1X9N,2HIV,3GDE,4HTO


Conserved Protein Domain Family
DNA_ligase_A_N

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pfam04675: DNA_ligase_A_N 
Click on image for an interactive view with Cn3D
DNA ligase N-terminus
This region is found in many but not all ATP-dependent DNA ligase enzymes (EC:6.5.1.1). It is thought to be involved in DNA binding and in catalysis. In human DNA ligase I, and in Saccharomyces cerevisiae, this region was necessary for catalysis, and separated from the amino terminus by targeting elements. In vaccinia virus this region was not essential for catalysis, but deletion decreases the affinity for nicked DNA and decreased the rate of strand joining at a step subsequent to enzyme-adenylate formation.
Statistics
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PSSM-Id: 335865
View PSSM: pfam04675
Aligned: 478 rows
Threshold Bit Score: 47.5387
Threshold Setting Gi: 81574497
Created: 18-Apr-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1X9N_A          57 PYLAVARTFEKIEEv---SarlRXVETLSNLLrsvVA------LSPpdLLPVLYLslnhLGPPQqGLELGVGDGVLLKAV 127
gi 308503002   163 SFYKFVKVCNVLKEisskS---EKSAAITSLLq-kKGf-----DGD--LMLWLTF----LIRESdKRNYNVSDETLIANF 227
gi 268562533   162 SFYKFLKVCSVMKDisssS---EKSAVITSMLq-kKGf-----DGD--LMLWLSF----LIRESdKRDYNVTDEKLVSYF 226
gi 341899724   162 SFYKFVKVCAVLKDtsnnT---EKSAVITSLLq-kKGf-----DGD--LKLWLTF----LIRESdERVYNVTDEQLIKNF 226
gi 167522421   225 SFAAFQELCRDIEAhpghT---DKGNIIRTFIt-kGTsgq-gfTGD--LYLVMRH----LLPQHpKRVYNMKEKQLVKIF 293
gi 514680568   332 TFANFCDLCNRIAArpsyN---DKTDAVRQYIt-kGNsagdgfKGD--LYLVIRL----LLPRNpKRVYNMKDKAFVRVF 401
gi 470251928    47 slkSMTGLCSVLEKesahS---GKMEVIQAF----CEe----fKGD--LYLLAKL----FLVKEdKRVFRIKDKQMVKIL 109
gi 1160562795    7 sFFSFYKLCKELENesshT---GKSKIVALF----VDk----fDGD--LYLLAKL----LLVKEdKRVFRIKDKQMVKIL 69
gi 330805110     8 slySLSKLCEKLKEesthS---GKTQIISSF----CKv----fNGD--LYLLAKL----LLCKEdKRVFRMRDKVMLKIC 70
gi 290973973    16 RFSEFVALCKDIEEvsahT---EKSQVMKEF----LSd----fKGD--VYLLYKL----LFAKEnQRKFNLKDKKLVDVC 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1X9N_A         128 AQATGRQLEsvraeaaeKGDVGLVAENSRs---TQRLX--LPPPPLTASGVFSKFRDIArltGSASTakkIDIIKGLFVA 202
gi 308503002   228 AKILDMDQAkiqkyvnkSKDVAMSISHAHe---KKVT---NEKSNWSLQKVDRYLEKLE---KLEDEdaiLSHLKFAAKR 298
gi 268562533   227 VKILDTDEAkilkyiskSNDVALSIAHAHe---KKVT---NEKSNWSLQKVDRFLEKLE---TLKEDdeiVKHLKFAAKR 297
gi 341899724   227 ARILDTDEAkiqkyvdkSGDVALSISHAHe---KKVT---NEKGKWSIQKVDRYLDKLS---KLEGEdevLNHLKFAAKR 297
gi 167522421   294 SALFHTSEQdlte-hleqGDVSDTMASFFa---TSQGLrpAAQSTLSLEDVENLLRQLE---NRTTIdeqTRVFRQHLPR 366
gi 514680568   402 SNLLGCDAAamta-dldkGDCPETCATFFa---KNKRIppKEKSTLTLAEVENFLRRME---GLTTIdaqTAEFRKLLPK 474
gi 470251928   110 AEIWDADLDdmta-dldkGDVTETAKKFMi---KSGKF--ADQSTYTLKQVDEFLDKLT---TVSKFddqVVVIKKFLKH 180
gi 1160562795   70 AEVWNEDLDemia-dldkGDVTETAYKFYq---RQENI--PTKSTLTLGQVDEFLDVLT---TISKFddqVKAISKFLKK 140
gi 330805110    71 AHIWDADLDdmia-dldnGDFTETCKKFYieygKYP-----EKSTLTLKQVDDFLDSLT---LSGKFdeqVKIISSLLKK 141
gi 290973973    79 ASAFGEDLDemidhmdsKGDVSETLKKYLv---RSDHA--RDKGIVTLKQVDDFLEELT---QLSKKedqIRAFKKFVND 150
                          170       180
                   ....*....|....*....|....*..
1X9N_A         203 -CrhSEARFIARSLSGRLRLGLAEQSV 228
gi 308503002   299 -FrhDELEVLIRLIRKELDTGADASVI 324
gi 268562533   298 -FrhDELEVLIRLIRKELDTGATATVV 323
gi 341899724   298 -MrhDELDVLIRLIRKELDTEASTATI 323
gi 167522421   367 -MttEDLRYVVRHIKHDLRIFAGSKII 392
gi 514680568   475 -CtvNDVRFILRSMKHDLRTFAGPKHI 500
gi 470251928   181 -CtpNDWRLVNRMIDSDLKVNTGAKFF 206
gi 1160562795  141 -CtaFDWRLVNRIIDSDLKINMGAKYF 166
gi 330805110   142 -CtpQDFRLICRIIDSDLKINTGAKFF 167
gi 290973973   151 kLtgDELKFICRIICKDLKIRAGPKYL 177
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