5DFZ


Conserved Protein Domain Family
APG6

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pfam04111: APG6 
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Autophagy protein Apg6
In yeast, 15 Apg proteins coordinate the formation of autophagosomes. Autophagy is a bulk degradation process induced by starvation in eukaryotic cells. Apg6/Vps30p has two distinct functions in the autophagic process, either associated with the membrane or in a retrieval step of the carboxypeptidase Y sorting pathway.
Statistics
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PSSM-Id: 335623
View PSSM: pfam04111
Aligned: 146 rows
Threshold Bit Score: 167.736
Threshold Setting Gi: 459656705
Created: 20-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5DFZ_D        181 ICQDCCNILINRLKSEYDDAIKERDTYAQFLSKLESQNK----------------------------------------- 219  Saccharomyces...
A0DRK9         20 YCEKCLQQQMKKEEEEVKQLENEINELQIQLKQVRDEMYk---------------------------------------- 59   Paramecium te...
Q5CPI7        104 LCVDCMNCSISQFSMALNKEISLLDKYKEISDSLISSECydedqm--------------------------------eds 151  Cryptosporidi...
XP_002177919  102 LCLECIQRVEQALLADTERLKYETKRYDEAVRDERDRQRsl--------------------------------------- 142  Phaeodactylum...
XP_003291506  777 lCGSCLSRFKTILDEFDQEESLESQMYKNFFLTKQKKQEkdeneedeelnq--------------------dddtdeedl 836  Dictyostelium...
EFA86429      526 LCGPCISTLKEYLERMNQELQRDYTTYTQFIQDHNINIKqdnnnndnnnnnsnntnnittfnsnntnkqsftpsihkske 605  Polysphondyli...
XP_002140137   95 VCVECIDKLIMQFELNLNKTIDETKTLNLLIGNIDYSVEd---------------------------------------- 134  Cryptosporidi...
XP_004027370   37 YCFEC-KQKLEQGTKEIEQLEKQINEIQINLTEINS-------------------------------------------- 71   Ichthyophthir...
XP_012655476   43 LCEPCLKIQLKNEFQDIEIIGQEITETQKKLQLVDENMIsi--------------------------------------- 83   Tetrahymena t...
XP_002670246  104 LCNTCMTDLFGGLSEEIEQLELECKLYDEKLKKSKKFDTn---------------------------------------- 143  Naegleria gru...
5DFZ_D        220 --EI----------SESNKE----KQyshnlsekeN-----------LK-----KEEERLLDQLLRLEMTD----DDLDG 263  Saccharomyces...
A0DRK9         60 -mET----------NQIEKK----ND---------K-----------IE-----LDKKNLDKEIYQLEQDE----QQQKK 95   Paramecium te...
Q5CPI7        152 evNF----------EPTSKEyleiMN---------Iyn-------efIKmeqynQEKTIINDENDNDEIDCtetdKDIKE 205  Cryptosporidi...
XP_002177919  143 -hQAlnavsfaglgDNFQPE----FM---------SqsadadsssplLQ-----RAEEAFRNEIEALQQCC----DQQED 199  Phaeodactylum...
XP_003291506  837 knEL----------LNIEKE----IN---------D-----------LE-----KEEKELIQEYLELENQN----QINLD 873  Dictyostelium...
EFA86429      606 weDL----------SNLSNEe---LD---------Aqi-------klIE-----LEEIELMNEYLQLERNN----NDVID 647  Polysphondyli...
XP_002140137  135 ------------------------IS---------Iid-------slIK--------DSLFDNEKDLPDKCnf-nQCIHD 165  Cryptosporidi...
XP_004027370   72 --KI----------SHVTHE----IN---------Lik-------tsEQ-----KNETEIEQEYKQLEQEE----EELNQ 110  Ichthyophthir...
XP_012655476   84 knKI----------EENEKL----IN---------Q------------------SQQQKQKLEIEELKMKE----QQLNQ 118  Tetrahymena t...
XP_002670246  144 -gMY----------KKYMKE----MD---------E-----------LR-----NEELVLREQVNVIQNDR----HRIGR 179  Naegleria gru...
5DFZ_D        264 ELVRL-----QEKK--V-------QLENEKLQKLSDQNL-MDLNNIQFNKNLQSLKLQYELSLNQL-DKLRKINIFNATF 327  Saccharomyces...
A0DRK9         96 ELIKL-----KNSI--L-------EQEHNEDNLWEHINK-FTRKLYSLFESNQIADNKLSQLNNEL-DRLSKLDVLNDLF 159  Paramecium te...
Q5CPI7        206 GYGKC-----RFQV--IntievddIVELRQNQNLESN---LKHELIQYELKREGMKNHLDFLRGYL-ERLKRSDFLNLSF 274  Cryptosporidi...
XP_002177919  200 EIGHLrslvkEQELikQ-------ELQATELLVAAERNS-LEVEARAFDNDHEQLCDHLLSIQKEV-ETLSSSQIRWPAF 270  Phaeodactylum...
XP_003291506  874 IKIKL-----EDIL--K-------EIKQEEKTHYDSVNN-YYQEYYDLKQEDEIWDNYISSIKDQI-ERVTQIDIKKAFF 937  Dictyostelium...
EFA86429      648 IRNKL-----EDIR--G-------EIKSEEKQHYNNVNH-FYQEYFNLLGQKKSLESQIATMKDDL-DSLSDLNIVKEVF 711  Polysphondyli...
XP_002140137  166 NLDYF-----EI------------LVKRQEKEI--RLNNiFKLEYIQRL--IDGTNSDIKFLQYHV-DLLRKINIFNTTF 223  Cryptosporidi...
XP_004027370  111 KIFEL-----KEKI--L-------TYEQQENEYWDEVNI-FEKNLYQVLEKKQIAENQEKHYNEQL-IKLNTYNTLNQVF 174  Ichthyophthir...
XP_012655476  119 EFEKL-----KKNV--L-------DFEIRESKYWVEVNS-FEKRLQTLLNKKQIADNLEQYYNDKLnNKLNKYNTINSVF 183  Tetrahymena t...
XP_002670246  180 NITSL-----QTEY--N-------TQQESEKNYWKIYFQ--FIHNNQFLAEENRRKSQLIDKEDKI----RRKSPLAGMF 239  Naegleria gru...
5DFZ_D        328 ----KIs---hS--G-PFATINGLRLGSIPESVVPWKEINAALGQLILLLATINKNLKIn-lVDYELQP-MGSFSKIk-- 393  Saccharomyces...
A0DRK9        160 ----KI-----SvqD-EVATINGLQIGKKGEQPVDWDDISAGVGHLTLLLVYLMKKFMYt-yQKIESIElNGSFSKIkik 228  Paramecium te...
Q5CPI7        275 ----YI-----QviE-GGACINGLRPALFEADFDNWNEVNAALGVSAMLLYTILERHKL----PLSIYP-NGSYSTI--- 336  Cryptosporidi...
XP_002177919  271 fldvRId---tR--GlRYPLINDLRLAYRAKGDLSWNEIQTAWSLAAQLLLIVGTIFEFa-sQEWKIVP-LSHCAKLi-- 341  Phaeodactylum...
XP_003291506  938 ----KIag-seDsnG--IASINGFRLGTLQNLKVDWDEINSAWGETSLLLHVLATQLEYn-fLNFKLIP-MGNKSIIq-- 1006 Dictyostelium...
EFA86429      712 ----QItfekiDehT--IVKINDLRLGTLPKNKVEWDEINGAMGQIVLLVHTIAKQLNYt-fTKHKLIP-MGNKPLIq-- 781  Polysphondyli...
XP_002140137  224 ----YI-----NqiN-GIGTINNLRLGLLDNSDENWREINGALGYTSLLLCCIAEKLNI----EVTLNP-YGNYSTItdr 288  Cryptosporidi...
XP_004027370  175 ----NI-----QcdE-QAGTINNIIIGKKLNQEIVWDETNAGLGQIAMLFSYLVKKYGYe-mKFIKDINlCANESQIc-- 241  Ichthyophthir...
XP_012655476  184 ----FI-----EvsE-QVGLINNLMIGKKLNEDINWDETNAGLGQVILLFLYLMNKFGYq-sSYIKDIQvCGNESYIc-- 250  Tetrahymena t...
XP_002670246  240 ----HLw---yE--G-SYGTINGLRMGRLRHDPVSWEEINAAWGLAVLLLDLTAQQLNNfkfTKYKLVP-KASCSSIk-- 306  Naegleria gru...
5DFZ_D        394 -KrmvnsveY----NnsttnapgdwliLPVYYD-ENFnlgr----ifrKETKFDKSLETTLEIISEItrqlstiassyss 463  Saccharomyces...
A0DRK9        229 dEyqntlctK----T------------LNLYLNnKTSq---------kDEEEFSDAFLQLYFEFQQF------------- 270  Paramecium te...
Q5CPI7        337 ---------K----Dses-------siWPLHGNtLCNsd-------ynECTNFDKGILSFVFLIDTV------------- 376  Cryptosporidi...
XP_002177919  342 -Q-------YpggkKqpp-------tvYNIGCS-GKQtslallawnalLH-----------EIIKDT------------- 381  Phaeodactylum...
XP_003291506 1007 -S-------K----Ndk--------vsYSLYGGdNIQfsrsf-lwfgaSDQRFDNGMEAFLSCVNEI------------- 1052 Dictyostelium...
EFA86429      782 -S-------K----Sdk--------eaYPLYGGdDIYfrsf----iwsREHKFDIGMEAFLGCINEM------------- 824  Polysphondyli...
XP_002140137  289 cIpeylsnfV----Keey-------siLPLYGNtSANsn-------ynQCIKFDSAIKALLSNISNI------------- 337  Cryptosporidi...
XP_004027370  242 --------eI----Ekn--------qiLQLYGPlNYQs----------EYSRFDQAIKLLLKEFYCF------------- 278  Ichthyophthir...
XP_012655476  251 --------eA----Nks--------eqLYLRGPfSNKg----------DEAKFNRAMKMILDEFSLF------------- 287  Tetrahymena t...
XP_002670246  307 -E-------L----Esg--------dkYDLFFSsTR------------NIQSFNEGMKCFLFCLEEL------------- 341  Naegleria gru...
5DFZ_D        464 qtlatsqdessmnnANDV---EN--------STSilELPYIMn-------kD--KING----LS-VKLhgsspN---LEW 515  Saccharomyces...
A0DRK9        271 --------------CKYLqdgDIlrk---rkINL--NLPFTM---------NgmSVDNk--iLS-LKQpaaqkW---QEW 316  Paramecium te...
Q5CPI7        377 --------------YNIIpgtNE-------------TLPYSVd-------qRngTIGG----IS-LNLlfn----erESW 413  Cryptosporidi...
XP_002177919  382 --------------SEKL---NQahkdglldLSVlpPLPFAM---------AktTIGD----LNlLRLsp-edD---VRW 427  Phaeodactylum...
XP_003291506 1053 --------------SSFVltkKNi------------NFNYRI---------NkdKIGDsnrfYS-IKIas-nsE---AHW 1092 Dictyostelium...
EFA86429      825 --------------CSLFkn---------------vVFPFKI---------EkdKIGGnngfQS-IRVtg-nsE---VNW 861  Polysphondyli...
XP_002140137  338 --------------AKYMncsD--------------KLPFIIn-------yDmnTIDG----VS-YNLlf-ndK---QTW 373  Cryptosporidi...
XP_004027370  279 --------------YEFLinqVKigd---yvEEV--KLPYNId-------iQkcEIDY----VE-ISImk-----niDLW 322  Ichthyophthir...
XP_012655476  288 --------------VDYLqqtYLqn----------iQLPFKId-------qSnsSIDGl--lLT-TQTaanaqYkglDNW 333  Tetrahymena t...
XP_002670246  342 --------------CQHIg----------------iVVPGSSigtrlivkaDegKIQDlsmlYS-VER-----E---YEW 382  Naegleria gru...
5DFZ_D        516 TTAMKFLLTNVKWLLAFS 533  Saccharomyces cerevisiae S288c
A0DRK9        317 TNSVKKFLANVKALIVAN 334  Paramecium tetraurelia
Q5CPI7        414 NRAMSMNLINLKWLLVRS 431  Cryptosporidium parvum
XP_002177919  428 SQAIQYTATNLQWLSVCT 445  Phaeodactylum tricornutum CCAP 1055/1
XP_003291506 1093 TSALKFMLSTLKKILDNL 1110 Dictyostelium purpureum
EFA86429      862 TKALKYMVTNIKCILTNL 879  Polysphondylium pallidum PN500
XP_002140137  374 NNAMKMLLINLKYLIINL 391  Cryptosporidium muris RN66
XP_004027370  323 TSGMKKFLINFKYIIYIN 340  Ichthyophthirius multifiliis
XP_012655476  334 TQAFKKLLINFKFLISFN 351  Tetrahymena thermophila SB210
XP_002670246  383 TKALKYLIINLKFVQKNV 400  Naegleria gruberi strain NEG-M
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