1L8D


Conserved Protein Domain Family
Rad50_zn_hook

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pfam04423: Rad50_zn_hook 
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Rad50 zinc hook motif
The Mre11 complex (Mre11 Rad50 Nbs1) is central to chromosomal maintenance and functions in homologous recombination, telomere maintenance and sister chromatid association. The Rad50 coiled-coil region contains a dimer interface at the apex of the coiled coils in which pairs of conserved Cys-X-X-Cys motifs form interlocking hooks that bind one Zn ion. This alignment includes the zinc hook motif and a short stretch of coiled-coil on either side.
Statistics
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PSSM-Id: 309531
View PSSM: pfam04423
Aligned: 53 rows
Threshold Bit Score: 37.5269
Threshold Setting Gi: 341882968
Created: 25-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
1L8D_A         29 LKNKIGDLKTAIEELKKAKGKCPVCGRELTD-EH-REELLSKYHLDLNNSK 77
gi 74690818   660 MHQTTLEFNRKALEVAINNDCCYLCSRSFEN-TEfRSKILKELKEKTDTKF 709
gi 403216237  659 MHQTTLEFNRKALDIAQNKDCCYLCSRKFENvEV-KSRLLAELKKKTDANF 708
gi 156848089  659 MHQTTLAFNKKALEIAENNNCCYLCSRAFDD-ESfKSSLLNQLKERTNDEF 708
gi 367012381  659 MHQTTVEFNKKALEVAEREDSCYLCSRKFET-EQfRSSLLAKLRVKVDSRF 708
gi 366999578  657 MHQTTLAFNRKALEVAENSNCCYLCSREFDS-TGlKSKLLNELKAKTNQQF 706
gi 254584660  658 IHQTTLEFNKKALEVAKTESCCYLCTRKFDD-EGfKSSILLRLQEKTDGKF 707
gi 444314453  660 MHQTTLAFNKKALEVAQNDDCCYLCSRKFED-ATfRSKILDELILKTDAKF 709
gi 410079156  657 MHQTTLDFNRKALEVAEYDNSCYLCLRSFDT-VEfKNEILQNLKAKTEAKF 706
gi 151944297  666 MHQTTLEFNRKALEIAERDSCCYLCSRKFEN-ESfKSKLLQELKTKTDANF 715
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