Conserved Protein Domain Family
Rpr2

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pfam04032: Rpr2 
RNAse P Rpr2/Rpp21/SNM1 subunit domain
This family contains a ribonuclease P subunit of humans and yeast. Other members of the family include the probable archaeal homologs. This family includes SNM1. It is a subunit of RNase MRP (mitochondrial RNA processing), a ribonucleoprotein endoribonuclease that has roles in both mitochondrial DNA replication and nuclear 5.8S rRNA processing. SNM1 is an RNA binding protein that binds the MRP RNA specifically. This subunit possibly binds the precursor tRNA.
Statistics
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PSSM-Id: 335586
View PSSM: pfam04032
Aligned: 283 rows
Threshold Bit Score: 37.6363
Threshold Setting Gi: 209878298
Created: 24-Mar-2017
Updated: 23-May-2017
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q6MFZ6        13 RLNFLYQAAHCvlsQNPENQALARFYCHTEKTIAKRLVL-R-------QDPSVKR----TLCRDCSSLLIPGLTCTQRQ- 79  Norway rat
Q54IA5        69 NLNYLWSLSHC---SQPINPSLGGYYMYKFREIANIAEMnG-------VPDQIET----RNCKNCGTFLIPGVNCRVRIv 134 Dictyostelium d...
EIE91350      10 RLDFLFNASHv---MFSQCPSLSRYYMNEFQQTLNEYEL-K-------PTKQIER----LACQSCGEIAIPGLNTRVNI- 73  Rhizopus delema...
CBJ29737      44 RMDFLWRASNCl---RLVSPAVSRIYSDQLRKLCAEYEA-RrpgsgplLPEWVSD----SLCNSCGGILTPGITCRIRV- 114 Ectocarpus sili...
XP_020435775 191 RLNHLWKAASLm--QVGGATDEARWLMFNFGECAVDNYV-Sg------VPTERKSsggiRICVKCANHLVPGVNCTLRV- 260 Polysphondylium...
XP_003293595  34 NLNYFWVLAHS---TQPRNPQLGGYYMYKFREMANIKQLrG-------VPTMIES----RTCSNCGTFLIPGINCRVRIi 99  Dictyostelium p...
XP_004350891 209 KLNFLWNACKY---NLSTSTTYSSLLMNQFQQLEDKWEYnA-------IPPKEND----SICEKCGSILIPGVNCNVRI- 273 Dictyostelium f...
XP_001630354  11 RSEFLSKIGAQ---YAQTIPEISRFYFNQFEQYSKEYQG-G-------QIQGLRE----KYCEKCGSQF-DAKNCKVRIv 74  starlet sea ane...
EPB85131      24 RLDFLFEAGHT---MLSECPSLSRYYMNEFQNTLTEYEL-T-------AHKPIAR----LSCKSCGQISIPGLNHRIEI- 87  Mucor circinell...
ESA00215       9 RLQFLWNASHT---FLSTVPSLSAFYMQQFNQFSAEKEL-S-------LAEAVKR----KYCSYCGSIFLPGINSQVRIe 73  Rhizophagus irr...
Q6MFZ6        80 -------------------RR------RK----------------------GQ---------R----------------- 86  Norway rat
Q54IA5       135 ----------------------------K----------------------RS---------Dlsirskslisttn---- 151 Dictyostelium d...
EIE91350      74 -------------------IQ------KNr---------------------REkkkmkkqtkN----------------- 90  Rhizopus delema...
CBJ29737     115 -------------------RH------RSlaspsvkkakaktrvektntnkCR---------N----------------- 143 Ectocarpus sili...
XP_020435775 261 -------------------KH------KSs---------------------SG---------N----------------- 268 Polysphondylium...
XP_003293595 100 ----------------------------K----------------------TD---------Qlsnksrslistntkein 120 Dictyostelium p...
XP_004350891 274 -------------------KNikdiggLK----------------------RN---------Klynreev---------- 293 Dictyostelium f...
XP_001630354  75 kkiksnkrrrykkqvsnsvDGi-----TS----------------------SR---------Krfgkyeh---------- 108 starlet sea ane...
EPB85131      88 -------------------IHk-----QS----------------------RK---------Qnktkk------------ 100 Mucor circinell...
ESA00215      74 knkkrkgnkkknsdldlvgQPk-----ES----------------------NV---------Ikqeknsqekkekr---- 113 Rhizophagus irr...
Q6MFZ6        87 ------------W------------------------TvQTCLTCQ 96  Norway rat
Q54IA5       152 leinslssklkqQsslkqnqs---------kkptnalI-QFCLQCC 187 Dictyostelium discoideum AX4
EIE91350      91 ------------L------------------------VeSTCLTCG 100 Rhizopus delemar RA 99-880
CBJ29737     144 ------------E------------------------VvTTCLTCG 153 Ectocarpus siliculosus
XP_020435775 269 ------------Qslqqqrksr-------kdnktvgfIkIHCNQCQ 295 Polysphondylium pallidum PN500
XP_003293595 121 slefrlkpspqqQqqqqqqqqqqqslsknsnklnnsiT-RVCLKCN 165 Dictyostelium purpureum
XP_004350891 294 ------innklnNkik------------------naiI-KTCTQCK 314 Dictyostelium fasciculatum
XP_001630354 109 -----stkskiaHrkr------------------cliS-KTCQICE 130 starlet sea anemone
EPB85131     101 --------ivqpNt----------------------iK-STCLTCG 115 Mucor circinelloides f. circinelloides 1006PhL
ESA00215     114 qiiyiypsnhnnNpkkqthik---------rqhknhvS-YVCNTCN 149 Rhizophagus irregularis DAOM 181602
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