Conserved Protein Domain Family
PMG

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pfam05287: PMG 
PMG protein
This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and PMG2). PMG1 and 2 contain characteristic repeats reminiscent of the keratin-associated proteins (KAPs). Both genes are expressed in growing hair follicles in skin as well as in sebaceous and eccrine sweat glands. Interestingly, expression is also detected in the mammary epithelium where it is limited to the onset of the pubertal growth phase and is independent of ovarian hormones. Their broad, developmentally controlled expression pattern, together with their unique amino acid composition, demonstrate that pmg-1 and pmg-2 constitute a novel KAP gene family participating in the differentiation of all epithelial cells forming the epidermal appendages.
Statistics
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PSSM-Id: 283053
View PSSM: pfam05287
Aligned: 11 rows
Threshold Bit Score: 108.365
Threshold Setting Gi: 88909179
Created: 26-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81905579    4 RNNCSSSGNCSsGSLRNTCHIPASSSIA--LCSTNMGCGEVFCVPSSCQDHTWFMDNCPETFAEPLSGQPPSREasgfen 81
gi 81861009    1 MSCNSCSGTFS-QSFGGQLQYPISSCGS--SYPNNVFYSTDLQTPITHQLGSSLHSGCQETFCEPTNCQTAYVV------ 71
gi 81905478    1 MSNNCCSEVHSsSSCRNSSHVPVTSPVTsgVCSTETRGKDAPCSPTSSQGSNTPRDNCQEPCGEPRSCQSTSCNrstgs- 79
gi 88909179    6 MSTTGYPGVCStTSYRTHCYIPVTSSVT--LSSSDLSPTFGHCLPSSYQGNLWLLDYCQESYGEAPTCKSPSCEpktcs- 82
gi 121942690   1 MPHSHC------HSLRSFHNAPPLSAIT--HGTNPITFEDRLCLPSSFHSRTCFLDNFQETCNETTSCQMTNCEqdlftd 72
gi 74737618    4 PNY--CSGNSNsGSLRTSRHIPLTSID---LCPTSVSCGDVLYLPTSSQDHTWVTDNCQETCGEPTSCQPVHCEtgnlet 78
gi 74735807    1 MSYNCCSGNFSsRSCGDYLRYPASSRGF--SYPSNLVYSTDLCSPSTCQLGSSLYRGCQEICWEPTSCQTSYVE------ 72
gi 81905491    1 MAYSCCSGNFSsRSLRSCLPSSGSCRGS--SYPSNLVYTTTSCSPSTCQLSSSVRSGCQESCIEPIRCQESCIEpircqe 78
gi 81878429    1 MSYGCYSGNFSsRSSGDHLSYPHSSCGS--SYPSHLLQSTRFYSPGTCHLGSSLHSGCQQNCFQPIRCQTSHVV------ 72
gi 81905486    1 MTYSCRSGSFSsRSYGGQLCYP-SSCGS--SFPRQLTHRTNFCSPRNRHLGSSFRHGYHQNCFQPIRCQTSHVV------ 71
gi 426217167   1 MSYNCCSGNFSsRSLQDHLRYSGSSCGS--SFPSNLVYSTDLCSPSSCQLGSSLYS--QETCCEPIRTQTVV-------- 68
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81905579   82 sc---------------csstycvPRHCQGSGYIPASSFISGSCLPASYRPVSYVSS--SCRPVSP----------Fmnn 134
gi 81861009   72 ------------------------SRPCQRPFYSQRIRGPCRPCQSTFSGSLGFGSR--GFQSFGC----------G--- 112
gi 81905478   80 -------------------psvcsPITSGISGSQEGTSCLPNTPRHSSFGRPAFCRQpmSCYVPSY----------Lsdg 130
gi 88909179   83 -------------------ttgcdPSNSSVPCNSPSAGQVFSVCETTNVSPSPSCSP--STQTNGYvcnchiptrnAska 141
gi 121942690  73 dscvqsncfpgvvqttysnsrpceRTACQSESSSAGLACVSQPCQSESTQQMGFVAQ--SCQPASL----------Kgns 140
gi 74737618   79 sc--------------gsstayyvPRPCQGSSFLPA-SFFSSSCLPVSCRPQRYVSS--GCRPLRP----------Llns 131
gi 74735807   73 ------------------------SSPCQTSCYRPRTSLLCSPCKTTYSGSLGFGSS--SCRSLGY----------Gsrs 116
gi 81905491   79 tyiepircqesciepircqrscvvPSPCQKPCYYPRSSTPCRPCQGTYAGSLGFGSR--SCSSLAY----------Gsrs 146
gi 81878429   73 ------------------------HSSCQRPCYSPRVSSVCSPCRTTYAGSQSFGSS--SCHSQGY----------Gsrs 116
gi 81905486   72 ------------------------HSSCQRPCYRPSVSSFCSPCRATYAGFLGFRSS--SCHSQVY----------Gsrr 115
gi 426217167  69 ------------------------SSPCQTSCYRPRTSTFFSPCQTTCSGSLGFGSS--NLQSAGHv------------- 109
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81905579  135 CRPVS-CVSGGYRPLPCGSNSCRPLGIVTY--GCRPSGCvtygpqtihIVSNSlRPlqpvcggcqpsipvfGTCRPSCSA 211
gi 81861009  113 YPSQG-FGSHGFQSVGCGTPTFSSLNCGSS--FYRPTCF---------STKSC-QS---------------VSYQPTCGT 164
gi 81905478  131 CQPLG-YMTYGRPPWRNLTYGSQPF-------SCMPGCY---------GSTSY-NY---------------SSFQPYSSS 177
gi 88909179  142 CQTLR-NGSNCFGQLNCLSKSFQTLN------HCRLSTL---------GYKSY-QN---------------PCFIPSYVS 189
gi 121942690 141 CPPKT-SKSKNFETLERASSQCQCQSQNPEssSCRPLVNvapepqlleSSPGV-EP---------------TC----CVT 199
gi 74737618  132 YQPIGdCVPNAYRPQFCLSKSCQPQNLLTS--GCQPSSClayrpqslhVVSSSlRPlgplfsgcqplthvfSTCRPSC-S 208
gi 74735807  117 CYSVG-CGSSGVRSLGYGSCGFPSLGYGSG--FCRPTYL---------ASRSC-QS---------------PCYRPAYGS 168
gi 81905491  147 CYPVG-CGSSGFRSLDCGVYGFPSLSYGSR--FYYPVYV---------ASTGF-QP---------------SCYRSVCGT 198
gi 81878429  117 SYSLN-CGSSGFRPQR-----VSSLGYGSG--FCHPSYV---------PYRTC-QS---------------PCYRPSCGT 163
gi 81905486  116 VYTSG-CGSSCFRPVSYRVCGYPSFGYGSR--FCHPTYV---------TSRNF-QS---------------SCHRPTCGS 167
gi 426217167 110 FPSLG-FGSGGFQSVGHSPNIFSSLSCRSS--FYRPTFF---------SSRSG-QS---------------LSFQPTCGS 161

                 ..
gi 81905579  212 QG 213
gi 81861009  165 GF 166
gi 81905478  178 LS 179
gi 88909179  190 PL 191
gi 121942690 200 GG 201
gi 74737618  209 GL 210
gi 74735807  169 TF 170
gi 81905491  199 GF 200
gi 81878429  164 GS 165
gi 81905486  168 TK 169
gi 426217167 162 GF 163
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