Conserved Protein Domain Family
Mid2

?
pfam04478: Mid2 
Mid2 like cell wall stress sensor
This family represents a region near the C-terminus of Mid2, which contains a transmembrane region. The remainder of the protein sequence is serine-rich and of low complexity, and is therefore impossible to align accurately. Mid2 is thought to act as a mechanosensor of cell wall stress. The C-terminal cytoplasmic region of Mid2 is known to interact with Rom2, a guanine nucleotide exchange factor (GEF) for Rho1, which is part of the cell wall integrity signalling pathway.
Statistics
?
PSSM-Id: 282349
View PSSM: pfam04478
Aligned: 9 rows
Threshold Bit Score: 142.166
Threshold Setting Gi: 74607836
Created: 23-Mar-2017
Updated: 23-May-2017
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Q6CY50       170 TTI-TSVINGVTILSDRYTTVTFTPTSTSDPDSRe-GQ--HT-GLSDKNKRIVIGVVVGLGVPILLVLLALIYIFCIKPK 244 Kluyveromyces l...
Q6FPX2       264 VII-TSVIEGKTILSNSYTTITYSPESTAHKSPQnkSG--NH-GLSSKNKKIVIGCVVGIGVPLLIAILVLLYIFCIMPT 339 [Candida] glabrata
Q6FTP5       168 PTI-TSIIEGKTILSDLYTTITYTPTATHGANNK--KV--HH-GLSKKNRNIVIGCVVGIGVPLIVLTLFLLYVFCIRSP 241 [Candida] glabrata
Q758Q5       271 STFrTTSLKIVTLLVDGSSTLTITASESQTT-----AP--SR-GLSKKDKNIIIGCVVGICVPLLIVIACVVFYTCVRED 342 Eremothecium go...
P53214       317 KTI-TSIIEGQTILSNYYTTITYSPTASASSGKN--SH--HS-GLSKKNRNIIIGCVVGIGAPLILILLILIYMFCVQPK 390 Saccharomyces c...
EGA85713     121 STI-TSIINGKTILSNHYTTVTYTPSATADSSNK--SK--SS-GLSKKNRNIVIGCVVGIGVPLILVILALIYMFCIQSS 194 Saccharomyces c...
XP_003687701 176 ATL-TTVINGSTILSDIYVTLSATATASANNNNT--NAnnHS-GLSKKNRNIVIGCVVGIGVPVLLALLIIFYIFCIQSK 251 Tetrapisispora ...
XP_003673145 238 LTV-TSIIHGKTVLSNLYTTVTYMPPDGSTNKNK---T--TS-GLSKKNRNIVIGCCVGIGVPLLLLILLFLYHYCIKPK 310 Naumovozyma cas...
XP_003669945 294 KTV-TSIIHGKTILSNYYTTITYTPTATANSSNS--KN--SHsGLTKKNRNIVLGCVLGIGIPLLLLIGLILYHFCIKSK 368 Naumovozyma dai...
Q6CY50       245 RTNFLNSEGKVVTAYTSGKVSKWWKAFMGKQ-T---DDYVTESPe-------sGI-DEPSVLAPTRN----NT 301 Kluyveromyces lactis
Q6FPX2       340 RTDFIDSDGKVITAYKRNIFVTIWYSLLGKN-LddaRNFSSESPm-------gSD-DNSSDFIITNDkdvaNT 403 [Candida] glabrata
Q6FTP5       242 KTDFINSDGKVITAYRPNKITKWWNALMGRE-It--EEYQSKSPlgg----eaSD-FEDSELAYADDddesLS 306 [Candida] glabrata
Q758Q5       343 RTNFINSDGKVITAYSTSRLSKWWSTLLGRK-I---DKYESDTPlgs---tplHD-DERIHL-KSSSahhsSP 406 Eremothecium gossypii
P53214       391 KTDFIDSDGKIVTAYRSNIFTKIWYFLLGKK-IgetERFSSDSPigs---nniQN-FGDIDPEDILNndnpYT 458 Saccharomyces cerevisi...
EGA85713     195 RTDFIDSDGKVVTAYRANKFTKWWYMLLGKK-Vs--DEYHSDSPlgg----saSS-AGGLDLDEADDvmeqSS 259 Saccharomyces cerevisi...
XP_003687701 252 KTDFINSDGQVVTAYSANKFTAWWYNLLGKD-Ts--EKYETKSPlgg----ssSDlDEQLNDRSSLNnddsLD 317 Tetrapisispora phaffii...
XP_003673145 311 QTNFIDSDGKVITAYKTNNLQRFFNSLIGKN-Kn-tEQYQTKSPlgntivtsmNN-N------KIQNndvtAN 374 Naumovozyma castellii ...
XP_003669945 369 STNFIDSDGKVITAYKTNNLHKLWNLLIGKKnNn--EEYHSNLPlg-----srNN-DGGENGYNFDNddilVQ 433 Naumovozyma dairenensi...
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap