Conserved Protein Domain Family
Upf2

?
pfam04050: Upf2 
Up-frameshift suppressor 2
Transcripts harbouring premature signals for translation termination are recognized and rapidly degraded by eukaryotic cells through a pathway known as nonsense-mediated mRNA decay. In Saccharomyces cerevisiae, three trans-acting factors (Upf1 to Upf3) are required for nonsense-mediated mRNA decay.
Statistics
?
PSSM-Id: 335592
View PSSM: pfam04050
Aligned: 124 rows
Threshold Bit Score: 78.1136
Threshold Setting Gi: 224000699
Created: 21-Mar-2017
Updated: 23-May-2017
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74616558    963 EEe---eIVVtrqqe------evdpEEEAEFEREFAKMMAESL-DS---RKFERKqq----fDLPLPiklkpre------ 1019
gi 303276689  1136 pvelapeERVkrvvp------kvskEVEADFDREMSKFLGPGI-VA---AKTPVVas---ygQTP--------------- 1187
gi 219129779  1236 didsesggnseeeeeefdeeaymrqLEEEAFERELRRVTIEAL-EK---GKNTSRklv--aeNMVSGsqtfk-------- 1301
gi 672276354    32 eeeeeggaedeaedlrdyvrehvqkEEELRFDADFAQMMLASL-NE---AKTLRRpt---ssEMKIPanvlk-------- 96
gi 224000699   935 deeesdneeedgideaaaeaayirqLQDEAFESELRKLTMDAL-ER---GKMSARtgaggkvSSQMPaapqf-------- 1002
gi 347963633   959 DEeqeeeer----------pvaqkqPEDLEFEREFERMAAEYC-QQ---RAKDAAkvn--pkHVPIPi------------ 1010
gi 1005949021 1018 TEgekerMVLddrsmp---pklvecPEDDLFRKEFDRIMSESL-IS---RGQEAIrgt--lnDIVIPmnklvaak----- 1083
gi 309363812   940 egeqefedsdeerqrglsmsnavtkEEDDDFQRELDRMMGEGF------RQSAAPaaa-vqyDVTLPaaaknrfsrnikf 1012
gi 397591250   230 SDysdgdDEMddvdeaeaeaaytrqLEDEAFEAELRRLTMDAI-EK---GKVTSKsgg-akvSSQMPv------------ 292
gi 672275322   311 DEaedlrDYVreh---------vqkEEELRFGADFAQMMLASLnEAktlRRPTSS-------EMKIPanvlketeslsea 374
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74616558   1020 ------stavgesS-----------------AANEAGPSEAPPS---G--EKMAFSL--------LTK-KGN--RQQTRT 1060
gi 303276689  1188 -------------------------------STVARAAPTTRGPgmnGpgPTVAFKM--------LVK-KDG--KPASRT 1225
gi 219129779  1302 --------kkptdL-----------------SKPVGASSAVAPTfglAgtPGITFQL--------L-K-KGNkgKVEAKE 1346
gi 672276354    97 --------eteslSeaprpsseeasarevltSGDADEGDLDPDGplpRptTAMRLVL--------RRPdKRN--RFVVRP 158
gi 224000699  1003 --------akkpgV-----------------AEPKQESEVDPTTnpfGgsEGMSFKLlkkgnkgkM----------EEKQ 1047
gi 347963633  1011 -------------Tf----------------RSDTKKTYDQLQEptnVkpDTVPFAL--------MIRsKGK--QQTYRK 1051
gi 1005949021 1084 ------ksvafsdIg----------------SAASSKDEENSEKlnnNetPTLNLMV--------MTRaKGN--KPLLKP 1131
gi 309363812  1013 aedtkarsspsrsSe----------------MDFDDEPSSSTGVaasGrqKQGRVTL--------MVRgKAN--KPALKT 1066
gi 397591250   293 -------------Ap----------------QFAAKKAGPADDAespFgaDGMSFKL--------FKRgNKG--RQEEVQ 333
gi 672275322   375 prpsseeassrevLt----------------SGDADDGDLDPDGplpRptTAMRLVL--------RRPdKRN--RFVVRP 428
                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 74616558   1061 VELPSDSHFAIAMKKKQQ---A---EKEEQQRIKNLVLN 1093
gi 303276689  1226 LDVPAEAEFVARVKEQAE---A---EQRERAELKRLVLM 1258
gi 219129779  1347 IVVPSDTNFAKVASKQDD---A---AARERNFIKQRVLQ 1379
gi 672276354   159 LAVPTDASLAEHSRRKDQqarQ---EKAERADLKKFVIE 194
gi 224000699  1048 FLVPTSTNLARRATKVDD---E---AVKEKEMIKARVLQ 1080
gi 347963633  1052 FEAPEDSPLAQYIREQER---K---LQEEKDSVKRLTLN 1084
gi 1005949021 1132 VQVPIDSDLALSLKQKEE---A---ERAEKQQVKKLTLH 1164
gi 309363812  1067 VNI-DDGELQRRWKEEKA---R---EEEERADMKRLTLG 1098
gi 397591250   334 FVVPRDNSLAQRATRQDD---E---AAKERELLKARALQ 366
gi 672275322   429 LAVPTDASLAEHSRRKDQ---QarqEKAERADLKKFVIE 464
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap