4GQB


Conserved Protein Domain Family
PRMT5

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pfam05185: PRMT5 
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PRMT5 arginine-N-methyltransferase
The human homolog of yeast Skb1 (Shk1 kinase-binding protein 1) is PRMT5, an arginine-N-methyltransferase. These proteins appear to be key mitotic regulators. They play a role in Jak signalling in higher eukaryotes.
Statistics
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PSSM-Id: 336045
View PSSM: pfam05185
Aligned: 31 rows
Threshold Bit Score: 225.154
Threshold Setting Gi: 74953024
Created: 22-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4GQB_A       295 NAYELFA-KGYEDYLQSPLQPLMDNLESQTYEVFEKDPIKYSQYQQAIYKCLLDRVPEEEKDTnv--------------- 358 human
Q8ID96       358 DNDSLFD-SFYWDYLQIPLQPLKDNLSSQTYEVFEKDRKKYEQYELATSKYLSNWKKGKKINNknkqsnknknnnnnnnm 436 Plasmodium falc...
Q7R936       364 DTHTLFD-SSYWDYLQIPLQPLKDNLSSQVYEIFERDKTKYEKYELAISKYLCDELNKKKYNNdnlnlsneennnsdksk 442 Plasmodium yoel...
P46580       346 DSTHYLNvIEYKDVLQAPLQPLSENLDSGVYNTFEQDQIKYDVYGEAVVGALKDLGADGRKTVv---------------- 409 Caenorhabditis ...
Q75DB6       277 LLQAPGE--DGAPRVMQPLQPHAVDLSSEVYQIFEQDKTKYDLYAKAITAALRSIRSTMNKMWlhd-------------- 340 Eremothecium go...
Q6CT32       303 DVVHSA------PTIMPPLLPHHDNLSNAVYQVFEKDTVKYELYERAIMVAVSEILTENSSSWrgpt------------- 363 Kluyveromyces l...
Q6FX40       302 KMLKACE-KLAEPRILPQLKPHSEDLSNQTYALFEEDIVKYDLYEVAIKDAILENTKIWKNRGssf-------------- 366 [Candida] glabrata
Q4UG56       334 TIRELYG-RGYEDLFQVPLQPLRDNLDSSTYNEFEKCSFKYNCYDQAIHSFISTKLISLNQLSklnsnisy--------- 403 Theileria annulata
XP_001644616 311 ENDITIEdNYWIPRVMPPLLPNSENLSNLVYSNFERDTVKYELYQRAIELAVRDQIDYRRSYNl---------------- 374 Vanderwaltozyma...
XP_001609241 290 TEAEKFK-QGFYDVLQEPLQPVRDNLETATYENFERCTRKYAQYEAAISAWLKDYLNGKIGSQdenvrqdc--------- 359 Babesia bovis T2Bo
4GQB_A       359 --------qvLMVLGAGRGPLVNASLRAAKQAD--R--------RIKLYAVEKNPNAVVTLENW-QFEE---WgSQ-VTV 415 human
Q8ID96       437 eeqqndhkitIFVVGAGRGPLVDTTLSALQKNEm-T--------DYEIYAIEKNDSAIIILNNRvQTEE---W--KnVKV 502 Plasmodium falc...
Q7R936       443 isksderhfiIFVVGAGRGPLVDCTLKALETNKi-N--------NYSIYAIEKNDSAILVLKNRlLNEK---W--KnVKV 508 Plasmodium yoel...
P46580       410 ----------IYLLGGGRGPIGTKILKSEREYNn-TfrqgqeslKVKLYIVEKNPNAIVTL-KYmNVRT---WkRR-VTI 473 Caenorhabditis ...
Q75DB6       341 -------dlnIIVVGAGRGGLVDRAYTCLRQLGi-S--------RFKLVALEKNPQAVIHLQKK-NIEK---WgNS-VDI 399 Eremothecium go...
Q6CT32       364 -------eliTLVAGAGRGPLVDKTFQVLHKLGv-T--------NFRLLAIEKNPQALLYLQKR-NFEH---WdNK-VEV 422 Kluyveromyces l...
Q6FX40       367 --------itILVAGAGRGPLVDRVFKVLQELSilS--------ECRVIAIEKNSRAYLYLQKR-NFDK---WqNR-VTL 425 [Candida] glabrata
Q4UG56       404 ---sspvnyiVYVLGAGRGPLVEVVMEVFKRNNipTn-------DFVVFALEKNPYTMLTLDHKiQNNR---W-TN-VRL 468 Theileria annulata
XP_001644616 375 ---------vILIAGAGRGALVDRTFEVANFLNilN--------NVKIIALEKNPQACLYLQKR-KFDS---WgEK-VEI 432 Vanderwaltozyma...
XP_001609241 360 ---gkskapvIYIVGAGRGPLVDCSLRALAYHNv-E--------EYSIFALEKNPAAVFALKHKiATNAikgW-DK-VQI 425 Babesia bovis T2Bo
4GQB_A       416 VSSDMREWVAPE----------KADIIVSELLGSFADNELSPECLDGAQH-----FLKDD-GVSI 464 human
Q8ID96       503 IHSDIRYLDIPK----------KADIIISELLGSFGDNELFPECMDGIKK-----FLKDD-GISI 551 Plasmodium falciparum 3D7
Q7R936       509 INSDMRHLKIDI----------KADLIVSELLGSFGDNELFPECLDSMEK-----YLKED-GISI 557 Plasmodium yoelii yoelii
P46580       474 IESDMRSLPGIAkdr----gfeQPDIIVSELLGSFGDNELSPECLDGVTG-----FLKPT-TISI 528 Caenorhabditis elegans
Q75DB6       400 VSANMREWSSKV----------KFDLCISELLGSFGCNELAPECLEAFEK-----TNCTDrTIFI 449 Eremothecium gossypii
Q6CT32       423 IRTDIREWDENI----------KVDLCISELLGSFGCNELSPECIAPIEA-----FHSKPnTRFI 472 Kluyveromyces lactis
Q6FX40       426 INEDIQNWQINMaes----qrtKVDLCISELLGSFGCNELSPECLLSLQK-----YHSQKeTVYI 481 [Candida] glabrata
Q4UG56       469 IYSDMRDLNRGMvqsnlnnaskTVHLVLSELLGSFGDNELSPECLYGFERsfnslFSQGVrLEFI 533 Theileria annulata
XP_001644616 433 IRDDMKKWGDSSi---------KVDICISELLGSFGCNELSPECLFNIQK-----NHSKPsTIFI 483 Vanderwaltozyma polyspora DSM ...
XP_001609241 426 IFHDMRTLKPTI----------PADLVLSELLGSFGDNELAPECLDGVQHafykaFPNHH-VTFM 479 Babesia bovis T2Bo
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