1JR8,3LLI


Conserved Protein Domain Family
Evr1_Alr

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pfam04777: Evr1_Alr 
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Erv1 / Alr family
Biogenesis of Fe/S clusters involves a number of essential mitochondrial proteins. Erv1p of Saccharomyces cerevisiae mitochondria is required for the maturation of Fe/S proteins in the cytosol. The ALR (augmenter of liver regeneration) represents a mammalian orthologue of yeast Erv1p. Both Erv1p and full-length ALR are located in the mitochondrial intermembrane an d it thought to operate downstream of the mitochondrial ABC transporter.
Statistics
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PSSM-Id: 368111
View PSSM: pfam04777
Aligned: 335 rows
Threshold Bit Score: 54.17
Threshold Setting Gi: 358331934
Created: 6-May-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1JR8_A               13 RASWKYFHTLLARFP-DEPTPeeREKL----HTFIGLYAELYPCG----ECSYHFVKlIEKYPv--qTSSRTAAAMW--- 78  baker's ...
WGS:AAPP:GF18057-PA 400 CSLWSLFHFLTVEAAkSp----nQLPPgtvlSAIHGFAKYFFGCS----DCSNHFQE-MAKRRrmdlVRTHDEEILW--- 467 Drosophi...
Q9VD62              412 CSLWTLFHYFTVLAAqMk-----VYPPssvtIGLYGLAKFFYDCK----DGSMYFVK-LAKRMniakVRTHDEEILW--- 478 fruit fly
EDW23799            419 CSLWTLFHYLTSRRQaTv-----LLQPdralG--------IHACStlaaDCADHFLA-LAERKhierVTDYDAEILW--- 481 Drosophi...
Q8IMY4              424 CSLWVLFHYLSVESKk--------LKPksvlLVFLGYVRFFMNCK----ECDMKISE-FKKLRpianVTNDDEQILW--- 487 fruit fly
EDX13855            412 CSMWTLFHHLTVEAAkPp----nYFEEgsilKTFHGFAKYFFGCT----DCSEHFQQ-MAIRRnltsVKTHDEEILW--- 479 Drosophi...
ESO01113            398 CSLWVTIHTLLVSAHrNPRGEnvQRVGmdilLAFRGYIEHFFRCI----ECRENFVK-YSKNWlt-ePKNAS----Wtak 467 Helobdel...
Q20514              419 CGLWTLAHTITVEAYkQEKHNtafKPVidvlEPFRAFIFHFLSCS----ECAQNFTK-EAEKNqlhlVTRPEDVYAW--- 490 Caenorha...
21_pfamImport         1 CGLWTLAHAVTVEAHkQERNNpsfSSVssvlSPFRHFIVRFLSCG----ECAANFAK-EADKHnlaaAEKTEDMVLW--- 72 
CBY18982            408 CGLWTSFHLFlsl--------spDEQAplfvEAMSEMILNHFSCL----ECRKNFKN-EIELFplsdVSDHSSGVRW--- 471 Oikopleu...
1JR8_A               79 -----GCHIHNKVNEYLKkdiYDCA---TI-LEDY 104 baker's yeast
WGS:AAPP:GF18057-PA 468 -----LWAGHNEVNKRLS---GDATedpKFpKIQF 494 Drosophila ananassae
Q9VD62              479 -----LWEAHNEVNEKLA---GDASgdpRFpKVQF 505 fruit fly
EDW23799            482 -----LWEAHNEVNKRLA---GDTTedpKFpKIQF 508 Drosophila persimilis
Q8IMY4              488 -----LWEAHNYVNKQLA---GDSTedpKFpKIQF 514 fruit fly
EDX13855            480 -----LWAAHNEVNARIA---GDSTedpKFpKIQF 506 Drosophila simulans
ESO01113            468 kasidIWRRHNLVNLNLHki-sPLTedpEFpKIQF 501 Helobdella robusta
Q20514              491 -----LWRVHNFVNKRLS---GSLTddpSFkKQQF 517 Caenorhabditis elegans
21_pfamImport        73 -----LWNTHNSVNTRLA---GAPAedpAHpKRTF 99 
CBY18982            472 -----LWKLHNSVNARIA---GEKSedpKFpKIQF 498 Oikopleura dioica
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