1WB9,5YK4,3THW,2O8E


Conserved Protein Domain Family
MutS_II

?
pfam05188: MutS_II 
Click on image for an interactive view with Cn3D
MutS domain II
This domain is found in proteins of the MutS family (DNA mismatch repair proteins) and is found associated with pfam00488, pfam01624, pfam05192 and pfam05190. The MutS family of proteins is named after the Salmonella typhimurium MutS protein involved in mismatch repair; other members of the family included the eukaryotic MSH 1,2,3, 4,5 and 6 proteins. These have various roles in DNA repair and recombination. Human MSH has been implicated in non-polyposis colorectal carcinoma (HNPCC) and is a mismatch binding protein. This domain corresponds to domain II in Thermus aquaticus MutS and has similarity resembles RNAse-H-like domains (see pfam00075).
Statistics
?
Aligned: 51 rows
Threshold Bit Score: 41.1554
Threshold Setting Gi: 694016563
Created: 5-May-2019
Updated: 18-Jul-2019
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
1WB9_A             131 NLLAA--IWq----DSKG-FGYATLDISSGRFRLSEPAD---RETMAAELQRTNPAELLYAEDFAEMs------------ 188  Escheric...
O13396             134 PVILAvkISak-asEART-VGVCFADASVRELGVSEFLDndlYSNFEALLIQLGVKECIVTQDKGEKekdpe-------- 203  Neurospo...
P43246             143 ASIGVvgVKms-avDGQRqVGVGYVDSIQRKLGLCEFPDndqFSNLEALLIQIGPKECVLPGGETAGdmgkl-------- 213  human
FlyBase:CG4215-PA  145 NSIISllVKld-ggGQRR-VGVASVEQNDCKFQLLEFLDddfFTELEATVVLLGPKECLLPSIegey------------- 209  fruit fly
P40965             104 CVLCC--IYev-prDISTrIGLCIINCNTGQMYLSDFMDsqiYIRVVHKLQIYQPTEILIPSSSLAPtvsklatmikfnv 180  Saccharo...
O94065              39 EVVMS--VYsp-kaDSMD-VGVSVLKLKTLELTLMSFCDsstFVRTVNQIQVYEPTSIILPEAQSHSqieklkyii--hs 112  Candida ...
O15457             155 SVIVAvvEGr---gLARGeIGMASIDLKNPQIILSQFADnttYAKVITKLKILSPLEIIMSNTACAVgnstk-------- 223  human
Q9VUM0             391 NYMLA--IVekdegTCSR-YGVCFIDTSIGDFHLGEFEDdknCSRLLTLVSHHMPVLFLNEKSALSQrtq---------- 457  fruit fly
O74502             501 TYCMAikESlqsdnEEPS-FGICFIDTSTGGFHMCEFTDdihRTKLDTLLTQVRPKELILEKSKISQksirai------- 572  Schizosa...
O74773             143 SVLLAvtTRvk--qDQRI-IGVAFIDPILKKLGVSEFVDsdaYTNFEALIVQVGAKECIISQSGHEStngnsavsi--nt 217  Schizosa...
1WB9_A             189 -----lIEGRRGLRRRPLWE-FEIDTA--RQQLN--LQF---GTRDLVGFGV-------ENAPRGLCAAGCLLQYAKDTQ 248  Escheric...
O13396             204 --laklRQIIDNCGVAIAER-SAGEFG--TKDIE--QDL---SRLLKDERAAsll--pqTDLKLAMGSASALIKYLGILH 271  Neurospo...
P43246             214 --rqiiQRGGILITERKKAD-FSTKDI--YQDLN--RLL---KGKKGEQMNSavl--peMENQVAVSSLSAVIKFLELLS 281  human
FlyBase:CG4215-PA  210 ---savKTLLDRNGVMITMP-KKSGDNdlLQDLN--RLLrfaKGQQEDATGLk-----eLQLQLASNALKTAIKYLDLVN 278  fruit fly
P40965             181 aetvkiEEGSRKCFNSQDGL-AAITKY--LMDDTk-KDL---KIEEIIDKTF------------ALCAASAAISYMEEII 241  Saccharo...
O94065             113 nisdkvRERFMKAKVFNAFDgMNSLKL--YTDIN--EST---LGQVISNR------------KLSLAAANACIDYCVSTK 173  Candida ...
O15457             224 --lftlITENFKNVNFTTIQ-RKYFNE--TKGLEyiEQL---CIAEFSTVlm-----evQSKYYCLAAVAALLKYVEFIQ 290  human
Q9VUM0             458 ----qiVRTVLGGILKEPVP-GNGKHAcsAEKTL--KLL---AERYYAGPGSd------DNWPLVLR-----------TM 510  fruit fly
O74502             573 kycvssSSIWNFIKPYTEFW-DNERVE--REIIA--GDY---FKNGLEG-APkilksylSEKPLAISAFGALFWYLRQLK 643  Schizosa...
O74773             218 aeinrlRNIIEGCGALVTTI-RSSEFS--ARDVE--LEL---SKVLDSPVTHalv--peLGLQLAMASCNALLRYLGPAL 287  Schizosa...
1WB9_A             249 RT-------TLPHIR 256  Escherichia coli
O13396             272 DPs------NFGQYQ 280  Neurospora crassa OR74A
P43246             282 DDs------NFGQFE 290  human
FlyBase:CG4215-PA  279 DAg------NLGHYE 287  fruit fly
P40965             242 SKss----rNLNAFR 252  Saccharomyces cerevisiae S288C
O94065             174 MFr------VTNKIR 182  Candida albicans
O15457             291 NS--------VYAPK 297  human
Q9VUM0             511 QSdm----dHLGLTP 521  fruit fly
O74502             644 LDkd---mcSMGNFD 655  Schizosaccharomyces pombe 972h-
O74773             288 LNpdmeddrENTSRK 302  Schizosaccharomyces pombe 972h-
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap