-H-Y-RAEVPDRVVYLTAGIDSQ-LD--RYEMRVWGWAPGEEAFLIDRV 426 Serratia protea...
WP_012206486 376 TLGQAW-EL--K-GE---GT-DDHVLQARAE-P-YALGTVPVGGLVLAAGVDVQ-RT--WWQINVWAWGRGMESWIVDRH 442 Delftia acidovo...
Q141S6       444 RIPG------------------DPATS-AedWDQII-NLIKRTYPLAdGSG--RaMPVRALGFDSYGqpGVTQQ-AYAAW 500 Paraburkholderi...
Q5FNH9       444 KVTA------------------DPATS-QkdWDDLLtSLEDARYPLAdGSS--RaMKILAVGYDSGGqdGVTLQ-AYGAW 501 Gluconobacter o...
Q3IVP6       474 AVAQppdhaprakgdderyralDPGRY-Ve-DADALlDLPERLYPVEgASW--S-LKPCALVIDFNGpaGWSDN-AEKFW 547 Rhodobacter sph...
Q8ZQH1       445 NITRslrcdes-----geamqiNPGAY-PedWHLLItDVLERAWPLVgHPE--QeMSVLCMGVDSGGedGVTDN-AYAFW 515 Salmonella ente...
Q8ZQ96       455 NIRYslrvned-----gesqpvNPAAR-PedWDLLKtDVLEKTYPLAaDPE--QfMPVLAMAVDSGGedGVTDN-AYAFW 525 Salmonella ente...
Q9PFZ8       409 VIDL------------------DPTVL-E--SYADLdAYLRGTWKTA-SGI--D-MPISAVAIDGG---NWTET-VAQFV 459 Xylella fastidiosa
ABQ68552     400 TIETladg----------ltsvQPLRYrE--HWAALlPLFSRDWPLA-DGSgqA-AQALTVAIDARG--GESDL-VTGFW 462 Sphingomonas wi...
WP_012091779 398 VIWG------------------LPDDD-A--TWTEIdAVLKMRFDHP-LGG--K-LGLDAVAIDSSD--GETMEnVYSFC 450 Ochrobactrum an...
WP_012006464 427 IIMG------------------RHDEE-E--TLLRVdEAINKQYQLA-DGT--I-MTIGRVCWDTGG--IDQTI-VYNRS 478 Serratia protea...
WP_012206486 443 IIEG------------------NPSSE-G--DWAPVtAYLQRRYRQAwHGG--S-LGLSAISIDSS---DQTQA-VYNYV 494 Delftia acidovo...
Q141S6       501 RRW-----KkagltrligkisgrdAWTVIPTKGADK-LAAPRLMVVYPD-TSRKANRaassgDVPVARFNPNLFKDDLA- 572 Paraburkholderi...
Q5FNH9       502 RRA-----RkrrsakrmgrfdgrdGWTILPLKGAST-INAPALVVTYPD-TQRKDRSaaargEIPVGFFNPNRFKDDAS- 573 Gluconobacter o...
Q3IVP6       548 RAR-----Rrn-----------gqGGLWWLSIGRGGfQQRDRVWHEAPErGS-KGRRa---rGIKLLNMATDRMKESVL- 606 Rhodobacter sph...
Q8ZQH1       516 RHC-----Rre-----------glAGRVYLFKGDST-ARSKIFSKSYPNnTGRSDRQaracgEVPLYLLQTNALKDRIA- 577 Salmonella ente...
Q8ZQ96       526 RRC-----Krk-----------gvAGRVYLFKGDST-RREKLITKTYPDnTERSERRakargDVPLYLLQTNALKDRVA- 587 Salmonella ente...
Q9PFZ8       460 KQHv----GwsgqsrildtpqgflKQTLYLVRGRAEvKSDRAVYRPSKTtVDERGKTla--rDVGVWGVGTSVLKHMIYg 533 Xylella fastidiosa
ABQ68552     463 HLCvaagiH---------------RNRVTLLQGGNN-PRAELISRARRSdEKAGGGVkr--nSPAKWTVNVHALKNILD- 523 Sphingomonas wi...
WP_012091779 451 FPR-----S---------------SRKVLAIKGVNG--NRPWIEKSKSKvK-----------GGALWIVGVDGLKSHLT- 496 Ochrobactrum an...
WP_012006464 479 KKL-----G---------------LFRVIPIKGASV-YGKPVANMPRKKnSH----------GVFLTEIGTDVAKEVIY- 526 Serratia protea...
WP_012206486 495 RTH-----Qh-------------mLPNLRAIKGDNN-DNRPIVGPASMQdLDWRGQKvk--qGIKLWLVGVDNAKDLLL- 552 Delftia acidovo...
Q141S6       573 ---GQLQLA----------EPGKLYVHFPhalrsQ-----E-----QPHVWFEQLTSET----RTKNGG----WEKSAag 621 Paraburkholderi...
Q5FNH9       574 ---TQLQVA----------DIGAWRVHFPagllaN-----E-----PPHPFFEQLVAEQ----RRPDGR----WAKVTps 622 Gluconobacter o...
Q3IVP6       607 ---AAVGRF----------EGGQGAQHVP-----S-----W-----LEAEHLDELLAER----RGAKG-----YEKRQga 649 Rhodobacter sph...
Q8ZQH1       578 ---SALDRK----------EPGANYVHIP-----D-----W-----LGDWFFEELTYEE----RGMDGR----WAKPGk- 620 Salmonella ente...
Q8ZQ96       588 ---AALERE----------EPGANYIHFP-----D-----W-----LGPWFYEELTYEE----RSADGK----WKKPGr- 630 Salmonella ente...
Q9PFZ8       534 wlgAALTAKdnaaqtgtveDLSARMLRFPggrgdDipdplHpdpgaLPEHYFAGLTAEYfdkd-------agrWIKPRg- 605 Xylella fastidiosa
ABQ68552     524 ---ARLRRE----------KPGPGYIHFP-----E-----D-----FRELHFDELTAEE----K-QDGK----WKKIR-- 564 Sphingomonas wi...
WP_012091779 497 ---ARLSRG--------------RTIRFS-----D-----R-----LPLSWFEQLASERvv-vRYTRGQpqrrFERIPg- 542 Ochrobactrum an...
WP_012006464 527 ---SRYKLErsa-----dgSPVPGLIHYP-----N-----Npa--vFDLTEAEQMTAEEli-eKYEKGKikllWDAKK-- 583 Serratia protea...
WP_012206486 553 ---GQLAIT----------DAGPGCVHFS-----E-----D-----LPREFFEQLTAEQrilaKVQ-GReayrWVKRR-- 601 Delftia acidovo...
Q141S6       622 RRNEALDLMVMTHMLAQLHGLNr-----iSW 647 Paraburkholderia xenovorans LB400
Q5FNH9       623 ARNEALDLMVMTNVLAFLFGIAr-----mPW 648 Gluconobacter oxydans
Q3IVP6       650 VRNETLDLSVQALAVAEFKGLNr-----iDW 675 Rhodobacter sphaeroides 2.4.1
Q8ZQH1       621 GANEALDLLCYAHALVMIRGYEr-----iNW 646 Salmonella enterica subsp. enterica serovar Typhimurium
Q8ZQ96       631 GNNEALDLMCYAHALAILRGYEr-----iNW 656 Salmonella enterica subsp. enterica serovar Typhimurium
Q9PFZ8       606 VRNEPLDTAVYALWATLAPALKvdvmresQW 636 Xylella fastidiosa
ABQ68552     565 PRNETLDLMVMSYAALLrspfagtrttmswv 595 Sphingomonas wittichii RW1
WP_012091779 543 RRAEALDCVVYGFAARQILNIN--------W 565 Ochrobactrum anthropi
WP_012006464 584 RRNEALDCFVYALAA---LRISv-----sRW 606 Serratia proteamaculans
WP_012206486 602 QRNEDLDCRNYAIHAAMAQGLHkyt--daRW 630 Delftia acidovorans
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap