Conserved Protein Domain Family
TRM13

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pfam05206: TRM13 
Methyltransferase TRM13
This is a family of eukaryotic proteins which are responsible for 2'-O-methylation of tRNA at position 4. TRM13 shows no sequence similarity to other known methyltransferases.
Statistics
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PSSM-Id: 336058
View PSSM: pfam05206
Aligned: 21 rows
Threshold Bit Score: 259.904
Threshold Setting Gi: 121974349
Created: 21-Mar-2017
Updated: 23-May-2017
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74610589  153 KQQSSLIQNLFDVEL----IPSGKIMEFGCGRAEFSRYINQ--TIINNdpyqlQDDLPKYVLIDRGSNRM--KFDKKFQD 224
gi 74850523  252 QQESSIINLLENSNLy---NSDNVYLEFGAGSGKLSNHIFM--SHEKK---------SGHILIDRMKFRSlkKVDRLIKN 317
gi 121974349 312 STDETVEEIKEENKDl------------------MDQEQNQkdDIQEDqp-syKPYHACHVLLELESRRN--KMDRLHRD 370
gi 74866043  183 TQTTSLLGILEHDHQl---MDHTSYIEFGAGKGQLAYFLAT--VLQEQ-----KLSHSQVVLIDRMSLRH--KKDNKLAN 250
gi 121990919 175 VQASALLGILEHDQQl---TDSTSFIEFGAGKGQLAFFLAT--ALETQ-----GLSHSQVVLIDRMSLRH--KKDNKVTN 242
gi 122116956 180 IQSASLLGILRRENFf---QNDVAFVEFGAGKGQVAFWLAT--VLQQS-----DLKNVKVFLVDKASHRH--KKDNKIED 247
gi 74804153  170 VQSSALLGLAEQCDFl---RPDTTFVEFGAGKGQVAYWLAR--IVETA-----PLARSAVLLVDRASHRH--KKDNKIET 237
gi 81898069  165 KQQASILGNIEKLKLl---GPRRCFVEFGAGKGKLSHWVDI--ALKDA-------ENVHFILVERVTTRF--KVDGKHRK 230
gi 156398419 161 KQQASLVGNMERLGLl---QPDTVYLEFGAGKGKLSHWVQQ--AHPE-------GGNVEYVLIDRASNRY--KFDSCHKR 226
gi 145342501 171 LQRVAIAEAVQKVRDvfdlSTNSALVELCSGRAYLSAEIMK--TW----------PFSKLLLVDRRSHRF--KADRFLRH 236
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74610589  225 DLMAlsknpekvkqrIAIDRLKLDIKDLKLSTVIE-----EH-DGC-------LAISKHLCGVATD--LTLRCLQNCIEE 289
gi 74850523  318 EKGC-----------HHFSRLLIDIRHLNLSNLSIl----eE-KPF-------VITSKHLCGCATD--FTLDSIFNLLNN 372
gi 121974349 371 NP--------------FYLRYRTNILDFNVNALHQil-leQK-YPYinqdlrvVGVSKHMCGGATD--LSINTLLNCQN- 431
gi 74866043  251 RE--------------VVQRIRADIADLKLSALPEl---kKT-QRT-------VAFSKHLCGAATD--LTLRCILGDGNA 303
gi 121990919 243 KE--------------LVQRIRADIGDLKISALPEl---kQT-KRN-------VALSKHLCGAATD--LTLRCVLAHRTA 295
gi 122116956 248 RE--------------IIQRVRADIGDLVLQKLDVl---rDS-RKI-------VGVGKHLCGGATD--LALRCLIRANKH 300
gi 74804153  238 RE--------------IVQRVRADIADLELHRVELieagaGR-SGV-------VGIGKHLCGAATD--LALRCLVRSGTS 293
gi 81898069  231 KDS-------------VFERLQIDIQHLCLNRVPVlr--eGR-LPV-------VGIGKHLCGVATD--VALRCLVETYAA 285
gi 156398419 227 GDNG-----------PDFKRVLLDIEHLNLGELPHl---gDKtRRI-------VAVSKHLCGTATGryLTLRCLLDTLHG 285
gi 145342501 237 QSE--------------LRRLLIDIKDLDLYKVSLl---nK--SEV-------TIVGKHLCGEATD--FALKCALSYLKD 288
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74610589  290 tn-----------------------------------gKFKLQGICIAMCCRHVCNARDYINpdyiksfleSKH----SQ 330
gi 74850523  373 sne---------------------------------kvNNNFKGIGIATCCHHICNFNTYSN---------QSYlkdqLN 410
gi 121974349 432 --------------------------------------PQKFEGMMIATCCHHRCSPDTYTN---------NEFlmneLG 464
gi 74866043  304 s----------------------------------------sDYVLIALCCHHRCSWRSYVG---------RKFlq-eAG 333
gi 121990919 296 p----------------------------------------tDYILIALCCHHRCSWRSYVG---------QTWlq-aAG 325
gi 122116956 301 rpe---------------------------------gdTLQSDGFVFALCCHHRCDWKTYAG---------KKFll-eKG 337
gi 74804153  294 g--------------------------------------tAVRGCLFALCCHHRCDWRTFAG---------KRFll-eSG 325
gi 81898069  286 sfeekdeeplakrikndktekesntlakegsekdvpetWTPVAGIVIALCCHHRCDWRHYVG---------KEYfk-aLG 355
gi 156398419 286 ssatepdstlkse-------------qkdakrrkldaaGPSVIGIVVALCCHHQCYWPHYVG---------RPFle-sLG 342
gi 145342501 289 s-------------------------------------tVTFRGLAIAPCCHHACKWSSFVN---------TPFle-tLG 321
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74610589  331 INYKtFFGHLSKMCSWAT-----SGRRpgmn------------------------------dddIVQIEGDNQ------- 368
gi 74850523  411 ITPL-EFQLICSISSWAT-----IDENkcnnddddneveed---------delikkdkkekkefENQLKIEFN------- 468
gi 121974349 465 YTSE-DLQILFYCSSWYV-----SGQIkeeimkkieqseqkqvseqlnqiqnensqdnkqeeskKVIEQSQPN------- 531
gi 74866043  334 IGPR-EFVILTKMVSWAV-----CGTGlsrer---------------------------rkameSADFQLTET------- 373
gi 121990919 326 LGHR-EFAIITKMVSWAV-----CGTGlsrer---------------------------rkamaEAHEELGEP------- 365
gi 122116956 338 ISRE-DFDLVVKMVSWAV-----CGTGtsrer-------------------------------rnaegDEGDG------- 373
gi 74804153  326 ITRA-EFESIVRMVSWAV-----CGTGrsrer----------------------------------qqeddKP------- 358
gi 81898069  356 LGAV-EFYYFQRMSSWAT-----CGMRtslegsdvtperkd---------aqrdeneehddggdRLTDGNTDS------- 413
gi 156398419 343 ITPQ-EFHLLCCMSSWAT-----CGMRppqgss--------------------------keaehCNTDESGETdddngvd 390
gi 145342501 322 FSET-DFGYLIRMTSWATtlstgCTSHgfss------------------------------dfaIHTEDMDAC------- 363
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 74610589  369 ---EQLSISLLQREKIGLFARYLIDNGRLEWVKQNlmnnkMKNAKIIKYIEPDVSRENNALLVY 429
gi 74850523  469 ---KQDVFSIKRKEELGYKAKRLIDYGRYLFIKEK-----LNLPNTKFWIYTNQSKENLFLVSN 524
gi 121974349 532 ---NKEWLSSEKKSLIGKMVKRTVDIGRILNLVKK-----GKKGRIVKYCDFILSPENFVIIAK 587
gi 74866043  374 ---NTQRLTRQEREQIGQQCKRVLDYGRLEHLRSH-----GYQAELKFYVPRDVTLENVVLLAR 429
gi 121990919 366 ---PTQRLTREQREQIGYQCKRVLDQGRLEHLRAN-----GFDASLKFYVPREITLENVVLIAK 421
gi 122116956 374 ---IKYGMTRSQREEVGRRCKRMLDWGRIQYLKEN-----GFEAGLKLYAKAETTLENVCLIGH 429
gi 74804153  359 ---DRCGMTRPEREAIGRRCKRLLDIARLRYMERH-----GYEASLKYYVTSDVTLENVCLVCV 414
gi 81898069  414 ---LPGILTVEEKKKIGHLCKLLIDQGRLQYLQQK-----GFSPALQYYTDPLVSLENVLLTAV 469
gi 156398419 391 gsdKGLGLSIADREEIGRQCKRLLDAGRVWYLREK-----GFNTSLAYYVDSSVSLENVVLLAt 449
gi 145342501 364 ---RT--LSSNDKLRVGRYVKLILNTARVLWCKER-----GFDVSLEEYTNVWVTPENQLILVR 417
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