5OF3


Conserved Protein Domain Family
DNA_primase_lrg
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pfam04104: DNA_primase_lrg 
Eukaryotic and archaeal DNA primase, large subunit
DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication. DNA primase is a heterodimer of two subunits, the small subunit Pri1 (48 kDa in yeast), and the large subunit Pri2 (58 kDa in the yeast S. cerevisiae). The large subunit of DNA primase forms interactions with the small subunit and the structure implicates that it is not directly involved in catalysis, but plays roles in correctly positioning the primase/DNA complex, and in the transfer of RNA to DNA polymerase.
Links
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Statistics
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PSSM-Id: 397980
Aligned: 43 rows
Threshold Bit Score: 67.4655
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
5OF3_B   136 KEFCVHFIDYLKYTK--DL------KedwklsgQILH-KGYVYLDKNQLIGLIAESIKSKIVE--------------MIr 192
Q9HJD1   126 HLYRIGVADFATYASrvTGskyrlsN-------QIVR-EGYVYVDEDVMAKVLREAFVSFMFDtldqir---kedaiETi 194 Thermoplasma acidop...
Q58112   142 LPNKISVWEFIKIASrsRIndlhleR-------LDLE-NGFVDITKIK-EIFAKEIIRVELMKlgeni----kkrklPDd 208 Methanocaldococcus ...
Q6M1A7   114 GDSKINIWDFIDVAAnsRNndlhleR-------MILE-GDTVLLNQKNQSIYNFEKIRLKLKNyvek------vrnaEMp 179 Methanococcus marip...
O29911   173 KGWKMHVSTFVRVSAriKDdkwrlvN-------RKLR-NGWVETTKAEVLRGLEELLRMKLFEkvpvs-----eavsEAv 239 Archaeoglobus fulgi...
CAI48434 139 GRFSVAATAYLELAAglDDpqwrlaT-------RPLS-AGTLPVSRPELYTLLREAVARRVAEglplsv---pdviaEPl 207
Q5UYQ8   135 DGYRVEVGAYLDLAAdqRGdswrlvN-------RPLT-DGEVRVTAEELNVLLKQAIRHRVTDglpftv---pdaiaDEl 203 Haloarcula marismor...
Q9HN47   138 DAHTVDVPTYLLLASslRDddwrlvN-------RALD-DGRVPVTDAELDTLIREAIRERVADglplsv---pdqiaDAl 206 Halobacterium salin...
Q8TVJ5   207 EQDHARRCS--NCRGrmRKpdpnllE-------MLKEpEGYLIMHFKTLARTFREDVRRLVVSdiesr----ddvedEEl 273 Methanopyrus kandle...
Q8ZVK5   111 TPVAIKWTSYLRYAPpdpf--wamiN-------RVVV-KGWVILPLDDFERILEEAYEEQILRiasenelavgrvsaSId 180 Pyrobaculum aerophilum

5OF3_B   193 pLnLKEIPekLKSLIERRGiI------------------------PPCIENIL----AKEKLNEEEIRTLITFYI----- 239
Q9HJD1   195 kSvLDDLEkiRESYRKAHNvrmiagk-------------gdasmfPPCMKEIIknleSGVNVSHMGRLALASFLH----- 256 Thermoplasma acidop...
Q58112   209 sVvKELLNeiSDYLKDKVKyeqisgikaln-----ykgniplewhPPCIRGILndilSGGSPSHYARRSFVVYWFcakfn 283 Methanocaldococcus ...
Q6M1A7   180 kEiKDLLVkkSEEAFEGIN-IgyniesgikvstkeysgeipedwhPPCMREILndilSGGSPSHYARRSFVVYRFvsqfd 258 Methanococcus marip...
O29911   240 rElSRKAKreSEKFAMDLGevdl-------------------nclPPCMREILselqRGMNIPHTARFAITSFLL----- 295 Archaeoglobus fulgi...
CAI48434 208 dGeLAAIRrqIEDLDPPTGfetvt-----------------pglfPPCMRALLsrarDGESLPDESAFSLVSFLL----- 265
Q5UYQ8   204 tAeVEQLEevLSELELTREidtvv-----------------pelfPPCMKSLLdqvqKGEHLEHHSRFAIATFLV----- 261 Haloarcula marismor...
Q9HN47   207 dEpVAAIQdaLADLDLTREidtvv-----------------pelfPPCMKHLLdqvqRGDHLPHHARFAITSFLS----- 264 Halobacterium salin...
Q8TVJ5   274 rEfCLKLFpkVRKRLERVEkgag-------------------grfPPCIRELLrraqEGENLPHEARFALAAFLV----- 329 Methanopyrus kandle...
Q8ZVK5   181 mSlIEDLLrkYAQRPVNITklst------------------egpdPPCMKAILdalkAGENLPHAARFAIATYLL----- 237 Pyrobaculum aerophilum

5OF3_B   240 ------------------DIGKGL------SGIVSIMKKYnvsNVEDLYR-KYR----------GDKGTRYIVYS----- 279
Q9HJD1   257 ------------------KAGYSE------DEIVPYFRNA-----PDFDEnITRyqik--hisgEISGTEYTPPK----- 300 Thermoplasma acidop...
Q58112   284 pnlrpldkngnlvnvsatDIASEEeierfiDELIEMLFK----NVEDFDEkKTRyyim--------hnigYKVGHgrlth 351 Methanocaldococcus ...
Q6M1A7   259 pnlrpi-eegiitnrsaqDIATEEqierflDEIINIFKSV-----GDFDVeKTKyyis--------hnigYKVANhi-th 323 Methanococcus marip...
O29911   296 ------------------NIGMTV------DEIIALFKSA-----PDFDDeKTRyqveh-iageRGKGAEYTSPS----- 340 Archaeoglobus fulgi...
CAI48434 266 ------------------GVGLDR------DAVIEL---------CSFDGeRAArvrdriqrleTDDGVVATPPS----- 307
Q5UYQ8   262 ------------------GIGMTT------DEIVDLFQVN-----PGFGEeATRyqvd--hirgDTSPTEYSTPA----- 305 Haloarcula marismor...
Q9HN47   265 ------------------NVGLST------DEIVDIYEVN-----PGFGEeMTRyqtd--hiqgDSSPTEYTAPS----- 308 Halobacterium salin...
Q8TVJ5   330 ------------------NVGWDV------DRVVEVFSNL-----PDFDEeRTQyqvrh-iageVGGGTRYLPPN----- 374 Methanopyrus kandle...
Q8ZVK5   238 ------------------HKGWEV------EQIVDLFRTS-----PDFNEkITRyqvqh-iagqVGGRKEYAVPN----- 282 Pyrobaculum aerophilum

5OF3_B   280 CAKMKQL------GLC-----------VSSCNVKNPLQLY 302
Q9HJD1   301 CETM----------RSnhlcymdddplCHREWMKHPLTYY 330 Thermoplasma acidophilum DSM 1728
Q58112   352 CEYCKNWqddggkGLSyyck---pdelCKKKFIIHPLDYL 388 Methanocaldococcus jannaschii DSM 2661
Q6M1A7   324 CEYCKNWrddggkGLGyycr---pdstCSRKDIIHPLDYL 360 Methanococcus maripaludis
O29911   341 CDTM----------RTys-------ncVADCRVSHPLIYY 363 Archaeoglobus fulgidus DSM 4304
CAI48434 308 CTVI----------DEygdcv-dpdetCNR--IQHPLSYY 334
Q5UYQ8   306 CSTM----------QSygdcv-nmddlCEA--ISHPMGYY 332 Haloarcula marismortui ATCC 43049
Q9HN47   309 CATM----------KAygncv-npddlCDA--INHPLSYY 335 Halobacterium salinarum NRC-1
Q8TVJ5   375 CDKM----------KAwgl------cpGKDCGVKNPLAYY 398 Methanopyrus kandleri AV19
Q8ZVK5   283 CETM----------NSwgl-----cptNLGCGVKNPLQYG 307 Pyrobaculum aerophilum
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