Conserved Protein Domain Family
Rtf2

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pfam04641: Rtf2 
Rtf2 RING-finger
It is vital for effective cell-replication that replication is not stalled at any point by, for instance, damaged bases. Replication termination factor 2 (Rtf2) stabilizes the replication fork stalled at the site-specific replication barrier RTS1 by preventing replication restart until completion of DNA synthesis by a converging replication fork initiated at a flanking origin. The RTS1 element terminates replication forks that are moving in the cen2-distal direction while allowing forks moving in the cen2-proximal direction to pass through the region. Rtf2 contains a C2HC2 motif related to the C3HC4 RING-finger motif, and would appear to fold up, creating a RING finger-like structure but forming only one functional Zn2+ ion-binding site. This domain is also found at the N-terminus of peptidyl-prolyl cis-trans isomerase 4, a divergent cyclophilin family.
Statistics
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PSSM-Id: 309676
View PSSM: pfam04641
Aligned: 18 rows
Threshold Bit Score: 198.353
Threshold Setting Gi: 145349214
Created: 19-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q5K8P8         1 MGADGGSI--PDRRDLVKT--KGKTEQA----D-KESLK-ALFFLCALSKKPLKKPVVIDPLGKLYNKDDLIEYFLDKsk 70  Cryptococcus ne...
A0DTQ1         1 MGNDGGSF--AERAELVKL--KKPEKRV----E-SLLVAkQRAQFCSLTKEKLRKPIACCRIGYLYNYDSLLKAFMEK-- 69  Paramecium tetr...
Q23KD1         1 MGNDGGSF--QTRTDLVKE--KPKEVKI----D-NTILAkFRARLCTLSKQRLKKPIVMCRLGNFYNFEEILKNLMEK-- 69  Tetrahymena the...
Q2UTA9         1 MGNDGGSI--PTRRELVRE--AARAPSTaqvkEaQRELQeHYWKTCPLSHKPLMRPIVADCVGNMYNKDAILKFLLPGee 76  Aspergillus oryzae
Q10154         1 MGNDGGSL--PTRNELVKEpgKVPPLDI----DfKRSVKsSQFSQCAITDEPLYPPIVSCGLGKLYNKASILQMLLDRs- 73  Schizosaccharom...
Q5SMK9        84 GGGDGGATgaESRDCYLSMylAKKPDKA----D-PNEARlSRFTCCALSGEPLAAPAVADRLGNLFNKEALVEALLHK-- 156 Japanese rice
Q6NQ98        84 GGGDGGATgaESRDCYLNMyaEKKPDKV----D-PNEQRlSKWLNCALSNEPLAEPCVIDLLGNLFNKEVLVHALLSK-- 156 thale cress
XP_001635139   1 MGCDGGTI--PTRDELVRM--KKAPEKV----E-KNYELnAKWFHCAISQEQLHSPIVSCELGNLYNKEKLLEFLLDRs- 70  starlet sea ane...
XP_002646542   1 MGADGGTI--PKRCELVQQ--KKKKEKL----D-KHVKNaTKWRNCQLTQLPLKKPVIACRFGKLYNKEDVINAILSKt- 70  Caenorhabditis ...
XP_011392039   1 MGNDGGAI--AKRDELVRT--KATFEKV----D-PELLRqSLWTVCSLSRQPLEPPVASDALGHLYNKDAVVTHLLERh- 70  Ustilago maydis...
Q5K8P8        71 -ygDGEQICG--------HLKGVKDLTTLNLTPNPdftfs---sasatVTTSRAPFICPLSLREMAGTFPFIALKSCGCV 138 Cryptococcus ne...
A0DTQ1        70 ---KIPQEFK--------HLQNLKKIKKLNITENP-------------DQNNEFPFVCLFSQKSLNGKEKFQALWTCGCV 125 Paramecium tetr...
Q23KD1        70 ---SMPSSFA--------HIKKAKDVKEVKLEPNP-------------DQKSEYPYICPLSQIEFNGLNKFVGLWDCGCV 125 Tetrahymena the...
Q2UTA9        77 iegISSKADCeei--lcgRVKGLRDVVELKFEIDTeqsq-----hpstKLDKQEGWICPVTAKQLGPNVKAVYLVPCGHV 149 Aspergillus oryzae
Q10154        74 ---SVPKSPS--------HIKSLKDVVQLQVELD---------------DSGKVLWLCPITRHVMSDTYQFAYIVPCGHV 127 Schizosaccharom...
Q5SMK9       157 ---RLPKALS--------HIRGLKDMIPIHLHPKPdad----------aagEEVRFQCPVTGLDFNGKYQFLALRKCGHV 215 Japanese rice
Q6NQ98       157 ---RLPKQFS--------YIKGLKDMVNIKLTPVAgsd-------gssQDTTSAQFQCPVSGLEFNGKYKFFALRGCGHV 218 thale cress
XP_001635139  71 --sATSDVAN--------HIRNLKDTKQLNLTVNPafeqktkeqaggyLDFQASQYICPVVGIEMNGRYKFCFLWKCGCV 140 starlet sea ane...
XP_002646542  71 --iSKSAAAS--------HIKGPRDFVELKLTENKdfkrgd-vkgddyNDVNQTEFLCPITNVPMNGIQSFLVNWQCGCV 139 Caenorhabditis ...
XP_011392039  71 --qNGSSASStkaidpipHIRGLRDITQLKLTPNTlyrpps--ptrssNEYSVYPFMCPLSSKQMDGQQRFIYIIDCGCV 146 Ustilago maydis...
Q5K8P8       139 FSDAALRAVV---P--------------NltkgtgakvipkddvpeegkpvvkenttevaCPNCGKTFNPTis------- 194 Cryptococcus ne...
A0DTQ1       126 FYKKLIKDLKikgL--------------K-------------------------------CPICTKPYTEK--------- 151 Paramecium tetr...
Q23KD1       126 FSEKLIQNLKgdsK--------------K-------------------------------CPVCSKSYSSK--------- 151 Tetrahymena the...
Q2UTA9       150 FSEEAVRQLK---G--------------Dk------------------------------CLQCNESYTEE--------- 173 Aspergillus oryzae
Q10154       128 FEYSALKQFG---E--------------Km------------------------------CFQCNQVYEEK--------- 151 Schizosaccharom...
Q5SMK9       216 LSVKALKEVK---T--------------Sa------------------------------CLVCHKEFDEA--------- 239 Japanese rice
Q6NQ98       219 MSAKALKEVK---S--------------Ss------------------------------CLVCHADVKDS--------- 242 thale cress
XP_001635139 141 FSERALKEVK---S--------------Vv------------------------------CHKCGKTFSQE--------- 164 starlet sea ane...
XP_002646542 140 YSEKAQQEVK---S--------------En------------------------------CHVCGGPYDAT--------- 163 Caenorhabditis ...
XP_011392039 147 MSATGLRTTV---AaakpsqpipnrpehKp------------------------------CPVCGKAFNAAglakgkqpe 193 Ustilago maydis...
Q5K8P8       195 --aAIIPVNPPKEvQDVLLEDLL-TSRAAAk----sSKK----------------------RKADKSTKANNDTGSPATL 245 Cryptococcus ne...
A0DTQ1       152 ---DIVQLCPTNE-EAEIKKAQLyKEIELK------EKQ----------------------KKDQKKQLKVSDAVNNLEL 199 Paramecium tetr...
Q23KD1       152 ---DVVQLNMSVE-EQEKKKIEI-LSESSK------KDK----------------------KSSQKDEKKNHASGEKVEK 198 Tetrahymena the...
Q2UTA9       174 ---NVIPILPTKSeDKQQLMARA-QKLAEQglthslKKA----------------------PGS-KKRKKQ-ANGDSAET 225 Aspergillus oryzae
Q10154       152 ---DVIPINPNAE-QLKTLSKRL-LDLALS------EKT----------------------HSLNKASKKSNKNGDKKRK 198 Schizosaccharom...
Q5SMK9       240 ---DKMPLNGTED-EVAALRLRM-EEERGK------VKE----------------------KK--EKKVGNGLSGSKHAA 284 Japanese rice
Q6NQ98       243 ---DKIVINGTEE-EVDLLRERM-EEEKAK------LRE----------------------KKGVSKKSKNGAAVVADTG 289 thale cress
XP_001635139 165 ---DVVVINGSED-EVEIMKEKM-NARRLK------AKQ----------------------EKKAKKAPKSAETTTSASP 211 starlet sea ane...
XP_002646542 164 ---KMVILNPEDE-QLELYKLKW-EAEKAE------KAAakkekakktaekmeaaamasegPSTSSDAPGPSAPGSRGMA 232 Caenorhabditis ...
XP_011392039 194 vggSVVTINPSDA-EEAEMRAAM-ENARAE------QTK----------------------KKKAKTRTADQA------- 236 Ustilago maydis...
Q5K8P8       246 EPPP-----KSARISssspapra----------tptvntpASLARSVHEKLAEqekKRLQAQENMSEAVK---------A 301 Cryptococcus ne...
A0DTQ1       200 QQKK-----KVCTEE-------------------------QKFKGQTMEDNKL---QNHTQDLKNNEIYQ---------S 237 Paramecium tetr...
Q23KD1       199 KVKT-----EKNSSLt------------------------SSGVSTLGSHKAAlieQLTETQKEQSQVFK---------S 240 Tetrahymena the...
Q2UTA9       226 EGAS-----Rsnts----------------------tpkpSASNGIKHAATAMltaRVLEEENEKKKRRKmmglnenldS 278 Aspergillus oryzae
Q10154       199 HVSK-----SNSKHAk----------------------------------hELrtnRMLDGENVKSETSV---------T 230 Schizosaccharom...
Q5SMK9       285 AAVM-----AGGAEKl------------------------ENGKKGEAPSLKRfkaGDHAPAYANKEVYA---------S 326 Japanese rice
Q6NQ98       290 AKVA-----KR-QIE-------------------------DGNVNGNGITVKKfkaADKVPVNATKEVYA---------S 329 thale cress
XP_001635139 212 SAGP-----SKPEIPfkkpkldskpgvngassrsvsskkgKSPKVNVTIPTELskyKTVAEDPNASKVYK---------S 277 starlet sea ane...
XP_002646542 233 SVGKsadlaKKLEIAk-----------------------lGAGASDRKAEKRKatsSDIQSDPTKSDTYK---------K 280 Caenorhabditis ...
XP_011392039 237 -------------IEs-----------------------gGLDSGHAKEDQAEqkrRKAERKSEMRARLA---------A 271 Ustilago maydis...
Q5K8P8       302 MFkpKTNEK 310 Cryptococcus neoformans
A0DTQ1       238 LF--HQQHK 244 Paramecium tetraurelia
Q23KD1       241 LFhtDKDLK 249 Tetrahymena thermophila SB210
Q2UTA9       279 LFtkDSKDG 287 Aspergillus oryzae
Q10154       231 DMerVKRVK 239 Schizosaccharomyces pombe 972h-
Q5SMK9       327 IFtsSKKSD 335 Japanese rice
Q6NQ98       330 LFtsSKKKs 338 thale cress
XP_001635139 278 LFasGHEKR 286 starlet sea anemone
XP_002646542 281 LFttCEAAK 289 Caenorhabditis briggsae
XP_011392039 272 LTaeLTAEQ 280 Ustilago maydis 521
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