2HHP,4LT6


Conserved Protein Domain Family
PAP_RNA-bind

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pfam04926: PAP_RNA-bind 
Click on image for an interactive view with Cn3D
Poly(A) polymerase predicted RNA binding domain
Based on its similarity structurally to the RNA recognition motif this domain is thought to be RNA binding.
Statistics
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PSSM-Id: 309866
View PSSM: pfam04926
Aligned: 113 rows
Threshold Bit Score: 88.4071
Threshold Setting Gi: 378756776
Created: 20-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2HHP_A       353 DFFFRYKFYLEITAYTRgSDEQHLKWSGLVESKVRLLVM--------KLEVLAGIKIAHPFTKPFESSYCCPTEDDYEM- 423
gi 122020735 371 KFFGEHKYYLHVLVSCT-DAEAYQGYVDAVESRIRFLWAgtaesrgyALENIRHVRI-RLNPRRYEAPEEVETRARLLKk 448
gi 167536365 383 rFFDEYQYFVRVVASAA-TESDRTEFEGLVESTVRHLVL--------NLQYTDNVAYAMAYPKAYH-------EDPVAd- 445
gi 514696520 347 PFFGVYSHYICVQALTN-SEQDRTLYEGLVESTVRNLVT--------SLEFHPAVTYAIPIPKAFRRSP----------- 406
gi 695377125 360 DFFAVHQHYLAVEVYTE-KQEEEAAWCGFCESRMRKLVE--------SLAYNPALCRLRAYTKKFPLSFVTGGEAPAGEq 430
gi 154334339 374 PFFGKFRHYLHIKVSCS-DAEHYQAYADGVESRIRILWAgnassrghTLEDYRQLRL-HLNPRRFEDPEEVQLRTRLASk 451
gi 146081651 374 PFFGKFQHYLQIKVSCS-DAEHYQAYADGVESRIRILWAgnassrghTLEDYRQLRL-HLNPRRFEDPEEVQLRTRLTSk 451
gi 402581474 134 NFFSRYKHFLALLCLSA-TEQDELVWCGLVESKIRFLIA--------SLERRESIRVCHVHTKYYQprn----------- 193
gi 357621141 377 NFFSRYKHFIVLLASSA-NTLDQLPWCGLVESKIRHLIT--------TLERNQHITIAHVNPECYNSVPLNTNNGHPLAl 447
gi 765142472 374 SFFQKYKHYIVLTASAS-TEENHLEWVGLVESKIRVLVG--------NLERNEYITLAHVNPQSFPGSKENRSEND---- 440
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2HHP_A       424 IQDKYGSHKTEtalnalKLVTDen-keEESIKDA----------------PKAYLSTMYIGLDFNIE-----Nk--kEKV 479
gi 122020735 449 TSRSSGGGNGS------MEVSShqtsgAVDDSSS----------------PKIFSCHYFIGMSVDPK-----At--sGKI 499
gi 167536365 446 ---------------------------KDGTEAT----------------TGPWRTAWYLALEFGIKqegriEpa-pSKL 481
gi 514696520 407 ----------E------KDPStle-deDTHERPP----------------EYCWRTLWFIGLVFDPK-----At---EQL 445
gi 695377125 431 --------------------------pNGAALAQ----------------PSKFGVCFYVGFDIDRR-----Qlr-sREV 462
gi 154334339 452 ASGAAAA-NHT------RGSVGsrttgQLSDSGStlrgsppmkdstvslgQTWLTANYFIGMTVDTK-----Vs--sAKI 517
gi 146081651 452 ATGAAAASSHT------RGSVGsrtsgQLGDGGSslvgsinakdssapsgPTWFTAHYFIGMAVDTK-----Vs--sAKI 518
gi 402581474 194 -------------------------dpFPVQVSL----------------QNPRCRLWFIGLDLNKT-----Vs---RKI 224
gi 357621141 448 PPGTPVQTEEH------GAAEVknd-----kgEI----------------VANVCSMWFIGLVFDKT-----N----VNV 491
gi 765142472 441 -----------------------------------------------------FVCMWFIGIIFKKV-----EnaesVNI 462
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
2HHP_A       480 DIHIPCTEFV-----NLCR----SFNEd-YgDHKVF---NLALRFVKGYDLPDEVFDENEK-RP 529
gi 122020735 500 YLAPSIRAFH-----GIVR----QLRQ--Y-KEGITrlpVITVEDIS--KIPAFVKSAAGF-KE 548
gi 167536365 482 DLQGPLVAFYgrlrdRTVT----MSR---Y-DETTM---NVDVQAMKQSKLPGYLYPGGVN-PH 533
gi 514696520 446 DILTVMSDFE-----RRVRfkesRMTR--Y-DPS-M---RYTVDPMARDEIPTWLHAEAKVaKP 497
gi 695377125 463 SIDNSVEYFKn----NDLY----RWNK----RTPTM---DVRVTPVVWKALPESVFEDMGG-RA 510
gi 154334339 518 DLAPAIRTFH-----AVVR----ELRQ--Y-REGVTrlpVITVVDMT--RIPTFVKEAAGY-VE 566
gi 146081651 519 DLAPAIRTFH-----TVVR----ELRQ--Y-REGVTrlpVITVVDMA--RIPTFVKEAAGH-VE 567
gi 402581474 225 DIQHEVQSFMd----LLNS----MATTqnI-YVEGM---SVIPHYLRKAELVKWLKMEDLT-RG 275
gi 357621141 492 DLTYDISSFTk----AVHY----QAENtnV-LREGM---TIEARHVRRKQLHQYL-SPSLL-RR 541
gi 765142472 463 DLTYDIQSFTd----TVYR----QANNinM-LKDGM---KIEATHVKKKQLHQYLPPELVQ-RK 513
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