Conserved Protein Domain Family
Glyco_transf_17
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pfam04724: Glyco_transf_17 
Glycosyltransferase family 17
This family represents beta-1,4-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase (EC:2.4.1.144). This enzyme transfers the bisecting GlcNAc to the core mannose of complex N-glycans. The addition of this residue is regulated during development and has functional consequences for receptor signalling, cell adhesion, and tumor progression.
Links
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Statistics
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PSSM-Id: 428090
Aligned: 24 rows
Threshold Bit Score: -1
Created: 20-Apr-2021
Updated: 29-Sep-2021
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_007855798  10 RRRSITLIL-PLLFLASLSLFYIHnnlyQLRNLLSYSTRPIWDSADGPTEIIPHYYAEGL-ADAYTCQLHGWKRRENPQn 87  Moniliophthora ...
Q9SKF0         8 KPPPVKLVFpTLIILFLTCLLCIL----TNFQTISYLFRPLWDKPPPPFKRIPHYYAENV-SMGHLCELHGWTPRLEPR- 81  thale cress
XP_006358295  22 RSHGKVIFI-VLLILVPILLFGIY----LHFHKISYFFRPLWDKPPPPFEHLPHYYAENV-SMDNLCRLHGWTLRPEPR- 94  potato
XP_002527177  12 RAPWKLFFL-ILLVLVPICVLGIF----VHIQKISYFFRPLWDNPPPPFKRLPHYYAENV-SMEHLCDLHGWSLRSEPR- 84  castor bean
XP_002324640  12 RVTFKVVFF-ILLILVPICVIGIL----THAQHVSYFLRPLWDNPPPPFKHLPHYYAENV-SMEHLCHLHGWSLRSEPR- 84  black cottonwood
XP_003549746  19 QKPPIFFCA-LLLLLLPICVVGIF----IHGQKITYFFRPLWDNPPAPFTSIPHYYAENV-SMEHLCRLHGWSLRSKPR- 91  soybean
XP_002978663   7 RGRKILAAA-LVLVLI-LCLHAGY----SNFLSLSYFLRPVWDTPPKPFDFITHYFAHNL-SRSDLCELHNWEVRETPR- 78  Selaginella moe...
XP_001755575  18 KFKLLTLTI-FGFFSIVATLVYVY-----DYRTVTYFLRPIWDTPPKSFQIIPHYYADGM-NLSELCALHGWTHRPTPR- 89  Physcomitrella ...
EDR09043       7 rtrSNVILL-FSFLFCTVILYLIVqnqyQLRNALSYATRPLWDSDSGPKDIIPHYHAEGLkADAHTCQLHGWEERRNn-- 83  Laccaria bicolo...
EKD01901       4 srQHRRFLF-LFLFVVVVSVLTFWsrlaLAWRDFGYLTRPLWDHPERPFTVVPHYPRSTL-SSSEWCSLHGWKPRTSTP- 80  Trichosporon as...
Q9SKF0         8 KPPPVKLVFpTLIILFLTCLLCIL----TNFQTISYLFRPLWDKPPPPFKRIPHYYAENV-SMGHLCELHGWTPRLEPR- 81  thale cress
XP_006358295  22 RSHGKVIFI-VLLILVPILLFGIY----LHFHKISYFFRPLWDKPPPPFEHLPHYYAENV-SMDNLCRLHGWTLRPEPR- 94  potato
XP_002527177  12 RAPWKLFFL-ILLVLVPICVLGIF----VHIQKISYFFRPLWDNPPPPFKRLPHYYAENV-SMEHLCDLHGWSLRSEPR- 84  castor bean
XP_002324640  12 RVTFKVVFF-ILLILVPICVIGIL----THAQHVSYFLRPLWDNPPPPFKHLPHYYAENV-SMEHLCHLHGWSLRSEPR- 84  black cottonwood
XP_003549746  19 QKPPIFFCA-LLLLLLPICVVGIF----IHGQKITYFFRPLWDNPPAPFTSIPHYYAENV-SMEHLCRLHGWSLRSKPR- 91  soybean
XP_002978663   7 RGRKILAAA-LVLVLI-LCLHAGY----SNFLSLSYFLRPVWDTPPKPFDFITHYFAHNL-SRSDLCELHNWEVRETPR- 78  Selaginella moe...
XP_001755575  18 KFKLLTLTI-FGFFSIVATLVYVY-----DYRTVTYFLRPIWDTPPKSFQIIPHYYADGM-NLSELCALHGWTHRPTPR- 89  Physcomitrella ...
EDR09043       7 rtrSNVILL-FSFLFCTVILYLIVqnqyQLRNALSYATRPLWDSDSGPKDIIPHYHAEGLkADAHTCQLHGWEERRNn-- 83  Laccaria bicolo...
EKD01901       4 srQHRRFLF-LFLFVVVVSVLTFWsrlaLAWRDFGYLTRPLWDHPERPFTVVPHYPRSTL-SSSEWCSLHGWKPRTSTP- 80  Trichosporon as...

XP_007855798  88 vKVLDAVLMSSELDLLELRLNELDGVVDQFFIIESNTTFTGLPKETYYDSHKGR-FEKFESKILYQFLPGQLQTa---DH 163 Moniliophthora ...
Q9SKF0        82 -RVFDAIIFSNELDLLEVRWRELEPYVSKFVILESNTTFTGIPKPLFFDSNKER-FAFAEGKIVHGVFPGKKRStgqpYE 159 thale cress
XP_006358295  95 -RVFDGIIFSNELDLLEVRWRELYPYVTKFVVLEANTTFTGLPKPLYFSDHRER-FAFAEDKIVHGVFPGRIASle-lHE 171 potato
XP_002527177  85 -RIFDGIIFSNELDILDIRWHELHPYVTKFVILESNTTFTGIPKPLFFASNRNR-FSFAEDKIVHGVFAGRTAIhg-lSE 161 castor bean
XP_002324640  85 -RVFDAIIFSNELDVLEIRWHELYPYITKFVILESNTTFTGIPKPLFFDSNRSR-FAFAKEKIVHGVFSGRIAArg-kNE 161 black cottonwood
XP_003549746  92 -RIFDAVIFSNELDMLEIRWHELSPYVSKFVILESNTTFTGIPKRLFFALNRER-FSFAKQKIVHDIYPGRIAVpg-sHE 168 soybean
XP_002978663  79 -RVFDAIIFSNELDLLEIRWRELYPFVTKFVLLEANGTFTGLAKPLFFAKNSYR-FLFAASKLFYREIWTRPLLe---NE 153 Selaginella moe...
XP_001755575  90 -RVFDAVIFSNEVDLLEIRMRELMPFVTKFLVLESNATFTGKPKPLYFADQKDSrFKFIHPQLLYSNIPSRPQIp---NR 165 Physcomitrella ...
EDR09043      84 vRVLDAVLMSSELDLLEIRMNELDAVVDYFLIVESNATFTGLPKETYFAKNRAR-YAKFERKIIYRFLPGYPLQp---GQ 159 Laccaria bicolo...
EKD01901      81 -KVFDAVIFSVEIDLLQLRLRELYDVVDGFVILESDRTFTGLPKNTTFADNKHL-FDWASDKIHYAFHEGHELKa---GE 155 Trichosporon as...
Q9SKF0        82 -RVFDAIIFSNELDLLEVRWRELEPYVSKFVILESNTTFTGIPKPLFFDSNKER-FAFAEGKIVHGVFPGKKRStgqpYE 159 thale cress
XP_006358295  95 -RVFDGIIFSNELDLLEVRWRELYPYVTKFVVLEANTTFTGLPKPLYFSDHRER-FAFAEDKIVHGVFPGRIASle-lHE 171 potato
XP_002527177  85 -RIFDGIIFSNELDILDIRWHELHPYVTKFVILESNTTFTGIPKPLFFASNRNR-FSFAEDKIVHGVFAGRTAIhg-lSE 161 castor bean
XP_002324640  85 -RVFDAIIFSNELDVLEIRWHELYPYITKFVILESNTTFTGIPKPLFFDSNRSR-FAFAKEKIVHGVFSGRIAArg-kNE 161 black cottonwood
XP_003549746  92 -RIFDAVIFSNELDMLEIRWHELSPYVSKFVILESNTTFTGIPKRLFFALNRER-FSFAKQKIVHDIYPGRIAVpg-sHE 168 soybean
XP_002978663  79 -RVFDAIIFSNELDLLEIRWRELYPFVTKFVLLEANGTFTGLAKPLFFAKNSYR-FLFAASKLFYREIWTRPLLe---NE 153 Selaginella moe...
XP_001755575  90 -RVFDAVIFSNEVDLLEIRMRELMPFVTKFLVLESNATFTGKPKPLYFADQKDSrFKFIHPQLLYSNIPSRPQIp---NR 165 Physcomitrella ...
EDR09043      84 vRVLDAVLMSSELDLLEIRMNELDAVVDYFLIVESNATFTGLPKETYFAKNRAR-YAKFERKIIYRFLPGYPLQp---GQ 159 Laccaria bicolo...
EKD01901      81 -KVFDAVIFSVEIDLLQLRLRELYDVVDGFVILESDRTFTGLPKNTTFADNKHL-FDWASDKIHYAFHEGHELKa---GE 155 Trichosporon as...

XP_007855798 164 DAWKVEAETRTAMSSFLRgyTKTLPSDTtfIVIMSDLDELPSAHTIKLLRDCD-FGETIHLQLRNYLYSFEWLLGLNSWR 242 Moniliophthora ...
Q9SKF0       160 DPFLLEGQQRVAMNWLLR--EAGVSDGD--AVIMSDADEIPSPHTVKFLQWCDgIPDVMHLEMREYMYSFEFPVDYSSWR 235 thale cress
XP_006358295 172 DPFKLEGQQRIAMNRLLH--AAGIFEDD--LLIMSDTDEIPSHHTIKLLQWCDgMPPVMHLELRHYMYSFEFPVDYSSWR 247 potato
XP_002527177 162 DPFVLESEQRAAMNSLII--RSGISHGD--LLIMSDTDEIPSPHTLKLLQWCDgIPPVLHLELRHYMYSFEFPVDYSSWR 237 castor bean
XP_002324640 162 DPFVLEFEQRKAMSGLLR--SSGISYGD--LIIMSDADEIPSPHTLKLLQWCDeIPHAMHLELKHYMYSFEFPVDYSSWR 237 black cottonwood
XP_003549746 169 DPFVLESKQRGAMNALLR--RAGISNGD--ILLMSDTDEIPSPHTLKLLQWCDgIPPIMHLELRNYMYSFEFPVDYSSWR 244 soybean
XP_002978663 154 SPFTTEVFQRQQMDRALV--AAGIEEGD--IVIMSDADEIPSWHTLELLRWCDgFPSPMHLQMRNYLYSFEFLVDEKAWR 229 Selaginella moe...
XP_001755575 166 DPFDNEKHHRIAMGNFLR--TAGIQDGD--LLITADADEIPSAHTIHLLQNCDgYPSPMHLQLRNYLYSFEFLVDSNSWR 241 Physcomitrella ...
EDR09043     160 SAWDSEAHTRNTMTTLLRshIGGFPSGTqsVVLMSDIDEIPSQHTVELLKACD-FGTSIHLQLRNFLYSFEWYLGLSSWR 238 Laccaria bicolo...
EKD01901     156 HPFDQEAQMRTSMNAALE--RAGVRQGN--LVLMSDVDELPRASTLELLKTCD-YGDVIHLQLANYVYSFEFLLGHDSWR 230 Trichosporon as...
Q9SKF0       160 DPFLLEGQQRVAMNWLLR--EAGVSDGD--AVIMSDADEIPSPHTVKFLQWCDgIPDVMHLEMREYMYSFEFPVDYSSWR 235 thale cress
XP_006358295 172 DPFKLEGQQRIAMNRLLH--AAGIFEDD--LLIMSDTDEIPSHHTIKLLQWCDgMPPVMHLELRHYMYSFEFPVDYSSWR 247 potato
XP_002527177 162 DPFVLESEQRAAMNSLII--RSGISHGD--LLIMSDTDEIPSPHTLKLLQWCDgIPPVLHLELRHYMYSFEFPVDYSSWR 237 castor bean
XP_002324640 162 DPFVLEFEQRKAMSGLLR--SSGISYGD--LIIMSDADEIPSPHTLKLLQWCDeIPHAMHLELKHYMYSFEFPVDYSSWR 237 black cottonwood
XP_003549746 169 DPFVLESKQRGAMNALLR--RAGISNGD--ILLMSDTDEIPSPHTLKLLQWCDgIPPIMHLELRNYMYSFEFPVDYSSWR 244 soybean
XP_002978663 154 SPFTTEVFQRQQMDRALV--AAGIEEGD--IVIMSDADEIPSWHTLELLRWCDgFPSPMHLQMRNYLYSFEFLVDEKAWR 229 Selaginella moe...
XP_001755575 166 DPFDNEKHHRIAMGNFLR--TAGIQDGD--LLITADADEIPSAHTIHLLQNCDgYPSPMHLQLRNYLYSFEFLVDSNSWR 241 Physcomitrella ...
EDR09043     160 SAWDSEAHTRNTMTTLLRshIGGFPSGTqsVVLMSDIDEIPSQHTVELLKACD-FGTSIHLQLRNFLYSFEWYLGLSSWR 238 Laccaria bicolo...
EKD01901     156 HPFDQEAQMRTSMNAALE--RAGVRQGN--LVLMSDVDELPRASTLELLKTCD-YGDVIHLQLANYVYSFEFLLGHDSWR 230 Trichosporon as...

XP_007855798 243 ASVVKWNA-GGYYSHIKRSEQALADSGWHCSYCFRALSEFVTKMQGFSHSDRIgGNMDLLKSE---KIQEKICRGDDIFG 318 Moniliophthora ...
Q9SKF0       236 ASVHIYSRkWTQYRHSRQTDLILSDAGWHCSFCFRRLNEFVFKMKGYSHADRV-KRKEFLDYQ---RIQKHICKGYDLFD 311 thale cress
XP_006358295 248 ASVHIYNR-WTKYRHSRQTDVILSDAGWHCSFCFRNLQDFVFKMTGYSHADRV-RRTNFLKYS---RIQKLICEGADLYD 322 potato
XP_002527177 238 ASVNVYGP-WTRYRHSRQTDLIFSDAGWHCSFCFRRLKEIVFKMTAYSHADRV-RRKDFLDYS---RIQKLICNGDDLFD 312 castor bean
XP_002324640 238 ATIQIFGP-RTGYRHSRQTDLILSDSGWHCSFCFRRLQEFVFKMTAYSHADRV-RRNEFLNYS---RIQKIICSGDDLFD 312 black cottonwood
XP_003549746 245 ATAHVYGP-RSQYRHSRQTDVIFSDAGWHCSFCFQYISEFVFKMTAYSHADRV-KRKYFLSHS---RIQDIICKGDDLCD 319 soybean
XP_002978663 230 PCVHLYQPgATKYGHFRRSDFILADAGWHCSFCFRHVSEILFKIRAYSHADRL-KASRLGSVDaeiRIQDAVCKGRDLFG 308 Selaginella moe...
XP_001755575 242 SSVELYRK-ETQYRHSRKTDHCLADAGWHCSFCFRYIRDFVFKMKAYSHADRI-RRPSLLNPE---RIQKIICKGSDIFD 316 Physcomitrella ...
EDR09043     239 ASANLWNS-DSFYRHSKSGERVLADSGWHCSYCFRTIPEYVVKMRGFSHADRIgGRIDLLDPK---RIQNTICKGKDIFG 314 Laccaria bicolo...
EKD01901     231 ASVRRHPS--TGYSHGRVSETLLGDAGWHCSFCFKHIADFQFKMQAYSHADR--SRAELLGEE---RIQKVICDGTDIFD 303 Trichosporon as...
Q9SKF0       236 ASVHIYSRkWTQYRHSRQTDLILSDAGWHCSFCFRRLNEFVFKMKGYSHADRV-KRKEFLDYQ---RIQKHICKGYDLFD 311 thale cress
XP_006358295 248 ASVHIYNR-WTKYRHSRQTDVILSDAGWHCSFCFRNLQDFVFKMTGYSHADRV-RRTNFLKYS---RIQKLICEGADLYD 322 potato
XP_002527177 238 ASVNVYGP-WTRYRHSRQTDLIFSDAGWHCSFCFRRLKEIVFKMTAYSHADRV-RRKDFLDYS---RIQKLICNGDDLFD 312 castor bean
XP_002324640 238 ATIQIFGP-RTGYRHSRQTDLILSDSGWHCSFCFRRLQEFVFKMTAYSHADRV-RRNEFLNYS---RIQKIICSGDDLFD 312 black cottonwood
XP_003549746 245 ATAHVYGP-RSQYRHSRQTDVIFSDAGWHCSFCFQYISEFVFKMTAYSHADRV-KRKYFLSHS---RIQDIICKGDDLCD 319 soybean
XP_002978663 230 PCVHLYQPgATKYGHFRRSDFILADAGWHCSFCFRHVSEILFKIRAYSHADRL-KASRLGSVDaeiRIQDAVCKGRDLFG 308 Selaginella moe...
XP_001755575 242 SSVELYRK-ETQYRHSRKTDHCLADAGWHCSFCFRYIRDFVFKMKAYSHADRI-RRPSLLNPE---RIQKIICKGSDIFD 316 Physcomitrella ...
EDR09043     239 ASANLWNS-DSFYRHSKSGERVLADSGWHCSYCFRTIPEYVVKMRGFSHADRIgGRIDLLDPK---RIQNTICKGKDIFG 314 Laccaria bicolo...
EKD01901     231 ASVRRHPS--TGYSHGRVSETLLGDAGWHCSFCFKHIADFQFKMQAYSHADR--SRAELLGEE---RIQKVICDGTDIFD 303 Trichosporon as...

XP_007855798 319 MLPEAYSYLDLFYQMNLQPQK-SMVGLPKYLLENAQHFKFLLPGGCQRD 366 Moniliophthora roreri MCA 2997
Q9SKF0       312 MLPEKYSFQELISKIGPIPPSaSAVHLPAFLIQNAARFRFLLPGGCLRE 360 thale cress
XP_006358295 323 MLPEEYSFQELIKKMGSIPRSaSAVHLPTHVIENTDKFRFLLPGGCQRS 371 potato
XP_002527177 313 MLPEEYSFQELIKKMGPIPRSaSAVHLPAYLIENADNFRFLLPGGCLRS 361 castor bean
XP_002324640 313 MLPEEHTFQELIKKMGPIPHSaSAVHLPSYLIENADKFRFLLPGNCLRt 361 black cottonwood
XP_003549746 320 MLPEEYSFQELIKKMGSIPRSaSAVHLPAYLIENADKFKFLLPGGCLRP 368 soybean
XP_002978663 309 LLPEEYTFKELVAKMGNAARShAAVHLPLWLLRNAHKFKFLLPGHCLRE 357 Selaginella moellendorffii
XP_001755575 317 MLPEEFTYKELISKLGAVAKSfSGVHMPKYLLENAETYRYLLPGNCIRD 365 Physcomitrella patens
EDR09043     315 MLPEAYSYLDLFSQMSLDPLT-SAVGLPRYLLENAEKFRFLLPGGCVRK 362 Laccaria bicolor S238N-H82
EKD01901     304 MLPEAYSWSELARKMAPMQRTnSAMDVPRLLKEKPEQYRYLLPGGCERE 352 Trichosporon asahii var. asahii CBS 8904
Q9SKF0       312 MLPEKYSFQELISKIGPIPPSaSAVHLPAFLIQNAARFRFLLPGGCLRE 360 thale cress
XP_006358295 323 MLPEEYSFQELIKKMGSIPRSaSAVHLPTHVIENTDKFRFLLPGGCQRS 371 potato
XP_002527177 313 MLPEEYSFQELIKKMGPIPRSaSAVHLPAYLIENADNFRFLLPGGCLRS 361 castor bean
XP_002324640 313 MLPEEHTFQELIKKMGPIPHSaSAVHLPSYLIENADKFRFLLPGNCLRt 361 black cottonwood
XP_003549746 320 MLPEEYSFQELIKKMGSIPRSaSAVHLPAYLIENADKFKFLLPGGCLRP 368 soybean
XP_002978663 309 LLPEEYTFKELVAKMGNAARShAAVHLPLWLLRNAHKFKFLLPGHCLRE 357 Selaginella moellendorffii
XP_001755575 317 MLPEEFTYKELISKLGAVAKSfSGVHMPKYLLENAETYRYLLPGNCIRD 365 Physcomitrella patens
EDR09043     315 MLPEAYSYLDLFSQMSLDPLT-SAVGLPRYLLENAEKFRFLLPGGCVRK 362 Laccaria bicolor S238N-H82
EKD01901     304 MLPEAYSWSELARKMAPMQRTnSAMDVPRLLKEKPEQYRYLLPGGCERE 352 Trichosporon asahii var. asahii CBS 8904
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