3R3Q


Conserved Protein Domain Family
UEV

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pfam05743: UEV 
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UEV domain
This family includes the eukaryotic tumor susceptibility gene 101 protein (TSG101). Altered transcripts of this gene have been detected in sporadic breast cancers and many other human malignancies. However, the involvement of this gene in neoplastic transformation and tumorigenesis is still elusive. TSG101 is required for normal cell function of embryonic and adult tissues but that this gene is not a tumor suppressor for sporadic forms of breast cancer. This family is related to the ubiquitin conjugating enzymes.
Statistics
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Aligned: 22 rows
Threshold Bit Score: 111.195
Threshold Setting Gi: 74585176
Created: 5-May-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3R3Q_A  33 TFHDSLALLDNFH----SLRPRTRVFTH-SDGTPQLLLSIYGTISTGEDgsspHSIPVIMWVPSMYPV------KPPFIS 101 baker's yeast
Q59WF8  24 VYAHVFQFLQLHLkknlNFKIRTQIYTSsGSGEPNLLINLFGTIQINEQ----IGTPIEIWVPFAYPYvdyenkGAPIVY 99  Candida albicans
Q75EU1  32 TFHDVVIALRAYK----KLRPRTRVFTD-EAGRSKLLLCLYGKV---------GNVDVLIWIPFEYPN------VAPHAY 91  Eremothecium gossypii
Q6FS29  27 VFHDAVQTLTEFK----NLRPRTRVFTD-EDGSPRLLLCLYGGIPIEQG----LDVPVLIWIPESYPI------AKPLLF 91  [Candida] glabrata
Q5BAA9  33 TYYDVANVLAKFP----TLAPETAVYTY-ENGFSALLLQLSGTLPVTFRgt-vYKFPIALWIPNTYPR------EPPIVY 100 Aspergillus nidulans
Q6ESB7  45 IRNHLVALADAFP----SLHPKAALFTH-NDGRAAHLLQADGTIPIHHAga-sYNLPAVLWLPEPYPR------SPPLVF 112 Japanese rice
Q9LHG8  37 IRQHLLNLISSYP----SLEPKTASFMH-NDGRSVNLLQADGTIPMPFHgv-tYNIPVIIWLLESYPR------HPPCVY 104 thale cress
Q4UHS4  19 LMCDINGLFGKYH----NFSCSM------STSFDCHRLNISGTVPYTFSgf-tLNAPLLIQVFSDYPF------SCPSFF 81  Theileria annulata
Q4N7T6  34 LMIDLDGLFLKYH----NFKCSM------STSFDGHRLNIVGLVPYTFSgf-tVNAPLVIQVLSDYPF------STPLFW 96  Theileria parva
P25604  31 TFHDSLALLDNFH----SLRPRTRVFTH-SDGTPQLLLSIYGTISTGEDgsspHSIPVIMWVPSMYPV------KPPFIS 99  Saccharomyces cerevis...
3R3Q_A 102 INLENFDmntissSLPIQE-YIDSNGWI-ALPILHAWDP--AAMN-----LIMVVQeLMS----LLHEPP 158 baker's yeast
Q59WF8 100 IVPDHSKg----wYLKPNN-NVDTQGMF-YHPYLTRWHRecLRSNpdslnMFSLVE-LANviyrSVTTDS 162 Candida albicans
Q75EU1  92 IDLEANKg----rSIIVNQ-RLDGDGLF-YLPILGHWHP--QNCN-----VVKLVQdLEQ----AIMAQE 144 Eremothecium gossypii
Q6FS29  92 IDLELLDkd---lQLATNE-SVEPDGRV-HTRLLRQWNP--QSAN-----LFNVIQdLAD----MCNAIA 145 [Candida] glabrata
Q5BAA9 101 VKPTQDM------VVRVGQ-HVTLEGRV-YHHYLAHWGGawERSS-----LLDLLSiLQD----VFAKEP 153 Aspergillus nidulans
Q6ESB7 113 LSPTRDM------VIKPHHpLVDRSGLVaNAPYLRSWVF--PSSN-----LVDLVRsLSH----LFGLDP 165 Japanese rice
Q9LHG8 105 VNPTADM------IIKRPHaHVTPSGLV-SLPYLQNWVY--PSSN-----LVDLVSdLSA----AFARDP 156 thale cress
Q4UHS4  82 VPSRNT-------KIVKNHpNVDLRGNV-TLKYLDEWNH---TSK-----LVQAVDhLCY----AFSKIS 131 Theileria annulata
Q4N7T6  97 IRGHNI-------KIVKNHpNVDLRGNV-TLKYLDEWNH---TSK-----LVQAVDcLHY----AFNKMS 146 Theileria parva
P25604 100 INLENFDmntissSLPIQE-YIDSNGWI-ALPILHCWDP--AAMN-----LIMVVQeLMSllhePPQDQA 160 Saccharomyces cerevisiae S288C
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