5L3Q


Conserved Protein Domain Family
SRP-alpha_N

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pfam04086: SRP-alpha_N 
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Signal recognition particle, alpha subunit, N-terminal
SRP is a complex of six distinct polypeptides and a 7S RNA that is essential for transferring nascent polypeptide chains that are destined for export from the cell to the translocation apparatus of the endoplasmic reticulum (ER) membrane. SRP binds hydrophobic signal sequences as they emerge from the ribosome, and arrests translation.
Statistics
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Aligned: 117 rows
Threshold Bit Score: 97.325
Threshold Setting Gi: 326436082
Created: 5-May-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5L3Q_B        27 GPVNALIRSVLLQERG-GNNSFTHE-----ALTLKYKLDNQFELVFVVGFQKILTLT--YVDKLIDDVHRLFRDKYRT-- 96  human
EGD81652      27 DPINGFIQDVLVEGRgatADSYTVQ-----NYNIKYRIDANNNLVFAAVYNKSVESEsgYIDNLLNVVKKDFVTRFQD-- 99  Salpingoeca ros...
XP_019078685  28 SPIDTLIRSCLLEERS-GaASYNYDap-gaAYTLKWTFHNELGLVFVAVYQRILHLL--YVDDLLAMLKREFSVIYDP-- 101 wine grape
XP_015581008  28 SPIDTLIRSCLLEERS-GaASYNYDap-gaAYTLKWTFHNELGLVFVAVYQRILHLL--YVDELLAMVKREFSEIYDH-- 101 castor bean
XP_002324537  28 SPIDTLIRSCLLEERS-GaASYNYDapgaaSYTLKWTFHNELGLVFVAVYQRILHLL--YVDELLEMVKREFSEIYDP-- 102 black cottonwood
XP_002309350  28 SPIDTLIRSCLLEERS-GtASYNYDap-gaSYTLKWTFHNDLGLVFVAVYQRILHLL--YVDELLAMVKHEFSQIYDP-- 101 black cottonwood
XP_003549540  28 SPIDTLIRSCLLEERS-GaASFNYDap-gaAYSLKWTFHNDLGLVFVAVYQRVLHLL--YVDDLLAAVKREFSRLYHP-- 101 soybean
KRH54945      28 SPIDTLIRSCLLEERS-GaAAYNYDap-gaSYTLKWTFHNDLGLVFVAVYQRILHLL--YVEDLLAMVKREFSQVYDP-- 101 soybean
ERN15977      28 SPIDALIRSCLLEERS-GdSAFNYDaa-gaSYTLKWTFHNELGLIFVAIYQRILHLL--YVDDLLSMVKREFSELYHP-- 101 Amborella trich...
Q54ZR7        26 SPINSLIKKVLLEERsaeTS-FQID-----SYSLKWTFSNEFDLIFVVVYQKIFTLL--YIEELLTTVKKRFIKMYKDll 97  Dictyostelium d...
5L3Q_B        97 -EIQqQSalSLLNGTFdFQN-DFLRLL-----REAEESskirapttmkkfedsekakkpvrsmie--------------- 154 human
EGD81652     100 -ELQqgti-----tgldYTN-VFQKALgkaqqDYAEETsrgmrtfeeterfahtakgsnltrkareqlrkerqqarggsh 172 Salpingoeca ros...
XP_019078685 102 -KRTay---------ddFDE-TFRQLR-----MEAEARaeelkkskpvakpvnnskkqgqvqkvgfeggnkkkggsgpgs 165 wine grape
XP_015581008 102 -KRLey---------ndFDE-TFRQLR-----KEAEARaeelkkskqvgkpvndgkkqglvrkggfqggnkkkidgndgg 165 castor bean
XP_002324537 103 -KRVey---------fdFDE-TFRQLR-----K--EARaeelrkvkpmgndgrkqqvvkkgsggfdggnkknksdakead 164 black cottonwood
XP_002309350 102 -KRVey---------fdFDE-TFRQLR-----KEAEARaeelrkvkpvgkgvndgrklvmkkgsgfgggnkknkseaneg 165 black cottonwood
XP_003549540 102 -QKTay---------rdFDE-IFQQLQ-----IEAESRsenfkkpnpvpalapnrkqngtwqgqglgqnagsekksdgdg 165 soybean
KRH54945     102 -KTTay---------pdFDE-TFRQLK-----MEALARtedlkrsnsnpvagnakkqvqgndksgfeggnkkkksgggad 165 soybean
ERN15977     102 -KRTyy---------edFDD-IFRQLQ-----KEAEARaeemkkskpqakpvesltkkegqiankkkgvllagkekvssk 165 Amborella trich...
Q54ZR7        98 lKLK-ES--SDFIIVDkFQEfNFEVIL-----EDVENRsklqqtsnsapkkyedtdkgklvkdqkneraikegrvekvkr 169 Dictyostelium d...
5L3Q_B       155 ------------------------------------------trgekpkekaknskkkgakkegsdgplATSKPVPAEKS 192 human
EGD81652     173 gedelssgegddddgssggdedtttggdatktgsgngpavsaeeqrrrralalknkgvrgrrsgggkkpRSAAQQPSSSS 252 Salpingoeca ros...
XP_019078685 166 dggdgngrkmengh----------------------------------------------------angntdetkvalva 193 wine grape
XP_015581008 166 dddngkgyklenghsn------------------------------------------------gnlvdiegsrsgvana 197 castor bean
XP_002324537 165 gddgkgrklenghsngn----------------------------------------------hnvvgegnrgmglangk 198 black cottonwood
XP_002309350 166 gngddgkgrklenghsng--------------------------------------------nhnavvvegnrgmglang 201 black cottonwood
XP_003549540 166 kkgrklendnfsvansns-------------------------------------------nanvnhsggkssvnnnigk 202 soybean
KRH54945     166 gddgkrklenghsn---------------------------------------------------gnflvakdtnlsrdv 194 soybean
ERN15977     166 ddasegnhtnghkl---------------------------------------------------engnsngrelgtktt 194 Amborella trich...
Q54ZR7       170 keqekkekaerr----------kqnkannindissdddsddsdsssgsdseensngatknqqtdvariensgykkkVKDT 239 Dictyostelium d...
5L3Q_B       193 glpvgpengvelskeelirrkreefiqkhgrgmeksnkstkSDAPKEkgkkaPRVWELG--GCA-NKEVLDYSTPTTNGT 269 human
EGD81652     253 sssp---------------------------------anppPRSRVS-----TRVEPTK-------HTQLSYCDPDDRPE 287 Salpingoeca ros...
XP_019078685 194 ngkenassnigafdvnklqklrakggkktdtvvnkgskvdpNKKITKk----NRVWDVSptEs-----KLDFTDPADQNG 264 wine grape
XP_015581008 198 ngkenassniaafdvtklqkrgkgakkidtvvvskgpnvdpKKKITKk----NRVWDDSpsEs-----KLDFTDPV-ENG 267 castor bean
XP_002324537 199 enarsnngafdvsklqklkskgvkkttdtsvvvskdskadpKKKITKk----NRVWDDSpkVa-----KLDFTDPVEENG 269 black cottonwood
XP_002309350 202 kenassnneafdvtklqklkskggkktsdtsvvskgsnvdpKKKVTKk----NRVWDDSpkDa-----KLDFTDHVEGNG 272 black cottonwood
XP_003549540 203 enessnvgafdvnrlqklkgkkgngngkkkdalvvaaakgePKKVDKp----NRVWDQPapQt-----KLDFTDHVDGDG 273 soybean
KRH54945     195 ngrhngspnvgafdvhklqklrtkggkktdtvvakaskaepNKKVTKk----NRVWDEAatTe----tKLDFTDHSGEDG 266 soybean
ERN15977     195 hadvkksvpesgafdvsklrklrskaskkmdtfskapkveqNKKTTKk----NRVWDDSpsEs-----KLDFTDPMAEKG 265 Amborella trich...
Q54ZR7       240 pdkq-----------------------------------asssTGKK-----ARTWEDGk-LSKkELEALNRSD---NSN 275 Dictyostelium d...
5L3Q_B       270 PEaALSedinLI----------RGTGSG-GQLQDLDCSS 297 human
EGD81652     288 AAdAIS----ADdiaea-krqaARMAEG---VQDVDFGF 318 Salpingoeca rosetta
XP_019078685 265 DE--------NAvivaa-degeSMMDKEeIVSSESETEE 294 wine grape
XP_015581008 268 NE--------NIevvat-dhgeSMMDKEdIISSDSESED 297 castor bean
XP_002324537 270 NE--------NIqvvaa-dqgeSMMDKEeIISSDSEEDE 299 black cottonwood
XP_002309350 273 NE--------NIevvaa-dqgeSMMDKEeIVSSDSEDEE 302 black cottonwood
XP_003549540 274 DR--------SAdflak-eqgeSMMDKEeILSSDSEVED 303 soybean
KRH54945     267 ER--------NIdfvvaadqgeSMMDKEeIVSSESEQEE 297 soybean
ERN15977     266 TE--------AVvvvd---qgeSMMDREeIVSSDSEIDE 293 Amborella trichopoda
Q54ZR7       276 GTeIVRe--------------kIQKFNIdMDVSSSDDDD 300 Dictyostelium discoideum
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