Conserved Protein Domain Family
Ctr

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pfam04145: Ctr 
Ctr copper transporter family
The redox active metal copper is an essential cofactor in critical biological processes such as respiration, iron transport, oxidative stress protection, hormone production, and pigmentation. A widely conserved family of high-affinity copper transport proteins (Ctr proteins) mediates copper uptake at the plasma membrane. A series of clustered methionine residues in the hydrophilic extracellular domain, and an MXXXM motif in the second transmembrane domain, are important for copper uptake. These methionine probably coordinate copper during the process of metal transport.
Statistics
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Aligned: 441 rows
Threshold Bit Score: 35.7348
Threshold Setting Gi: 402468190
Created: 4-Jun-2019
Updated: 18-Jul-2019
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EGF84162            290 MYFHF-GYSDY-ILFDSWVPRSTFSYALGCLFCFLLAIGYEFLLvvgsGLDTAWKMVEssrhsndvglgDTLELPMSGSD 367 Batracho...
WGS:AFBI:EDEG_02289  15 MTLNNkKYLSS-FIVKSKPITNK-NFYILLLTIIITSFLLEFVNiltkSRLHKYKTKItihskkqrkheKDSIKNIGYNN 92  Edhazard...
ETO24326             47 STFQW-TVNVC-LLFEPWHVKHGWQYSICLIVIVLVCIFREYLQlfsaQFPNCLESLFgklgnkkteerFIKKDIEESYD 124 Reticulo...
22_pfamImport         1 MTFTN-KLPFF-LLLKSIEITTYMDLTIACFTLFLVGFIYESLKtvrlRIATMTSCPVsccgcqeqrdvSAKSDVNGLVA 78 
XP_015791719         68 SYFHT-TLGDT-LLFKSWVLDSSSRTIVACIVFFLMALLYEGLKsyreFL-------------------------FTRVA 120 two-spot...
EDO34368            221 SAFHA-TTKQAqLLFEDWKLSSSTILIGSCAGVFFLSILSECVRalrsRIADQTTSENpnatttyktsfPKSTKNEEFQK 299 starlet ...
EFX67187             23 MYFYA-DYKAV-VLFQGWDIQTVGAMVGSCIGIFLMGILYEGLKyfreYL-------------------------SSKHY 75  common w...
XP_002128630          3 EYFSWwNLPLE-FLFDAWKISNAVGLLFTCIAVFCVALIFEGFRilsaILSSRFFVLPlvpcnrdddssSSSINGSVEIT 81  vase tun...
XP_003390825         33 MYFHF-DACQR-LLFSSWKITNSRELIGAMVAVILMAILYEGLKtlreWL-------------------------IYHDL 85  Amphimed...
XP_015791703         68 NYFHI-TFGDT-VLFKGWSLQSTTDVLIACTVFFLLAIFYEGLKslreFL-------------------------FRREA 120 two-spot...
EGF84162            368 HSFGLYRSPMENPNISvlsddtpllrprsritgkrrtslnisthpklqpnhesqnlplcpttdltdqidmgpdgeeesvf 447 Batracho...
WGS:AFBI:EDEG_02289  93 SDSILQYNTF---------------------------------------------------------------------- 102 Edhazard...
ETO24326            125 YDPSLHNESIN--------------------------------------------------------------------- 135 Reticulo...
22_pfamImport        79 LTKLITKQPQQNGNGMngndgsggk------------------------------------------------------- 103
XP_015791719        121 SKRCYSVSVINT-------------------------------------------------------------------- 132 two-spot...
EDO34368            300 DLQTEANGPQRDVSSSeaatde---------------------------------------------------------- 321 starlet ...
EFX67187             76 TSVTYNNVKTPG-------------------------------------------------------------------- 87  common w...
XP_002128630         82 DSLN---------------------------------------------------------------------------- 85  vase tun...
XP_003390825         86 KRSKKNKKRSDSTN------------------------------------------------------------------ 99  Amphimed...
XP_015791703        121 RSGSYQVSLYTPTNA----------------------------------------------------------------- 135 two-spot...
EGF84162            448 dhsmsessshihqrvishgntsqaaglsdFlQhhsgdishhsnqhTPTQYLSRLYTKKWTHLQMR-----------IGRA 516 Batracho...
WGS:AFBI:EDEG_02289 103 -------------------------------------------------FRKTFFRKFRLLFEHL-----------FAAF 122 Edhazard...
ETO24326            136 ------------------------------------------------NRTSKQKKDIWMCFSPQ-----------IEEG 156 Reticulo...
22_pfamImport       104 ---------------------dgrdgrngF-Hdte--------vrISNDKQTGPRSKQKSAVAIH-----------LIEV 142
XP_015791719        133 -----------------------------------------------GSNGCPENCGDGKPPARNvvtcrmwswahFYQS 165 two-spot...
EDO34368            322 -----------------------ntactiQ-Ngs---------gnELLPDIKQERPKLKITSKIH-----------FLQL 357 starlet ...
EFX67187             88 ------------------------------------------------EAGSETSSQVNRTPMSFktsvt--sashYIQT 117 common w...
XP_002128630         86 -------------------------------------------------------HVKWERTKNH-----------ILQT 99  vase tun...
XP_003390825        100 ---------------------------------------------NEKDDKMELLDPEKKSNRVKsfsis--lsmhIIQS 132 Amphimed...
XP_015791703        136 ---------------------------------------------CPDDMIATSVNQSDEHPTPTlincsmwskahFYQS 170 two-spot...
EGF84162            517 LIRLVTITLAYI--------CMLLVMSFNVGLFLSVVVGLAVGKFMW 555 Batrachochytrium dendrobatidis JAM81
WGS:AFBI:EDEG_02289 123 YLVFVPTVFVFFcs----wsIMMLSMTSNVYILCAIVLGKVSAKLVS 165 Edhazardia aedis USNM 41457
ETO24326            157 VLKTIQDGIVFVtvlfidycIMLLLMSYNYGIAITILASLCAGRFLg 203 Reticulomyxa filosa
22_pfamImport       143 LVHGAQLFVSYI--------IMLAVMTYNVCIVASVICGCMTGYLVC 181
XP_015791719        166 LLHVLQVIASYT--------LMLGFMSYNIWICLAIALGAGHGYFLF 204 two-spotted spider mite
EDO34368            358 SLHILQVILGYA--------LMLVIMTMDIWLGLAVVLGLGTGYFIC 396 starlet sea anemone
EFX67187            118 ALHLLQMIISYL--------LMLIVMTYNVWLFMAVVLGCTVGYFFF 156 common water flea
XP_002128630        100 AIHVFKVAASYG--------LMLAVMSYNAYIAISVLLGATLGYFVF 138 vase tunicate
XP_003390825        133 LLHVVQVGYGYI--------LMFIAMTFNGWLFLSVCFGAGIGYFIF 171 Amphimedon queenslandica
XP_015791703        171 SLHAIQVTISYT--------LMLGFMTFNTWICLSILLGAGLGYFLF 209 two-spotted spider mite
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