1NG9,1EWR,3THW


Conserved Protein Domain Family
MutS_III

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pfam05192: MutS_III 
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MutS domain III
This domain is found in proteins of the MutS family (DNA mismatch repair proteins) and is found associated with pfam00488, pfam05188, pfam01624 and pfam05190. The MutS family of proteins is named after the Salmonella typhimurium MutS protein involved in mismatch repair; other members of the family included the eukaryotic MSH 1,2,3, 4,5 and 6 proteins. These have various roles in DNA repair and recombination. Human MSH has been implicated in non-polyposis colorectal carcinoma (HNPCC) and is a mismatch binding protein. The aligned region corresponds with domain III, which is central to the structure of Thermus aquaticus MutS as characterized in.
Statistics
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PSSM-Id: 336050
View PSSM: pfam05192
Aligned: 1255 rows
Threshold Bit Score: 56.6136
Threshold Setting Gi: 503378634
Created: 26-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1NG9_A        272 ATRRNLEITQN-LagGaENTLASVLDCTVTPMGSRMLKRWLHMPVRDTRVLLERQQTIGALQ------------------ 332  Escherichia coli
XP_014751364  441 NALQQLEVLKNnSdgSvEGSLFQAMNNTCTAFGSRLFRHWLTHPLCDRNLICARHDAVSEISesmgsrqhsdsmlhdged 520  Brachypodium ...
XP_020189582  428 NALQQLEVLKNnSdgSiEGSLFQTMNNTCTAFGSRLFRHWLTHPLCDRNLICARHDAISEISesmgsrqdsvsirqdegd 507  Aegilops taus...
KQL12722      401 NTLQQLEVLRNnSdgTtEGSLFQTMNNTCTAFGSRLFRNWLTHPLCDRHRICARHDAVSEISesmgsrhsinnl-qdggd 479  foxtail millet
XP_001758062  437 NALRQLEILRNnAdgTnKGTLLWLMDHTHTLFGARLMRHWVTHPLQDEGLIAARLDAVTEIAesmgsvgvaqg--hgsfp 514  Physcomitrell...
XP_002969897  315 NTIRQLEILHNqTdgTeNGSLFWLMNHTKTAFGARLLKYWVTHPLRDRMLISQRLDAVAEIAesi--------------- 379  Selaginella m...
XP_002981370  181 NTIRQLEILHNqTdgTeNGSLFWLMNHTKTAFGVRLLKYWVTHPLRDRMLISQRLDAVAEIAesi--------------- 245  Selaginella m...
XP_002981371  181 NTIRQLEILHNqTdgTeNGSLFWLMNHTKTAFGARLLKYWVTHPLRDRMLISQRLDAVAEI------------------- 241  Selaginella m...
XP_005847684  496 NTLRQLEIFRN-VdgSpKGSLVSVMDHTKTAFGRRLLHSWVGKPLRQRAAIEARLDAVQELA------------------ 556  Chlorella var...
XP_002408552  164 ATLRRLDLFRNsLdgTsRGSLLDVMDHTATAFGRRLLFSWLGQPLADLGVIIERQDAVEDI------------------- 224  black-legged ...
1NG9_A        333 ------DFTA--GLQPVLRQ-VG---DLERILARLALRTARPRD-----LARmRHAFQQlPELRAQLETVDSAPVQalre 395  Escherichia coli
XP_014751364  521 ggctasVRSDlsTVLSSILTmLGrslDSQRGITRIFHCKATAKEf----VGV-IEAILT-AGKQLQKLVLEDTDTVssq- 593  Brachypodium ...
XP_020189582  508 gccaasARSDlsTILSSVLTmLGrslDSQRGITRIFHCKATAKEf----VGV-IQAVLT-AGKELRKLVLEDTDNVssq- 580  Aegilops taus...
KQL12722      480 gscaalARSDlsTILSSVLEmLGkslDIQRGITRIFHCKATAKEf----VGV-IHSILT-AGKQMQKLVLEDIDIVssq- 552  foxtail millet
XP_001758062  515 gsgrggGNVGkqGLLVSLLMsLGklpDVERGITRIFLRTATAAEf----VSV-VQGLIK-ASRQLRQLHFDHKDSDmeld 588  Physcomitrell...
XP_002969897  380 ---gdkGRGTtvATLASTLLlLGklpDLERGITRIYHKTATTYEf----INV-INAIMK-AASQFQ---RVR--DA---- 441  Selaginella m...
XP_002981370  246 ---gdkGRGTtvATLASTLLlLGklpDLERGITRIYHKTA-TYEapflfCNP-V--VIL-SDRNFQ---RVR--DT---- 308  Selaginella m...
XP_002981371  242 -------AEs-iGD--------------KR--QRIYHKTATTYEf----INV-INAIMK-AASQFQ---RVR--DA---- 282  Selaginella m...
XP_005847684  557 ------EAGGdhPVLCRLVStLRklpDLERGITRAFHATIRPSDl----AAL-LHQFSQ-LQEQLGVGAGAAAPGTsgdt 624  Chlorella var...
XP_002408552  225 -------LSSgsTAFSDLRKfLSrmpDVQRGLCAILHKKVKPSDa----FEI-LTSLAS-VRD------L----F----- 276  black-legged ...
1NG9_A        396 -------------------------------------kmgeFAElrDLLERaIIDTPPVLVRDGGVIASGYNEELDEWRA 438  Escherichia coli
XP_014751364  594 --------------------------------------rksVHS--SLLRR-LISTASSSTVLSNAVKLLSCLNKDAADQ 632  Brachypodium ...
XP_020189582  581 --------------------------------------hrtVHS--SLLRR-LISTASSSAVLANAVKLLSCLDKDAADQ 619  Aegilops taus...
KQL12722      553 --------------------------------------hkpVHS--SLLRR-LISTASSSTVLNTAVKLLSCLNKEAADQ 591  foxtail millet
XP_001758062  589 d-----------------------------------vhpksVKS--SLMRR-LVAAASSVSVSEPAAQLLSSLDTDAAAS 630  Physcomitrell...
XP_002969897  442 ------------------------------------------RS--ALLSR-LISAVTSTSVIDHANKLVTSLNAEAAAA 476  Selaginella m...
XP_002981370  309 ------------------------------------------RS--ALLSR-LISAVTSTSVIDHANKLVTSLNAEAAVA 343  Selaginella m...
XP_002981371  283 ------------------------------------------RS--ALLSR-LISAVTSTSVIDHANKLVTSLNAEAAAA 317  Selaginella m...
XP_005847684  625 ggsccegagpvaaaspqpagggseaeggasgaaappvalpgVRS--QLLRQ-LLRAAADPSVAAAARQMLDCMDLQAAAA 701  Chlorella var...
XP_002408552  277 -------------------------------------------S--SLQND-LTLGTLDVTLRCLDAQAARSNNMAGLFT 310  black-legged ...
1NG9_A        439 LADGATDYLERLEVRERERTGLDTLKVGFNAVHGYY--------------------------IQISRGQSHLAPINYMRR 492  Escherichia coli
XP_014751364  633 GDMLNIFIASVDQFPEVAEGHVTVEMAKRKLDLLIVeyrkqlgmrn------leyktvagttYLIELPVDRRVPSNWMKV 706  Brachypodium ...
XP_020189582  620 GDMINLFISSVDQFPEVAEGHVTVQMAKQKLDLLIVeyrkqlgmrs------leyktvsgtaYLIELPVDRRVPSNWMKV 693  Aegilops taus...
KQL12722      592 GDMLNLFIASVDNFPEANPSLLVAEGHVNVEMAQHKlelliieyrkqlgmsnlefktvagttHLIELPVDRRVPSNWVKI 671  foxtail millet
XP_001758062  631 GDKLKLFHCRDGKFPEVKNCRLAIEAIEQQLEDLLPnirkvlkspr------leymsvsgttHLIQMPVAHRVPANWIKV 704  Physcomitrell...
XP_002969897  477 GDKINLFVAGQFPEVDECKENIKSIEEDLESFLPSYrkllkcsnl--------eylsvsgtsFLVEVPCVQRVPADWVKI 548  Selaginella m...
XP_002981370  344 GDKINLFVAGQYPEVDECKENIKSIEEDLESFLPSYrk----------------------llKCSNLEYLSVLETSFLVE 401  Selaginella m...
XP_002981371  318 GDKINLFVAGQYPEVDECKENIKSIEEDLESFLPSYrkllkcsnl--------eylsvsgtsFLVEVPCAQRVPADWVKI 389  Selaginella m...
XP_005847684  702 NDKANVLKPSERFPEVLRWREEAAAAERALQGLLPQyrralqistlq----fqtlqnqgeylVEVPTDLVKRVPKDWQKV 777  Chlorella var...
XP_002408552  311 DLSHWPDLMQRKQDVINTEEKLVALKKTIAGQLGLLtfdyktv-------------sgmpylIEVPTRRLSSVPSNWLKI 377  black-legged ...
1NG9_A        493 QTLKNAERYIIPELKEYEDKVLTSKGKALALEKQLYEELFDLLLP-HlEALQQSASALAELDVLVNLA 559  Escherichia coli
XP_014751364  707 NSTKKTIRYHTPEIVKNLDNLVLAKEELAVICRTTWHTFLMDFGKyY-AQFQATVESLAALDCLYSLA 773  Brachypodium distachyon
XP_020189582  694 NSTKKTIRYHTPEVLKNLDNLLLAKEELAVICRKTWHKFLMDFGKyY-AQFQASVESLAALDCLYSLA 760  Aegilops tauschii subsp. ...
KQL12722      672 NSTKKTIRYHTPEILKNLDNLLLAKEELAVICRSTWHKFLTDFSKyY-AQFQAAVESLASLDCLYSLA 738  foxtail millet
XP_001758062  705 NSTKAMHRYHPPEVLEALDALTLAKEELSIACGRAWDAFLAEFAShY-VAFRAAVQALAALDCLHSLA 771  Physcomitrella patens
XP_002969897  549 NSTKKANRYHPPEVLEASERMALAKEQLNISCAKAWDMFLTDFTSyH-MEFRAAVQALAALDCLYSLA 615  Selaginella moellendorffii
XP_002981370  402 IGTKKANRYHPPEVLEASERMALAKEQLNISCAKAWDMFLTDFTSyH-MEFRAAVQALAALDCLDSLA 468  Selaginella moellendorffii
XP_002981371  390 NSTKKANRYHPPEVLEASERMALAKEQLNISCAKAWDMFLTDFTSyH-MEFRAAVQALAALDCLYSLA 456  Selaginella moellendorffii
XP_005847684  778 SSVKKGVRYHPPEVTAGLQRLALAREHLKAACDAAWRQFLLDFGShY-LGFRAAVQAAAALDCLCSLA 844  Chlorella variabilis
XP_002408552  378 SSTKTAERFRSPAVDSLYKELCVGQELVLVESRKTWNAFLGEVSQgY-NNYQRAVRAIATVDCFLSLA 444  black-legged tick
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