Conserved Protein Domain Family
Gar1

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pfam04410: Gar1 
Gar1/Naf1 RNA binding region
Gar1 is a small nucleolar RNP that is required for pre-mRNA processing and pseudouridylation. It is co-immunoprecipitated with the H/ACA families of snoRNAs. This family represents the conserved central region of Gar1. This region is necessary and sufficient for normal cell growth, and specifically binds two snoRNAs snR10 and snR30. This region is also necessary for nucleolar targeting, and it is thought that the protein is co-transported to the nucleolus as part of a nucleoprotein complex. In humans, Gar1 is also component of telomerase in vivo. Naf1 is an essential protein that plays a role in ribosome biogenesis, modification of spliceosomal small nuclear RNAs and telomere synthesis, and is homologous to Gar1.
Statistics
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PSSM-Id: 335776
View PSSM: pfam04410
Aligned: 232 rows
Threshold Bit Score: 84.5827
Threshold Setting Gi: 122058432
Created: 26-Mar-2017
Updated: 23-May-2017
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74685265  296 KkyaeAgtEQVTSVTGGPTKKISKAEPTFTSagTVVVRAMqsRPgDFddgwLEEGSILCW-E-DGR-VLGTVYETFGPLT 372
gi 124461673  49 PeskeQreFNFNYKNSDRIQLIGKIESLTKE--NIIIYSN------LlefvINLDQLIVN-G-QQE-ILGKVDDVFGKVE 117
gi 121967660 152 SdmerLvrFGVQFKGNEVLVELGQIMTIVDD--KIIIATNneMReAEkriiVDLDNIIFN-E-QKN-IIGNVDDVFGNIK 226
gi 196012616 283 EnlpeVeeIDFKLDESIAMQNIGSISSVIDT--LVIVKANal--aPA----LDIDSLLFL-E-NRL-CIGKIFETFGPVN 351
gi 307182661  35 DdlppIedLKINV-PEVLCELLGEVDKIVEQ--LVIVKPKsn--kPA----LHIETVLFM-EkGGR-ALGKILDVFGPVS 103
gi 332028093 321 EdlppIedLKISV-PEVLCNPLGKIEKIVEQ--LVIVKPNpgEVt------LNLDTVLFV-N-KGTkALGKIFDVFGSVN 389
gi 541040922 128 DgmpqLerLTIHVEQDVPLKPLGSVVSVVDC--LVVVQANsnIA-------LDFDTVLFD-H-RRN-AIGKVYDILGAVS 195
gi 312070532 138 DtmpaIeeLRIHVEEDIILKQFGKIMNIVDR--LVVIEADsnTA-------LDFETVIFD-A-ERN-AVGRVFDIFGPVV 205
gi 341881893 149 DdlppLenLTIECNSN--LLEFGFVSKVIDC--QVIIVSTc---tEV----LDFDSYLFD-E-KGN-SIGQVYDIFGQVK 214
gi 307205599  14 nglppVedLKISVSEV-TCDLFGEIIGIVEE--LVIIKPRae--kPA----LREETVLFIeQ-GQK-TLGKIFDIFGPVK 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74685265  373 SPFYTVRLPpppfpypTPGSL----ATGTRLFYPFN-PSYRSFvnmiavr-----------------dprykgTDASniy 430
gi 124461673 118 RPHYSILLDgy----vNNLVQtnqlKIGDDVFINIDstsvlnp-----------------------dainkkgCDASnqf 170
gi 121967660 227 NPFYCVIIDky----tEEMIAqkrlQVGQKVYMIEG---YNKLlmkaqle----------------fllrqkgCDASnrf 283
gi 196012616 352 SPYYSLRFNs-----kSAIERmd-lIPSIVVYSAPEvKDFTGYvlieql-------------------rrvkgSDASwkn 406
gi 307182661 104 EPNYCIRFNs-----sEHIQEnn-iKVGMPVYYCPN-TQYTSLiflhel-------------------hklnsHDAmdd- 156
gi 332028093 390 EPYYCVRFNn-----aKHIQDnd-vKVGMQVYYCPN-SEYTSLvflhel-------------------tklkaCDAigd- 442
gi 541040922 196 APLYAIRFNt-----pHE--Ans-hEVGMEIFYAPTvEEFTRHvfteql-------------------rkeriTDPCwdg 248
gi 312070532 206 KPMYAILFNd-----iKEASEw---KVGTAMYYAPA---ASQFthtvlte----------------klrhekaTDGCwdg 258
gi 341881893 215 TPQYVVRFNs-----sEEASMm---PINMKIYYAPT---DEKFsktpfkglnlaaanremirvlnrkldhkaaVERVaer 283
gi 307205599  83 EPHYTIRFNn-----vEHIQErq-iTVGTPVYYCPD-SCYTFFvflsel-------------------tkikgSDANcdg 136
                        170       180       190
                 ....*....|....*....|....*....|.
gi 74685265  431 --deeVPEE-EMEWSDDEAEAAAKRErKQKK 458
gi 124461673 171 --deeVLNDcDVEYSDDEIEAVSKKRgNKEe 199
gi 121967660 284 --deeVLNDnEIEYSDDEMESKAKTKrNNKe 312
gi 196012616 407 --diePPPD-HIEYSDDEKERQEKARlRNng 434
gi 307182661 157 ---deLP-----EFSDDEEERAYYEMlKQKn 179
gi 332028093 443 ---dePP-----EFSDDEKEQAYYENlKQKG 465
gi 541040922 249 --egeCPED-ELVFSDDEAEKRYKAKhRCKK 276
gi 312070532 259 --dgeCPDD-MLAFSDDEAEQRYKAKhRsvk 286
gi 341881893 284 nqiaeIDSD--VEFSDDEAEKQYRKSkQNAq 312
gi 307205599 137 gsdgdHP-----DFSDDEEEKRYYEKlNrqr 162
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