Conserved Protein Domain Family
PAXNEB

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pfam05625: PAXNEB 
PAXNEB protein
PAXNEB or PAX6 neighbor is found in several eukaryotic organisms. PAXNED is an RNA polymerase II Elongator protein subunit. It is part of the HAP subcomplex of Elongator, which is a six-subunit component of the RNA polymerase II holoenzyme. The HAP subcomplex is required for Elongator structural integrity and histone acetyltransferase activity. This protein family has a P-loop motif. However its sequence has degraded in many members of the family.
Statistics
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Aligned: 71 rows
Threshold Bit Score: 232.094
Threshold Setting Gi: 0
Created: 5-May-2019
Updated: 18-Jul-2019
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WGS:AAPU:GI21177-PA   9 VQKPIR-GTRTSPHTGQVITSSGNPSLDLILGGGLPIGSICLIEEDRFMTHAKVLAKYFLAEGLLSKQELFLGSLdd-lP 86  Drosophi...
XP_002316217         19 SAPQLP-GIKCGP-NGTFFVSSGIPDLDKILGGGFPLGSLVMIMEDAEAPHHMLLLRNFMSQGLVQNQPLLYASPak-dP 95  black co...
EER90094             24 SSSGAA-GVRIGP-NGAAFVSSGIPDLDRILGGGFLLGSVVMIMEDADAPHHLLLLRCFMSQGVVHKQPLLFSGAmk-eP 100 sorghum
XP_010646438         19 PAPQAP-GLKSGP-NGTIFLSSGIPDLDKILGGGFPLGSLVMVMEDTEAPHHMLLLRNFMSQGLVHNQPLLYASPsk-dP 95  wine grape
XP_006593446         18 VTSQNH-GLKHGP-NGTMFISSGIPDLDKILGGGFSLGSLVMVMEDPEAPHHMLLLRNFMSQGLVQKQPLLYASAsr-dP 94  soybean
EFH61096             20 SSPQIP-GLKSGP-NGTAFISTGIRDLDRILGGGYPLGSLVMVMEDPEAPHHMDLLRTFMSQGLVNNQPLLYASPsk-dP 96  Arabidop...
XP_015166714         19 ATTQIP-GVKLGP-NGTSFLSSGIPDLDQILGGGFTLGSLVMVMEDAEAPHHMLLLRNFMSQGLIHKQTLLYASPer-dP 95  potato
EGD74014             13 ARKPPP-ATKPSLANGQLLTSTGMDAIDHLLGGGVAVGSVFLIEAQAKSPYADVVLKYFLSQGICHNHHVTLMSAdt-dP 90  Salpingo...
Q54XS0               42 AAKKLPnGCKISIKNSNLLTSTGLTDLDDIIGGGIPIGSILMIEEDINSSYYMFLLKYFLAEGVLQQQGVFFSSLigidP 121 Dictyost...
XP_002121089         15 SGVVIP-GTHPSLHNGLLLVSTGIPSLDVVLGGGLPVGSIMMVEEDLFGRFSKIILKYYLAEGVMCNHSLFVASFed-kN 92  vase tun...
WGS:AAPU:GI21177-PA  87 EEMLRRLPKPLTd-------eEVEQEQRLEQEQQAdk-----ngLRIAFRYND-----LPLVNS--EQATA-----KIGH 142 Drosophi...
XP_002316217         96 RGFLGTLPCPSSs-------kDDKSRNHDTEqe---------kgLRIAWQYKKy----FSENQK--NIDDHkdsnqEFCN 153 black co...
EER90094            101 RLFLGTLPAPVSs-------sKEDGRHRAMGAAASsdgrandegLRIAWQYKKy----FGDD----SRAEHkdnkqEFSN 165 sorghum
XP_010646438         96 RAFLGTLPSPVLs-------kDDRSHNRDPEQLqe-------kgLRIAWQYKKy----FGEHRP--NFDSHrdtkhEYCN 155 wine grape
XP_006593446         95 KSFLGTLPSPASp-------kGDNKSSDLShe----------kdLRIAWQYKKy----FGEPQL--NLNTNnggqhDYCN 151 soybean
EFH61096             97 RGFLGTLPHPASs-------kEDKSTAPDPDqg---------esLRIAWQYRKy-------------LESQknsidDYSN 147 Arabidop...
XP_015166714         96 RGFLGTLPSPMAs-------kEEKSHERPAEqd---------anLRIAWQYKKy----FGEQ----NSEGQrggkaEYCN 151 potato
EGD74014             91 SKFLKSCPRSVDtlnipesasVEKpe----------------kdMKIAWRYKN-----LPKVSSvvGTASRttfstKFCH 149 Salpingo...
Q54XS0              122 FEILNKLPARITkeeeieadkNDTTNNINTNINTNnnnkqptdeLKIAWRYQQyvsneLSKQQQ--QQSAStimnqTFCH 199 Dictyost...
XP_002121089         93 EEILTQLPKPVTk-------dILTGSKtd--------------dMKIAFRYRD-----LSTATN--SLDAp----pKYGH 140 vase tun...
WGS:AAPU:GI21177-PA 143 HFNLMEHMDAMMLS-YAHATIWNdkktnqedyedfdvandseqpragggeslpdpsesmlysyaqvvgskadpdqegeqS 221 Drosophi...
XP_002316217        154 DFDLRKPLEKHFYS-----------------------------------------------------------------G 168 black co...
EER90094            166 DFDLRKPLERHLLN-----------------------------------------------------------------G 180 sorghum
XP_010646438        156 DFDLRKPLERYFLT-----------------------------------------------------------------A 170 wine grape
XP_006593446        152 DFDLRKPLDRHFFS-----------------------------------------------------------------G 166 soybean
EFH61096            148 DFDMRKPLERQFLS-----------------------------------------------------------------G 162 Arabidop...
XP_015166714        152 DFDLRKPLERHFYS-----------------------------------------------------------------G 166 potato
EGD74014            150 TFNLSQQVEEKDLS-----------------------------------------------------------------N 164 Salpingo...
Q54XS0              200 SYDFTRKMNVQSMNpELIHTLSHda----------------------------------------------------qsQ 227 Dictyost...
XP_002121089        141 YYDISRTMDKIDYE-HCGITTLNln-----------------------------------------------------kL 166 vase tun...
WGS:AAPU:GI21177-PA 222 PppdaaptqaaaaaaetdeatpmeqsdgqktapninnnnnnnmdnstannttsttgttttttptaspptgKPQ--FFYNA 299 Drosophi...
XP_002316217        169 Qrv------------------------------------------------------------------dCVS--IKDSP 180 black co...
EER90094            181 Qni------------------------------------------------------------------eCVS--IQDAD 192 sorghum
XP_010646438        171 Qni------------------------------------------------------------------cCLS--IQDPP 182 wine grape
XP_006593446        167 Nnv------------------------------------------------------------------dCVS--IKDSP 178 soybean
EFH61096            163 Rpi------------------------------------------------------------------dCVS--LLDSS 174 Arabidop...
XP_015166714        167 Qrv------------------------------------------------------------------dCIS--LRDSP 178 potato
EGD74014            165 Dti------------------------------------------------------------------hTAD--LRISK 176 Salpingo...
Q54XS0              228 A----------------------------------------------------------------------EG-----TS 232 Dictyost...
XP_002121089        167 I---------------------------------------------------------------------REDtvVPVST 177 vase tun...
WGS:AAPU:GI21177-PA 300 rYDRLLNYIQLLLNDsifEPG------ANmqe----knLCRVCLTSLGSPLWy--------------------dDHFAED 349 Drosophi...
XP_002316217        181 nLATLHDRCATFLAQfprNDG------SFs-------cMGRIAIQSLCAPQCe--------------------lSKMDWD 227 black co...
EER90094            193 tLSSLQDCCSAFLSKlprKDG------GSl-------tAGRIAIQSLCAPQCr--------------------yFEKDWD 239 sorghum
XP_010646438        183 nLAAFRDCCAKFLAQfsrNNS------SIs-------cAGRVAIQSFCAPQCe--------------------ySNMEWD 229 wine grape
XP_006593446        179 nLTALQDCCAGFLAKfsrNEG------SIs-------sAGRIAIQSFCSPQCk--------------------ySNEEWH 225 soybean
EFH61096            175 dLSVAQDHCSTFLSKfsrSSS------NIa-------sIGRIAIQSFSSPLCe--------------------ySDKESD 221 Arabidop...
XP_015166714        179 nLAPLLERCSTFSAQiakSDD------NIt-------cAGRIAIQSLCSPQCd--------------------fSDKDWE 225 potato
EGD74014            177 sGNTFADAMQLILEAvepFRM------VPqpgplvsaaVHRIGVHRLGSSAWdlgatdkdddggggynddqysvEERVQA 250 Salpingo...
Q54XS0              233 pYRNLFLEIQNLVYKynkEAA------MNpdq----trVLRLCIQSFSSPLW----------------------SNDEEG 280 Dictyost...
XP_002121089        178 mLRSTLNKLNTIASDiqhTAPksivakTKl-------nIIRAAIPGLGSPLWce------------------ntEDNVSS 232 vase tun...
WGS:AAPU:GI21177-PA 350 LLKFLTILRGSVRSCTAVCFITMPMHLIAkYDSSLVPKIRQLVDYAIELESFAGSERETHpa---fkEYSGLLHLHKMSA 426 Drosophi...
XP_002316217        228 MLSFIRSLKSMLRSANAVAIITFPSSLL---SPSFCKRWQHMADVLLSVKAIPDEDKELGklltgyqDMVGFLNVHKIAR 304 black co...
EER90094            240 MVSFIRSLKAMVRSSNSVAVITFPSTVL---SNSFCKRWQHLADTLLSIKAIPDEDKDLAklltgyqDMVGFLHVHKVAQ 316 sorghum
XP_010646438        230 MLSFIRSLKGMIRDSNAVAVITFPPSLL---SPSSSKRWQHIADTLLSVKAIPDEDKELAnlltgyqDMVGLLNVHKVAN 306 wine grape
XP_006593446        226 MLSFIRSLKGMARSSNAVIVVTFPPSLL---PPSCSKRLQHMADTLLSVKAIPDEDKELAklltgyqDMIGLLNVHKVAR 302 soybean
EFH61096            222 MLSFIRLLKSMLMVSNAVAIVTFPPSLL---SPSSSKRLQHMADTLLSIKAIPDGDKELEklltgykDINGFLNIHKVAR 298 Arabidop...
XP_015166714        226 MLSFIRSLKGMVRSSGAVAVISFPPSLV---SPAFLKRWQHLADTLISVKAIPDEDKELAklltgyqDMLGLLSVHKVAR 302 potato
EGD74014            251 ACAFLHQLRGIARRSCAVVFVTVPSSLLS-SSPHHRHRIHLLADAVVRMEGFAGTSNEHHpa---lkEYHGFFKVLRMPQ 326 Salpingo...
Q54XS0              281 VIEFLHALKGLLRSSVATCVISVPTYIY---SGAFVKKIAHLCDTVVSINSFSGLGGETPeq---faEYLGLFNIRKIAR 354 Dictyost...
XP_002121089        233 IARFLHALRALARNSLMTCVVTVPTHLY---TPHQVNVIRHMVDCSIELESF--SKEKTNpvf---sqFHGLIRLKKLPC 304 vase tun...
WGS:AAPU:GI21177-PA 427 INTLAVHM-PETTDLAFKLRRKK-FVIEKLHLPPDLQESSeqtaksadvlpipncG--------VNSNVSMDF 489 Drosophila moja...
XP_002316217        305 INTQVPMIlE-ATTFSIKLHKRRfLVLECLNQAPIDGssg-------------tsYgtsggcsgSSRSGALDF 363 black cottonwood
EER90094            317 TNSQVPVIlE-ASTLSLKLRKRRlLVLERLNQAPVDGstg-------------psSaas--sscSSQGSQLDF 373 sorghum
XP_010646438        307 VNTQVPVIlE-ATTFSIKLQKRRyLVLECLNQAPVDGssg-------------ssYastgscsgSTKTGTLDF 365 wine grape
XP_006593446        303 LNTQVPVIlE-ATTFSIKLQKRRfLVLECLNQAPVDGssg-------------ssYgtsggcsgSTKAGPLDF 361 soybean
EFH61096            299 INTQVPVIlE-AKTFSMSLKKRRfLALECLNQAPVDGssg-------------tsYgts--gscSSKSGALDF 355 Arabidopsis lyr...
XP_015166714        303 INTQVPAIlE-ATTFSMKLRKRRaLVLECLNQAPVDGssg-------------ssYgtsgscsgSSKTGNLDF 361 potato
EGD74014            327 LNSLVAAT-PDTADLVFKLKKKQ-FVIEKFHLPPELSDMPsrpqeda-----------pvtpssSSSSSSSSS 386 Salpingoeca ros...
Q54XS0              355 LNTLSLSFhPDMLTFVFKMKRRK-MCIETIHLPPESSrag-------------dsKpdnndsnkNKSDQNNIV 413 Dictyostelium d...
XP_002121089        305 LNSLVPFI-PQSLDLGFELKKTK-FQIKCLHLPPDMSDGAaesdgk----tqkspCd------sNTLHRKLDF 365 vase tunicate
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