4YKE


Conserved Protein Domain Family
Mre11_DNA_bind

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pfam04152: Mre11_DNA_bind 
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Mre11 DNA-binding presumed domain
The Mre11 complex is a multi-subunit nuclease that is composed of Mre11, Rad50 and Nbs1/Xrs2, and is involved in checkpoint signalling and DNA replication. Mre11 has an intrinsic DNA-binding activity that is stimulated by Rad50 on its own or in combination with Nbs1.
Statistics
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Aligned: 158 rows
Threshold Bit Score: 80.3379
Threshold Setting Gi: 323447217
Created: 5-May-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4YKE_A        291 EVEKIPLRTVRPFVIREITLATDKRfkg--------leKKQDNRQEVTKRLMQI-VEE-MIAEANEMWrslhe------- 353 Chaetomium the...
Q23255        356 ASKPIPLQTVRPMVCDELLL---DKippgsrpilktdrPKHTDGRYIDEIAIEAkINE-MITTAKAKR------------ 419 Caenorhabditis...
EGT55264      357 ASKPIPLQTVRPMVCDELVL---DKippgcrpvtrterPKNRDGRYIDEIAIEAkLNE-MIARATSGR------------ 420 Caenorhabditis...
EFP00620      355 ASKPIPLQTVRPMICDELLL---DKippgcrpatkldrPRNRDGRYIDEMAIEAkLNE-MISRAKAKR------------ 418 Caenorhabditis...
11_pfamImport   2 KMNYLKLKTVRPFVFEDLVLNDYNDei----------sSYKSRQDAVEEFVDNY-IENtLITKATEQLt----------- 59 
EGI60927      295 KIKPLKLQSVRPFIFDNLVLHDHDIkm----------rNCVSLANAISQYVDQY-IENnIMPKVAEQIt----------- 352 Panamanian lea...
EFN86093      296 KMKSIKLNSIRPFVFDNMILRDHHDi-----------kVGISLAESISQYVDQY-IENnIMCKVAEQLt----------- 352 Jerdon's jumpi...
EFZ09289      296 KMKDLKLKSVRPYIFENMILRDHDIksk--------vgNYISMQETVLKYVDHY-IENeIMPKVAKQLt----------- 355 red fire ant
EFN61231      296 KMKPLKLKSVRPYIFENLILSDHDIki----------hDCISLADSVSQYVDRY-IENeLMPKVAKQLt----------- 353 Florida carpen...
EZG43837      308 RFHSFPLLTPRAFVLRQVGIASRDDlwqrltveaelalKETHVFNSDRKICWDRsIAI-LNSELELEPssvvasdnndng 386 Gregarina niph...
4YKE_A        354 ------dsqddEDEEQPLPLIRLKVEYSspegTKFEVENPQRFSNRFAGKVANQNDVVHFYRKKTGTTRKPKE-GKRELP 426 Chaetomium the...
Q23255        420 -----------RPRQPELPLIRLKVIYDgd-wLNITPANAKRIGLRYENVVANAVDMVFIKKNNKPKEGKLQT-ENEKNI 486 Caenorhabditis...
EGT55264      421 -----------GPRQPELPLIRLKVIYDgd-wINVLPANAKRIGLRYENTVANAVDMVTIKKVSSNQAKEKKM-KDDETQ 487 Caenorhabditis...
EFP00620      419 -----------GPRQPELPLIRLKVIYDge-wLNITPANAKRIGLRYENTVANAVDMVTIKKNISSEARARRQrGQQNNE 486 Caenorhabditis...
11_pfamImport  60 ----------aHPKQPQAPLIRLRVFYS----EDRDVFDTLQLSQKYYHVTANPNDMILFRKCSSKLKKKDIK-VQEQDL 124
EGI60927      353 ----------gYPGQPLQPLIRLRIFYD----HDSEQFDTLSLAQRYCDEVANPMDMILFRKRKTGDKGKRTI-EDEIDD 417 Panamanian lea...
EFN86093      353 ----------gYPDQPLQPLIRLRIFHE----DDNQIFDTLSLARKYCDEVANPMEMIIFRKIKNVEKIRRAI-RDGLED 417 Jerdon's jumpi...
EFZ09289      356 ----------gYPNQPVQPLIRLRIFYD----DENEQFDTISLAQRYCDEVANPMDMILFRKIKAGDK-KRVI-PDLIDD 419 red fire ant
EFN61231      354 ----------gYPNQPSQPLIRLRIFYN----DDNEQFDTLSLAQKYCDEVANPMEMIIFRKMKSGEKSKRF--NDEIDD 417 Florida carpen...
EZG43837      387 dpgseleqqirSLNDNSLPLIRLRVELPt--dYNTDTFSASRFGANFQDLLANPQDMILLSRLSKAKQNPGND-KNPNDD 463 Gregarina niph...
4YKE_A        427 eg---iaEALEDSDS--ISVDALVQEFFAQQ----SLKILPQAPFGDAV 466 Chaetomium thermophilum var. thermophilum DSM...
Q23255        487 te---maDEMGQVSA--TNLQTIINDYFINQplvdQMTVLKPIGIGRAL 530 Caenorhabditis elegans
EGT55264      488 f-----kDELGHVSA--ANLQTIINDYFINQpiaeQLTVLKPFGIGKAL 529 Caenorhabditis brenneri
EFP00620      487 l-----aDELGHVSA--ANLQTMINDYFTHQplddQMTVLKPFGIGKAL 528 Caenorhabditis remanei
11_pfamImport 125 gevseifRFDENEKDwkRTVQGGMTEYFNKPdkvnKLTVLSLTGLNESL 173
EGI60927      418 pddiaelFEGDKGENwtSTVQGGIKKYFDMEenkdKLTILTVTAMNEAL 466 Panamanian leafcutter ant
EFN86093      418 veeitelFQGNLEQDwnRTVPGGIKKYFDMEenkdKLTVLTVTALNEAL 466 Jerdon's jumping ant
EFZ09289      420 mdditelFQGDVEQDwtSTVPGGIKKYFDMEenkdKLTVLTVTALNEAL 468 red fire ant
EFN61231      418 ldditelFQADIGQDwiSTVPGGIKKYFDMEenkdKLTVLTVTALNEAL 466 Florida carpenter ant
EZG43837      464 ve---mpNNEDGDDD--DDPENMIFKYMEDKg---ALKIFAQQDLNNCV 504 Gregarina niphandrodes
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