6G18,5WWN,5JPQ


Conserved Protein Domain Family
RIBIOP_C

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pfam04950: RIBIOP_C 
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40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal
RIBIOP_C is a family of eukaryotic proteins from the C-terminus of pre-rRNA-processing protein or ribosome biogenesis proteins BMS1 and TSR1. These proteins act, in the nucleolus, as a molecular switch during maturation of the 40S ribosomal subunit. This domain, domain IV of translation elongation factor selb, adopts the same fold as translation proteins such as domain II of GTP-elongation factor Tu proteins.
Statistics
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Aligned: 220 rows
Threshold Bit Score: 159.557
Threshold Setting Gi: 402471170
Created: 6-May-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6G18_u                488 VDTPRDVAARIRFQKYRGLKSFRTSPWdPKEN---LPQDYARIFQFQNFTNTRKSIFK-----Eve------------eK 547  human
CAM69421              786 QGGSLTEEQERLLQKKMAKKRAFDQDYd-------TGNVDGGKNTTFSYYHRLNRQVEe---kKerinealddvgddmdK 855  Leish...
Q384C0                744 GGKPLTEEQERLLQKRMAKKKAFNELYd-------M----GGKNNTYSHYHEMTREVEa---kKerldtalqevghditN 809  Trypa...
EFC48321              781 NDDILDELQKKRMEKKKSFDAQFDEKK-SSDKkegSAGVEEEEEDPITTIEKLKKKLReddpqMilnktef--qnltreQ 857  Naegl...
LoveMIT:GQ68_02490T0  709 EELTLEEKRQLNAKKKEKLRQQFEDEE----GenfLEEGQE---DHDTWYEFQKAKMAk---qLeinksel--eeldeqT 776  Komag...
ESW96063              652 SDMSFERQRERNAKRKEKLRQQFEEEE----DltnNNDIFD---ETDTWYDYQKAKMAk---qLeinksel--tdmsedV 719  Ogata...
Q54JS8                745 KENSIENERERNKSKKEKQIEKINAKY---------------QENEKDFQGELNEEVKr---qRainekef--enddqfY 804  Dicty...
EGC30096              723 ESSDVEKEREKNKSKKQKQIEKINAKF---------------EEGEKDYEGELNAEARr---qReinekef--eqddqfY 782  Dicty...
GAA26761              708 KDLTMEQEREMNAAKKEKLRAQFEIEE----GenfKEDDEN--NEYDTWYELQKAKISk---qLeinniey--qemtpeQ 776  Sacch...
XP_011272494          715 PSLSLDERRALNAKKKEKLRLQFEAEE---GGkeiGTEDPE--NEEDTWYEIQKAKMAk---qLdinkaef--esmdpaI 784  Wicke...
6G18_u                548 EVeGae---vGWYVTLHVsE--VPVSVvecfrqgtPLIAFSLLPHEQKMSVLNMVVRRDPGNTEPVKAKEELIFHCGFRR 622  human
CAM69421              856 KI-QlvgyfsGLYLRIVIdSvpVEFLKafd--pavPLIAGGINAGEDEFRIVQARIKRHRWFPKILKAQDPLLLSMGWRR 932  Leish...
Q384C0                810 KI-KlvghfsGLYVRFVLeNvpVEFVQlfd--psvPIIAGGVNAGEDQFQVVHAKLKRHRWFPKILKAQDPLLLSMGWRR 886  Trypa...
EFC48321              858 RE-EiegispGSYVRLEInSfpTEFIEnvn--fknPIIVGGMHPEECRMGLIKMRMKRHRWYPRTLKNKDPLVFSIGWRR 934  Naegl...
LoveMIT:GQ68_02490T0  777 RL-HiegyraGSYVKLTFkNvpMEFVEnfn--piyPVIVGGLLQTEEKFGYLNVRIRRHRWHKKILKTNDPLVLSLGWRR 853  Komag...
ESW96063              720 RA-HiegftaGSYVKLTFnNlpMEVIEnfd--pkyPLVIGGLLQTEDRFGFLNARIRRHRWHKKVLKTNDPLILSLGWRR 796  Ogata...
Q54JS8                805 RQ-KyegfpiGVYVRIEFeKipCEFSEyfd--pkfPVVVGGLLSSEENLGMINVSLKKHRWHKRILKSNDPLMISVGWRR 881  Dicty...
EGC30096              783 RT-KyegfpiGVYVRVEFeKipCEFSEyfd--pryPVVVGGLLSNEENLGMINVNIKKHRWHKKILKSNDPLIVSVGWRR 859  Dicty...
GAA26761              777 RQ-RiegfkaGSYVRIVFeKvpMEFVKnfn--pkfPIVMGGLLPTEIKFGIVKARLRRHRWHKKILKTNDPLVLSLGWRR 853  Sacch...
XP_011272494          785 RA-RiegyraGSYVRLVFeQvpPELIEnfn--pkyPLVLGGLLPSEERFGYMDARIRRHRWHKKILKSNDPLILSLGWRR 861  Wicke...
6G18_u                623 FRASPLFSQHTaADKHKLQRFLtADmA-LVATVYAPITFPPASVLLFKQ----KsNGMHSLIATGHLMSVDPDRMVIKRV 697  human
CAM69421              933 FQTQPIFSTEDpNGRCRYLKYT-PLhMhCMAAFYAPVAPPNTGFLAIPVr--dPrVSSFRIPCTGYTIGNDVSTPIVKKL 1009 Leish...
Q384C0                887 FQTQPILATEDpNGRMRYLKYT-PMhMhCAAAFYAPVAPANTGFVAIPVr--eQrSPNFRISCTGYTVGNDLASNIVKKL 963  Trypa...
EFC48321              935 FQSIPTYCMQDdNGRHRQIKYT-PEyMhCIAAIYGPFVPQNTGVIAFQTl--sEkVDTFRVSATGYVMEMDQDFSIVKKL 1011 Naegl...
LoveMIT:GQ68_02490T0  854 FQTLPIYTTTDsRTRTRMLKYT-PEhAyCGATFYGPLVAPNTTFCGVQVvsnsAtTGSFRIAATGVVEDLNADVEIVKKL 932  Komag...
ESW96063              797 FQTLPIYTTSDsRTRNRLLKYT-PEhTyCFATFYGPLVAPNTTFCGVQAvskeLtTGSFRIAATGIVEDLNADVEIVKKL 875  Ogata...
Q54JS8                882 FQTIVLYSTKDiNGRNRMLKYT-PEhMhCHASFYGPLTPPGTGFIGFTNa--nNnQAGFRVSATGTVLDLDSSINVVKKL 958  Dicty...
EGC30096              860 FQTMVLYSTKDiNGRNRMLKYT-PEhMhCHASFYGPLTPPGTAFAAFTNs--nNnQASFRVSATGTVLDLDSSIDVVKKL 936  Dicty...
GAA26761              854 FQTLPIYTTTDsRTRTRMLKYT-PEhTyCNAAFYGPLCSPNTPFCGVQIvansDtGNGFRIAATGIVEEIDVNIEIVKKL 932  Sacch...
XP_011272494          862 FQTLPVYTTSDsRTRTRMLKYT-PEhTyCSATFYGPLVAPSTTFCAVQVvansDtTGSFRISATGVIDKVDSSTEIVKKL 940  Wicke...
6G18_u                698 VLSGHPFKIFTKMAVVRYMFFNREDVLWFKPVELRTKWGRRGHIKEPL----GT-HGHMKCSFDGKLKSQDTVLMNLYKR 772  human
CAM69421             1010 KLTGTPAKVEKTTAFIKGMFSSDVEAAKFIGAKLRTVSGIRGIIKSVM----KGkQGLVRATFEDKLFPSDIVFISAWKS 1085 Leish...
Q384C0                964 KLIGTPQKIMKTTAFIKGMFNSDLEAAKYVGAKLKTVAGIRGIVKTVL----KGkNGLIRATFEDKIFPSDIVFCRAWKM 1039 Trypa...
EFC48321             1012 KLLGYPKIVHKNTCIVTKMFTSDLEVAKYEGASLRTVSGLRGSVKKPFrgdkASp-GDFRATFEDKLIRGDIIFLRCWYA 1090 Naegl...
LoveMIT:GQ68_02490T0  933 KLVGYPYKVFKNTAFIKDMFSSALEVAKFEGASIKTVSGIRGEIKRAL----SKpDGYFRAAFEDKIQMSDIVFLRTWYP 1008 Komag...
ESW96063              876 KLVGHPYKVFKNTAFIKDMFSSALEVAKFEGATIRTVSGLRGEIKRAL----SKpEGHFRATFEDKILMSDIVFLKTWYP 951  Ogata...
Q54JS8                959 KLIGQPDKIMKKTCFVNGMFTSRLEVAKFVGATIRTVSGIRGQIKKPL----SHpEGSFRATFEDRLLPSDIIFLRTWYT 1034 Dicty...
EGC30096              937 KLIGHPDKILKKTCFVNGMFTSRLEVAKFVGATIRTVSGIRGTIKKPL----SHpEGAFRATFEDKLIPSDIVFLRTWYT 1012 Dicty...
GAA26761              933 KLVGFPYKIFKNTAFIKDMFSSAMEVARFEGAQIKTVSGIRGEIKRAL----SKpEGHYRAAFEDKILMSDIVILRSWYP 1008 Sacch...
XP_011272494          941 KLVGYPQRIERNTAFIKDMFTSSLEVARFEGAQIKTVSGIRGEIKRAM----SKpEGNFRATFEDKIIMSDIVILRTWYP 1016 Wicke...
6G18_u                773 VFP 775  human
CAM69421             1086 VEP 1088 Leishmania infantum JPCM5
Q384C0               1040 VEP 1042 Trypanosoma brucei
EFC48321             1091 LEL 1093 Naegleria gruberi
LoveMIT:GQ68_02490T0 1009 VQA 1011 Komagataella phaffii GS115
ESW96063              952 IKP 954  Ogataea parapolymorpha DL-1
Q54JS8               1035 ITP 1037 Dictyostelium discoideum AX4
EGC30096             1013 VTP 1015 Dictyostelium purpureum
GAA26761             1009 VRV 1011 Saccharomyces cerevisiae Kyokai no. 7
XP_011272494         1017 VGV 1019 Wickerhamomyces ciferrii
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