Conserved Protein Domain Family
Rtf2

?
pfam04641: Rtf2 
Rtf2 RING-finger
It is vital for effective cell-replication that replication is not stalled at any point by, for instance, damaged bases. Replication termination factor 2 (Rtf2) stabilizes the replication fork stalled at the site-specific replication barrier RTS1 by preventing replication restart until completion of DNA synthesis by a converging replication fork initiated at a flanking origin. The RTS1 element terminates replication forks that are moving in the cen2-distal direction while allowing forks moving in the cen2-proximal direction to pass through the region. Rtf2 contains a C2HC2 motif related to the C3HC4 RING-finger motif, and would appear to fold up, creating a RING finger-like structure but forming only one functional Zn2+ ion-binding site. This domain is also found at the N-terminus of peptidyl-prolyl cis-trans isomerase 4, a divergent cyclophilin family.
Statistics
?
Aligned: 18 rows
Threshold Bit Score: 199.515
Threshold Setting Gi: 144579265
Created: 5-May-2019
Updated: 18-Jul-2019
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Q5K8P8     1 MGADGGSIPDRRDLVKT--KGKTEQA----D-KESLK-ALFFLCALSKKPLKKPVVIDPLGKLYNKDDLIEYFLDKsk-y 71  Cryptococcus neofor...
A0DTQ1     1 MGNDGGSFAERAELVKL--KKPEKRV----E-SLLVAkQRAQFCSLTKEKLRKPIACCRIGYLYNYDSLLKAFMEK---- 69  Paramecium tetraurelia
Q23KD1     1 MGNDGGSFQTRTDLVKE--KPKEVKI----D-NTILAkFRARLCTLSKQRLKKPIVMCRLGNFYNFEEILKNLMEK---- 69  Tetrahymena thermop...
Q2UTA9     1 MGNDGGSIPTRRELVRE--AARAPSTaqvkEaQRELQeHYWKTCPLSHKPLMRPIVADCVGNMYNKDAILKFLLPGeeie 78  Aspergillus oryzae
Q10154     1 MGNDGGSLPTRNELVKEpgKVPPLDI----DfKRSVKsSQFSQCAITDEPLYPPIVSCGLGKLYNKASILQMLLDRs--- 73  Schizosaccharomyces...
KIS66334   1 MGNDGGAIAKRDELVRT--KATFEKV----D-PELLRqSLWTVCSLSRQPLEPPVASDALGHLYNKDAVVTHLLERhqng 73  Ustilago maydis 521
EDO43076   1 MGCDGGTIPTRDELVRM--KKAPEKV----E-KNYELnAKWFHCAISQEQLHSPIVSCELGNLYNKEKLLEFLLDRs--- 70  starlet sea anemone
Q5ZJN1     1 MGCDGGTIPKRHELVKG--PRKAVKV----D-KTAELvARWYYCTLSQEKLCRPIVACELGRLYNKDAVIEFLLDKsa-d 72  chicken
Q99K95     1 MGCDGGTIPKRHELVKG--PKKVEKV----D-KDAELvAQWNYCTLSQEILRRPIVACELGRLYNKDAVIEFLLDKsa-e 72  house mouse
CAP37413   1 MGADGGTIPKRCELVQQ--KKKKEKL----D-KHVKNaTKWRNCQLTQLPLKKPVIACRFGKLYNKEDVINAILSKt--- 70  Caenorhabditis brig...
Q5K8P8    72 gDGEQICG------HLKGVKDLTTLNLTPNPdftfs----sasatVTTSRAPFICPLSLREMAGTFPFIALKSCGCVFSD 141 Cryptococcus neofor...
A0DTQ1    70 -KIPQEFK------HLQNLKKIKKLNITENP--------------DQNNEFPFVCLFSQKSLNGKEKFQALWTCGCVFYK 128 Paramecium tetraurelia
Q23KD1    70 -SMPSSFA------HIKKAKDVKEVKLEPNP--------------DQKSEYPYICPLSQIEFNGLNKFVGLWDCGCVFSE 128 Tetrahymena thermop...
Q2UTA9    79 gISSKADCeeilcgRVKGLRDVVELKFEIDTeqsq------hpstKLDKQEGWICPVTAKQLGPNVKAVYLVPCGHVFSE 152 Aspergillus oryzae
Q10154    74 -SVPKSPS------HIKSLKDVVQLQVELD----------------DSGKVLWLCPITRHVMSDTYQFAYIVPCGHVFEY 130 Schizosaccharomyces...
KIS66334  74 sSASSTKAidp-ipHIRGLRDITQLKLTPNTlyrpps---ptrssNEYSVYPFMCPLSSKQMDGQQRFIYIIDCGCVMSA 149 Ustilago maydis 521
EDO43076  71 sATSDVAN------HIRNLKDTKQLNLTVNPafeqktk-eqaggyLDFQASQYICPVVGIEMNGRYKFCFLWKCGCVFSE 143 starlet sea anemone
Q5ZJN1    73 kTPMEAAS------HIKSLKNVTELNLADNPawsgdkeskkgdtyDDIQSARFICPVVGLEMNGRHRFCFLRNCGCVFSE 146 chicken
Q99K95    73 kALGKAAS------HIRSIKNVTELRLSDNPawegdkgntkgdkhDDLQRARFICPVVGLEMNGRHRFCFLRCCGCVFSE 146 house mouse
CAP37413  71 iSKSAAAS------HIKGPRDFVELKLTENKdfkrgd--vkgddyNDVNQTEFLCPITNVPMNGIQSFLVNWQCGCVYSE 142 Caenorhabditis brig...
Q5K8P8   142 AALRAV--V---PNltkgtgakvipkddvpeegkpvvkenttevaCPNCGKTFNPTis---------aAIIPVNPPKEvQ 207 Cryptococcus neofor...
A0DTQ1   129 KLIKDL--KikgLK-------------------------------CPICTKPYTEK------------DIVQLCPTNE-E 162 Paramecium tetraurelia
Q23KD1   129 KLIQNL--KgdsKK-------------------------------CPVCSKSYSSK------------DVVQLNMSVE-E 162 Tetrahymena thermop...
Q2UTA9   153 EAVRQL--K---GDk------------------------------CLQCNESYTEE------------NVIPILPTKSeD 185 Aspergillus oryzae
Q10154   131 SALKQF--G---EKm------------------------------CFQCNQVYEEK------------DVIPINPNAE-Q 162 Schizosaccharomyces...
KIS66334 150 TGLRTTvaAakpSQpipnr---------------------pehkpCPVCGKAFNAAglakgkqpevggSVVTINPSDA-E 207 Ustilago maydis 521
EDO43076 144 RALKEV--K---SVv------------------------------CHKCGKTFSQE------------DVVVINGSED-E 175 starlet sea anemone
Q5ZJN1   147 RALKEI--K---TEv------------------------------CHKCGVPFQEE------------DVIILNGNKE-D 178 chicken
Q99K95   147 RALKEI--K---AEv------------------------------CHTCGAAFQEE------------DIIVLNGTKE-D 178 house mouse
CAP37413 143 KAQQEV--K---SEn------------------------------CHVCGGPYDAT------------KMVILNPEDE-Q 174 Caenorhabditis brig...
Q5K8P8   208 DVLLEDLL-TSRAAAk----sSKKRKADKSTKANNDTGSPATLEPPPKSARISssspapra--------------tptvn 268 Cryptococcus neofor...
A0DTQ1   163 AEIKKAQLyKEIELK------EKQKKDQKKQLKVSDAVNNLELQQKKKVCTEE--------------------------- 209 Paramecium tetraurelia
Q23KD1   163 QEKKKIEI-LSESSK------KDKKSSQKDEKKNHASGEKVEKKVKTEKNSSLt-------------------------- 209 Tetrahymena thermop...
Q2UTA9   186 KQQLMARA-QKLAEQglthslKKAPGS-KKRKKQ-ANGDSAETEGASRsnts--------------------------tp 236 Aspergillus oryzae
Q10154   163 LKTLSKRL-LDLALS------EKTHSLNKASKKSNKNGDKKRKHVSKSNSKHAk-------------------------- 209 Schizosaccharomyces...
KIS66334 208 EAEMRAAM-ENARAE------QTKKKKAKTRTADQAIESG---------------------------------------- 240 Ustilago maydis 521
EDO43076 176 VEIMKEKM-NARRLK------AKQEKKAKKAPKSAETTTSASPSAGPSKPEIPfkkpkldskpgvn----gassrsvssk 244 starlet sea anemone
Q5ZJN1   179 VEVLKKRM-EDRRLK------SKLEKKSKKCKSA-ESAAQQVTTEDSPGPSKVknskdciasssgek--rhiiftkssdd 248 chicken
Q99K95   179 VEMLKKRM-EERRLR------AKLEKKTKKPKTATECASKPGTTQDSAGPSKVksgkpeeadpdpre--kkstpaprgaa 249 house mouse
CAP37413 175 LELYKLKW-EAEKAE------KAAAKKEKAKKTAEKMEAAAMASEGPSTSSDApgpsapgsrgmasvgksadlakkleia 247 Caenorhabditis brig...
Q5K8P8   269 tpASLARSVHEKLAEqekKRLQAQENMSEAVK---------AMFkpKTNEK 310 Cryptococcus neoformans
A0DTQ1   210 --QKFKGQTMEDNKL---QNHTQDLKNNEIYQ---------SLF--HQQHK 244 Paramecium tetraurelia
Q23KD1   210 --SSGVSTLGSHKAAlieQLTETQKEQSQVFK---------SLFhtDKDLK 249 Tetrahymena thermophila SB210
Q2UTA9   237 kpSASNGIKHAATAMltaRVLEEENEKKKRRKmmglnenldSLFtkDSKDG 287 Aspergillus oryzae
Q10154   210 ------------hELrtnRMLDGENVKSETSV---------TDMerVKRVK 239 Schizosaccharomyces pombe 972h-
KIS66334 241 --GLDSGHAKEDQAEqkrRKAERKSEMRARLA---------ALTaeLTAEQ 280 Ustilago maydis 521
EDO43076 245 kgKSPKVNVTIPTELskyKTVAEDPNASKVYK---------SLFasGHEKR 286 starlet sea anemone
Q5ZJN1   249 rsSSVPGKVNKASTat-kRSIADTATRNLRHT---------NLFttHSSAK 289 chicken
Q99K95   250 tnGSASGKVGKPPCGalkRSIAD-SEESETYK---------SIFtsHSSAK 290 house mouse
CAP37413 248 klGAGASDRKAEKRKatsSDIQSDPTKSDTYK---------KLFttCEAAK 289 Caenorhabditis briggsae
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap