4XPU,3GA2


Conserved Protein Domain Family
Endonuclease_5

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pfam04493: Endonuclease_5 
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Endonuclease V
Endonuclease V is specific for single-stranded DNA or for duplex DNA that contains uracil or that is damaged by a variety of agents.
Statistics
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PSSM-Id: 335811
View PSSM: pfam04493
Aligned: 168 rows
Threshold Bit Score: 161.829
Threshold Setting Gi: 56404424
Created: 24-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4XPU_A        14 IELASSVIREDrLDKDP-------P---DLIAGADVGFeq--gGEVtRAAMVLLKYP-SLELVEYKVARI-ATTMPYIPG 79  Escherichia col...
Q10348        18 IELKGMLQLIP-KFQSL-------Ne-iRYVVGLDISFdksspKA--VSALVIYDLE-QRMIIYKDYLCIeKLEEDYVPG 85  Schizosaccharom...
EPB90206      22 NDLKKQLVLED-GLSFDttt-ladL---KYVGGVDLSFplgdhENA-VACLVVMRMP-DLQIVYKEFLQT-KLHLPYISG 93  Mucor circinell...
ETE65486      23 IQMKEDVIEQD-TEEWQsnfsfagL---ERIGGMDLSYlkedaTRA-CASLMVLSYP-ELEVLYEDCYVV-AVNAPYVAG 95  king cobra
XP_001568876 162 STFARQLPAL------------------TFVGGVDISFipgtnDG--VACLAILRYP-SMELVKTYLHRC-TLREPYVSG 219 Leishmania braz...
XP_013024124  17 llLKERIVFTS-KFKDV-------Ds-iRYIAGLDISFdktspKA--VSAIVIYDLQ-NAQVIYKDYLVIdNLREDYVPG 84  Schizosaccharom...
EFX70609      19 mksklIISNTE-KWQA--------DrklNLVGGMDISFckadsSIA-ICTLVVCSVSqQLKVVYEDSLHV-KLSTPYIPG 87  common water flea
NP_567868     35 DDFTWKLSSST-ELSQG-------SeilKYVGGVDMSFckedsSVA-CACLVVLELP-SLRVVHHDFSLL-RLHVPYVPG 103 thale cress
XP_004358966 333 ldktnrVKKLP-NGQLn----------iKYVAGSDISFakgnkIDA-CASIVVMEYP-SLKVVYESYKMI-KLTQPYIAG 398 Dictyostelium f...
XP_020432766 301 lkmAASVVKTN-SNNLK-------LsdlKYIGGVDISFaknnkIDA-CASIVVIEYP-SLKVVYESYKMV-KLTQPYIAG 369 Polysphondylium...
4XPU_A        80 FLSFREYPALLAAWEMLSQ-----K-----PDLVFVDG------HGISHPRRLGVASHFGLLVDVPTIGVAKKR------ 137 Escherichia col...
Q10348        86 FLSFREIKWYLPLLNHIPHqf--------riDIILVDG------NGVLHPVGFGLACHLGVLLNLPVVGVAKNY------ 145 Schizosaccharom...
EPB90206      94 YLAFREVEPLMELIQQLKT-----NqpdlyPQVILVDGmytfvgNGLLHPRQFGIASHLGVLCNTPTIGVAKNF------ 162 Mucor circinell...
ETE65486      96 FLAFREVPFLLEAVQRLETqkpglK-----PQVLLVDG------NGILHQRGFGIACHLGVLTGLPCIGVAKNLlqvegl 164 king cobra
XP_001568876 220 FLSFREIQPVCELIDAVRAel-leTqt--lPQVLVVDG------NGVLHPRRCGLATHLGIVLDIPTIGCSKKM------ 284 Leishmania braz...
XP_013024124  85 FLSFREIEYYLPLLKRIPPsy--------cfDLIMVDG------NGILHPIQFGLACHLGVLTNSPTMGVAKNY------ 144 Schizosaccharom...
EFX70609      88 FLAFREFEPCLSLYTKLTSk---hSel--iPQVLMFDG------NGILHPRGLGLASHFGVCTNTCTIGVAKNL------ 150 common water flea
NP_567868    104 FLAFREAPVLLQILQKMRDe---kHpf--yPQVLMVDG------NGILHPRGFGLACHLGVLAHLPTIGVGKNL------ 166 thale cress
XP_004358966 399 YLAMREVDHLVALWQSLKRt---hPqf--tPDIMVVDG------NGVNHMRGMGLACHLGILIDCPTLGVAKNL------ 461 Dictyostelium f...
XP_020432766 370 YLAFREIPHLLPLWNDLKRn---aPyl--vPQVMVLDG------NGINHMRGLGAACHLGVMIDCPTIGVAKQL------ 432 Polysphondylium...
4XPU_A       138 ----LC------------G----KFEp-LSSEPGAL-----APLMd----kGEQLAWVWRSKAR-C--NPLFIATGHRVS 184 Escherichia col...
Q10348       146 ----LHcvgl----teslDahreTLKkhVLKKTTDH-----PILIhsidqsSEILGAAVWTSSN-Sk-RPVYVSIGNQMN 210 Schizosaccharom...
EPB90206     163 ----LVipsefddmaaikS----QYKq-ALHKKGDR-----FELVga--asGSTYGTALRTSDNaV--NPVFVSQGHLIT 224 Mucor circinell...
ETE65486     165 andeLH------------K----KQIq-DLQAGGDA-----FPLTss---sGKIMGMALRSCAN-Sr-KPIYISVGHKIS 217 king cobra
XP_001568876 285 ----LRvdg------lgrDavetALAtlSEAESSTSslpciVPLLgts-lpTQLYGYAVHNHLN-SvkKCIYVSPGHCVG 352 Leishmania braz...
XP_013024124 145 ----FHcfgl----neslDdhrqHLSnyISTNTSKP-----PLFLysigepSIVLGAAVWTRKE-Sk-RPIYVSIGNQIS 209 Schizosaccharom...
EFX70609     151 ----YQmgs------ilrDenhfSQIn-SLSAPGDH-----FFIKnsegngGEILGAALKTTQE-Ak-RPVYISIGHRIG 212 common water flea
NP_567868    167 ----HHvdg------lnqSevkqSLQl-QINEHEQT-----ITLVgn---sGITWGVGFRPTLS-Sl-KPIYVSVGHRIS 225 thale cress
XP_004358966 462 ----LVchg------iteEyldeQFDyaTLGEA--------VQMKsd--qtNELLGYCTYNNEN----ERLYISPGHKID 517 Dictyostelium f...
XP_020432766 433 ----LVchg------vtnEliedQFNqrGNSAT--------IEMRns--mnNELLGYAMKNVDS----ENIYISPGHKMD 488 Polysphondylium...
4XPU_A       185 VDSALAWVQRCMkGY-RLPEPTRW 207 Escherichia coli S88
Q10348       211 LEQSIQLVQKCSsSHsRVPEPIRQ 234 Schizosaccharomyces pombe 972h-
EPB90206     225 LASAVNVVLATCpKH-RIPEPIRa 247 Mucor circinelloides f. circinelloides 1006PhL
ETE65486     218 LLSAVRLVHSCC-KY-RIPEPIRQ 239 king cobra
XP_001568876 353 FAVATALVITML-RY-RIPEPIRA 374 Leishmania braziliensis MHOM/BR/75/M2904
XP_013024124 210 LDIAIQLVFRTSgVVsKIPEPIRQ 233 Schizosaccharomyces cryophilus OY26
EFX70609     213 LETAIWAVMQCIdRY-RIPEPTRQ 235 common water flea
NP_567868    226 LDSAVEVVKITC-KY-RVPEPIRQ 247 thale cress
XP_004358966 518 AYTALQVYEQTTkTH-NLPEPTYI 540 Dictyostelium fasciculatum
XP_020432766 489 AKLALEIAKATLnNR-PIPEPTFQ 511 Polysphondylium pallidum PN500
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