Conserved Protein Domain Family
FA_hydroxylase

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pfam04116: FA_hydroxylase 
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Fatty acid hydroxylase superfamily
This superfamily includes fatty acid and carotene hydroxylases and sterol desaturases. Beta-carotene hydroxylase is involved in zeaxanthin synthesis by hydroxylating beta-carotene, but the enzyme may be involved in other pathways. This family includes C-5 sterol desaturase and C-4 sterol methyl oxidase. Members of this family are involved in cholesterol biosynthesis and biosynthesis a plant cuticular wax. These enzymes contain two copies of a HXHH motif. Members of this family are integral membrane proteins.
Statistics
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PSSM-Id: 309300
View PSSM: pfam04116
Aligned: 111 rows
Threshold Bit Score: 42.7941
Threshold Setting Gi: 74567174
Created: 19-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4ZR0_A       229 FCVGVFVWTLIEYGLHRfLFHFddwlpesniAfaTHFLLHGC-HH----YLPMDK-YRLVMPPTLFVILCA--PFYK--- 297
gi 123880166 174 TILFDLFADIGFYNIHR-NLHEt----------pFLRTFHIPdHHkntgKHNKLMaYETYTISTIETLSIA--LTYFigf 240
gi 122164110 150 SVGAAVGMEFWARWAHRaLWHa-----------sLWH-MHES-HHk---PREGPF-ELNDVFAIINAVPAI--ALLN--- 207
gi 74567174   12 IVSGLIGMEFIARLTHKyLMHG---------I--LWP-IHKD-HH-----------IPSGRRFQRNNLFALf-FAFI--- 63
gi 81319589   47 AALGLVAWSLLEYLLHRfVLHGl----------sPFRQWHQS-HH-----QRPGA-LIGLSTLSSAALFIG--LVYL--- 104
gi 81354848   19 IAVAILGFPLVWYVTHRwIMHGhwmf-kvpfLsgLWKRIHYD-HHl---DPDHLEvLFGALYTTLPSVALAtaLPGY--- 90
gi 75365444   39 MLAGLLVWSLLEYSLHRfLFHS------------LYRREHWT-HH-----VDVLA-YIGVSSWKISSVYSG--LLLF--- 94
gi 75116427  135 VVLHVAVSEPAFYWAHR-ALHLg----------pLFSRYHSL-HHs---FQATQA-LTAGFVTPLESLILT--LVAW--- 193
gi 145306562  20 ALLHAGPVEFLYYWFHRaLHHH---------F--LYSRYHSH-HHa---SIVTEP-ITSVIHPFGEHIVYF--TLFA--- 78
gi 119455412 129 FLMRIAAADFCFYVTHW-LFHRr-----------FLLKIHLK-HHe---FIDTSS-FVAGYKSLIEYILVT--ITDV--- 186
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4ZR0_A       298 -LVF---ALLP-----LYWAYAGfaGGLFGYVCYDECHFFlh-----hsKLpPFm-------RKLKKYHLEHHY-KNY-- 353
gi 123880166 241 gALI---LVYG-----KLSTLIVsiMVSWMHTVELMGHTElswt--pkfTYnRIvhdi-lgiSLTSKDHLIHHI-YPT-- 306
gi 122164110 208 -FGF---FHKGl---iPGLCFGAglGITVFGMAYMFVHDGlv-----hrRFpVGpianvpyfRKVAAAHQIHHTdKFQ-- 273
gi 74567174   64 -SMS---LFIAsfetkDFIYMSFgiGMLFYGILYLIIHDMiih----nyYLhLRnrkhsryiNKLIEVHELHHI-NDGrg 134
gi 81319589  105 -PAL---LALG-----PWRGSSLalGIMSGYLAYILTHHAvh-----hfDHsGNaw-----lARRQLCHHLHHSaLWQ-- 163
gi 81354848   91 -------LIGG-----FGGACIGyaVGLLSTCFYEFCHCIqh------lGYkPKnk----rlALMKKRHLEHHF-HDE-- 145
gi 75365444   95 -ASF---AGLT-----SAFAGLVlgYFTYISLHYV-MHRP----------RhWAyr----fiPRLVANHDLHHR-KGV-- 147
gi 75116427  194 -APLagaFMAG-----HGSVSLVygHILLFDYLRSMGYSNvevishktfQDfPFlr----ylIYTPSYLSLHHR-EKD-- 260
gi 145306562  79 -IPMlstVYMGn---gSALVFVL--YIVYIDFMNNMGHCNfelvpkwmfQVfPPlk----ylMYTPSFHSLHHT-QFR-- 145
gi 119455412 187 -LPV---FIFGy----DITQILA--WTLIGNAYNLEGHSSls------------------ifFISSDFHDLHHT-HFK-- 235
                        170       180
                 ....*....|....*....|.
4ZR0_A       354 QL-GFGVt--SWF-WDEVFGT 370
gi 123880166 307 -T-NYSKr--TRL-MDYICNT 322
gi 122164110 274 GV-PYGLf-lGPKeLEEVGGN 292
gi 74567174  135 KGmNWGFllyIPG-IDKTrad 154
gi 81319589  164 AG-HFGVt--SAF-WDRLFAS 180
gi 81354848  146 DG-NFGIt--NFF-WDKLLGT 162
gi 75365444  148 EK-NFGVs--SPL-WDHLFRT 164
gi 75116427  261 -S-NFCLf--MPL-FDALGGT 276
gi 145306562 146 -T-NYSLf--MPF-YDYIYST 161
gi 119455412 236 -G-NYGIr---GF-WDRVFNT 250
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