5YK4,1WBB,1NNE,2O8E,2O8B


Conserved Protein Domain Family
MutS_IV

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pfam05190: MutS_IV 
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MutS family domain IV
This domain is found in proteins of the MutS family (DNA mismatch repair proteins) and is found associated with pfam01624, pfam05188, pfam05192 and pfam00488. The mutS family of proteins is named after the Salmonella typhimurium MutS protein involved in mismatch repair; other members of the family included the eukaryotic MSH 1,2,3, 4,5 and 6 proteins. These have various roles in DNA repair and recombination. Human MSH has been implicated in non-polyposis colorectal carcinoma (HNPCC) and is a mismatch binding protein. The aligned region corresponds in part with globular domain IV, which is involved in DNA binding, in Thermus aquaticus MutS as characterized in.
Statistics
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Aligned: 49 rows
Threshold Bit Score: 57.2355
Threshold Setting Gi: 3914060
Created: 20-Mar-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5YK4_A  427 GFHPELDELRRIQNHGDEFLLDLEAKERE--RTGL---STLK---VEFNRVHGFYIELSKTQAEQA--PA-DYQR--RQT 493  Neisseria gonorrhoe...
Q9TXR4  448 DFVPEIQEISEKLEQMERVAEKLRKKYSA--KFEC---DNLK---LDKNSQYGFYFRVTLKEEKSIrkKD-VHIL--ETT 516  Caenorhabditis elegans
O74773  489 EFDEELLDLRQRLDELQHSIFEEHKRVGS--DLHQdteKKLH---LEQHHLYGWCLRLTRTEAGCLrgrssHYTE--LST 561  Schizosaccharomyces...
Q19272  449 GIDEELDEIRDTYENMPMVLTAIAKQEEA--RLGLppySNVA---CVYIPLVGFVLSVPRDYGVES--QP-DMTL--LYS 518  Caenorhabditis elegans
O43196  398 NIDPEIDEKKRRLMGLPSFLTEVARKELEnlDSRI---PSCS---VIYIPLIGFLLSIPRLP-SMV--EAsDFEIngLDF 468  human
Q9N3T8  767 GCDEEYDEALNRVKEALNELNDYKDSVAK--KYSC----SIK---FVDSGKVKYLLEMP-ENTKVSs----SFEL--KSR 830  Caenorhabditis elegans
Q9VUM0  767 GMDAEYDAAMDSIGEVEKRLKTYLVEQER--HFGC---RITY---FGSDKKR-YQLDVPESHASKAnk--sYTLE--GQT 833  fruit fly
Q03834  780 GFDIEFDKSMDRIQELEDELMEILMTYRK--QFKC---SNIQ---YKDSGKEIYTIEIPISATKNV--PS-NWVQ--MAA 846  Saccharomyces cerev...
P52701  932 GFDSDYDQALADIRENEQSLLEYLEKQRN--RIGC---RTIVywgIGRNR---YQLEIPENFTTRNl-PE-EYEL--KST 999  human
O04716  886 GADEEYDCACKTVEEFESSLKKHLKEQRK--LLGD---ASIN---YVTVGKDEYLLEVPESLSGSV--PH-DYEL--CSS 952  thale cress
5YK4_A  494 --LKNAER---FITPELKAFEDKVLTAQD 517  Neisseria gonorrhoeae FA 1090
Q9TXR4  517 --KGSGVK---FSVGELSDINDEFLEFHL 540  Caenorhabditis elegans
O74773  562 --QKNGVY---FTTKRLHSLNNSYMDHQK 585  Schizosaccharomyces pombe 972h-
Q19272  519 --THEDLR---VRNATTSRLDDEFGDILM 542  Caenorhabditis elegans
O43196  469 --MFLSEEklhYRSARTKELDALLGDLHC 495  human
Q9N3T8  831 --RKGFIR---YSTPDSEQLVAALDAVEK 854  Caenorhabditis elegans
Q9VUM0  834 kgKKPSRR---YTTAETRALLKDMQHAED 859  fruit fly
Q03834  847 --NKTYKR---YYSDEVRALARSMAEAKE 870  Saccharomyces cerevisiae S288C
P52701 1000 --KKGCKR---YWTKTIEKKLANLINAEE 1023 human
O04716  953 --KKGVSR---YWTPTIKKLLKELSQAKS 976  thale cress
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