1L8D


Conserved Protein Domain Family
Rad50_zn_hook

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pfam04423: Rad50_zn_hook 
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Rad50 zinc hook motif
The Mre11 complex (Mre11 Rad50 Nbs1) is central to chromosomal maintenance and functions in homologous recombination, telomere maintenance and sister chromatid association. The Rad50 coiled-coil region contains a dimer interface at the apex of the coiled coils in which pairs of conserved Cys-X-X-Cys motifs form interlocking hooks that bind one Zn ion. This alignment includes the zinc hook motif and a short stretch of coiled-coil on either side.
Statistics
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PSSM-Id: 309531
View PSSM: pfam04423
Aligned: 53 rows
Threshold Bit Score: 37.5269
Threshold Setting Gi: 341882968
Created: 25-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1L8D_A         29 LKNKIGDLKTAIEELKKAKGKCPVCGRELTD-EH-REELLSKYHLDLNNSK 77   Pyrococcus furiosus
Q6FNZ8        660 MHQTTLEFNRKALEVAINNDCCYLCSRSFEN-TEfRSKILKELKEKTDTKF 709  Candida glabrata
CCK70734      659 MHQTTLEFNRKALDIAQNKDCCYLCSRKFENvEV-KSRLLAELKKKTDANF 708  Kazachstania naganishii CBS 8797
XP_001646927  659 MHQTTLAFNKKALEIAENNNCCYLCSRAFDD-ESfKSSLLNQLKERTNDEF 708  Vanderwaltozyma polyspora DSM 70294
XP_003680691  659 MHQTTVEFNKKALEVAEREDSCYLCSRKFET-EQfRSSLLAKLRVKVDSRF 708  Torulaspora delbrueckii
XP_003684525  657 MHQTTLAFNRKALEVAENSNCCYLCSREFDS-TGlKSKLLNELKAKTNQQF 706  Tetrapisispora phaffii CBS 4417
XP_002497898  658 IHQTTLEFNKKALEVAKTESCCYLCTRKFDD-EGfKSSILLRLQEKTDGKF 707  Zygosaccharomyces rouxii CBS 732
XP_004177884  660 MHQTTLAFNKKALEVAQNDDCCYLCSRKFED-ATfRSKILDELILKTDAKF 709  Tetrapisispora blattae CBS 6284
XP_003957159  657 MHQTTLDFNRKALEVAEYDNSCYLCLRSFDT-VEfKNEILQNLKAKTEAKF 706  Kazachstania africana CBS 2517
EDN62575      666 MHQTTLEFNRKALEIAERDSCCYLCSRKFEN-ESfKSKLLQELKTKTDANF 715  Saccharomyces cerevisiae YJM789
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