Conserved Protein Domain Family
Terminase_3

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pfam04466: Terminase_3 
Phage terminase large subunit
Initiation of packaging of double-stranded viral DNA involves the specific interaction of the prohead with viral DNA in a process mediated by a phage-encoded terminase protein. The terminase enzymes are usually hetero-oligomers composed of a small and a large subunit. This region is found on the large subunit and possess an endonuclease and ATPase activity that require Mg2+ and a neutral or slightly basic reaction. This region is also found in bacterial sequences.
Statistics
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Aligned: 7 rows
Threshold Bit Score: 235.401
Threshold Setting Gi: 81507717
Created: 5-May-2019
Updated: 18-Jul-2019
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
P45916    18 QKFQFLVGGYGSSKSYHVALKIVLKLLRE---KRTALV-IREVYDTHRDSTFSLFDELVSDLKLDHIVRCVSSPMQI-RF 92  Bacillus subtilis s...
Q65PP9    28 HLTEVWYGGASSGKSHGVVQKVVLKSLQHwnvPRKVLW-LRKVDRTVKNSIFTDVTECLSGWNILQYCHVNRSDKTI-VL 105 Lactobacillus johns...
P39786    19 QTYQFLVGGYGSSKSYHTALKIVLKLLKE---KRTALV-IREVFDTHRDSTFALFQEVIEELGLTKAVASLSSPLQL-RF 93  Bacillus subtilis s...
O50744    19 AEIFIYYSSRGTGKTYDIATVNLERKFSA---DGGDTLaIRKKKNKTTQSIHKEILELLSIYNLRKFFNISKAKIESkSL 95  Lyme disease spiroc...
ACQ68288   5 KRIKVYFGGRGGMKTVSFAKIALITASMH---KRRFLC-LREFMNSIEDSVHAVLQAEVETLGLQNRFRILNTYI---EG 77  Candidatus Hamilton...
Q8Y4X9    33 HNHIIAKGGRSSMKSSVISLKLVEKKMAN---PQSNMVcLRKVANTLYKSVYQQIKWALYEMGVADQFKFGKSPMEIiHK 109 Listeria monocytogenes
Q9A018    27 NFYRVVKGSRGSKKSKTTALNFIVRLLKY---PWANLLvIRRYSNTNKQSTYTDFKWACNQLKVTHLFKFNESLPEItVK 103 Streptococcus pyoge...
P45916    93 SNGSR--IIFKGM-DKPAKLKSIN----NISLIWIEECSEVKYEG-FKELLGRLR----HPTLPLHMILSTN-PVGEDNW 159 Bacillus subtilis s...
Q65PP9   106 PNGAI--FLFQGM-DDPEKIKSIK----GLSDVVMEEASEFNHND-YTQLTLRLRe---PKHKQRQIFCMFN-PVSKLNW 173 Lactobacillus johns...
P39786    94 HNGSR--IMFKGM-DNPAKLKSVH----NISLIWIEECSEVKYEG-FKELIGRLR----HPELKLHMICTTN-PVGTSNW 160 Bacillus subtilis s...
O50744    96 IFGKKraFVFEGG-HDTRDLKSYA----HFKDLWLEEANQFSADD-IEMLVPTMR------EQGGRIYMSSN-PVPKSHW 162 Lyme disease spiroc...
ACQ68288  78 INDSI--FKYGQLaRNIASIKSKH----DFDVAWVEEAETVSEKS-LDTLIPTIR------KPGSELWFSFN-PAEEDGA 143 Candidatus Hamilton...
Q8Y4X9   110 EWGTG--FYFSGC-DDPAKLKSMKipvgYVSDLWFEELAEFSGVTdIDVVEDTFIredlPDGQEVTIYMSFNpPRNPYEW 186 Listeria monocytogenes
Q9A018   104 ATGQK--ILFRGL-DDELKITSITvdvgALCWAWFEEAYQIETEDkFSTVVESIRgsldAPDFFKQITVTFN-PWSERHW 179 Streptococcus pyoge...
P45916   160 TFKHFFkddrekrfvlDDKELYEkriivSNDTYYHHSTADDNL--FLPESYVQQLEELKE----YDPDLYRIARKGH 230 Bacillus subtilis subs...
Q65PP9   174 TYQTWF----------DPSADYD-----RSRVAIHQSTYKDNR--FLDEDNIRTIEELKN----TNPAYYKIYTLGE 229 Lactobacillus johnsonii
P39786   161 TYRHFFrderkkrfvlDDSELYEkrtivKGDTYYHHSTANDNL--FLPESYVKQLDGLKE----YDPDLYRIARKGR 231 Bacillus subtilis subs...
O50744   163 LYKRYLsn-------qDN-----------PAVCIIKSTYRDNP--FLNGGDVQAWLEKQRlayhGNDIGFRIEVLGE 219 Lyme disease spirochete
ACQ68288 144 VYKRFVk--------pYKAIIDKqgyyeDDDLYVGKVSYLDNP--WLPAELKNDAQKMKR----ENYKKWRHVYGGE 206 Candidatus Hamiltonell...
Q8Y4X9   187 VNEYV-----------DSKRSD-------DDYLIHHTTYLDDEkgFLSKQIIKKIEKYKK----NDLDYYRWMYLGE 241 Listeria monocytogenes
Q9A018   180 LKRVFF----------DEETKR-------ADTFSGTTTFRVNE--WLDDVDKRRYEDLYK----TNPRRARIVCDGE 233 Streptococcus pyogenes...
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