Conserved Protein Domain Family
Rcd1

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pfam04078: Rcd1 
Cell differentiation family, Rcd1-like
Two of the members in this family have been characterized as being involved in regulation of Ste11 regulated sex genes. Mammalian Rcd1 is a novel transcriptional cofactor that mediates retinoic acid-induced cell differentiation.
Statistics
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PSSM-Id: 335608
View PSSM: pfam04078
Aligned: 62 rows
Threshold Bit Score: 227.452
Threshold Setting Gi: 667640313
Created: 23-Mar-2017
Updated: 23-May-2017
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74988618   139 LIFDLCF--SEK--RESALLELSR-----KR--------EKYND-IAPVLWNSFGTITTLLQEIVSIYPQLS-------- 192
gi 74622172    55 VVSNPK--------ETSKLDELFE-----RL--------KKSPG-MALEIWRYDSMPIFLLQEVVAPYMILS-------- 104
gi 75103860    52 WVCDIHK--PKSymSDFALHNLAY-----HR--------NDFEF-LPSLLWESKNTVYIMLQEVFEAYRHLAghislrlf 115
gi 685306554   43 WINDLHNeiPFV--SNSALQNLVT-----HR--------NTYEI-LPLLLWKSPCTMAMMLQEIVKIYPHIS-------- 98
gi 586693962   61 VILDLQR--EEN--REYALRCLSS-----FLilrreddpENYQR-AGFFLFNSCATMTILLQELVSAYWKMV-------- 122
gi 672805834   63 LIADLAD--IEK--RLDSLNALSV-----IA--------DKHPD-LAIPLWYSYGTVVILLEEIVSVYPYISgk------ 118
gi 484854505   15 vcsNLLK--DSN--KTIHLEKLLS-----FL--------SKNQI-YSLLVWESNGIPILLLQEVVNPYFELG-------- 68
gi 906375610    9 edicghiirnEN--KDESLKQLRT-----IL--------SEKAE-CKSRIVQEFGILTVFLKDISSIYEYLT-------- 64
gi 667640313    3 qnveklrkdllL--EENTLKTLEK-----VLsv-----vESSSK-ACELFWKADELVFVLFQNFIDSFYTLN-------- 61
gi 1104622197  23 LIKHLH----GGnnRDEVLKQLNNlikqqSS--------EAMRInLGFHLWNSSLTTTTLLQEVVAAYAKFE-------- 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74988618   193 -PPLL---T-TSSS-NRVCNSLALLQCVASHPETKQHFLN--------AHIPLFLYPFLN-AESKNRPFEYLRLTSLGVI 257
gi 74622172   105 -TSKF---D-EREC-HRLYTVLNILQILVSEPKIKKVFVD--------ARFPYYIYRYLV-MSDSNSKHETLRISALGVI 169
gi 75103860   116 pHP--------LNP-LRVYNVFLLFQSMACHPDTSRQFLR--------AKMPNYFYPLMD-TGLIDKSDECMRLAALGVI 177
gi 685306554   99 -TPVH---SrEGKP-PRAYNILLLFQCIAHYPETRGYFLK--------AEMPHYLFPLMD-INLTDKPIECLRLGALGVL 164
gi 586693962  123 -DGSL---T-VRET-RRLGNVLTLFQSVAANNETRLKFVQ--------AFIPNFLVPLIL-FESTEEAYENIRGMSLSVI 187
gi 672805834  119 hKETLavsS-YSLI-QRVCKALALLQTIASHPKTQHFLIG--------IDIIYFLTPIFA-LTQVEREIEYLRLTSLGVI 187
gi 484854505   69 -TQSF---N-EDKAkNLILVLKILEILLLEDKSIKKVFVD--------SCFHYYLYKYIT-IYEQAPVYENLRKLTLNVL 134
gi 906375610   65 -LER------ACLP-ENIYTVLEIIILLTDEDKFISYAID--------SNLLLFLYPIIN-SSIRNEEIEELKYITLRII 127
gi 667640313   62 -TELF---D-EGEM-HKIKLCIDILTNIAQKIKIEEFFLK--------LQLDYYIYPFLM-----SSGDESIKISTLKLF 122
gi 1104622197  83 -VSTL---N-MAES-LQVCKALTVWQCIA--------SYPdgrrglvnARIPHYLLPYLGmSTKVIWSLQFLRLRILEFL 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74988618   258 GALVK-V-DN---PDVINFLLQTEIIPLCLRIMETGSELSKTVATFIVQKILIDELGLNYIC--ATPERFYAVSTVLSNM 330
gi 74622172   170 ASLLQ-N-GD---QYIHKQLKTTEVVPLLLKIVDLGSEASQLLSANIFGLIIGNDDGLNYAC--QTFDRFSAINLMFNSL 242
gi 75103860   178 AHMLKaS-ED---GAVNRYLMESGVVGFCVKPIEFGSTETKKVALYILDKIMSTDQGLYYCC--VLADRFYVIDELLKKV 251
gi 685306554  165 AHMLK-ApID---GAAVRFLMDNGALRYCIKAIEIGSTESKTVSVFILNKILSTNEGLQYCC--VLADRFFLIDGLLKNL 238
gi 586693962  188 GIICQ-E-RE---PDIIKWAVDNNIVEICRRGIQIGGELSKVIAMHIIEAILQDKSGISYICkpEADHLLKNLLETWEHM 262
gi 672805834  188 GAMSK-T-RD---PQIVKYLMDKEVLMICIVSIQHAAEISRVIATFILSKLFSESTALENVC--ETPQKILSIANLLCHS 260
gi 484854505  135 YALLH-N-SD---LHVHNQMKNTEIVPIILKSIDLGTEAVKIQSIDLFFKIVSSEDGLNYAC--QTFDRFSAINQVLNSV 207
gi 906375610  128 KCILQrN-KI---EHLIEFFKNTELVPLCLRNMELGRKKTKIEASEVFYLIISVQEGLEYSC--QTYDRFMAISMILNSV 201
gi 667640313  123 SALLK--------DERHEGMRISELLPLILKIVDSGSEECQILALETLGLVLIGN-GLDYAV--QTIDRFRAIDVVLNPL 191
gi 1104622197 149 VALAK-F-DElhgQEILHVLLDTNLFSLCLHCIRHGDTQIQKAATLILMKILMQEDGLKYCC--AYPDDFQSLIQVLRQL 224
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74988618   331 V---N--ALIENP---SSRLLKHIVRCYLRLSENPRALEALKCCLPD---SLKhiNKAFIPCLKEDPYTKKWLIQLLYNI 399
gi 74622172   243 AsqaV--SLg------STRLIKVALRIYIRLCAKPHIRALLSSKKPD---GLF--TDEASLLIASDGECKALFKtftnli 309
gi 75103860   252 LfylS--NM-VRP---PSSLFSLVTGCYVKLSQNSRARNGIRRYTPF---LLF--DGTFSRLYAEDPVAANNRIQLLQNL 320
gi 685306554  239 L---VylSSMTNP---SPSLFNLIAGCYAKLSQKPRAREGLWRFPPV---MLL--NGTFASLFAEDPDAVNYRKQLIRNM 307
gi 586693962  263 V---M--VLSVNKd-hSPRLLFHIIRCYVLLCTDTRGFNMLIDYLPE---PIT--NNSFQQITEEFPVIRRMLEQLLMNt 331
gi 672805834  261 I---V--TTVMQKrdvNGRLVRYSLDCLNRLSTNPKATPQLHSVVTEykgLFK--DHLLEYIVSKEPSLKPKYDEFCRNI 333
gi 484854505  208 M---Y--HAVQIK---SSRIIKSIIRVYLRLCDKQQIRTNLSASKPD---NLS--NEEIKKVIQNDPECCKMYKEFLEII 274
gi 906375610  202 L---V--QMETIQ---SPKLLELTIKIYTKLCDMPNAKIAFNKNRPH---MLY--TESIREIVKSNPAVKAAYDEFLAIL 268
gi 667640313  192 V---K--RSVLSK---NLIFLKQLLKIYTRLCDHNNVRMKVREKPPE---GLD--SKEMMSLCERDEELLSIWTKFMHTL 258
gi 1104622197 225 VeetF--TF-EIP---CPQHLKYVIQCYLCISRVAredg----------------------------------------- 257
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