Conserved Protein Domain Family
IncA

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pfam04156: IncA (this model, PSSM-Id:309330 is obsolete)
IncA protein
Chlamydia trachomatis is an obligate intracellular bacterium that develops within a parasitophorous vacuole termed an inclusion. The inclusion is non-fusogenic with lysosomes but intercepts lipids from a host cell exocytic pathway. Initiation of chlamydial development is concurrent with modification of the inclusion membrane by a set of C. trachomatis-encoded proteins collectively designated Incs. One of these Incs, IncA, is functionally associated with the homotypic fusion of inclusions. This family probably includes members of the wider Inc family rather than just IncA. Members are usually either 2 or 4TM proteins.
Statistics
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PSSM-Id: 309330
View PSSM: pfam04156
Aligned: 51 rows
Threshold Bit Score: 41.3015
Threshold Setting Gi: 81554598
Created: 26-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q822I0  49 ILSSKVTYVAAVILALLgIIACAIGT-IFFPAYAnFIVIGGAILSVIAIALVSALLAHGKKEVgaLHAELQTSDAKIdql 127 Chlamydia caviae
O84290  32 AKAMRITGIALAALSLLaVVACVIAVs--------AGGAAIPLAVISGIAVMSGLLSAATIICsaKKALAQRKQKQLee- 102 Chlamydia trachomatis...
Q255P9  24 PRACLVVNVFSLFLSLL-IVVTGITA-LAFFSVE-LGMLHSVILSLCILAALFSLAISTYSIAhrRTSSCMSVLQKQelq 100 Chlamydia felis Fe/C-56
Q821Y6  25 SKVCLVINVFSIVLSLL-ILVTGITT-LIFFSVG-LGMMHSAILGMCVLAAVFFLVMNAYYLAnrKHTVGMSALQNQris 101 Chlamydia caviae
Q821Z1  39 PHSVLISSVVATILGLA-VLAASIAL-LVLFGAQ-GSAVFHGIIVGVILAALLLFFIGGIHSAivFKLVRSRQV------ 109 Chlamydia caviae
Q255P6  25 PYLVLITSVITTILGLA-VIAASIAL-LVLFGAQ-ASAVFNGLMVGVILGIALLLLIGGIRSAliLNLTCVRKK------ 95  Chlamydia felis Fe/C-56
Q5L584  25 PHVVLITSIIAGILGLV-VIAAGIAL-LVISPAQ-SSAIFNGILISVVVGVALMLCIGGRLSCmiLQLAHLHSS------ 95  Chlamydia abortus
Q255Q1  25 SRVRLVATIVSVMVSLL-MLSGAITL-AILFGAQ-LGILYSTVIIGLSVVIGILLITASLKCFtcLALVPQSPRISGqal 101 Chlamydia felis Fe/C-56
Q5L580  25 SRVHFLTTIVSLIASLL-IITGAIAA-VILFGTQ-LGVLYSTVIIGVSVAIGVLLFSASLQCFscPAVVSQSQRFSEdnp 101 Chlamydia abortus
Q9F7L2  23 VPQPSLMDKIKKIAAIAsLILIGTTGfLALLGHL-VGFLIAPQITIVLLALFIISLAGNALYLqkTANLHLYQDLQRev- 100 Chlamydia trachomatis
Q822I0 128 ldqynelvdeynqdsvddeqsiekltadyntlaqqyndllqqysdlqeDKSWSESEIADADaQKISQ--LEQQNADLVIQ 205 Chlamydia caviae
O84290 103 ----------------------------------------------slPLDNATEHVSYLT-SDTSYfnQWESLGALNKQ 135 Chlamydia trachomatis...
Q255P9 101 qemsrpps-----------------------------lshtrtdeiseDQNFENQKIQEME-RENQR--MSSRILELESQ 148 Chlamydia felis Fe/C-56
Q821Y6 102 qdstrsslqgap----------------------tslgtsqvfseiqgELSSKNQQIQEMQ-AERER--MSARILELEAR 156 Chlamydia caviae
Q821Z1 110 ------------------------------------------------ESSIFENTELNLQ-RQLQD--LQSRLSKKESD 138 Chlamydia caviae
Q255P6  96 ------------------------------------------------EISGFSKTLKEFQ-DLLQD--RQKHISEQENF 124 Chlamydia felis Fe/C-56
Q5L584  96 ------------------------------------------------EVSGSESIMQKLQ-TYPQD--EENRVSEEDDL 124 Chlamydia abortus
Q255Q1 102 r--------------------------------------------gcgEDMEAQHISVGAL-EDFDT--IETALSSELLE 134 Chlamydia felis Fe/C-56
Q5L580 102 r--------------------------------------------shiHDSKLSEATTLTE-ESVEA--IERELHTLLSE 134 Chlamydia abortus
Q9F7L2 101 -----------------------------------------------gSLKEINFMLSVLQ-KKFLH--LSKEFATTSKA 130 Chlamydia trachomatis
Q822I0 206 NNLLQEENTSLQnncgtlfHEKTEEESRNLELSDNCKKLQKELAELRaalekkkseisdhklqcdmqt-----seishlk 280 Chlamydia caviae
O84290 136 LSQIDLTIQAPEk-----kLLKEVLGSRYDSINHSIEEISDRFTKMLsllrlrehfyrgee------------------- 191 Chlamydia trachomatis...
Q255P9 149 VLSQKEDQGRIR-------GFERIDPSSELNVNKERCAFESRIRDLEealakseslsqer-------------------- 201 Chlamydia felis Fe/C-56
Q821Y6 157 ALRCQEDQGRIC-------GFEEQENSSLITLNNERRTFESRIHDLEqalsdaesqsqshtsvlest--------lktlq 221 Chlamydia caviae
Q821Z1 139 ICNLRAQLDKETvk---vqKVLKLKQEELDSLIRRYAAMAQESSDLAalvlhlrtesadl-------------------- 195 Chlamydia caviae
Q255P6 125 IASLQNQLDEESnk---ynKLLTTKQEELTSLTRRYIATTSESSNLEetvnnlrse------------------------ 177 Chlamydia felis Fe/C-56
Q5L584 125 PPSQQNEEMEDVlh---mqTLLKSKQDELDSLTHRYAAMAQERSDLEnmvtrlreelvelrhvle------------enq 189 Chlamydia abortus
Q255Q1 135 YSQKDPAYQDLE-------DKLARVKENLAAAKIAFAIAAEECRRLEnlckdveada----------------------- 184 Chlamydia felis Fe/C-56
Q5L580 135 YEQERLAYECCI-------SQRNLVKISMDSAKEEFDNAYADVQRLHrlftaedsnnlsnecqeslsryreksidyarsi 207 Chlamydia abortus
Q9F7L2 131 SLLYLKIFILVC-------KDLEITIKVLNLFWMSIKTLQKK-------------------------------------- 165 Chlamydia trachomatis
Q822I0 281 tdlthlqqkmadhqRASQK------T 300 Chlamydia caviae
O84290 192 ryapylsppllnknRLLTQ------I 211 Chlamydia trachomatis D/UW-3/CX
Q255P9 202 --ssaaetrlgelqTERSQ------F 219 Chlamydia felis Fe/C-56
Q821Y6 222 eerlqlqnriaeleTTVAT------H 241 Chlamydia caviae
Q821Z1 196 --krvlekntitsnAIIEK------L 213 Chlamydia caviae
Q255P6 178 -----lmelrssssELIDK------L 192 Chlamydia felis Fe/C-56
Q5L584 190 atshrvieklqasnELLNQesiiarQ 215 Chlamydia abortus
Q255Q1 185 ----sinsqyressLALWRa----cL 202 Chlamydia felis Fe/C-56
Q5L580 208 qryedlfqqmhshqDLMHF------Q 227 Chlamydia abortus
Q9F7L2 166 -------------------------C 166 Chlamydia trachomatis
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