Conserved Protein Domain Family
Pex14_N

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pfam04695: Pex14_N 
Peroxisomal membrane anchor protein (Pex14p) conserved region
Family of peroxisomal membrane anchor proteins which bind the PTS1 (peroxisomal targeting signal) receptor and are required for the import of PTS1-containing proteins into peroxisomes. Loss of functional Pex14p results in defects in both the PTS1 and PTS2-dependent import pathways. Deletion analysis of this conserved region implicates it in selective peroxisome degradation. In the majority of members this region is situated at the N-terminus of the protein.
Statistics
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PSSM-Id: 335869
View PSSM: pfam04695
Aligned: 143 rows
Threshold Bit Score: 60.7824
Threshold Setting Gi: 164656583
Created: 21-Mar-2017
Updated: 23-May-2017
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q4X0M5       128 RSELIEQAKKFLQDDSIRDAPIDRKIAFLESKGLRSEEIDSLLAN-SRETDS--STnlAEgsk------stpDSTTSSTS 198 Aspergillus fum...
Q6BH03         2 NDELINSAVSFLKDANVSSSPLNKKIEFLESKGLNEQEIEEALKRangqssssqtanqqQltqpqqqqqqqpLPS----- 76  Debaryomyces ha...
Q59KC3         2 NEELINSAVSFLKDPQVGGSPLTKKVEFLESKGLNQEEIEEALKRandnstttssssssVassnssnttsspSYQSQQQQ 81  Candida albicans
Q6FV35         7 RKELFDSAVSFLQDSAIKDAPLDKKVEFLKSKGLGDEEVELALQEagrrfrdagnaasdEetatqgnlghslNTTTRRRQ 86  [Candida] glabrata
XP_011276053   4 REDLVTNAVSFLKDPQTVSAPLDKKIEFLKSKSLTQEEIDEALKRaNGE------------------------SNEASTS 59  Wickerhamomyces...
CCE81991       2 NEELINSAVSFLTDANVASAPVAKKVEFLETKGLNQEEIEEALKRaGGNEKS--QA--LTst--------ssNG------ 63  Pichia farinosa...
XP_002617744  21 NEELVASAVSFLRDPNVSTSPLDKKIEFLQSKGLNQEEIEEAMKRa--------------------------------NA 68  Clavispora lusi...
XP_002545760   2 NDELINSAVTFLKDPQVASSPLTKKVEFLESKGLNQQEIEEALKRaNDNA------------------------------ 51  Candida tropica...
CCE42748       2 NDELINSAVSFLRDPNVASAALAKKVEFLESKGLNQEEIEEALKRvnesdssatitpstSntttstttnsqhASQPQP-- 79  Candida parapsi...
XP_001525316   2 NDELINSAVAFLQDPNVATSPLAKKIEFLESKGLDQVEIEEAMKRandpshaagtgtrtGtgtasssgtthaATTPSTSI 81  Lodderomyces el...
Q4X0M5       199 NESQspkePSALSPISSassPTTPAAPTATknstprdVPPIITypEFLMQQSK--PPPLVTLRSILYTLYGAAGLGASLY 276 Aspergillus fum...
Q6BH03        77 -------------------------------------QPPIDYy------NVAapQVPERTWQDYFIMATATAGVTYGLY 113 Debaryomyces ha...
Q59KC3        82 QQQVy-------------------------------sQPPIDYy------NVVppPVPEKSWKDYFIMATATAGVTYGLY 124 Candida albicans
Q6FV35        87 EYMYe----------------------------------------------aIppPLPQRDWKDYFVMATMTAGLFYGVY 120 [Candida] glabrata
XP_011276053  60 EIQPksstSQSPSPAND---SSHS----------------ITYppQYYTAPPP--PVPERDWKDYFIMATATAGVGYALY 118 Wickerhamomyces...
CCE81991      64 --------------SGQ---TFSRNYSVPQ-------QPPIDYynV----APP--AVPERTWKDYFIMATATCGVAYGAY 113 Pichia farinosa...
XP_002617744  69 PTSGapvaSASPSTSTS---PVTSYHNVQN-------APPLDYypL-----AP--AVPERTWKDYFIMATATAGVTYGLY 131 Clavispora lusi...
XP_002545760  52 --SQsqsvGTTQSSSSS---SSYAPPTPQQ-------GPPIDYy-----NAPP--PIPERSWKDYFIMATATAGITYGFY 112 Candida tropica...
CCE42748      80 -------------------------------------QLPIDYy-------NVapPVPERSWKDYFIMASATVGVTYGLY 115 Candida parapsi...
XP_001525316  82 DSARaspsSSAQ-------------------------QLPLDYy-------NLppPVPERSWKDYFIMATATAGVTYGLY 129 Lodderomyces el...
Q4X0M5       277 GASEYLVKPML 287 Aspergillus fumigatus
Q6BH03       114 QVVSKYLIPSI 124 Debaryomyces hansenii
Q59KC3       125 QVVTRYLIPSI 135 Candida albicans
Q6FV35       121 EVTKRYVVPNL 131 [Candida] glabrata
XP_011276053 119 QITTRYLIPNI 129 Wickerhamomyces ciferrii
CCE81991     114 QVISKYLIPNV 124 Pichia farinosa CBS 7064
XP_002617744 132 QVVSRYLIPSI 142 Clavispora lusitaniae ATCC 42720
XP_002545760 113 QVLTRYVIPTI 123 Candida tropicalis MYA-3404
CCE42748     116 QVVTKYLVPSI 126 Candida parapsilosis
XP_001525316 130 QVISRYLVPSI 140 Lodderomyces elongisporus NRRL YB-4239
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