Conserved Protein Domain Family
Zot

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pfam05707: Zot 
Zonular occludens toxin (Zot)
This family consists of bacterial and viral proteins which are very similar to the Zonular occludens toxin (Zot). Zot is elaborated by bacteriophages present in toxigenic strains of Vibrio cholerae. Zot is a single polypeptide chain of 44.8 kDa, with the ability to reversibly alter intestinal epithelial tight junctions, allowing the passage of macromolecules through mucosal barriers.
Statistics
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Aligned: 7 rows
Threshold Bit Score: 196.166
Threshold Setting Gi: 137965
Created: 5-May-2019
Updated: 18-Jul-2019
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q9I5K2     2 SIKIHHGPNGSYKTSGAIQDDAVP----ALK---D----GRVIIT-NVRGFT-LERAYQVFPDLPN--Ta-------eII 59  Pseudomonas aeruginosa
P38442     2 SIFIHHGAPGSYKTSGALWLRLLP----AIK---S----GRHIIT-NVRGLN-LERMAKYLKMDVSdiS---------IE 59  Vibrio cholerae O1 ...
BAC59821   2 ATSFRYGHGGSYKSACAVWFDLLP----ALR---E----GRICIT-NIHGMQpLEVIEQRLGEKFPd-Ta-------rLI 61  Vibrio parahaemolyt...
P03656     2 AVYFVTGKLGSGKTLVSVGK-IQD----KIV---A----GCKIAT-NLD-LR-LQNLPQVGRFAKTp----------rVL 56  Escherichia virus M13
Q8NL40     1 MLVFNEGVPRAGKSYDAVKNHILP----ALK---K----GRRVFA-RLNGLR-FDRIAKhl-----gmAendvqhllvLV 62  Xanthomonas campest...
Q9PCA6     1 MLNLVTGAPGNGKTLYAVDWLIRQieidKSLvksGa--vPRSFYT-DIEGFD-VEAVRRLTGYVVQ-------------- 62  Xylella fastidiosa
Q9JY47     1 MIYLFTGNMGTGKTSRVVSMILNNedglFKMkleDgtevDRPLYFcHIDGLD-KRQFKAh-------------------- 59  Neisseria meningiti...
Q9I5K2    60 NLD---LESLEDLEKMRTWFQwa----pRGAFLIFDETQLLFPKSWRe--KDlerfdypgg------------------- 111 Pseudomonas aeruginosa
P38442    60 FIDtdhPDGRLTMARFWHWAR-------KDAFLFIDECGRIWPPRLTv-tNLkaldtpp--------------------- 110 Vibrio cholerae O1 ...
BAC59821  62 RISsrnPEGFELWKYFFCWAP-------IGAFILIDECQQIFSVNAGf--KManihkrpftdfephlpegfselfhsrwl 132 Vibrio parahaemolyt...
P03656    57 Ri----PDKPSISDLLAIGRGndsydenKNGLLVLDECGTWFNTRSWndkER---------------------------- 104 Escherichia virus M13
Q8NL40    63 DTKdvsKLFACTQDESGKWCIpd---efKDALVVIDEVHEFYVNERKpl------------------------------- 108 Xanthomonas campest...
Q9PCA6    63 -------------SAPEDWRTt-----pQGSVIVYDEAHRMFPAGRPg-rSD---------------------------- 95  Xylella fastidiosa
Q9JY47    60 ------ELTEEQIMSAPLRDVi-----pEGAVLIVDEAHYTYPVRAAg-rPV---------------------------- 99  Neisseria meningiti...
Q9I5K2   112 ------------------peaahaadrPMGWL-DAWTRHRHFNWDIVLTTPNISYIRDDIR-MTCEMAYKHSNLAVIGIP 171 Pseudomonas aeruginosa
P38442   111 ---------------------dlvaedRPESFeVAFDMHRHHGWDICLTTPNIAKVHNMIR-EAAEIGYRHFNRATVGLG 168 Vibrio cholerae O1 ...
BAC59821 133 tidtssldngeiddcqrtrfdeqgriiYPENFnNAFMEHRHYNWDIVLLTPDFAQIPKELK-GVAELAKQHKGKD--GIF 209 Vibrio parahaemolyt...
P03656   105 ----------------------------QPII-DWFLHARKLGWDIIFLVQDLSIVDKQARsALAEHVVYCRRL------ 149 Escherichia virus M13
Q8NL40   109 ---------------------------aPAVE-NFWALLGQNGGDAVIMTQWINRLHSAVK-ARIEKKNTFQKLTAIGMK 159 Xanthomonas campest...
Q9PCA6    96 ----------------------------DPRV-CDLDTHRHGGYDLMFVTQWPTKIHHELR-RLVGEHVHLNRAMGLQTA 145 Xylella fastidiosa
Q9JY47   100 ----------------------------PPYI-QELTELRHHGHTVILMTQHPSQLDIFVR-NLVSKHVHLERK-AIGMK 148 Neisseria meningiti...
Q9I5K2   172 GRY--KE--AQHDAq-LNRPPADgt-------iiEYKRIRKQTFALYQ-STATGK 213 Pseudomonas aeruginosa
P38442   169 AKFtlTThdAANSGqmDSHALTR-----------QVKKIPSPIFKMYA-STTTGK 211 Vibrio cholerae O1 biovar El Tor str. N16961
BAC59821 210 FSNrkPR--ILE------HDPTRtvtkpskddvvYNLKVPLDVHLLYA-STVTGQ 255 Vibrio parahaemolyticus RIMD 2210633
P03656   150 DRItlPF--VG--------TLYSli-------tgSKMPLPKLHVGVVKyGDSQls 187 Escherichia virus M13
Q8NL40   160 GRYrvTYfhTTSP---G---KFEkv-------ggQTLKYDPAIFPLYD-GYAPGA 200 Xanthomonas campestris pv. campestris
Q9PCA6   146 GLYrwSR--AQDDP--YDIHQREka-------eeEVWKFPKDRYALYA-SSTLHT 188 Xylella fastidiosa
Q9JY47   149 QYY---WykCVTSL--DNPAGVSgv-------evASWKPPKEAFKYYK-SASQHQ 190 Neisseria meningitidis serogroup B
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