Conserved Protein Domain Family
DUF812

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pfam05667: DUF812 
Protein of unknown function (DUF812)
This family consists of several eukaryotic proteins of unknown function.
Statistics
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Aligned: 35 rows
Threshold Bit Score: 363.948
Threshold Setting Gi: 586727187
Created: 5-May-2019
Updated: 18-Jul-2019
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WGS:AAGF:cds.TTHERM_00756350A   31 MEDTDQLLFASLQQFGFNLgNKKITSLFDV----------DGDILRSICFQFLE-FMGSKVtINSM-----------KGQ 88   Tetrahymena thermophila SB210...
7_pfamImport                     1 MEEVDQIIIGSLLNIGCEF-AEGMTSLKQF----------TTENVVEATVKCLR-IINPDY--KMShif------ppGMS 60  
EGD82579                         1 MDEVDKIILLTLRQLGTDV-EEDVASLADL----------PTKAFVEGAARCIN-TINGND--EMPlsl------pgSMA 60   Salpingoeca rosetta...
EDQ91553                       453 MEEVDRIILLNLKHLGTEI-PETVQTVSDL----------GTDVFVEGCARCLN-VINQSD--EMPlkl------psTMA 512  Monosiga brevicollis MX1...
ETO24313                         1 MEEADKIIIPILKSAGCKL-DDSIRSMSQF----------TAPLVVHCCATCLN-AMDSSN--SIPtel-----pkhSKT 61   Reticulomyxa filosa...
Q01GI4                           3 aADADEVLFHALRSSGIDV-HPSWSAIDDVvndvddessaNTNALLNIVRQCLC-LIDATAyESLPrgfplddgsgtSVA 80   Ostreococcus tauri...
EEY56005                         1 MAEADAFISAALQQSGWLE-ADASWSVADL----------SSDALIVLVLKFLArLQDADNgVNFSlscte-akapvGVA 68   Phytophthora infestans T30-4...
Q54MP2                           1 MDEADGIILITLKDLGCEI-EENE-TIKNF----------DSEMVYKCILAYLR-VINEQKvINLTntl------pkNMS 61   Dictyostelium discoideum...
EFA84683                       358 MDEADGIILLTLRDLGCEL-GDEI-TIKDF----------DAEIVYKACLAYLR-VINEAKvANLTati------pkNMS 418  Heterostelium album PN500...
XP_026693321                     1 MEEVDQIIIGSLLNIGCEF-AEGLESLKQF----------TTDNVVEGTVKCLR-IINPDY--KMShif------ppGMS 60   vase tunicate...
WGS:AAGF:cds.TTHERM_00756350A   89 QKFRQSTQISEELKNL---CNLRIDINSLLSPSKDDLRKIVVAILQKIsmheegdnPRLNISQR---------------- 149  Tetrahymena thermophila SB210...
7_pfamImport                    61 ARFRVGTSIANTCKSIg--YQGDIGYQTFLYSAERDVRQIFMFLVEKL--------PRKEGVKEdtv------------- 117 
EGD82579                        61 ARFRVGTTLATACQDLg--YGSNIGYNTFLYSNEDDCRQLLMWLIERL--------PKETTSTTgae------------- 117  Salpingoeca rosetta...
EDQ91553                       513 ARFQVGTTLAKACQALg--YTSSIGYNTFLYGNENDCRNILMWLIERL--------PQDVSDATqas------------- 569  Monosiga brevicollis MX1...
ETO24313                        62 QQFGVGNTIKMACIKLgypYPNDIGYETFIYPNEQDTRKILRWLVEKL--------QKHSKSNAtgetkgdtmnldedeq 133  Reticulomyxa filosa...
Q01GI4                          81 ERFRVAGRYASALIEVggeQRDGDGFQQFLYPSASSARAMLKRLLELL--------PRRDVDEAvreae----------k 142  Ostreococcus tauri...
EEY56005                        69 ARHRVGSQLANILKELg--YAGDCGYNHFLYPSEKETRNILSWLVGKL--------PRSKHEENed-------------- 124  Phytophthora infestans T30-4...
Q54MP2                          62 ARVNACSLIANIIKDSg--YRSELSYHNLLYPNVNDIRKIFIFLGQLL--------PKKEVESG---------------- 115  Dictyostelium discoideum...
EFA84683                       419 ARVNSCSVLAATIRETg--YRAELSYHNLLYPNINDVRRIFVFLGQHL--------PKKEVVEG---------------- 472  Heterostelium album PN500...
XP_026693321                    61 ARFRVGTSIANACKEAg--YRGDVGYQTFLYSAERDVRQIFMFLVEKL--------PRKEGVKEd--------------- 115  vase tunicate...
WGS:AAGF:cds.TTHERM_00756350A  150 ---GgAQAFDsyedkIRYLQEQRRKEILKNWVNEEW-------------IHPALGNNKFNQFRMY-------------DN 200  Tetrahymena thermophila SB210...
7_pfamImport                   118 qtvA-ESNVL-----QRRIGQVLREKCSTMWMPFYCk-----------------pLIEGVPFRTQplfip----kyskgH 170 
EGD82579                       118 -tlG-QEAML-----QRAITAEIDKQLSCPWIPPAFhrdglc-wsnnrtAWHLISRRGVRSFRSTtlftse--mdaanTA 187  Salpingoeca rosetta...
EDQ91553                       570 -agTtGLARF-----RAAVAADVRRRIELPFLPHAIyrdgai--aldakTTLQMNPRAQRPFRTNtleia---------d 632  Monosiga brevicollis MX1...
ETO24313                       134 emlG-GRKWL-----DKQILENLKQWTQSP-------------------YSFLTKPQMKCAFKSVpiffpl--ksgplIK 186  Reticulomyxa filosa...
Q01GI4                         143 arvSaASARLg---sRARAMVARSTKAEAAW------------------------GRAAGALKGFagvaaa--arakkRT 193  Ostreococcus tauri...
EEY56005                       125 -evS-KSEVLasmgaNSSIAEAAASVLASDRLANIFsswkrektlhmlpNQNVQGLRGFQRLPLQtsplelpwsrpgkST 202  Phytophthora infestans T30-4...
Q54MP2                         116 ---GvSIQKL-----EDQICQYLQGCVKESWIPYFCp-----------fSKRIPGNYSTATLFTTtggnlr-ipsrgrQL 175  Dictyostelium discoideum...
EFA84683                       473 ---D-STASL-----KDLICNHLASSIKESWMPYFCp-----------fTKRIPGNYSTAKLFTVaplki---pargrQL 529  Heterostelium album PN500...
XP_026693321                   116 --iE-SASVL-----QRRIGQVLREKCAVLWMPFYCh-----------------tSPKKIPFRTQpinis----kysqGY 166  vase tunicate...
WGS:AAGF:cds.TTHERM_00756350A  201 ELVLDSNSLSNKlIIDIIN----------GKMKQNLYAslakiiENRALKAQIDEMEVyadvqkiseqrhqLQIEEIKKQ 270  Tetrahymena thermophila SB210...
7_pfamImport                   171 RNSKT--------------------------------------------------------------------------- 175 
EGD82579                       188 RAAYETT------NQQTIPqqr----svaTSSLASILA------RNSRLLASERAREEeltaa---grdpaLPNEDFVRQ 248  Salpingoeca rosetta...
EDQ91553                       633 sngsQERVAYETeHMPLVTaqp----mrsANRLTSLLA------KHAALQARRAVWQEewstl---gmtsgKTEQQYRHD 699  Monosiga brevicollis MX1...
ETO24313                       187 ENKKSNTTIKKHfLCIYMHm---------------hMH------MHMHTCGSEQEQNEenggegldggghhHNAIDWKKL 245  Reticulomyxa filosa...
Q01GI4                         194 DDTTNAREFYTSrLTTSSSggffgnlsadTYAVPSVLE-----------YAARVRAEEeaeedarrlkfsgVVRAEFIGP 262  Ostreococcus tauri...
EEY56005                       203 HN---------------LFekf----ssdSIKATSLLEalavakRGSTMFLREDEFDDdvee--------dnvDAQLKQG 255  Phytophthora infestans T30-4...
Q54MP2                         176 KVTPGLEQYYSQ-YLEPLTlqt----nrfEDIAPSVFE------YNLSIYAEAQERDNewndk---gvssgMNPIDYRKN 241  Dictyostelium discoideum...
EFA84683                       530 KLTPGLEDFYIK-HLRPINqqp----nrtDDVAPSVFE------YNLSIYAEAQERENewntk---gsqsgLNPLEYKKN 595  Heterostelium album PN500...
XP_026693321                   167 KNSKSQDE---T-TYDFVHrqi----knrDQLTPSLLE------LNSKQTVSVTSLDKasg----------------qds 216  vase tunicate...
WGS:AAGF:cds.TTHERM_00756350A  271 VatevtkaSKKKVNRIAEQFTEQPQQTEEEVkqQLNEEKQTIFNLEMQFqeeqtvhnpvldpqnDEKNERSLnkSNAETL 350  Tetrahymena thermophila SB210...
7_pfamImport                   176 ---------------------------NILSf-LQLPDAIPFDSSLDEV---------------IQIVTGQSlkTNRSRF 212 
EGD82579                       249 K-------RTTTRRTISAKVKAALFNDA--------KQEVDMAKFLAKF--------------------SGIelGKMSMF 293  Salpingoeca rosetta...
EDQ91553                       700 K-------QDSILKNMRQQLQKGIAADMTAH-----RQRQDIRTFLDGF--------------------ANVqlGKKSLF 747  Monosiga brevicollis MX1...
ETO24313                       246 I-------GESIKQELSQFKRKIATVPNAGIhhGTSl-------------------------------------SRAVTF 281  Reticulomyxa filosa...
Q01GI4                         263 DgkpfdlrKRGGLRGLVAEIFRLALEGGFYTepRAIQACAELEE---------------------------------TQV 309  Ostreococcus tauri...
EEY56005                       256 Q-------VEGLLTDATRAGESGFLSPQEAEaeDDEFATIEPQTFLSSAlpdvp-----lslnnPSSGTTDTmaTEGATT 323  Phytophthora infestans T30-4...
Q54MP2                         242 K-------QKQVLSKMNDSIRQSIIDGGNNQisSNCNSGDSFLDIISEF--------------------RGNslDVGGQF 294  Dictyostelium discoideum...
EFA84683                       596 K-------SKTILSKMNDSIRSAMVDGSs----ADSRRNNTFDHVIGQF---------------GMGSADDD----YGQF 645  Heterostelium album PN500...
XP_026693321                   217 K-------RRKVQKEAFQWKHKSM-----------ITDKIPLDSSFDDV---------------IQAVTGNSgnIKQSRF 263  vase tunicate...
WGS:AAGF:cds.TTHERM_00756350A  351 NSSNALlnssnSLlnsanNNSsttqaskpmtsaa---------------------------------------------- 384  Tetrahymena thermophila SB210...
7_pfamImport                   213 AHAKDL-----QF-----TTVsddgcinyschkplqirpvipqkpshlaklenkevfylssldwgsdyfrtgfidgehlt 282 
EGD82579                       294 RAKHKL-----QF-----AKEdeaa------------------------------------------------------- 308  Salpingoeca rosetta...
EDQ91553                       748 RKREEL-----QF-----QSEas--------------------------------------------------------- 760  Monosiga brevicollis MX1...
ETO24313                       282 TQAPKTvkpggKV-----EKD----------------------------------------------------------- 297  Reticulomyxa filosa...
Q01GI4                         310 VDEDKVvesanDV-----ENA----------------------------------------------------------- 325  Ostreococcus tauri...
EEY56005                       324 DSTGSAsigasQFavlqtAND----------------------------------------------------------- 344  Phytophthora infestans T30-4...
Q54MP2                         295 NRKKAF------------TNElnnnnnnnnd------------------------------------------------- 313  Dictyostelium discoideum...
EFA84683                       646 ARKKAF------------TNEevase------------------------------------------------------ 659  Heterostelium album PN500...
XP_026693321                   264 AHAKSL-----QF-----TTEeqksfrlrptvpqkpshlikhenkkk--------------------------------d 301  vase tunicate...
WGS:AAGF:cds.TTHERM_00756350A  385 -------------nnsrlslgksnlNIGINIDELKTNNSKEISTLSQKYEELQNKKQKYAKEREKMETNIQQKTEEAEVL 451  Tetrahymena thermophila SB210...
7_pfamImport                   283 pptkdrtqddptssvdeasssadvaKDQEELEEIRFQREED--EMNKMISDVVEDEEKYKEDLKMVEMSMKQIVVNTQEL 360 
EGD82579                       309 ----------------------vaaTKTVTDEELKQQREDELSALQGEVEDLESSLQAMRDNLASLQSTAEALAEQTARM 366  Salpingoeca rosetta...
EDQ91553                       761 -----------------------daPKAATQEELEQQRQAELEELETRLSDLMATMQSLQGELSTFDKDAVKMDSKLAEL 817  Monosiga brevicollis MX1...
ETO24313                       298 ----------------------------ETEEEVEKRRNEELDELRSKIQDLEAKLKAMEEEIKKEKQRKEELEKTIEQE 349  Reticulomyxa filosa...
Q01GI4                         326 --------------------------AMDTLEDRIKARERDLEDVHRRIDEAMSVVSTVDDEIAACASKVKEAMEATDAK 379  Ostreococcus tauri...
EEY56005                       345 ------------------------------------NEEQSLDEVQKQVDDTERRIAAMRKVLDRERGHLQQVEQHVLET 388  Phytophthora infestans T30-4...
Q54MP2                         314 ----------------sttntnkveTEIETEEQRQLKRQAEIDALQSQIDEISESIQLHNKEMLDFLSLMRQSESENLEQ 377  Dictyostelium discoideum...
EFA84683                       660 ---------------------piepKAKETEEERQQKQQEEIDQLQSVLEELANRMANATSEMDDWIQQIRQLEAQINEE 718  Heterostelium album PN500...
XP_026693321                   302 daetdnqessedgvdgssagggedaVIPEEPEEVKFKREEE--EIKVKILDADAGEEKYKEELKMVELSIKQLMIKTEEL 379  vase tunicate...
WGS:AAGF:cds.TTHERM_00756350A  452 KEQNKQTKKDIENMEMLIKEL--E---TKGGSSELKKEIKELEQDIQQIEIEWKEYQETDIKKLEELKDELTKKKEKREL 526  Tetrahymena thermophila SB210...
7_pfamImport                   361 ESTNEERIKQVKLKEKTLKLLp-N---AEENMEKLKAMVDASSQRLVELGKLWEEKRIPLVAEIRRLKQSKTETEFDAER 436 
EGD82579                       367 QEENEALTKEQKVRKRVLDLLp-N---AEENMQLLKDKIDEVAAKLAALAERWEEHRVALIKEYRDLKVAAANKNSEARK 442  Salpingoeca rosetta...
EDQ91553                       818 KALAEELAANNAVRKRVLDLLp-N---ADENIERLGQAIDALARKLIAIGEKWEPHRRELLREYQQLKSAAADQMSEIKV 893  Monosiga brevicollis MX1...
ETO24313                       350 KKQNEQLQEELNTKEKVHQLIggS---ADENIKKLEEIVKKQRDKLKNAVDQWENRKQLWTDEYRSKKTSMERREKSCND 426  Reticulomyxa filosa...
Q01GI4                         380 RALTAELESNYLLHKQAVGMVlaTdrpVEESEAELNKVLVAAKERLEQLSAEWNAAKTPLLAAIEAHAEGAREKRKKAKN 459  Ostreococcus tauri...
EEY56005                       389 QSTGQELQKQLARQKQLLAMLp-Q---AQANILKLEAICQSNAEKKVEISQQMGSARGPLLLEYAALEGQKSSRKARCRQ 464  Phytophthora infestans T30-4...
Q54MP2                         378 DQQREVLEKQYKIKKKTFSLLd-D---AEGNMKELQSLCNQTSSNLLEMSGEWEKVRKPIIEKYRSLKDKQNNQADETKS 453  Dictyostelium discoideum...
EFA84683                       719 DRKRAELEKEYKVKKKTFGLLe-N---AEENFAKLQELCQQTSASLIEMSGEWEKVRRPIIEKYRQLKDEKANQSDEAKS 794  Heterostelium album PN500...
XP_026693321                   380 ETNNEEEVKNVKLKEKTLKLLp-N---AEENMEKLKSLVDASSKRLVELGRLWEEKRVPLIEDIRRLKQSKTESEFDAER 455  vase tunicate...
WGS:AAGF:cds.TTHERM_00756350A  527 IKDKIKRIDTELQQVIQDLQMAYEKKVQL----------VEDYKRMPQGGNRQEYIKKIMEIKKNYDKQRGDIQKIIQDV 596  Tetrahymena thermophila SB210...
7_pfamImport                   437 KVEEIRLLRSRMKDVSEETKQKDQLIKQL----------KTELDSVKRDISRQSYTRRILEIVASIHKQKQEIQRVIEDV 506 
EGD82579                       443 QAESIQELRSQAKQIIADAKQKEQLFQQL----------VQDYERMNKDILRSSYTSRILEIVKSIDKQKREIQKILVET 512  Salpingoeca rosetta...
EDQ91553                       894 QMAYVQEMRETTQGILAGAKAKEQRVAEL----------QAEYEKRNNATQRSWYVERILEIIKSINKQSADIETSILDI 963  Monosiga brevicollis MX1...
ETO24313                       427 LLEELKLMRKEMKQCAKEIREKEDMLEKV----------VARLNKLPKTFDRQAYVDRILNVVANLETQNRQIKQALEDI 496  Reticulomyxa filosa...
Q01GI4                         460 QLEEIEKWRSEGKDTSSLLRIKEQEQRQL----------LDQYEAAPKSVHRPSFVRRVNEIIKNIKKQEREIVKIVGDT 529  Ostreococcus tauri...
EEY56005                       465 LIREMKAFRAEMLEISGIIQSKMESLKALervqerqlakLGQKKDADGPMTRNMYTSRIMDIIKQVHKQKQDIAKILDDI 544  Phytophthora infestans T30-4...
Q54MP2                         454 KLDRIKEMRILIKKLVSEVQQKDDQFQQL----------QDQYKQAPKDSNRSQYTRRILETVKNIKKQKVDIDKVLLDT 523  Dictyostelium discoideum...
EFA84683                       795 KVERIKEIRALIKKMIADIRAKEELFTQL----------QDTYKAMPKDTNRSMYTRRIIESVKNIKKQKEDIDRILLDT 864  Heterostelium album PN500...
XP_026693321                   456 KVEEIRMLRTRMKDVAEETKLKDQLTKQL----------KAELESVKRDISRQSYTRRILEIVASIHKQKQEIQRVIQDV 525  vase tunicate...
WGS:AAGF:cds.TTHERM_00756350A  597 KSVEESIQYYQGTLERHMNELEAIYNTDAKK--NESLSK--QifkiYQEYRTI---FDQTVNNLREVGNKMIESRSIEAK 669  Tetrahymena thermophila SB210...
7_pfamImport                   507 KLVQKTMNKLKGRANRTFSAADEVIFRDAKQ--DEGSKQ--A----YKYLVSLhdnCAALLKTVEETGLIMREIRDLEGQ 578 
EGD82579                       513 RGLQKDLGLLEGKIERTFTVAEEEIFKESKA--NPAARL--A----YKHLANLhaeCGRLIDVVKSTGTVAREIRDLEDQ 584  Salpingoeca rosetta...
EDQ91553                       964 RAMQREINQISDRLSRQFTVVDEMVFKDAKK--DADIKR--A----YQLLASLhtgCEDLIQCVENIGSLEKECRELDNA 1035 Monosiga brevicollis MX1...
ETO24313                       497 HELQRETNKVTEKSKRAFNICDDMIFQAAQNamEENAKK--QlnkcYRNVVAIreqFDKIVETTKKTSNIQNEIRDLQSQ 574  Reticulomyxa filosa...
Q01GI4                         530 RSVQSDINSAQACLERTYTVVEEILFREARS--DELCRA--A----YKHLHGMhagFADLIDKVEATGVARRSQTDLQRK 601  Ostreococcus tauri...
EEY56005                       545 KGLQKQLNTASERLKRTEAVAEDKLYSAASTskSTSSTKadAyvecYRKFAQVrelFEELIVVVGDVGKKENAARDLQNW 624  Phytophthora infestans T30-4...
Q54MP2                         524 KNLQKEINTITDTAVRTFELVKDLLYNDAKK--DQTAKQ--A----IKSFAIIddkFQKLFKTIDETGNFQNNILNLNSK 595  Dictyostelium discoideum...
EFA84683                       865 RTLQKEINTITDTAVRTFDAVKDMLYADAKK--DQTAKT--A----IKSFAVIdekFQTLLTAIDETGTYQNNIFTLTSK 936  Heterostelium album PN500...
XP_026693321                   526 KQVQKTMNRLKGRAERTFSAADEVIFKDAKH--DEGSKQ--A----YKYLVSLhdnCATLLKTVEETGLIMREIRDFEGQ 597  vase tunicate...
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