Conserved Protein Domain Family
IncA

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pfam04156: IncA 
IncA protein
Chlamydia trachomatis is an obligate intracellular bacterium that develops within a parasitophorous vacuole termed an inclusion. The inclusion is non-fusogenic with lysosomes but intercepts lipids from a host cell exocytic pathway. Initiation of chlamydial development is concurrent with modification of the inclusion membrane by a set of C. trachomatis-encoded proteins collectively designated Incs. One of these Incs, IncA, is functionally associated with the homotypic fusion of inclusions. This family probably includes members of the wider Inc family rather than just IncA. Members are usually either 2 or 4TM proteins.
Statistics
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PSSM-Id: 309330
View PSSM: pfam04156
Aligned: 51 rows
Threshold Bit Score: 41.3015
Threshold Setting Gi: 81554598
Created: 26-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75539525   49 ILSSKVTYVAAVILALLgIIACAIGT-IFFPAYAnFIVIGGAILSVIAIALVSALLAHGKKEVgaLHAELQTSDAKIdql 127
gi 14195328   32 AKAMRITGIALAALSLLaVVACVIAVs--------AGGAAIPLAVISGIAVMSGLLSAATIICsaKKALAQRKQKQLee- 102
gi 123483738  24 PRACLVVNVFSLFLSLL-IVVTGITA-LAFFSVE-LGMLHSVILSLCILAALFSLAISTYSIAhrRTSSCMSVLQKQelq 100
gi 75539468   25 SKVCLVINVFSIVLSLL-ILVTGITT-LIFFSVG-LGMMHSAILGMCVLAAVFFLVMNAYYLAnrKHTVGMSALQNQris 101
gi 75539473   39 PHSVLISSVVATILGLA-VLAASIAL-LVLFGAQ-GSAVFHGIIVGVILAALLLFFIGGIHSAivFKLVRSRQV------ 109
gi 123483731  25 PYLVLITSVITTILGLA-VIAASIAL-LVLFGAQ-ASAVFNGLMVGVILGIALLLLIGGIRSAliLNLTCVRKK------ 95
gi 81312477   25 PHVVLITSIIAGILGLV-VIAAGIAL-LVISPAQ-SSAIFNGILISVVVGVALMLCIGGRLSCmiLQLAHLHSS------ 95
gi 123483740  25 SRVRLVATIVSVMVSLL-MLSGAITL-AILFGAQ-LGILYSTVIIGLSVVIGILLITASLKCFtcLALVPQSPRISGqal 101
gi 81312473   25 SRVHFLTTIVSLIASLL-IITGAIAA-VILFGTQ-LGVLYSTVIIGVSVAIGVLLFSASLQCFscPAVVSQSQRFSEdnp 101
gi 75413506   23 VPQPSLMDKIKKIAAIAsLILIGTTGfLALLGHL-VGFLIAPQITIVLLALFIISLAGNALYLqkTANLHLYQDLQRev- 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75539525  128 ldqynelvdeynqdsvddeqsiekltadyntlaqqyndllqqysdlqeDKSWSESEIADADaQKISQ--LEQQNADLVIQ 205
gi 14195328  103 ----------------------------------------------slPLDNATEHVSYLT-SDTSYfnQWESLGALNKQ 135
gi 123483738 101 qemsrpps-----------------------------lshtrtdeiseDQNFENQKIQEME-RENQR--MSSRILELESQ 148
gi 75539468  102 qdstrsslqgap----------------------tslgtsqvfseiqgELSSKNQQIQEMQ-AERER--MSARILELEAR 156
gi 75539473  110 ------------------------------------------------ESSIFENTELNLQ-RQLQD--LQSRLSKKESD 138
gi 123483731  96 ------------------------------------------------EISGFSKTLKEFQ-DLLQD--RQKHISEQENF 124
gi 81312477   96 ------------------------------------------------EVSGSESIMQKLQ-TYPQD--EENRVSEEDDL 124
gi 123483740 102 r--------------------------------------------gcgEDMEAQHISVGAL-EDFDT--IETALSSELLE 134
gi 81312473  102 r--------------------------------------------shiHDSKLSEATTLTE-ESVEA--IERELHTLLSE 134
gi 75413506  101 -----------------------------------------------gSLKEINFMLSVLQ-KKFLH--LSKEFATTSKA 130
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75539525  206 NNLLQEENTSLQnncgtlfHEKTEEESRNLELSDNCKKLQKELAELRaalekkkseisdhklqcdmqt-----seishlk 280
gi 14195328  136 LSQIDLTIQAPEk-----kLLKEVLGSRYDSINHSIEEISDRFTKMLsllrlrehfyrgee------------------- 191
gi 123483738 149 VLSQKEDQGRIR-------GFERIDPSSELNVNKERCAFESRIRDLEealakseslsqer-------------------- 201
gi 75539468  157 ALRCQEDQGRIC-------GFEEQENSSLITLNNERRTFESRIHDLEqalsdaesqsqshtsvlest--------lktlq 221
gi 75539473  139 ICNLRAQLDKETvk---vqKVLKLKQEELDSLIRRYAAMAQESSDLAalvlhlrtesadl-------------------- 195
gi 123483731 125 IASLQNQLDEESnk---ynKLLTTKQEELTSLTRRYIATTSESSNLEetvnnlrse------------------------ 177
gi 81312477  125 PPSQQNEEMEDVlh---mqTLLKSKQDELDSLTHRYAAMAQERSDLEnmvtrlreelvelrhvle------------enq 189
gi 123483740 135 YSQKDPAYQDLE-------DKLARVKENLAAAKIAFAIAAEECRRLEnlckdveada----------------------- 184
gi 81312473  135 YEQERLAYECCI-------SQRNLVKISMDSAKEEFDNAYADVQRLHrlftaedsnnlsnecqeslsryreksidyarsi 207
gi 75413506  131 SLLYLKIFILVC-------KDLEITIKVLNLFWMSIKTLQKK-------------------------------------- 165
                        250       260
                 ....*....|....*....|....*.
gi 75539525  281 tdlthlqqkmadhqRASQK------T 300
gi 14195328  192 ryapylsppllnknRLLTQ------I 211
gi 123483738 202 --ssaaetrlgelqTERSQ------F 219
gi 75539468  222 eerlqlqnriaeleTTVAT------H 241
gi 75539473  196 --krvlekntitsnAIIEK------L 213
gi 123483731 178 -----lmelrssssELIDK------L 192
gi 81312477  190 atshrvieklqasnELLNQesiiarQ 215
gi 123483740 185 ----sinsqyressLALWRa----cL 202
gi 81312473  208 qryedlfqqmhshqDLMHF------Q 227
gi 75413506  166 -------------------------C 166
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