4GQB


Conserved Protein Domain Family
PRMT5

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pfam05185: PRMT5 
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PRMT5 arginine-N-methyltransferase
The human homolog of yeast Skb1 (Shk1 kinase-binding protein 1) is PRMT5, an arginine-N-methyltransferase. These proteins appear to be key mitotic regulators. They play a role in Jak signalling in higher eukaryotes.
Statistics
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PSSM-Id: 336045
View PSSM: pfam05185
Aligned: 31 rows
Threshold Bit Score: 225.154
Threshold Setting Gi: 74953024
Created: 22-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4GQB_A       295 NAYELFA-KGYEDYLQSPLQPLMDNLESQTYEVFEKDPIKYSQYQQAIYKCLLDRVPEEEKDTnv--------------- 358
gi 74842609  358 DNDSLFD-SFYWDYLQIPLQPLKDNLSSQTYEVFEKDRKKYEQYELATSKYLSNWKKGKKINNknkqsnknknnnnnnnm 436
gi 74878077  364 DTHTLFD-SSYWDYLQIPLQPLKDNLSSQVYEIFERDKTKYEKYELAISKYLCDELNKKKYNNdnlnlsneennnsdksk 442
gi 44889023  346 DSTHYLNvIEYKDVLQAPLQPLSENLDSGVYNTFEQDQIKYDVYGEAVVGALKDLGADGRKTVv---------------- 409
gi 74695331  277 LLQAPGE--DGAPRVMQPLQPHAVDLSSEVYQIFEQDKTKYDLYAKAITAALRSIRSTMNKMWlhd-------------- 340
gi 74606759  303 DVVHSA------PTIMPPLLPHHDNLSNAVYQVFEKDTVKYELYERAIMVAVSEILTENSSSWrgpt------------- 363
gi 74638000  302 KMLKACE-KLAEPRILPQLKPHSEDLSNQTYALFEEDIVKYDLYEVAIKDAILENTKIWKNRGssf-------------- 366
gi 74953024  334 TIRELYG-RGYEDLFQVPLQPLRDNLDSSTYNEFEKCSFKYNCYDQAIHSFISTKLISLNQLSklnsnisy--------- 403
gi 156843094 311 ENDITIEdNYWIPRVMPPLLPNSENLSNLVYSNFERDTVKYELYQRAIELAVRDQIDYRRSYNl---------------- 374
gi 156083515 290 TEAEKFK-QGFYDVLQEPLQPVRDNLETATYENFERCTRKYAQYEAAISAWLKDYLNGKIGSQdenvrqdc--------- 359
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4GQB_A       359 --------qvLMVLGAGRGPLVNASLRAAKQAD--R--------RIKLYAVEKNPNAVVTLENW-QFEE---WgSQ-VTV 415
gi 74842609  437 eeqqndhkitIFVVGAGRGPLVDTTLSALQKNEm-T--------DYEIYAIEKNDSAIIILNNRvQTEE---W--KnVKV 502
gi 74878077  443 isksderhfiIFVVGAGRGPLVDCTLKALETNKi-N--------NYSIYAIEKNDSAILVLKNRlLNEK---W--KnVKV 508
gi 44889023  410 ----------IYLLGGGRGPIGTKILKSEREYNn-TfrqgqeslKVKLYIVEKNPNAIVTL-KYmNVRT---WkRR-VTI 473
gi 74695331  341 -------dlnIIVVGAGRGGLVDRAYTCLRQLGi-S--------RFKLVALEKNPQAVIHLQKK-NIEK---WgNS-VDI 399
gi 74606759  364 -------eliTLVAGAGRGPLVDKTFQVLHKLGv-T--------NFRLLAIEKNPQALLYLQKR-NFEH---WdNK-VEV 422
gi 74638000  367 --------itILVAGAGRGPLVDRVFKVLQELSilS--------ECRVIAIEKNSRAYLYLQKR-NFDK---WqNR-VTL 425
gi 74953024  404 ---sspvnyiVYVLGAGRGPLVEVVMEVFKRNNipTn-------DFVVFALEKNPYTMLTLDHKiQNNR---W-TN-VRL 468
gi 156843094 375 ---------vILIAGAGRGALVDRTFEVANFLNilN--------NVKIIALEKNPQACLYLQKR-KFDS---WgEK-VEI 432
gi 156083515 360 ---gkskapvIYIVGAGRGPLVDCSLRALAYHNv-E--------EYSIFALEKNPAAVFALKHKiATNAikgW-DK-VQI 425
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
4GQB_A       416 VSSDMREWVAPE----------KADIIVSELLGSFADNELSPECLDGAQH-----FLKDD-GVSI 464
gi 74842609  503 IHSDIRYLDIPK----------KADIIISELLGSFGDNELFPECMDGIKK-----FLKDD-GISI 551
gi 74878077  509 INSDMRHLKIDI----------KADLIVSELLGSFGDNELFPECLDSMEK-----YLKED-GISI 557
gi 44889023  474 IESDMRSLPGIAkdr----gfeQPDIIVSELLGSFGDNELSPECLDGVTG-----FLKPT-TISI 528
gi 74695331  400 VSANMREWSSKV----------KFDLCISELLGSFGCNELAPECLEAFEK-----TNCTDrTIFI 449
gi 74606759  423 IRTDIREWDENI----------KVDLCISELLGSFGCNELSPECIAPIEA-----FHSKPnTRFI 472
gi 74638000  426 INEDIQNWQINMaes----qrtKVDLCISELLGSFGCNELSPECLLSLQK-----YHSQKeTVYI 481
gi 74953024  469 IYSDMRDLNRGMvqsnlnnaskTVHLVLSELLGSFGDNELSPECLYGFERsfnslFSQGVrLEFI 533
gi 156843094 433 IRDDMKKWGDSSi---------KVDICISELLGSFGCNELSPECLFNIQK-----NHSKPsTIFI 483
gi 156083515 426 IFHDMRTLKPTI----------PADLVLSELLGSFGDNELAPECLDGVQHafykaFPNHH-VTFM 479
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