2EBM,1UKX,2DMF,2EBK,2DAX,2DAW


Conserved Protein Domain Family
RWD

?
pfam05773: RWD 
Click on image for an interactive view with Cn3D
RWD domain
This domain was identified in WD40 repeat proteins and Ring finger domain proteins. The function of this domain is unknown. GCN2 is the alpha-subunit of the only translation initiation factor (eIF2 alpha) kinase that appears in all eukaryotes. Its function requires an interaction with GCN1 via the domain at its N-terminus, which is termed the RWD domain after three major RWD-containing proteins: RING finger-containing proteins, WD-repeat-containing proteins, and yeast DEAD (DEXD)-like helicases. The structure forms an alpha + beta sandwich fold consisting of two layers: a four-stranded antiparallel beta-sheet, and three side-by-side alpha-helices.
Statistics
?
Aligned: 122 rows
Threshold Bit Score: 41.1442
Threshold Setting Gi: 82252779
Created: 5-May-2019
Updated: 18-Jul-2019
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
2EBM_A        13 EEQRNELEALESIYPDSF--------------TVLS---ENPPS----FTITVTSEAGE-N------------------- 51  human
Q4CVK5       249 AACEEEIGLLTSMYGEEC--------------VQRN----KTPV----VFLPLLLDGVSdEas----------------- 289 Trypanosoma cruzi
Q4D6B4         5 DDNAEEVELLLSISPEVV--------------CRDP---THSST----LVFLLPFR------------------------ 39  Trypanosoma cruzi
Q4QCY6         6 EMQEMEMEMVQGMY-DTY--------------ERLS---DDPPS----YCVSLAATQDE--------------------- 42  Leishmania major
Q4DGH6         5 EMQSMEMDTVQSMYDSYEl-------------ISVD---P--------PTYSVLLTATAd-------------------- 40  Trypanosoma cruzi
Q640E2        10 ELQLLEMEMLLSMFPNKE--------------LILEnanSVLYIrrylEGIRESLPPVIeFsvfl-------------ni 62  African clawed ...
XP_008004661  10 QLQLLEMEMLFSMFPNQGe-------------VKLE---DVNAL----TNIKRYLEGTReAlppkief------vitlqi 63  green monkey
Q4RFR0         8 ESQLAEIELLTSMFPSQEe-------------LEVT---DQLAL----AELRASVEGTAaTdppprsrpqflikqkldae 67  spotted green p...
Q5PQ37         7 EAQLSELDLLSSMFPTEDefvvtdqvalaelrDYAEk--RAASApsskIQFTVNVKLEEsNtg----------------- 67  African clawed ...
P57060        37 EAQLAELDLLASMFPGENelivndqlavaelkDCIEk--KTMEGrsskVYFTINMNLDVsD------------------- 95  human
2EBM_A        52 -DETVQTTLKFTYSEK-YP-DEAP-LYEIFSQE-----NLEDNDVSDILKLLALQAEEN--LGMVMIFTLVTAVQEKL 118 human
Q4CVK5       290 dMSLSALRICMTLPRR-YP-AELP-KLDVVGGPaahhvFFERWKLQLITKTLAYLRDDLg-VGNAMLLPAMMFAGEQA 363 Trypanosoma cruzi
Q4D6B4        40 ------FVLHVTLPPRgYPdVSRP-SLFVAAGP-------NAHLVNQFSSQLNKALREEvpLGGPMLLHIFTLAQDIA 103 Trypanosoma cruzi
Q4QCY6        43 ---PPQLRVIITYPTEeYP-ESAPcVVAVECIS-----KARRIQVGAITKQVASICEEN--IGMHSVVLALQQVQDFL 109 Leishmania major
Q4DGH6        41 --DPPELRVTIVYDSEgYPeTAAP-TVRLEHIA-----KHRRMQTAALAKEIEDLCAEQ--IGMHSVISVLQKAQEYL 108 Trypanosoma cruzi
Q640E2        63 qNSEVKAVMHVSLPQS-YP-QEEP-QVFVRSVA------LDRQQQNFLNKELGSYIRSLd-RGELCISMAVQWLQDNI 130 African clawed frog
XP_008004661  64 eEPKVKIDLQVTMPHS-YP-YVAL-QLFGRSSE------LDRHQQLLLNKGLTSYIGTFd-PGELCVCAAIQWLQDNS 131 green monkey
Q4RFR0        68 gGERTDILLSCAYPPE-YP-RVLP-EITVRCSG------LSRAQQTQLHTELHDYLLENc-QGDVCVLAALDWVKDNL 135 spotted green puf...
Q5PQ37        68 qGTGKEIALHCSYPLQ-YP-TVPP-EILVRSIS------LVRSQQAQLNLDLSNYLKSNc-SGDVCILSATEWVRDNA 135 African clawed frog
P57060        96 -EKMAMFSLACILPFK-YP-AVLP-EITVRSVL------LSRSQQTQLNTDLTAFLQKHc-HGDVCILNATEWVREHA 162 human
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap