2ZME,2ZME,1U5T,1W7P


Conserved Protein Domain Family
EAP30

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pfam04157: EAP30 
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EAP30/Vps36 family
This family includes EAP30 as well as the Vps36 protein. Vps36 is involved in Golgi to endosome trafficking. EAP30 is a subunit of the ELL complex. The ELL is an 80-kDa RNA polymerase II transcription factor. ELL interacts with three other proteins to form the complex known as ELL complex. The ELL complex is capable of increasing that catalytic rate of transcription elongation, but is unable to repress initiation of transcription by RNA polymerase II as is the case of ELL. EAP30 is thought to lead to the derepression of ELL's transcriptional inhibitory activity.
Statistics
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PSSM-Id: 335641
View PSSM: pfam04157
Aligned: 236 rows
Threshold Bit Score: 86.497
Threshold Setting Gi: 676378643
Created: 24-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2ZME_A         6 VGAGAIaKKKLAEaKykeRGTVLAEDQLA--QMSKQLDMFKtNLEEFASKHKQ-E-IRK--N------------PEFRVQ 67  human
Q387W7       170 AGIAGLmRASAEKtA---QG-----ETLR--DIDDVMRNAS-SLVASIRNLQQ-K-QQN--I------------AGttka 222 Trypanosoma brucei
AJV77223     323 IGISSLeKSRENQlL---NNDILFNNALT--DLNKLMSLAT-SIERLYKNSNI-T-MKN--KtlnlqdestvnePKTRR- 391 Saccharomyces c...
XP_004181665 306 TGISTLeQSRETQlA---RNDILLNNALS--DLSNLMSFAD-DIEKLYSRYNKnD-ISS--S------------KMNSKQ 364 Tetrapisispora ...
GAV47558     335 IGITSLeKSGETQlL---NNDIIFNNALT--DLNRLMSLAN-DIEQLYTGISP-KlLGE--R------------KEGGHK 393 Zygosaccharomyc...
XP_003678488 305 IGITSLeRSRENQlL---NNDILFNNALS--DLNSLISLAN-NIERLYRSTKN-----S--Q------------QQTNSS 359 Naumovozyma cas...
XP_001009663 140 nmytgikdmqkkeeqkqqeqqkIVQSSFQkgDISSLFQNAR-ELKEISQYLKG-N-LSKvdK------------QHEQSD 204 Tetrahymena the...
XP_653571      7 YGIKSYiEAKEKDqN---DIDNLFSNAFE--SLDTVIQYWD-QLDKVATKFLK-E-SNM--E------------KENHEY 64  Entamoeba histo...
XP_001465035 163 FGIAGVqQASAQSaA--------MSETLK--DIDDVMNKAS-KLVNDIRRLRE-R-SEA--A------------AAAGSD 215 Leishmania infa...
XP_013934284 312 AGIHGLeTLTSLKnS---EVSTFLNSSLG--DLQNLMDKSK-DLAKIGDDYRR-M-LMS--S------------KTVDKE 369 Ogataea parapol...
2ZME_A        68 FQD-----------MC--ATIG--V-DPL------------ASGkGFWs----------eMLG------VGDFYYELGVQ 103 human
Q387W7       223 ed------nmtiesIE--ATLG--LgATVrasgagwglvsaHAG----------------------------FHKELAWE 264 Trypanosoma brucei
AJV77223     392 ---------------------------PL------------LTLdREK------------FLN------KELFLDEIARE 414 Saccharomyces c...
XP_004181665 365 V-----------------PSLI--V-D--------------------Rd----------kFYN------KNIFIEEIARE 388 Tetrapisispora ...
GAV47558     394 ------------------PSLI--L-D--------------------Re----------kFYN------KSLFLDEIARE 416 Zygosaccharomyc...
XP_003678488 360 SHR-----------IAkkPALI--I-D--------------------Re----------kFYN------KELFLDEIARE 389 Naumovozyma cas...
XP_001009663 205 LDK-----------IL--SDLG--Y-FNV------------ITKeEAG----------------------NSYLDQLSHQ 234 Tetrahymena the...
XP_653571     65 QS------------LI--TYLD--ItEPV------------TKKlfg-----------------------nnYEEALMDE 93  Entamoeba histo...
XP_001465035 216 AGsetaverttiesIE--STLG--LgAIV------------TRNhsng--------------------sdsrFHRDLAVE 259 Leishmania infa...
XP_013934284 370 VGHavell-srsrnSL--KLLGnlLddr--------------etiNEAndfytveslnllKQAggtqagSSLYVEELSRQ 432 Ogataea parapol...
2ZME_A       104 IIEVCL----AL-----KHRN---------G------G--LITLEELHQQVLK-G-RGkFaQDVSQDDLIRAIKKL---- 151 human
Q387W7       265 IHSWIT----HEkn--hHVFG---------Sm-----P--LIPLIELFSLYNK-A-Rge-cdLVSTNDVLHACRALd--- 316 Trypanosoma brucei
AJV77223     415 IYEFTL----SEfkdlnSDTN---------Y------M--IITLVDLYAMYNKsM-RIgT-GLISPMEMREACERFe--- 468 Saccharomyces c...
XP_004181665 389 IYEFATsefkDE-----QQRE---------Gc-----V--MISLVDLYAMYNK-AmRIgV-GFVSPLEMREACESFe--- 442 Tetrapisispora ...
GAV47558     417 IYEFAI----SEfk--aEKER---------L------GyvMVTLVDLYAMYNKcM-RIgT-GLISPQEMREACERFe--- 470 Zygosaccharomyc...
XP_003678488 390 IYDFAM----SE-----FNETttttqneniH------I--MVTLVDFYAIYNKsM-RIgT-GLISPLEMKEACQRFe--- 447 Naumovozyma cas...
XP_001009663 235 IYSICN----EL-----FPKL---------G------G--IITLLDVFYFVNK-K-RQ-T-CLLNPQEVLDACSKFq--- 281 Tetrahymena the...
XP_653571     94 IDEFCY--------------L---------YfqkkkeM--AIMLSDLYAIYNR-A-Rg---iLISPKELRNVCELLn--- 140 Entamoeba histo...
XP_001465035 260 MHTWMT----HEsn--sKLFN---------Dm-----P--VVPLIELFALYNK-A-RGg--dLVSPLDVLHACTYMaa-- 311 Leishmania infa...
XP_013934284 433 VYDFII----QEni--lRDKN----------------G--LVTALDLYCLFN--K-RKgf-ySVSPHNFLLATVSLkryn 484 Ogataea parapol...
2ZME_A       152 --KALGtgfg-------iipVGgtylIQSV-PAELNMD--H----TVVL--QL---------Aek--------------- 189 human
Q387W7       317 -qQEYAqytl------krlsSG----RYAL-QRKDPS--------IVLK--KLehilgprlcNekesgkfttsadsspih 374 Trypanosoma brucei
AJV77223     469 --H-LGlnelk----lvkvnKR----ILCV-TSEKFDVvkE----KLVD--LI---------Gdn--------------- 506 Saccharomyces c...
XP_004181665 443 --R-LGltklk----ltkinQR----ILCL--GSDNAL--E----IIKT--KI---------Vqiie------------- 479 Tetrapisispora ...
GAV47558     471 -eLGLKnlkl-------tkiNGr---VLCL-ASKNSFD--F----VKTKilDI---------Vne--------------- 508 Zygosaccharomyc...
XP_003678488 448 --K-LGlnnlk----ltrinNR----VLCL-STKDSFN--F----VKSQ--IL---------Stid-------------- 484 Naumovozyma cas...
XP_001009663 282 -aLGLNaiv--------teyGN----VKVVeQTTFDTE--K----DFQE--NI---------Gkyit------------- 318 Tetrahymena the...
XP_653571    141 --DKGKyvgl-------mnvNK----SLII-HERDFTL--E----KFQN--TIldalk---------------------- 176 Entamoeba histo...
XP_001465035 312 -kMSGScydl------vtlpSG----RKAL-VNRDDS--------LLLA--KLttvlgpqlvNakgssvqdawkktsshr 369 Leishmania infa...
XP_013934284 485 pdLQLIelqlqslqkvegktAGettek-arslYAICSS--TmnakSISR--SIlevlesgvsGgy--------------- 544 Ogataea parapol...
2ZME_A       190 --------------------------ngY----VTVSEI----------------KASL---K------WETERARQVLE 214 human
Q387W7       375 ngrd---ggvtqpvtqtavfpesssmlkG----VNEVTFas----------------vL---H------VTCSVSMDLLE 422 Trypanosoma brucei
AJV77223     507 --------------------------pgSdllrLT-QIL----------------SSNNsksN------WTLGILMEVLQ 537 Saccharomyces c...
XP_004181665 480 -------------------------qfpG----SHLLQI----------------SKKL---NeysqsdWTIGVITEVLQ 511 Tetrapisispora ...
GAV47558     509 --------------------------saG----CDPLLL----------------TQLL---NrdssnaWTFAIITEVLQ 539 Zygosaccharomyc...
XP_003678488 485 -------------------------qnpG----SDLLNLtnlintpstktannnkMETN---N------WTIGVIMEILQ 526 Naumovozyma cas...
XP_001009663 319 -------------------------hsvG----ITAEQL----------------GRKL---N------ISPVICRIKLN 344 Tetrahymena the...
XP_653571    177 -----------------------------srqkISSFTIaq----------------hY---G------IQYAIVQTLMD 202 Entamoeba histo...
XP_001465035 370 qqqrsgdasslvrvpttsdfpkasrdlkS----VSDVSLae----------------kM---Q------VATEVAADILT 420 Leishmania infa...
XP_013934284 545 ---------------------------sA----LEFQNMcs--------------------iQ------TNLLLLQSVLN 567 Ogataea parapol...
2ZME_A       215 HLLKEGLAWLD 225 human
Q387W7       423 ELELQGYLCRS 433 Trypanosoma brucei
AJV77223     538 NCVDEGDLLID 548 Saccharomyces cerevisiae YJM451
XP_004181665 512 NCIDSGILVVD 522 Tetrapisispora blattae CBS 6284
GAV47558     540 NCIDHGDIVID 550 Zygosaccharomyces rouxii
XP_003678488 527 NCVDEGDLLID 537 Naumovozyma castellii CBS 4309
XP_001009663 345 KALKTGKLVID 355 Tetrahymena thermophila SB210
XP_653571    203 QLEQNELICRD 213 Entamoeba histolytica HM-1:IMSS
XP_001465035 421 LLMQKGYLCCV 431 Leishmania infantum JPCM5
XP_013934284 568 VLTRDGVLCVD 578 Ogataea parapolymorpha DL-1
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