Conserved Protein Domain Family
TRM13

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pfam05206: TRM13 
Methyltransferase TRM13
This is a family of eukaryotic proteins which are responsible for 2'-O-methylation of tRNA at position 4. TRM13 shows no sequence similarity to other known methyltransferases.
Statistics
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Aligned: 21 rows
Threshold Bit Score: 273.017
Threshold Setting Gi: 121974349
Created: 5-May-2019
Updated: 18-Jul-2019
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EDK42053          1 MQQSSLIGNLKRLDMl---SQEFFYMEFGCGKGELSRYINQ--CILEDvkgekhqkkmeeknsikngEGSHYGYGLIDRG 75  Lodderomyces...
Q54BD5          252 QQESSIINLLENSNLy---NSDNVYLEFGAGSGKLSNHIFM--SHEKK-----------------------SGHILIDRM 303 Dictyosteliu...
Q236Z5          312 STDETVEEIKEENKDl------------------MDQEQNQkdDIQEDqp---------------syKPYHACHVLLELE 358 Tetrahymena ...
jgi:OSTLU_24121 171 LQRVAIAEAVQKVRDvfdlSTNSALVELCSGRAYLSAEIMK--TW------------------------PFSKLLLVDRR 224 Ostreococcus...
NP_192097       186 inveccesdLEEKDD----NTAPAVVEFGAGRGYLTQMLAD--CY------------------------GIKKVYLVERK 235 thale cress
Q8SX24          183 TQTTSLLGILEHDHQl---MDHTSYIEFGAGKGQLAYFLAT--VLQEQ-------------------KLSHSQVVLIDRM 238 fruit fly
Q298B0          175 VQASALLGILEHDQQl---TDSTSFIEFGAGKGQLAFFLAT--ALETQ-------------------GLSHSQVVLIDRM 230 Drosophila p...
Q16QR4          180 IQSASLLGILRRENFf---QNDVAFVEFGAGKGQVAFWLAT--VLQQS-------------------DLKNVKVFLVDKA 235 yellow fever...
Q7QEF3          170 VQSSALLGLAEQCDFl---RPDTTFVEFGAGKGQVAYWLAR--IVETA-------------------PLARSAVLLVDRA 225 Anopheles ga...
Q8BYH3          165 KQQASILGNIEKLKLl---GPRRCFVEFGAGKGKLSHWVDI--ALKDA---------------------ENVHFILVERV 218 house mouse
EDK42053         76 KNRL--KADSKIITDSESsessqilPQIKRSKIDIKDLNVSKFLEd---vDYKNV-------VTVSKHLCGAATDLTLKL 143 Lodderomyces...
Q54BD5          304 KFRSlkKVDRLIKNEKGC-------HHFSRLLIDIRHLNLSNLSIl----eEKPF-------VITSKHLCGCATDFTLDS 365 Dictyosteliu...
Q236Z5          359 SRRN--KMDRLHRDNP----------FYLRYRTNILDFNVNALHQil-leQKYPYinqdlrvVGVSKHMCGGATDLSINT 425 Tetrahymena ...
jgi:OSTLU_24121 225 SHRF--KADRFLRHQS----------ELRRLLIDIKDLDLYKVSLl----nKSEV-------TIVGKHLCGEATDFALKC 281 Ostreococcus...
NP_192097       236 SYKL--KADRSLRQKES--------LVLERMRIDIEDLNLNAVESl----hGVPY-------VAVGKHLCGPATDLSLRC 294 thale cress
Q8SX24          239 SLRH--KKDNKLANRE----------VVQRIRADIADLKLSALPEl---kKTQRT-------VAFSKHLCGAATDLTLRC 296 fruit fly
Q298B0          231 SLRH--KKDNKVTNKE----------LVQRIRADIGDLKISALPEl---kQTKRN-------VALSKHLCGAATDLTLRC 288 Drosophila p...
Q16QR4          236 SHRH--KKDNKIEDRE----------IIQRVRADIGDLVLQKLDVl---rDSRKI-------VGVGKHLCGGATDLALRC 293 yellow fever...
Q7QEF3          226 SHRH--KKDNKIETRE----------IVQRVRADIADLELHRVELieagaGRSGV-------VGIGKHLCGAATDLALRC 286 Anopheles ga...
Q8BYH3          219 TTRF--KVDGKHRKKDS---------VFERLQIDIQHLCLNRVPVlr--eGRLPV-------VGIGKHLCGVATDVALRC 278 house mouse
EDK42053        144 LLNSDLFS-------------------------------------KDKFAGVLIAMCCRHVCSHDQLLPqsKKYlf-dHG 185 Lodderomyces...
Q54BD5          366 IFNLLNNSne---------------------------------kvNNNFKGIGIATCCHHICNFNTYSN--QSYlkdqLN 410 Dictyosteliu...
Q236Z5          426 LLNCQN---------------------------------------PQKFEGMMIATCCHHRCSPDTYTN--NEFlmneLG 464 Tetrahymena ...
jgi:OSTLU_24121 282 ALSYLKDSt-------------------------------------VTFRGLAIAPCCHHACKWSSFVN--TPFle-tLG 321 Ostreococcus...
NP_192097       295 CLSRQDGE-------------------------------------SPVLRGLAIATCCHHLSQWKSYIN--KEYil-sLG 334 thale cress
Q8SX24          297 ILGDGNASs----------------------------------------DYVLIALCCHHRCSWRSYVG--RKFlq-eAG 333 fruit fly
Q298B0          289 VLAHRTAPt----------------------------------------DYILIALCCHHRCSWRSYVG--QTWlq-aAG 325 Drosophila p...
Q16QR4          294 LIRANKHRpe---------------------------------gdTLQSDGFVFALCCHHRCDWKTYAG--KKFll-eKG 337 yellow fever...
Q7QEF3          287 LVRSGTSGt--------------------------------------AVRGCLFALCCHHRCDWRTFAG--KRFll-eSG 325 Anopheles ga...
Q8BYH3          279 LVETYAASfeekdeeplakrikndktekesntlakegsekdvpetWTPVAGIVIALCCHHRCDWRHYVG--KEYfk-aLG 355 house mouse
EDK42053        186 FESKqSFNVLKKIVSWAVDAKDdkptgtkfne-----gdesnkcneSNGrtetnarnenNKVNAIDENNPSGLTSKQRQE 260 Lodderomyces...
Q54BD5          411 ITPL-EFQLICSISSWATIDENkcnndddd---------neveeddELIkkdkkekkefENQLKIEFNKQDVFSIKRKEE 480 Dictyosteliu...
Q236Z5          465 YTSE-DLQILFYCSSWYVSGQIkeeimkkieqseqkqvseqlnqiqNENsqdnkqeeskKVIEQSQPNNKEWLSSEKKSL 543 Tetrahymena ...
jgi:OSTLU_24121 322 FSET-DFGYLIRMTSWATTLSTgct-------------------shGFSsdfaihtedmDACRT--------LSSNDKLR 373 Ostreococcus...
NP_192097       335 ISKD-EFHIMTSFTSWAVDDDHgsklpgv-----------ddidllDSNakeeeegevrDASLISVEEVVKKMKPMERAV 402 thale cress
Q8SX24          334 IGPR-EFVILTKMVSWAVCGTGlsrer---------------------------rkameSADFQLTETNTQRLTRQEREQ 385 fruit fly
Q298B0          326 LGHR-EFAIITKMVSWAVCGTGlsrer---------------------------rkamaEAHEELGEPPTQRLTREQREQ 377 Drosophila p...
Q16QR4          338 ISRE-DFDLVVKMVSWAVCGTGtsrer-------------------------------rnaegDEGDGIKYGMTRSQREE 385 yellow fever...
Q7QEF3          326 ITRA-EFESIVRMVSWAVCGTGrsrer----------------------------------qqeddKPDRCGMTRPEREA 370 Anopheles ga...
Q8BYH3          356 LGAV-EFYYFQRMSSWATCGMRtslegsdv---------tperkdaQRDeneehddggdRLTDGNTDSLPGILTVEEKKK 425 house mouse
EDK42053        261 YGLKARRIIDESRAFAMRSIlgeDYNVELFWYIDDNITLENVCLSIV 307 Lodderomyces elongisporus NRRL YB-4239
Q54BD5          481 LGYKAKRLIDYGRYLFIKEK---LNLPNTKFWIYTNQSKENLFLVSN 524 Dictyostelium discoideum
Q236Z5          544 IGKMVKRTVDIGRILNLVKK---GKKGRIVKYCDFILSPENFVIIAK 587 Tetrahymena thermophila SB210
jgi:OSTLU_24121 374 VGRYVKLILNTARVLWCKER---GFDVSLEEYTNVWVTPENQLILVR 417 Ostreococcus lucimarinus CCE9901
NP_192097       403 LGFKCKQIIDAGRMKWVKKH---GLNSKLVKYIPASISPENTLLIAg 446 thale cress
Q8SX24          386 IGQQCKRVLDYGRLEHLRSH---GYQAELKFYVPRDVTLENVVLLAR 429 fruit fly
Q298B0          378 IGYQCKRVLDQGRLEHLRAN---GFDASLKFYVPREITLENVVLIAK 421 Drosophila pseudoobscura
Q16QR4          386 VGRRCKRMLDWGRIQYLKEN---GFEAGLKLYAKAETTLENVCLIGH 429 yellow fever mosquito
Q7QEF3          371 IGRRCKRLLDIARLRYMERH---GYEASLKYYVTSDVTLENVCLVCV 414 Anopheles gambiae str. PEST
Q8BYH3          426 IGHLCKLLIDQGRLQYLQQK---GFSPALQYYTDPLVSLENVLLTAV 469 house mouse
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