2IF6


Conserved Protein Domain Family
Peptidase_C92

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pfam05708: Peptidase_C92 
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Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
Amidase_YiiX is a family of permuted papain-like amidases. It has amidase specificity for the amide bond between a lipid and an amino acid (or peptide). From the structure, a tetramer, each monomer is made up of a layered alpha-beta fold with a central, 6-stranded, antiparallel beta-sheet that is protected by helices on either side. The catalytic Cys154 in UniProtKB:Q74NK7, Structure 3kw0, is located on the N-terminus of helix alphaF. The two additional helices located above Cys154 contribute to the formation of the active site, where the lysine ligand is bound.
Statistics
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PSSM-Id: 310368
View PSSM: pfam05708
Aligned: 18 rows
Threshold Bit Score: 142.149
Threshold Setting Gi: 118504480
Created: 25-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2IF6_A         5 PQTGDIIFQISR-SS-QSKAIQLATH----SDYSHTGMLVMRN---------------------KK-PYVFEA------- 49  Escherichia coli
Q8P4Z8        19 LHDGDLLFVTAArTG-LSGAIDDATAtqgaPSFDHVGLVAHDG---------------------RA-RVVLHAd------ 69  Xanthomonas cam...
Q8ZNV4         9 YETGDIVFTCIG-AA-LFGQISTASQ----CWSNHVGIIIGHN---------------------GDdYLVAESr------ 55  Salmonella ente...
Q1CXU9        28 LQTGDIVLHTSR-SS-QSQAIQKATQ----SPLSHVGMVEVTE---------------------QG-AWVVEA------- 72  Myxococcus xant...
P32167        21 PQTGDIIFQISR-SS-QSKAIQLATH----TDYSHTGMLVIRN---------------------KK-PYVFEA------- 65  Escherichia col...
WP_006486296  38 PEIGDIVFIRVT-VR-PFLEVASATR----SWTNHVGIVVGER---------------------GGeTLIAESt------ 84  Burkholderia ce...
WP_011516635  14 LQVGDIVFIRVR-AR-PFREVATATA----SWTNHVGIVVANS---------------------GTgTSIAESt------ 60  Cupriavidus met...
EAQ42499      11 LNEGDLLFQNTG-TDeIDNAIKDVTAtaiaKNYSHVGIAMQEN---------------------NQ-WFVVEAi-----p 62  Polaribacter sp...
ACE03132      32 LENGDIILRYGK-GL-WSQFFRDVSRr--dKRFSHAGIVVREE---------------------GA-FYVIHAaaaeltg 85  Chlorobium phae...
ABL00963     295 LKAGDILLEKTP-FR-LTDKLIP-------GYWGHAAVWIGTEvelkelgiwnnplvarhhdeiRQgRLVVEAl------ 359 Pelobacter prop...
2IF6_A        50 VGPVKYTPLKQWIAHg----eKGKYVVRRVEGGlSVEQQQKLAQTAKRYLGKPYDFSFSW-SD-DRQYCSEVVWKVYQNA 123 Escherichia coli
Q8P4Z8        70 EEGSRQQPLADFIRQar--akQRQIFVYRLNAA-QRAAIPDAIAQARRMLGKPYNLTYVQ-DD-NSYYCSDFIERAFRAH 144 Xanthomonas cam...
Q8ZNV4        56 VPLSTVTTLSLFIQRs----aGQRYAVRRLCGGlTVEQKLAIMEQVPARLNKFYHTGFKY-ES-SRQFCSKFVFDIYKEA 129 Salmonella ente...
Q1CXU9        73 VQPVQRIRFSKWKARg----aKGGILVLRPREL-SDAQRQQAVAAAKAHLGKPYDWLFGW-GD-DAMYCSELVRKAYAQG 145 Myxococcus xant...
P32167        66 VGPVKYTPLKQWIAHg----eKGKYVVRRVEGGlSVEQQQKLAQTAKRYLGKPYDFSFSW-SD-DRQYCSEVVWKVYQNA 139 Escherichia col...
WP_006486296  85 FPLSRVTTMSRFLARs----dRGACVIARLRQPlDAAQRRELVAAAMRRIGVVYDTGFNL-AS-RRQFCSRFVREVVCEA 158 Burkholderia ce...
WP_011516635  61 FPLSRTTSLKRFAARs----eHGRIAIARLRQPlTASQQLRLSEAVRHRMGIWYDTGFNL-HS-RRQFCSRFVREVLAES 134 Cupriavidus met...
EAQ42499      63 KKGVRKTPLNEFLARnknkdnRSQTTVARLTNY-YAPYISRAIQYGLERVNTPYDEIFLW-DD-NSYYCSELVYKMFSSQ 139 Polaribacter sp...
ACE03132      86 VGKVTCDPLGAFLEA------SSDYAVYRLAV--SGPVRQKIAHNARNYLGVSFDTSFDLsEQ-ERLYCTEMVMQAVNKA 156 Chlorobium phae...
ABL00963     360 RSGVEMNTLQHFLN-------IDSLGILRKPDQ-SREARATTIMLALRQVGKPYDFNFDV-ESkERVYCSKLVYLSYsgi 430 Pelobacter prop...
2IF6_A       124 lgmrvgEQQKLKEFDLSNpLVQAKL---------------KERYGknipleetvVSPQAVFDAPQLTTV 177 Escherichia coli
Q8P4Z8       145 ------QVFALQPMNFKNpQSGQMSaywtefyrskgmdvpQGLPG---------TNPNDMARAPALQAL 198 Xanthomonas campestris pv....
Q8ZNV4       130 lcipvgDIETFEELLHSNpDAKLAFwkfwf-----lgsipWDRKT---------VTPASLWHHPNLELI 184 Salmonella enterica subsp....
Q1CXU9       146 agleygKMERLDSLRVKGlEQQLRErygk--------rvpLDLEL---------VTPASIAADVRLEVV 197 Myxococcus xanthus DK 1622
P32167       140 lgmrvgEQQKLKEFDLSSpQVQAKLkeryg------knipLEETV---------VSPQAVFDAPQLTTV 193 Escherichia coli K-12
WP_006486296 159 trivlgDVETFYTLLHRNpDHPLGFwriwy-----fgripWHRRT---------VTPASILDSGALRVV 213 Burkholderia cepacia complex
WP_011516635 135 adigvgEAETFKALLARQpDAALGFwrlwy-----fgripWERET---------VTPASLLCSPALELL 189 Cupriavidus metallidurans
EAQ42499     140 nlpkdsVPFLTHPMTFNDkSGKPMSswvkyyk-ernhvipEGIEG---------TNPNLMASSPHLTFV 198 Polaribacter sp. MED152
ACE03132     157 tgfvviRPTAASGIAV--------------------------------------VAPDNCYEHRLVRSV 187 Chlorobium phaeobacteroide...
ABL00963     431 ---dwpTRKSLGRTTFTPdDVA-----------------------------------TKVAKDGALQLV 461 Pelobacter propionicus DSM...
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