Conserved Protein Domain Family
DUF445

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pfam04286: DUF445 
Protein of unknown function (DUF445)
Predicted to be a membrane protein.
Statistics
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PSSM-Id: 309427
View PSSM: pfam04286
Aligned: 79 rows
Threshold Bit Score: 141.982
Threshold Setting Gi: 81766417
Created: 19-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81738481   59 AEAATIGGLADWYAVVALFKrP-----LG-LPIP-HTAIIQSNQARIADKLGEFIQVHFLEAGP---VEAKLNEIDFGSF 128
gi 264664545  16 VIGALIGAVTNHLAIRMLFR-PleakyIGkYRIPfTPGLIPKRRDELAANLGRTVVKHLLTPEG---ISKRLQQPIVYQA 91
gi 81366460   12 VVGAIVGAATNALAIRMLFR-PhraysIGkWQLPfTPGLLPRRQKELAVQLGNIVANHLLTAEG---LGKKFGSTAFAAE 87
gi 81766417    9 LIGAVIGYITNWLAIKMLFR-PreakyIFgMKLPfTPGLIPKEKSRIANKVGETVGTHLLNSDS---LSKALKDDKIKSK 84
gi 81711186   30 IVGALIGFTSDTLAIKMLFR-PykpkyFLgRQIPlTPGLFPKGQERFARKVAQMLTDKLLTPDEvhrIAQRLLTPERLEE 108
gi 123557000  14 VVGGIIGYFTNDLAIRMLFR-PyrpvvIGgWQLPfTPGLIPANQGRLARRIADAILGSLLTPDAlhdLARRLLELPRLEA 92
gi 123500634  11 LAGLVIGYFTNDIAIKMLFR-PyrpyrVFgWRIPfTPGLIPQNQPRLAKQIAKTIMGSLLTPEElhnLARKLLQTERMQA 89
gi 122964533  12 IAGGIIGYFTNDIAIKMLFR-PyrpyyIFrRKLPfTPGLIPANQERLAKRVADTIMGSLLTPSElqnLARRLLQTERMEA 90
gi 81769363   21 ILGGIIGYFTNDIAIKMLFR-PyraiyIGgRRVPfTPGLIPRNQERLAKNISDTIMGSLLTPDElqkLARRLLKTERVQG 99
gi 81672056   21 IAGGIIGYFTNDLAIKMLFR-PykplfLGpYQLPfTPGLIPRNQERLAKRVSDTIMGSLLTPEElqrLARKLLQRERVEG 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81738481  129 VADWLR----------DRKRSEDL------------------------ARFALRLLPEAFSATETSGLMTFIIRRMS--- 171
gi 264664545  92 ITRMIQqevqk-wtrsTKTIREIAer---------------------fVANPEGKLQQQIEQRIDQELESMAVAIKT--- 146
gi 81366460   88 LTNWLKkqlas-wlrsERTVESILkpl-------------------fqADIGREHLVVQSKSWLKDRLKRYLQKNKE--- 144
gi 81766417   85 FNEVAKekinq-vinsNSTLEESLkntlgenyyalkgnminniaktilESIQEEEFKNKLKFYIVDSIKERLNKNPKkii 163
gi 81711186  109 GLRFALlyalgeysdgRKRARLA------------------------------VALGDILQEVFSESLPKWIDALSRs-- 156
gi 123557000  93 AIAWLVsllle-rlreVRDPRSI------------------------------EVAADVLRDLAGSALPRWLRAIVRq-- 139
gi 123500634  90 GIRWLLgvaldrlqnpEQQQQTA------------------------------QVLARILADLFNESLPRLVKVLARq-- 137
gi 122964533  91 AILWLLqmsld-qlklNTDTKST------------------------------KILANILRDLLGQSLPRLLKVWAKr-- 137
gi 81769363  100 AILWLLqlaid-qiktDTDKKSA------------------------------KIVAGILRDLIGESLPRLLKVLARr-- 146
gi 81672056  100 ALGWLLqlalk-qireDKQQKTA------------------------------QILANILRDLFSESLPRLLKALARq-- 146
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81738481  172 ----------------------------------------SQLQAIDLAPLAAGTlrgfvaEGRHQILFDDLL------R 205
gi 264664545 147 ----------------------------------------ARLTEVLGEGGTTKI------KTAIPGMVEVLL------H 174
gi 81366460  145 ----------------------------------------VPIKSVVPQELQDRL------TDWLPEASALLL------K 172
gi 81766417  164 dfinsnkfreviintleeektrdiigkallkevktlekedLTIEEVIPENIKPYI------EEYVKSQKDTLV------D 231
gi 81711186  157 ----------------------------------------SASNKIFEQIFDQVAgslrieEAQAVRLAEWIEknvftpD 196
gi 123557000 140 ---------------------------------------rQGLDAQIDRWFEQQLlsqklgPLQAQQLGDWLLegafppD 180
gi 123500634 138 ---------------------------------------eTFLEGPINQLFDQVLlelrlsSEQAKQLSEWILkqalppK 178
gi 122964533 138 ---------------------------------------eYFLEAQINQIFDQILlefqltEIQAAQLSDWLLkvvvppD 178
gi 81769363  147 ---------------------------------------eDFLEAQINQIFDQILlelqlsEEQASRLADWFLevvlppD 187
gi 81672056  147 ---------------------------------------dNFLSDQINRIFDQILlefrlsELQSRQFADWLLgtvlppD 187
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81738481  206 VMHDTLNQKETMAMIREKVRAELPTLlrl---yraDKFLVNKIVASaTAFFNEVRSDPKHPFRGEFDRMvltFVDRLGTd 282
gi 264664545 175 QTEQYFDSPAGKMKLEETVAQFIQSKl--------gGGMFGMLLAN-VNIVEMIQPELKRVIQGKSTHQ---FISEMVE- 241
gi 81366460  173 RATAYIDSEEGEQRIGAMVRQFLTTKg-------kVGSMVSMFFSA-DKLTEYVLPEIKKFLHDEQTKE---TVQSLLQ- 240
gi 81766417  232 IIKNLLRDDEVSYKIKSAINDN-------------IPSIVSMFLSG-DVIYGKLVSLVDKSLSEEENKE---YICDAAL- 293
gi 81711186  197 RLRLALINLLTNQTIDTLDKEARERAqgglwlvanVVGIKGPLSRFkSFCVEQPEAANELFTRFLAEAEvreRLTGALNg 276
gi 123557000 181 QIRRVMLDFLTDDNIRNLDRIVRDRTrgtdwvianLFGVQSSLQRLrQFLREQPEAGDAVIAELSQRLAlrqQLSQALQt 260
gi 123500634 179 VLRQNLVDFLTDRNIESLDEEFRERAtgsywvvanLFGLKNALLRLrTYCLEEPEGAEAILEDLLKDINasrRLTEILQn 258
gi 122964533 179 VLRKTLIDFLTDQNISIIDEGFREKAsgtywvvanLFGLRNTLTRLrTFCLDERDLTNQRLMELITALAvkeRITEWLHs 258
gi 81769363  188 VIRQAIVDFLTDRTIQIIDESFREKTsgtywvvanLFGLRNTLTRLrTFCLDEKEATNNRLTELIQDLQmrdRFRKILQn 267
gi 81672056  188 TIRLALVDFLSDRNIQVIDEGFREKTsgtywvvanLFGVRNSLTRLrAFCLEEKETANLRLKELLLSLEirnRLKDWLQq 267
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81738481  283 qayiDRIDGLKRDLLARPELADLART---VWANTRSFIERSASG-Et------qVLQHHLVGMFVAAGE----------- 341
gi 264664545 242 ----QEVHTLLERTVGSLLEPEAERQ---IIERMKSEIVTRIPLaA--------LLDTPLHEFLEPLEV----------- 295
gi 81366460  241 ----TEWHRMLNRPLASFQAENYVDQ---FVDKAAEELEGKIPVlN--------WYNAPLSTWTTPYAE----------- 294
gi 81766417  294 ----AFVHESMKKKVSDVINNVGEEKlevISDALGDKISKKLNTeE--------NIDSIISKLNCKISSfnsyeeiikvl 361
gi 81711186  277 ----LSVQTLSMATVQDLKRQFVTSLtaaLSAQGPGLSQRLGESiDwsrwaaevLDRVVTSEKTLGWID----------- 341
gi 123557000 261 ----FQLTDLPQTTLTDLRLQLRQGLrqwLDQDGLSLLEGALGGlDwtaaaralLDRLRTAVISDEAIA----------- 325
gi 123500634 259 ----LSLQNLPVSAVRQLRRALRDGIqdyLRSQGPEVIKGLGETiDwekvaslvLGRLRNSKALITSID----------- 323
gi 122964533 259 ----LSMQNLPVSTVRELRNTMQNSVrlyLQENGTDLIQALSLSvAwehiadliINRLQASSIMNSSLE----------- 323
gi 81769363  268 ----LTLQNLPIGTVRQLRKTTRETVrqyVQTSGSDLLQGLTDSiNweniaellLNRLSNSPVVISSLE----------- 332
gi 81672056  268 ----LSLENLPVSTVRQLRRTTGEVVrtyIRERGEPLLKDFGSSvDwdnvavliVNRLQSSTAVTGSLG----------- 332
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81738481  342 ------------------------------ALAGD--AELRGEIN-----------------------KGLVTVLRSFVA 366
gi 264664545 296 ------------------------------RISQEmvPMLSKQMV-----------------------NRLIEQVEQIMA 322
gi 81366460  295 ------------------------------PLVERgvPVIVGMVT-----------------------VYMEQHIADILS 321
gi 81766417  362 fndyenilidnidsmisqivnnnqlsgeisKIIEKvfDKFLQNSLndicynkqnlensimsildnlynDFVENKSAKVLE 441
gi 81711186  342 ------------------------------RIAEGssRLLDRYLT-----------------------RELEPLVMKFLP 368
gi 123557000 326 ------------------------------AFSHEvaLILDQRLE-----------------------HELEDLVAAALP 352
gi 123500634 324 ------------------------------QISADlaLVLERYLE-----------------------RDLESLMMQVIP 350
gi 122964533 324 ------------------------------LVSRElaLILERYLE-----------------------RDLENIVALAIP 350
gi 81769363  333 ------------------------------VVSQElaLILERYLE-----------------------KDLEAIVAQVIP 359
gi 81672056  333 ------------------------------LVSEElaSILERYLE-----------------------DDLEKIVKQIIP 359
                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 81738481  367 DqkSGVSTFISDQVKAWDMAQLISLIEINIGRDLQYIRFNGSLIGGLAGla-lySVEFLL 425
gi 264664545 323 T--LDLETIVREEVDLLDTAYLEEIVLSISRREFRAITWLGGLLGGLIGmi-qaIL-LIV 378
gi 81366460  322 K--LRLEEVIEEQVASFSMAHLEKLIMNITRRELHMITLLGGLIGGIVGli-qaVIVHFF 378
gi 81766417  442 I--VDISSIVEEQINAFEVDYAEEIIIGIANKELKAITWLGALLGGILGil-spLLSTIY 498
gi 81711186  369 A--LGLEQMVITKICNTSPQELEAAIEQVARNELRAIPYVGMVLGFCVGlfevfLITVVI 426
gi 123557000 353 I--LALEDLIIGRVEATPAADLEAAIQGIVRSELQAIVNIGGVLGVLLGcv-qsLINVWS 409
gi 123500634 351 V--LNLDQVIADKVNATSPADLEQAIQQIVRQELQAIVNLGGLLGFLVGcv---qVLFLL 405
gi 122964533 351 I--LNIDQVIIDRIKGTSAEELEVAVNVIVKNELQAIVNLGGVLGVVVGsf-qtILLVLQ 407
gi 81769363  360 I--LSIDQVIVDRVKSTSPADLEAAIEGIVKNELQAIVSLGGILGLIVGlf-qtAFFIFS 416
gi 81672056  360 I--LAIDQVIINRINETPAAELETAVQAIVRSELQAIVNLGGVLGLIIGgl-qtGFFLVS 416
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