1X9N,2HIV,3GDE,4HTO


Conserved Protein Domain Family
DNA_ligase_A_N

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pfam04675: DNA_ligase_A_N 
Click on image for an interactive view with Cn3D
DNA ligase N-terminus
This region is found in many but not all ATP-dependent DNA ligase enzymes (EC:6.5.1.1). It is thought to be involved in DNA binding and in catalysis. In human DNA ligase I, and in Saccharomyces cerevisiae, this region was necessary for catalysis, and separated from the amino terminus by targeting elements. In vaccinia virus this region was not essential for catalysis, but deletion decreases the affinity for nicked DNA and decreased the rate of strand joining at a step subsequent to enzyme-adenylate formation.
Statistics
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PSSM-Id: 335865
View PSSM: pfam04675
Aligned: 478 rows
Threshold Bit Score: 47.5387
Threshold Setting Gi: 81574497
Created: 18-Apr-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1X9N_A         57 PYLAVARTFEKIEEv---SarlRXVETLSNLLrsvVA------LSPpdLLPVLYLslnhLGPPQqGLELGVGDGVLLKAV 127  human
XP_003113685  163 SFYKFVKVCNVLKEisskS---EKSAAITSLLq-kKGf-----DGD--LMLWLTF----LIRESdKRNYNVSDETLIANF 227  Caenorhabditi...
XP_002646686  162 SFYKFLKVCSVMKDisssS---EKSAVITSMLq-kKGf-----DGD--LMLWLSF----LIRESdKRDYNVTDEKLVSYF 226  Caenorhabditi...
EGT55659      162 SFYKFVKVCAVLKDtsnnT---EKSAVITSLLq-kKGf-----DGD--LKLWLTF----LIRESdERVYNVTDEQLIKNF 226  Caenorhabditi...
XP_001745548  225 SFAAFQELCRDIEAhpghT---DKGNIIRTFIt-kGTsgq-gfTGD--LYLVMRH----LLPQHpKRVYNMKEKQLVKIF 293  Monosiga brev...
XP_004987871  332 TFANFCDLCNRIAArpsyN---DKTDAVRQYIt-kGNsagdgfKGD--LYLVIRL----LLPRNpKRVYNMKDKAFVRVF 401  Salpingoeca r...
XP_004359061   47 slkSMTGLCSVLEKesahS---GKMEVIQAF----CEe----fKGD--LYLLAKL----FLVKEdKRVFRIKDKQMVKIL 109  Dictyostelium...
XP_020430287    7 sFFSFYKLCKELENesshT---GKSKIVALF----VDk----fDGD--LYLLAKL----LLVKEdKRVFRIKDKQMVKIL 69   Polysphondyli...
XP_003290530    8 slySLSKLCEKLKEesthS---GKTQIISSF----CKv----fNGD--LYLLAKL----LLCKEdKRVFRMRDKVMLKIC 70   Dictyostelium...
XP_002669721   16 RFSEFVALCKDIEEvsahT---EKSQVMKEF----LSd----fKGD--VYLLYKL----LFAKEnQRKFNLKDKKLVDVC 78   Naegleria gru...
1X9N_A        128 AQATGRQLEsvraeaaeKGDVGLVAENSRs---TQRLX--LPPPPLTASGVFSKFRDIArltGSASTakkIDIIKGLFVA 202  human
XP_003113685  228 AKILDMDQAkiqkyvnkSKDVAMSISHAHe---KKVT---NEKSNWSLQKVDRYLEKLE---KLEDEdaiLSHLKFAAKR 298  Caenorhabditi...
XP_002646686  227 VKILDTDEAkilkyiskSNDVALSIAHAHe---KKVT---NEKSNWSLQKVDRFLEKLE---TLKEDdeiVKHLKFAAKR 297  Caenorhabditi...
EGT55659      227 ARILDTDEAkiqkyvdkSGDVALSISHAHe---KKVT---NEKGKWSIQKVDRYLDKLS---KLEGEdevLNHLKFAAKR 297  Caenorhabditi...
XP_001745548  294 SALFHTSEQdlte-hleqGDVSDTMASFFa---TSQGLrpAAQSTLSLEDVENLLRQLE---NRTTIdeqTRVFRQHLPR 366  Monosiga brev...
XP_004987871  402 SNLLGCDAAamta-dldkGDCPETCATFFa---KNKRIppKEKSTLTLAEVENFLRRME---GLTTIdaqTAEFRKLLPK 474  Salpingoeca r...
XP_004359061  110 AEIWDADLDdmta-dldkGDVTETAKKFMi---KSGKF--ADQSTYTLKQVDEFLDKLT---TVSKFddqVVVIKKFLKH 180  Dictyostelium...
XP_020430287   70 AEVWNEDLDemia-dldkGDVTETAYKFYq---RQENI--PTKSTLTLGQVDEFLDVLT---TISKFddqVKAISKFLKK 140  Polysphondyli...
XP_003290530   71 AHIWDADLDdmia-dldnGDFTETCKKFYieygKYP-----EKSTLTLKQVDDFLDSLT---LSGKFdeqVKIISSLLKK 141  Dictyostelium...
XP_002669721   79 ASAFGEDLDemidhmdsKGDVSETLKKYLv---RSDHA--RDKGIVTLKQVDDFLEELT---QLSKKedqIRAFKKFVND 150  Naegleria gru...
1X9N_A        203 -CrhSEARFIARSLSGRLRLGLAEQSV 228  human
XP_003113685  299 -FrhDELEVLIRLIRKELDTGADASVI 324  Caenorhabditis remanei
XP_002646686  298 -FrhDELEVLIRLIRKELDTGATATVV 323  Caenorhabditis briggsae
EGT55659      298 -MrhDELDVLIRLIRKELDTEASTATI 323  Caenorhabditis brenneri
XP_001745548  367 -MttEDLRYVVRHIKHDLRIFAGSKII 392  Monosiga brevicollis MX1
XP_004987871  475 -CtvNDVRFILRSMKHDLRTFAGPKHI 500  Salpingoeca rosetta
XP_004359061  181 -CtpNDWRLVNRMIDSDLKVNTGAKFF 206  Dictyostelium fasciculatum
XP_020430287  141 -CtaFDWRLVNRIIDSDLKINMGAKYF 166  Polysphondylium pallidum PN500
XP_003290530  142 -CtpQDFRLICRIIDSDLKINTGAKFF 167  Dictyostelium purpureum
XP_002669721  151 kLtgDELKFICRIICKDLKIRAGPKYL 177  Naegleria gruberi strain NEG-M
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