2ZPA,1W36


Conserved Protein Domain Family
Helicase_RecD

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pfam05127: Helicase_RecD 
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Helicase
This domain contains a P-loop (Walker A) motif, suggesting that it has ATPase activity, and a Walker B motif. In tRNA(Met) cytidine acetyltransferase (TmcA) it may function as an RNA helicase motor (driven by ATP hydrolysis) which delivers the wobble base to the active centre of the GCN5-related N-acetyltransferase (GNAT) domain. It is found in the bacterial exodeoxyribonuclease V alpha chain (RecD), which has 5'-3' helicase activity. It is structurally similar to the motor domain 1A in other SF1 helicases.
Statistics
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PSSM-Id: 310013
View PSSM: pfam05127
Aligned: 102 rows
Threshold Bit Score: 101.091
Threshold Setting Gi: 56966628
Created: 22-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2ZPA_A        197 VTAARGRGKSALAG----QLISRIAGRAIVTAPAKASTDVLAQFA----------------------------------- 237
gi 124481282  271 ISAARGRGKSAAIGmaaaAALKLGFSNIFVTAPSPENLVTFFEFLissletldfrqnqhfdviq------stnpdfnnav 344
gi 74880281   368 LLANRGRGKSATLGlilsLSIYFNYSNIITCSGNNDSVHTIFEFLdkglnilgynefkdyeki--------yvngkikei 439
gi 122052617  278 ILSDRGRGKSATIGlflsSALQLDFRNILIVAPNVENVSTLFDFLqrglkclgideysgytvtr------tegypsylkl 351
gi 75167385   259 MTSGRGRGKSSVLGlaccSAIAYGFSNIFITSTTVENVNTFYAFLilgletiglkenkdfeii---------fnkrkkci 329
gi 74621579   259 ITASRGRGKSAALGisiaQAVNLGLLSVYIASPAIENVKTVFMFLitgleklgykryvdfkiiy-------qfrgnkrfm 331
gi 156088325  282 IISARGRGKSATIGlflsAALNMGFRNILIVAPAIENVQTLFSFLesglhllgtpenakviinrkd---syiesvtlsvk 358
gi 901864277   40 LLANRGRGKSATLGlliaLSIYFNYTNVILCSGNDDGMQTIYEFIdeglrllgykefihyervyl-----lgklkeiiif 114
gi 123455656  303 ITAARGRGKSAAIGlslaAALALGYSNIFVTAPSIANLTALFEFVivgltalgfregesedfevvksnptsskerpyvtr 382
gi 159108010  380 LIAARGRGKSASLGlivaLMIFQGYNHVLISAPNPINVQTVFEFCiiglkaldyqeardytvrr-------agpkatdpi 452
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2ZPA_A        238 ---------GEKFRFIAPDALLASDeQA------------DWLVVDEAAAIPAPLLHQL---VsRFPRTLLTTTVQGYEG 293
gi 124481282  345 irvnaykthRQFVQYIQPQDFVKVAnNA------------DLVFCDEAAAIPIQFVKSM---F-GSHTLVLSSTINGYEG 408
gi 74880281   440 iifknikylKQKIRYLDIIENDNIP-NC------------ELMIIDEAACIPIDILKNK---I-KGEITILSTTLNGYEG 502
gi 122052617  352 nkrnsgvkfMSSTEIKNPEEFIKMF-SW------------DILIIEEAASIPLPIVDVL---S-SKGIVIISSTTGGYEG 414
gi 75167385   330 hkvnifnthKQFIKFVKPEEINEKKdFI------------ELLIIEESATFQFEILKTF---T-GPFITIFSTTYEGYEG 393
gi 74621579   332 qkieftggrKQIIEYFNPLDELKY--YP------------DLLVVDEAAAIPLTYLMKL---I-FPNFVIMATTASGYEG 393
gi 156088325  359 gstcvkfveSSSID---PKSGASNYlY-------------DILIIEEAASIPLPIVESL---C-KKGIVILSSTVGGYEG 418
gi 901864277  115 kdphnqsrlKQRVRYFNILEEDLV--NS------------ELMIIDEAACIPIDVLKGK---I-KGEVTILSTTLNGYEG 176
gi 123455656  383 vnvhlshgrRQTVQYVRPNMTQYLG-QC------------EILAIDEAAAIPLPIVRQL---M-GPYTTLFSSTVDGYEG 445
gi 159108010  453 ielritrkvKQVIAYIMPSTLATYC-QAnerasssilnfiDAILLDECAAIPLKLVRQIvdnVeANMLCFISSTCYGYEA 531
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
2ZPA_A        294 TGRGFLLKFCAR---------------------FP-HLHRFELQQPIRWAQGCPLEKXVSEALVFD 337
gi 124481282  409 TGRSLSLKLLQKlret-------------kqtgQArLLKELQMNDPIRYSNKDIVEKWLYELLLLD 461
gi 74880281   503 TGKTFTFKLLKQlkkkfvtqltydefkqikylyFDkAFIDITLKSPIRYSYDDQVENWLNNFLCLN 568
gi 122052617  415 TGRSISLKLIQKfkk----------------tlsSdTLSEITLKQPIRYARNDPIESWLNSLLCLN 464
gi 75167385   394 SGRSFNVKFLDWikkdinle------nktryinKIiYYKEIILSEPIRYSTDDYLEKWINDYFFFK 453
gi 74621579   394 TGRAFSVKLSETlrks-------------siesNSfVYKELAMNESIRYGQNDPVEDWLYRALVLD 446
gi 156088325  419 TGRSLSLKLIERfr-----------------ntNPeALTEITLKEPIRYSKNDSIEAWLNSLLCLG 467
gi 901864277  177 TGKTFIFKLLKQlkkkfvtqltygefkemkrlyFErAFIEVSLDTPIRYSYNDQVEAWLNDFLCLN 242
gi 123455656  446 TGRALSLKLFKEfq-----------------rtMKsRFTQTTLTKPIRYAEGDPIEAWLHNLLLLD 494
gi 159108010  532 SGRALSLKLLHDlers--------------gskRGqGLVKLSLNEPIRYAPNDSIEKWVNQLLCLD 583
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