4LU6,4Z43


Conserved Protein Domain Family
Trp_halogenase

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pfam04820: Trp_halogenase 
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Tryptophan halogenase
Tryptophan halogenase catalyzes the chlorination of tryptophan to form 7-chlorotryptophan. This is the first step in the biosynthesis of pyrrolnitrin, an antibiotic with broad-spectrum anti-fungal activity. Tryptophan halogenase is NADH-dependent.
Statistics
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Aligned: 23 rows
Threshold Bit Score: 320.432
Threshold Setting Gi: 81322487
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4LU6_A  27 KILIVGGGTAGWMAASYLGKALQGt--ADITLLQAPDIPTLGVGE-ATIPNLQTaFFDFLGIPEDEWVRECNASYKVAIK 103 Lentzea aerocolonigenes
Q9A4M4   3 RVLIVGAGIDAWMTAAALATATRG-----LTQVVVAETGPPPVGRiAALPSLQG-LHARLGISEPTLAQATEARPRLAAR 76  Caulobacter vibrioides
P55699  10 RIGIIGGGIVGWLAAIALRRVFDVd--VDVTVIEAPTVFPLGPGEgGSLNLIDTlCRNELDLD--VFIGEAGATHKLGVL 85  Sinorhizobium fredii ...
Q6MN71  29 TIGILGGGTAGYLAALALKKYHPE---VEVTVIESSKIPVIGVGE-STTTEIVPfLHRGLEIDPAEFFREVEPTLKFGIR 104 Bdellovibrio bacterio...
Q8KLM2   7 DVVVAGGGPAGSTAASLVAMQG-----HRVLLVEKEVLPRHRVGE-SLLPSTVHgVCRMLGVTDE--LAETDFPVKRGAT 78  Streptomyces toyocaensis
Q8EBK1   5 KIAIIGGGTSGWLAANHLGRALKGrsgLSISVIESPDIPIIGVGE-GTVPSIRK-SLQSFGISESEFIRTCDVTFKQSIK 82  Shewanella oneidensis
Q9RPF9  14 KIIIVGGGSSGWMAAAYLSKALNFn--ADITLIESPTIPRIGVGE-ATIPTIKEeLFDFLEIPEEEWMSECKATYKLGIR 90  Myxococcus fulvus
4Z43_A   7 NIVIVGGGTAGWMAASYLVRALQQq--ANITLIESAAIPRIGVGE-ATIPSLQKvFFDFLGIPEREWMPQVNGAFKAAIK 83  Pseudomonas fluorescens
Q9A9K8  11 KIVIVGGGSAGWISAAMLSHYFQNg-gCAVELIESEEIGTIGVGE-STIPPFLQ-LLASLGVDEREFIQATQASFKLGIR 87  Caulobacter vibrioides
Q9A9K9   8 KLVIVGGGTAGWMAAAALRRHFHGg-pLEITLVESEEIGTVGVGE-ATIPTIRG-FYQQLGLSDIEVMRATQATCKLGIR 84  Caulobacter vibrioides
4LU6_A 104 FINWRTagegtseareldgGPDHFYHSFGL--LKYHEQIPLSH-----YWFDRLYRGkTVEPFDYACYMEPVILDANR-S 175 Lentzea aerocolonigenes
Q9A4M4  77 YGD--------------------AIEPFGEt-GVGIDGVAFHH-----YWL---AAG-RPGPLSDWSLAALAAARGRF-A 125 Caulobacter vibrioides
P55699  86 YENWRGg-----------gIPDRYYRMFGGs-GIPEIECRVGG-----FFPLLSARI-AAGENLHTCIPGFELITKKA-S 146 Sinorhizobium fredii ...
Q6MN71 105 F-DWG--------------CPGDYKFNFSFfaGHQYES----------YY--------YENDIKNSNWPSVLMNENKIpV 151 Bdellovibrio bacterio...
Q8KLM2  79 F-QWGG-------------RAEPWAFSFGA-------------------------------------------------S 95  Streptomyces toyocaensis
Q8EBK1  83 FVNWLD-------------KTRHGKHNFy---HHLFDIINLHQgdavsAWLAEQSGH-FADFVSTQHLACEVAKAPKL-I 144 Shewanella oneidensis
Q9RPF9  91 FQNWKKpa---------sqGGDHYYHNFGE--MPQVKGVPLSH-----LWMYKHQLQgFAEPMAYSCYPTSPICDAQK-S 153 Myxococcus fulvus
4Z43_A  84 FVNWRKspd--------psRDDHFYHLFGN--VPNCDGVPLTH-----YWLRKREQG-FQQPMEYACYPQPGALDGKL-A 146 Pseudomonas fluorescens
Q9A9K8  88 FEDWKQ-------------KGQRYYHPFGAi-GGPIGPHEFYQ-----CWLRAKANG-HPSNLQDFAPGTVMADQWKF-I 146 Caulobacter vibrioides
Q9A9K9  85 FNGWLR-------------EGQSFIHPFGHf-GQDLRGVPFHH-----YWRKLAQAG-EPTDIADYCLGASLAAAGKF-M 143 Caulobacter vibrioides
4LU6_A 176 PRRLD-----GSKVTSYAWHFDAHLVADFLRRFATEKlGVRHVEDRVEHVQRDA-NGNIESVRTAT----GRVFDADLFV 245 Lentzea aerocolonigenes
Q9A4M4 126 PPSPDpr--sPLSTLSYGLSLDAAGYAALLKRVALAA-GAKVVEGRP---------------------------DADLKV 175 Caulobacter vibrioides
P55699 147 QVEIDellatGESGLYPSFHFNHAGFERYLRRVGLAR-GITSRRAVVHGMRLDD-RGHVNAFQL-G----GEELEVDFAV 219 Sinorhizobium fredii ...
Q6MN71 152 IRNKNgtltsFLASIPFSYHIDNKNLIRFLNKEVKSR-GIDILDAEVHEVKLDE-RGYVASLESKE----GHSLSYDLYI 225 Bdellovibrio bacterio...
Q8KLM2  96 SRLTD--------ATSFAYQADRARFDEILLKNAKRK-GVVVREGCSVTAVVEE-GDRVTGLRHTDpdggEHEVGARFVI 165 Streptomyces toyocaensis
Q8EBK1 145 TTPEY------AGVLGYAYHLNAAKFAKLLAKNAIEKfNVEHILTTVHDVCLGV-DGAIESLQTEQ----GN-LSFDFYI 212 Shewanella oneidensis
Q9RPF9 154 PRYMD-----GTKAVHYAYHFDALLVANFLKKWSIER-GLTFISDDIVDTQLDD-GGSIKHLRGAS----GRSYAADLYI 222 Myxococcus fulvus
4Z43_A 147 PCLSD-----GTRQMSHAWHFDAHLVADFLKRWAVER-GVNRVVDEVVDVRLNN-RGYISNLLTKE----GRTLEADLFI 215 Pseudomonas fluorescens
Q9A9K8 147 PPIKAqr--tLIAGASYALHVDARLVAKFLRDYAEAR-GVKRTEGIVTDVVTHP-DGSVAKVIMKD----GREVEGDLFI 218 Caulobacter vibrioides
Q9A9K9 144 APPRNpt--sTLSVFDWALHFDAGLFAQLMRRVAEDN-GVRRIEGKITKVNLRPeDGFVAWLDLEG----GARVEGDLFI 216 Caulobacter vibrioides
4LU6_A 246 DCSGFRGLLINKAMEEPFLDMSDHLLNDSAVATQVPHDDda-nGVEPFTS---AIAMKSGWTWKIPMLGRFGT-GYVYSS 320 Lentzea aerocolonigenes
Q9A4M4 176 DASGGERRLVAH---ETWTDWSARLPNGVALA-----------------------------------QDSLVS---TFAP 214 Caulobacter vibrioides
P55699 220 DASGFARLGLGKVFNTRWCSFANVLPTDRAIIFELEPRG-----SSPVTR---ATAMKAGWMWEAPLNRSISA-GYAFSS 290 Sinorhizobium fredii ...
Q6MN71 226 DCSGFRSKILGQALKTEFTPFTDTLVTDRALTFDMPNKD----VVDCYTS---VITMNNGWCWKIPMRTEDHY-GYVFSS 297 Bdellovibrio bacterio...
Q8KLM2 166 DASGHESPLSASV--GGTRDRAGSF---RGLALSGYFGNgckrLPEPRSGdglSVTFDGGWFWYVPLFGGLTSvGAVVSE 240 Streptomyces toyocaensis
Q8EBK1 213 DCSGFESILLAKALKVPFISKAQQLFIDTALVAQIPTQPa--dVIPPYTK---ATAHQAGWIWDIALTQRRGT-GFVYSS 286 Shewanella oneidensis
Q9RPF9 223 DCTGFAGLLIEQALGEPKVTFHDSLLTDRAVAINIPSDPat-eGIRPYTT---ASAFSSGWTWEIPLYGRAGN-GYVYSS 297 Myxococcus fulvus
4Z43_A 216 DCSGMRGLLINQALKEPFIDMSDYLLCDSAVASAVPNDDar-dGVEPYTS---SIAMNSGWTWKIPMLGRFGS-GYVFSS 290 Pseudomonas fluorescens
Q9A9K8 219 DCTGFRSLLIGKTLDVPFNDWSDMLLCDRAVVVQTENVG----APHPYTV---SKAEDAGWRWRIPLQHRAGN-GYVFSS 290 Caulobacter vibrioides
Q9A9K9 217 DCSGFRGLLIEEALHTGYESWSDLLFCDRAWAVQSEGQG----DPPPYTD---VTAHSAGWRWRIPLQHRYGN-GYVFSS 288 Caulobacter vibrioides
4LU6_A 321 RFA-----TEDEAVREFCEMWHLDPETQPlNRIRFRVGR-------------NRRAWVGNCVSIGTSSCFVEPLESTGIY 382 Lentzea aerocolonigenes
Q9A4M4 215 APA--------------------------------KTGR-------------IAQAMRGDTVAVGAAYGAIGAGDGGDLH 249 Caulobacter vibrioides
P55699 291 RYA-----DAAMAIAEVENHYGFRVEAK--HELSLDQGY-------------FSTAWVNNFVALGTASGFVEPLEAALAA 350 Sinorhizobium fredii ...
Q6MN71 298 KFC-----DEETALAEARARFG---HFEKyKMVEFRSGR-------------HTQAWVKNVFSLGNSYGFIEPLESTAIQ 356 Bdellovibrio bacterio...
Q8KLM2 241 ERAeklqdDREEAFKALIAECPAISDLLS-EGMRVTAGKygklrvredyvyhRTTFWRPGMLLVGDAACSVDPLFSSGVH 319 Streptomyces toyocaensis
Q8EBK1 287 AHM-----NQAEAERKFDHYLGGKLADIPhRKIPMTVGY-------------RQQFWVKNCVALGLAQGFLEPIEATSIL 348 Shewanella oneidensis
Q9RPF9 298 AFQ-----TPEDAEREVRAWFGKKADALDvRHIKFVSGR-------------RRRSWVKNCVSIGLASSFLEPLESTGLY 359 Myxococcus fulvus
4Z43_A 291 HFT-----SRDQATADFLKLWGLS-DNQPlNQIKFRVGR-------------NKRAWVNNCVSIGLSSCFLEPLESTGIY 351 Pseudomonas fluorescens
Q9A9K8 291 RHL-----SDDAARATLVQNVEGQMLMNP-MFIAFKTGM-------------RRRLWHKNVVAVGLAGGFIEPLESTALH 351 Caulobacter vibrioides
Q9A9K9 289 RHI-----SDEDALAELKAAVPDPLLHEP-RLIRFNPGR-------------REQVWNKNVIALGLASGFLEPLESTSIA 349 Caulobacter vibrioides
4LU6_A 383 FVYA----ALYQLVKHFPDKSLN-PV-LTARFNREIETMFDDTRDFIQAHFYFSPRTDtPFWRANK-DLRLADGMQEKID 455 Lentzea aerocolonigenes
Q9A4M4 250 LLQG----DVSRLIALFPTG----PA-AVAEYNRLAQSALERARDMAILR-----------WGDLS---NPPEPLARKIE 306 Caulobacter vibrioides
P55699 351 HTFE----ALRNLERILANGSGIvPArAIEGYNSANARCWTGVRDFLRLHYD-SKRIDtPFWRDLA-AAELPEGYANLRA 424 Sinorhizobium fredii ...
Q6MN71 357 TAVH----SINVLCRLMPKTLDD-QI-SITGINNEIAVTWDTFRWFVGMHYKFNKKLDtPFWKHCReKTNIGHA-QTIVN 429 Bdellovibrio bacterio...
Q8KLM2 320 LATYsallAARSINSVLAGDVDE-KT-ALTEFEARYRRELGAFSELLTTFHTM--------------TGEEHPEPESFVD 383 Streptomyces toyocaensis
Q8EBK1 349 LTDF----SARFLAERFPANIDDvDY-LAKRFNDTVGYAWERVVEFAKLHYCLSDRTDsAFWLDNQrEETISEPLKERLN 423 Shewanella oneidensis
Q9RPF9 360 FVYA----ALYQLVACFPSKHIE-PV-LRDKFNERVSYMVDDVRDFIVLHFCTSPRTDtPYWKANQnELKLPDTLKEVLE 433 Myxococcus fulvus
4Z43_A 352 FIYA----ALYQLVKHFPDTSFD-PR-LSDAFNAEIVHMFDDCRDFVQAHYFTTSRDDtPFWLANRhDLRLSDAIKEKVQ 425 Pseudomonas fluorescens
Q9A9K8 352 LIYR----GMDFLLRFFPDRDFD-PA-LAAEYNRRMTADYEEIRDFIVLHYCTTQRDDtPFWRDVR-NAPIPDSLKERMA 424 Caulobacter vibrioides
Q9A9K9 350 LIET----GIEKIKALFPDRDFA-PE-LADEFNDWSRREMERVRDFIILHYWANKRRDtAFWRDCN-AVTLPDTLQRKID 422 Caulobacter vibrioides
4LU6_A 456 MYRAGmainapasddaqlyyGNFEEGFRNFWNNSNYYCVLAGLGLVPDAPSPRLAHMPR 514 Lentzea aerocolonigenes
Q9A4M4 307 QFQSR---------------GRVVTYDEEAWPESAWIHAMLARGIVPKRWDPLADRLGT 350 Caulobacter vibrioides
P55699 425 CFQKRtprf-------idiqPYVGSGWQSLFHEIDWISVAVPLGVVPQ-----AAACAE 471 Sinorhizobium fredii NGR234
Q6MN71 430 LFNQRpplsag----nfgsnSQFTATEALVFNSYSYDTLIFGQK---EVYKPL--AAPE 479 Bdellovibrio bacteriovorus
Q8KLM2 384 VAAGV----------------------------SSGEWALAAQG---------GGAAAP 405 Streptomyces toyocaensis
Q8EBK1 424 MWKSFsp------------iAEDFPSKFEVFNLDNYLYVLYGMKYPTQPHDRGLVAKAN 470 Shewanella oneidensis
Q9RPF9 434 LQRAGipirrsy-htndalySSFEAGFDRFWTNSNFQSIFAGVGYLPRQPMPLLHSRPD 491 Myxococcus fulvus
4Z43_A 426 RYKAGlplttts-fddstyyETFDYKFKNFWLNGNYYCIFAGLGMLPDRSLPLLQHRPE 483 Pseudomonas fluorescens
Q9A9K8 425 LFQAQ---------------GVLREGVDDMFRNPSWQSVMEGMGVRPRRYQQLVDTAPY 468 Caulobacter vibrioides
Q9A9K9 423 LFLGR---------------GHFVRYRWEMFAPPSWMAIYAGFELLPSAVDPSLDGVDP 466 Caulobacter vibrioides
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