Conserved Protein Domain Family
Motilin_ghrelin

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pfam04644: Motilin_ghrelin 
Motilin/ghrelin
Motilin is a gastrointestinal regulatory polypeptide produced by motilin cells in the duodenal epithelium. It is released into the general circulation at about 100-min intervals during the inter-digestive state and is the most important factor in controlling the inter-digestive migrating contractions. Motilin also stimulates endogenous release of the endocrine pancreas. This family also includes ghrelin, a growth hormone secretagogue synthesized by endocrine cells in the stomach. Ghrelin stimulates growth hormone secretagogue receptors in the pituitary. These receptors are distinct from the growth hormone-releasing hormone receptors, and thus provide a means of controlling pituitary growth hormone release by the gastrointestinal system.
Statistics
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PSSM-Id: 309678
View PSSM: pfam04644
Aligned: 8 rows
Threshold Bit Score: 38.731
Threshold Setting Gi: 17865464
Created: 19-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20
                 ....*....|....*....|....*..
gi 17865464   25 SSFLSPEHQKLQ-RKEAKKPSGRLKPR 50
gi 127254     28 PIFTYGELQRMQeKERNKGQKKSLSVQ 54
gi 17865508   28 PIFTYSELRRTQeREQNKRLRKSLRVQ 54
gi 620987486  25 PIFTHSDVQRMQeRERNKGQKKSLTVQ 51
gi 924442891  28 PIFTHSELQKIReKERNKGQKKSLILQ 54
gi 344298855  28 PIFTYSEIRRMQeRERNNGQKKLLSVQ 54
gi 880864187  25 SSFLSPEHQKAQqRKESKKPQAKLQPR 51
gi 564258048  28 PIFTHSDMQRMQeRERNKGQKKSLTLQ 54
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