4Y97,3E0J,3FLO


Conserved Protein Domain Family
DNA_pol_E_B

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pfam04042: DNA_pol_E_B 
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DNA polymerase alpha/epsilon subunit B
This family contains a number of DNA polymerase subunits. The B subunit of the DNA polymerase alpha plays an essential role at the initial stage of DNA replication in S. cerevisiae and is phosphorylated in a cell cycle-dependent manner. DNA polymerase epsilon is essential for cell viability and chromosomal DNA replication in budding yeast. In addition, DNA polymerase epsilon may be involved in DNA repair and cell-cycle checkpoint control. The enzyme consists of at least four subunits in mammalian cells as well as in yeast. The largest subunit of DNA polymerase epsilon is responsible for polymerase epsilon is responsible for polymerase activity. In mouse, the DNA polymerase epsilon subunit B is the second largest subunit of the DNA polymerase. A part of the N-terminal was found to be responsible for the interaction with SAP18. Experimental evidence suggests that this subunit may recruit histone deacetylase to the replication fork to modify the chromatin structure.
Statistics
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Aligned: 30 rows
Threshold Bit Score: 129.72
Threshold Setting Gi: 157434696
Created: 5-May-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4Y97_A       343 LVACGPYTTs---DSIT----YDPLLDLIAVIN---------HD-RPDVCILFGPFLDAKHEQVENCLL----------- 394 human
Q19366       187 AFVSGLDLTgdleDDRLtisgLEFMADWMNVQVgn-----enQCpPIDRLVVIGPLVETKSNGCDVQSVvrtlt------ 255 Caenorhabditis ...
P46957       215 ALVSGLNLNn---TSPDrllrLEILREFLMGRInnk----idDIsLIGRLLICGNSVDFDIKSV---------------- 271 Saccharomyces c...
Q7PWN0       175 VLISGLNESa---ANDFst-pLELLQQWVFGNLeglldghdwEAaSIVRIVIAGNSVKASPKPKNHHSSkv--------- 241 Anopheles gambi...
Q9W088       176 VLASGLDQLq---AHKFve-aLNLFQYWLAGSLgn-----nkEAgSMVRLIVAGNSVRASAMAHVPTLQvar-------- 238 fruit fly
O48520       183 VLLSGLCIGs---KSANpl-qFQLLVDHITGHLgdee--eqgLAaQIVHVVIAGNSFEFPRKLINGQNLas--------- 247 thale cress
O35654       197 LLVSGLGLGg---GGGEsllgTQLLVDVVTGQLgdeg--eqcSAaHVSRVILAGNLLSHNTQSRDSINKakyl------- 264 house mouse
P87324       187 AAVSGLGLSn---DGIEgi-qVHQLVDFLRGTLphv---ssfSPsSIKRLIILGNCLAPSIEIADSASAsvpigkkkvkr 259 Schizosaccharom...
3E0J_A       201 rfvllvsglglgggggesllgTQLLVDVVTGQLgdeg--eqcSAaHVSRVILAGNLLSHSTQSRDSINKakyl------- 271 human
XP_009302412  20 LLASGLGLNg---SRADsmmgLQLLVDMVTGQLgdeg--eqsGAaSISRVILAGNLLSRSTQDKDSTNKakyl------- 87  zebrafish
4Y97_A       395 ----TSPFEDIFKQCLRTIIEGTR---SSgSHLVFVPSLRDVHHEPVYPQPPFSYSDLSREDKKq--------VQFVSEP 459 human
Q19366       256 lsraEKHSSTASLITVDKIINSIAekpLV-NTVDVTPGVGDPCSS-MWPLPPIHRVCLPRCGMSdk------kVNLVTNP 327 Caenorhabditis ...
P46957       272 ----NKDELMISLTEFSKFLHNIL---PS-ISVDIMPGTNDPSDK-SLPQQPFHKSLFDKSLESyfngsnkeiLNLVTNP 342 Saccharomyces c...
Q7PWN0       242 --ttETDALLGAVKTVDSLIHNLA---QS-VPIDLMPGEFDPANH-MLPQQPMHHCLFPRSKGFa-------sFRGVPNP 307 Anopheles gambi...
Q9W088       239 -tqaNANDTVQAVSQLDQWFASWA---RS-LPVDIMPGPYDPANF-MLPQQPFHKCMFPQAAQLa-------tFQAVTNP 305 fruit fly
O48520       248 ---kDQSTLYEPIKELDIMLSQIA---AG-VSVDIMPGTNDPANF-ALPQQPLNRCLFPGSSPYn-------tFRSCTNP 312 thale cress
O35654       265 -tkkTQAASVEAVKMLDEILLQLS---AS-VPVDVMPGEFDPTNY-TLPQQPLHPCMFPLATAYs-------tLQLVTNP 331 house mouse
P87324       260 ygydTSAYNPNPTFQLDNFLDQVC---SS-IDVTLMPGPYDYSST-ILPQQPLHPALLTKSKVWlg-----ssLQTVTNP 329 Schizosaccharom...
3E0J_A       272 -tkkTQAASVEAVKMLDEILLQLS---AS-VPVDVMPGEFDPTN-YTLPQQPLHPCMFPLATAYs-------tLQLVTNP 338 human
XP_009302412  88 -tkkTQAGSVEAIRLLDELLMQLV---AS-VSVDVMPGQYDPTNY-TLPQQPLHRCMFPLSIPFp-------tLQLVSNP 154 zebrafish
4Y97_A       460 CSLSINGVIFGLTSTDLLFHLGAEEISSSSG-----------------TSDRFSRILKHILTQRSYYPLYPpqEDMAIDY 522 human
Q19366       328 YEFEVNGLRVMTMSGENVSELLRTSLKWTG-----------------------ADAIENIIKWQHVAPNCPd-TLDAFPV 383 Caenorhabditis ...
P46957       343 YEFSYNGVDVLAVSGKNINDICKYVIPSNDNgesenkveegesndfkdDIEHRLDLMECTMKWQNIAPTAPd-TLWCYPY 421 Saccharomyces c...
Q7PWN0       308 YAFDLADRYVVGTSGQNVLDVMRYSKIESP-----------------------LEALKATLRWGHLIPTAPd-TLPCYPY 363 Anopheles gambi...
Q9W088       306 YSCRLDEALVVGTSGQNVSDLLRSTSLDSA-----------------------LEALRCTLTWGHVAPTAPd-TLACYPY 361 fruit fly
O48520       313 HSFDVDNIRFLGTSGQNIDDLGKYSEAKSK-----------------------LDFVERTLRWRHLAPTAPn-TLGCYPF 368 thale cress
O35654       332 YQATIDGVRFLGTSGQNVSDIFRYSSMEDH-----------------------LEILEWTLRVRHISPTAPd-TLGCYPF 387 house mouse
P87324       330 TWLSLGNHFVLATSGQNINDLRKYHPKKSS-----------------------LQCMENTLLWNHITPTSPd-TLWCYPF 385 Schizosaccharom...
3E0J_A       339 YQATIDGVRFLGTSGQNVSDIFRYSSMEDH-----------------------LEILEWTLRVRHISPTAPd-TLGCYPF 394 human
XP_009302412 155 YQAIVDGVRFLGTAGQNVSDMVKYSSVDDH-----------------------LEILESTLRLRHLAPTAPd-TLGCYPF 210 zebrafish
4Y97_A       523 ESFYVYAqLPVTPDVLIIPS-ELRYFVK 549 human
Q19366       384 AERDPLI-MDITPHVIICGNqPHAEFRH 410 Caenorhabditis elegans
P46957       422 TDKDPFV-LDKWPHVYIVAN--QPYFGT 446 Saccharomyces cerevisiae S288C
Q7PWN0       364 YEKDPFI-IGECPHVYFAGN--VGEFST 388 Anopheles gambiae str. PEST
Q9W088       362 IESDPFI-LRECPHVYYAGN--CESFAT 386 fruit fly
O48520       369 TDRDPFL-IETCPHVYFVGN--QDKYDN 393 thale cress
O35654       388 YKTDPFI-FPECPHVYFCGN--TPSFGS 412 house mouse
P87324       386 TDKDTFV-MEEMPDLYLCGN--QPKFGC 410 Schizosaccharomyces pombe 972h-
3E0J_A       395 YKTDPFI-FPECPHVYFCGN-T-PSFGs 419 human
XP_009302412 211 YQKDPFI-LEECPHVYFSGN--APSYqs 235 zebrafish
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