Conserved Protein Domain Family
TRM13

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pfam05206: TRM13 
Methyltransferase TRM13
This is a family of eukaryotic proteins which are responsible for 2'-O-methylation of tRNA at position 4. TRM13 shows no sequence similarity to other known methyltransferases.
Statistics
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PSSM-Id: 336058
View PSSM: pfam05206
Aligned: 21 rows
Threshold Bit Score: 259.904
Threshold Setting Gi: 121974349
Created: 21-Mar-2017
Updated: 23-May-2017
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q6FVH2       153 KQQSSLIQNLFDVEL----IPSGKIMEFGCGRAEFSRYINQ--TIINNdpyqlQDDLPKYVLIDRGSNRM--KFDKKFQD 224 [Candida] glabrata
Q54BD5       252 QQESSIINLLENSNLy---NSDNVYLEFGAGSGKLSNHIFM--SHEKK---------SGHILIDRMKFRSlkKVDRLIKN 317 Dictyostelium d...
Q236Z5       312 STDETVEEIKEENKDl------------------MDQEQNQkdDIQEDqp-syKPYHACHVLLELESRRN--KMDRLHRD 370 Tetrahymena the...
Q8SX24       183 TQTTSLLGILEHDHQl---MDHTSYIEFGAGKGQLAYFLAT--VLQEQ-----KLSHSQVVLIDRMSLRH--KKDNKLAN 250 fruit fly
Q298B0       175 VQASALLGILEHDQQl---TDSTSFIEFGAGKGQLAFFLAT--ALETQ-----GLSHSQVVLIDRMSLRH--KKDNKVTN 242 Drosophila pseu...
Q16QR4       180 IQSASLLGILRRENFf---QNDVAFVEFGAGKGQVAFWLAT--VLQQS-----DLKNVKVFLVDKASHRH--KKDNKIED 247 yellow fever mo...
Q7QEF3       170 VQSSALLGLAEQCDFl---RPDTTFVEFGAGKGQVAYWLAR--IVETA-----PLARSAVLLVDRASHRH--KKDNKIET 237 Anopheles gambi...
Q8BYH3       165 KQQASILGNIEKLKLl---GPRRCFVEFGAGKGKLSHWVDI--ALKDA-------ENVHFILVERVTTRF--KVDGKHRK 230 house mouse
XP_001638186 161 KQQASLVGNMERLGLl---QPDTVYLEFGAGKGKLSHWVQQ--AHPE-------GGNVEYVLIDRASNRY--KFDSCHKR 226 starlet sea ane...
XP_001416220 171 LQRVAIAEAVQKVRDvfdlSTNSALVELCSGRAYLSAEIMK--TW----------PFSKLLLVDRRSHRF--KADRFLRH 236 Ostreococcus lu...
Q6FVH2       225 DLMAlsknpekvkqrIAIDRLKLDIKDLKLSTVIE-----EH-DGC-------LAISKHLCGVATD--LTLRCLQNCIEE 289 [Candida] glabrata
Q54BD5       318 EKGC-----------HHFSRLLIDIRHLNLSNLSIl----eE-KPF-------VITSKHLCGCATD--FTLDSIFNLLNN 372 Dictyostelium d...
Q236Z5       371 NP--------------FYLRYRTNILDFNVNALHQil-leQK-YPYinqdlrvVGVSKHMCGGATD--LSINTLLNCQN- 431 Tetrahymena the...
Q8SX24       251 RE--------------VVQRIRADIADLKLSALPEl---kKT-QRT-------VAFSKHLCGAATD--LTLRCILGDGNA 303 fruit fly
Q298B0       243 KE--------------LVQRIRADIGDLKISALPEl---kQT-KRN-------VALSKHLCGAATD--LTLRCVLAHRTA 295 Drosophila pseu...
Q16QR4       248 RE--------------IIQRVRADIGDLVLQKLDVl---rDS-RKI-------VGVGKHLCGGATD--LALRCLIRANKH 300 yellow fever mo...
Q7QEF3       238 RE--------------IVQRVRADIADLELHRVELieagaGR-SGV-------VGIGKHLCGAATD--LALRCLVRSGTS 293 Anopheles gambi...
Q8BYH3       231 KDS-------------VFERLQIDIQHLCLNRVPVlr--eGR-LPV-------VGIGKHLCGVATD--VALRCLVETYAA 285 house mouse
XP_001638186 227 GDNG-----------PDFKRVLLDIEHLNLGELPHl---gDKtRRI-------VAVSKHLCGTATGryLTLRCLLDTLHG 285 starlet sea ane...
XP_001416220 237 QSE--------------LRRLLIDIKDLDLYKVSLl---nK--SEV-------TIVGKHLCGEATD--FALKCALSYLKD 288 Ostreococcus lu...
Q6FVH2       290 tn-----------------------------------gKFKLQGICIAMCCRHVCNARDYINpdyiksfleSKH----SQ 330 [Candida] glabrata
Q54BD5       373 sne---------------------------------kvNNNFKGIGIATCCHHICNFNTYSN---------QSYlkdqLN 410 Dictyostelium d...
Q236Z5       432 --------------------------------------PQKFEGMMIATCCHHRCSPDTYTN---------NEFlmneLG 464 Tetrahymena the...
Q8SX24       304 s----------------------------------------sDYVLIALCCHHRCSWRSYVG---------RKFlq-eAG 333 fruit fly
Q298B0       296 p----------------------------------------tDYILIALCCHHRCSWRSYVG---------QTWlq-aAG 325 Drosophila pseu...
Q16QR4       301 rpe---------------------------------gdTLQSDGFVFALCCHHRCDWKTYAG---------KKFll-eKG 337 yellow fever mo...
Q7QEF3       294 g--------------------------------------tAVRGCLFALCCHHRCDWRTFAG---------KRFll-eSG 325 Anopheles gambi...
Q8BYH3       286 sfeekdeeplakrikndktekesntlakegsekdvpetWTPVAGIVIALCCHHRCDWRHYVG---------KEYfk-aLG 355 house mouse
XP_001638186 286 ssatepdstlkse-------------qkdakrrkldaaGPSVIGIVVALCCHHQCYWPHYVG---------RPFle-sLG 342 starlet sea ane...
XP_001416220 289 s-------------------------------------tVTFRGLAIAPCCHHACKWSSFVN---------TPFle-tLG 321 Ostreococcus lu...
Q6FVH2       331 INYKtFFGHLSKMCSWAT-----SGRRpgmn------------------------------dddIVQIEGDNQ------- 368 [Candida] glabrata
Q54BD5       411 ITPL-EFQLICSISSWAT-----IDENkcnnddddneveed---------delikkdkkekkefENQLKIEFN------- 468 Dictyostelium d...
Q236Z5       465 YTSE-DLQILFYCSSWYV-----SGQIkeeimkkieqseqkqvseqlnqiqnensqdnkqeeskKVIEQSQPN------- 531 Tetrahymena the...
Q8SX24       334 IGPR-EFVILTKMVSWAV-----CGTGlsrer---------------------------rkameSADFQLTET------- 373 fruit fly
Q298B0       326 LGHR-EFAIITKMVSWAV-----CGTGlsrer---------------------------rkamaEAHEELGEP------- 365 Drosophila pseu...
Q16QR4       338 ISRE-DFDLVVKMVSWAV-----CGTGtsrer-------------------------------rnaegDEGDG------- 373 yellow fever mo...
Q7QEF3       326 ITRA-EFESIVRMVSWAV-----CGTGrsrer----------------------------------qqeddKP------- 358 Anopheles gambi...
Q8BYH3       356 LGAV-EFYYFQRMSSWAT-----CGMRtslegsdvtperkd---------aqrdeneehddggdRLTDGNTDS------- 413 house mouse
XP_001638186 343 ITPQ-EFHLLCCMSSWAT-----CGMRppqgss--------------------------keaehCNTDESGETdddngvd 390 starlet sea ane...
XP_001416220 322 FSET-DFGYLIRMTSWATtlstgCTSHgfss------------------------------dfaIHTEDMDAC------- 363 Ostreococcus lu...
Q6FVH2       369 ---EQLSISLLQREKIGLFARYLIDNGRLEWVKQNlmnnkMKNAKIIKYIEPDVSRENNALLVY 429 [Candida] glabrata
Q54BD5       469 ---KQDVFSIKRKEELGYKAKRLIDYGRYLFIKEK-----LNLPNTKFWIYTNQSKENLFLVSN 524 Dictyostelium discoideum
Q236Z5       532 ---NKEWLSSEKKSLIGKMVKRTVDIGRILNLVKK-----GKKGRIVKYCDFILSPENFVIIAK 587 Tetrahymena thermophila SB210
Q8SX24       374 ---NTQRLTRQEREQIGQQCKRVLDYGRLEHLRSH-----GYQAELKFYVPRDVTLENVVLLAR 429 fruit fly
Q298B0       366 ---PTQRLTREQREQIGYQCKRVLDQGRLEHLRAN-----GFDASLKFYVPREITLENVVLIAK 421 Drosophila pseudoobscura
Q16QR4       374 ---IKYGMTRSQREEVGRRCKRMLDWGRIQYLKEN-----GFEAGLKLYAKAETTLENVCLIGH 429 yellow fever mosquito
Q7QEF3       359 ---DRCGMTRPEREAIGRRCKRLLDIARLRYMERH-----GYEASLKYYVTSDVTLENVCLVCV 414 Anopheles gambiae str. PEST
Q8BYH3       414 ---LPGILTVEEKKKIGHLCKLLIDQGRLQYLQQK-----GFSPALQYYTDPLVSLENVLLTAV 469 house mouse
XP_001638186 391 gsdKGLGLSIADREEIGRQCKRLLDAGRVWYLREK-----GFNTSLAYYVDSSVSLENVVLLAt 449 starlet sea anemone
XP_001416220 364 ---RT--LSSNDKLRVGRYVKLILNTARVLWCKER-----GFDVSLEEYTNVWVTPENQLILVR 417 Ostreococcus lucimarinus CCE9901
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