6GMH


Conserved Protein Domain Family
Paf1

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pfam03985: Paf1 
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Paf1
Members of this family are components of the RNA polymerase II associated Paf1 complex. The Paf1 complex functions during the elongation phase of transcription in conjunction with Spt4-Spt5 and Spt16-Pob3i.
Statistics
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Aligned: 43 rows
Threshold Bit Score: 235.689
Threshold Setting Gi: 388583757
Created: 6-May-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6GMH_V   112 VCRVKYCNSLPDIPFDPKFITYPFDQ---NRFVQYK-ATSLEKQHKHDLL-------TEPDLGVTIDLINPDTYRI---- 176 human
CCF55803   8 IAKIRYENNLPPPTVPPKLLNYQINP---DEDVD---SPQLITSLYTRTNvtp-lvdINGDLGMPMDLMEIPGLLNkndt 80  Kazachstania africa...
EDO16459   8 IAKISYQNNLPPPLLPPSLLKFQDNE---NENAD---SPQLITSLYTKTNvns-lvnLDSELGMPLDLFKIPGLLNnsdt 80  Vanderwaltozyma pol...
CCE81444  13 ISKVRYINDLPPPPLNPKFLEYNTTE---RSSTKTE-SEQVISSLFRKENfhsliecIDEDMGMNLNLLNNKGFLDende 88  Millerozyma farinos...
EPY53462   9 ILRVRYHNPLPPPPFPPRLINISNPV---KQYALPNfVSNLIQEKKIAIE-------NDAELGMPMDLAAVDGFFEgdts 78  Schizosaccharomyces...
Q9US06     9 ILRVRYHNPLPPPPFPPKLINIPNPV---KQYALPNfVSTLVQEKKIPIE-------NDIELGMPLDLAGITGFFEgdts 78  Schizosaccharomyces...
CCD51508  14 IARIRYSNALPPPPNPPKLLDIPNTGlasGQYTTPGfATRLARDQPLNIE-------ADAELGMPLDLVGMPGIFDgdes 86  Botrytis cinerea T4
EHK48006  18 IARIRFSNALPPPPNPPKLLDIPNTGlasGQYTTPGfASRLAREQPLNIE-------ADAELGMPLDLVGMPGVFDgder 90  Trichoderma atrovir...
EGR52726  19 IARIRFSNALPPPPNPPKLLDIPNTGlasGQYTTPGfASRLAREQPLNIE-------ADAELGMPLDLVGMPGVFDgder 91  Trichoderma reesei ...
GAA21825   8 IAPIKYQNSLPVPQLPPKLLVYPESP---ETNAD---SSQLINSLYIKTNvtn-liqQDEDLGMPVDLMKFPGLLNklds 80  Saccharomyces cerev...
6GMH_V   177 -Dp-------------nVLLDPADEKLLEEEiqapTSSKRSQqHAKVVPWMRKTEYISTE-FNRYGISN--EKPEVKIGV 239 human
CCF55803  81 rYlys---------fdnVKLDPKDRILLRDP----RVDRLTKtDMSKVKFLRRTEYVSST---------------IAASN 132 Kazachstania africa...
EDO16459  81 kFlng---------fenVRLHADDRILLRDP----RVDRLTKtDISKVSFLRRTEYISTSi---------sSHSDSLTSN 138 Vanderwaltozyma pol...
CCE81444  89 sVigmflneknkkdnkpVTLHERDRELLRDA----GIERIAR-SELGVSFLRRTEYISEKqFMKPSANGveNGAHKLTKg 163 Millerozyma farinos...
EPY53462  79 wNqsd---------msgMNLEPVDRSLLKVAggs-------gsSHVEVPFLRRTEYISAE-------VGrnSSTRGNLRL 135 Schizosaccharomyces...
Q9US06    79 wMhsd---------lssVNLDPIDRSLLKVAggs-------gsTHLEVPFLRRTEYISSE-------VAraASNRGNLRL 135 Schizosaccharomyces...
CCD51508  87 sIqap---------lhpPQLHPHDRALLRPL----ATLGKPKfSDTGVSFLRRTEYISSGfTSKARMEGttSAKGLVDTR 153 Botrytis cinerea T4
EHK48006  91 sIqap---------sqpLAVHPHDRALLRPI----AALGKPKvAEANVSFLRRTEYISSL-IPKRFe---aNHPRALLAK 153 Trichoderma atrovir...
EGR52726  92 sIqas---------sqpPPVHPHDRALLRPI----AALGKPKvAEANVSFLRRTEYISSL-MPKRLe---aNHPRALLAK 154 Trichoderma reesei ...
GAA21825  81 kLlyg---------fdnVKLDKDDRILLRDP----RIDRLTKtDISKVTFLRRTEYVSNTi---------aAHDNTSLKR 138 Saccharomyces cerev...
6GMH_V   240 SVKQqf----tEEEIYKDRDSQITA-IEKTFEDAQKSIS-----QHYSKPRVTPVEVMPVFPDFKMWINP--CAQVIFDS 307 human
CCF55803 133 TKKRprnrledDDDKVLNPAEIVTR-VENTFEAMTDDLSk---lRHPVKRHLKATKVWNLIPDTASMDQN--YFTLKLVG 206 Kazachstania africa...
EDO16459 139 KKRTrdsshdeDDDRILNSHEISEK-VEGTFEKNSEDLSs---fRHPIKKKLQAVKSWKLLPDTSSMDQN--YFTLRLVG 212 Vanderwaltozyma pol...
CCE81444 164 k---------eDNQEKLDADAQLQA-VEKTFADAQKTLQdfqniKHPRRKNLKAVAAWPILPDTSMLDSK--FLNVKFFG 231 Millerozyma farinos...
EPY53462 136 TASTskaiaeqRGRSLREIPNQIQA-IEQTFSAVQQPLEn---lKHPTKPELKPVGAWNFLPNDSMAGIQ--HLMLRVSD 209 Schizosaccharomyces...
Q9US06   136 TASTskalaeqRGRSLREVPKQLEA-INESFDVVQQPLEq---lKHPTKPDLKPVSAWNLLPNTSMAGIQ--HLMLRVAD 209 Schizosaccharomyces...
CCD51508 154 KPKPv-----qNLPADRESPAYIKAqVEKGFETAAANLKdrtrvRHPTKRNVQLVNAVPLIPDLDAFPDAggYVLLKFLT 228 Botrytis cinerea T4
EHK48006 154 SRRPv-----kRPEPAADSPQAIKRkIDKGFEVAEQDLKdpkriKHPSKKHLKLVDALPLVPDLDAFPDSgaYVTIKFLT 228 Trichoderma atrovir...
EGR52726 155 NRRPa-----kRPEPAADSPQVIKRkIDKSFEIAEQDLKdpkrvKHPSKKHLKLVDAAPLLPDLDAFPDSgaYVTIKFLT 229 Trichoderma reesei ...
GAA21825 139 KRRLdd---gdSDDENLDVNHIISR-VEGTFN----KTDk---wQHPVKKGVKMVKKWDLLPDTASMDQV--YFILKFMG 205 Saccharomyces cerev...
6GMH_V   308 DPAP----KDTSGAAA--------LEMMSQAMIRGm-MDEEGN---------------------QFV--AYFLPVEETLK 351 human
CCF55803 207 SAALdkreKE--------------ALALKTTIFRPveLEED-----------------------EWM--SMYTTDMKDSE 247 Kazachstania africa...
EDO16459 213 SATLskqeKN--------------TLALQTTIFRPveLEED-----------------------DWI--SMYTTDVKDSK 253 Vanderwaltozyma pol...
CCE81444 232 SASFsremQLLKRQEKekydeqfqKNSLETSIFRP--ITSDDG---------------------EWI--SLYQSKDPQRT 286 Millerozyma farinos...
EPY53462 210 NLTDrtptSSTPGEEDv-------SNRHKVALFMP--SSAEGE---------------------QYL--SYYLPSEESAE 257 Schizosaccharomyces...
Q9US06   210 DLSErshsYSSLVNLQegh---nlTKRHEVALFMP--SSAEGE---------------------EFL--SYYLPSEETAE 261 Schizosaccharomyces...
CCD51508 229 NPVPpsstYD---------------ARVESSVLRPadPTEAELemkeaarqayeldphnnpppdEKIqyEMFMPDTVTDA 293 Botrytis cinerea T4
EHK48006 229 NPVSssneYD---------------NRLRSGLFRPidRTAAEEaaleaameaynqdpvsnpkpaNLMnyDFYLGQSRADA 293 Trichoderma atrovir...
EGR52726 230 NPVSssseYD---------------TRLRSGLFRPidRTAAEEaaleaameaytqdpvnnpkpaNLMnyDFYLGQTRADA 294 Trichoderma reesei ...
GAA21825 206 SASLdtkeKK----------------SLNTGIFRPveLEED-----------------------EWI--SMYATDHKDSA 244 Saccharomyces cerev...
6GMH_V   352 KRKR-------------DQEEEMDYAp-dD----VYDYKIAREYNWNV----KNKASkgy----eenYFFIFRE------ 399 human
CCF55803 248 TLEK-------------SIERVIDENltaDdsnkVFRFRRLRDFDMKQakstDSSLSe---------LAIVLNNek---- 301 Kazachstania africa...
EDO16459 254 ILSN-------------ELEKKIDDSsngLek-kVYKFKRLRDFDMKQiqtmENMGPsqqt--qlndLALIFNDek---- 313 Vanderwaltozyma pol...
CCE81444 287 QILKdklnssekekqvyVLDEEEDAE--------EYKFEHIKEYDMSFqrynKPYEE----------LAIKFASegepns 348 Millerozyma farinos...
EPY53462 258 KIQ--------------QASNNSSSTe------gPFLYNLFRNFDASM--------LvnpsgledlcLSICTDQenp--- 306 Schizosaccharomyces...
Q9US06   262 EI---------------QAKVNDASAdvhE----PFVYNHFRNFDASM--------HvnstgledlcLTFHTDKdhp--- 311 Schizosaccharomyces...
CCD51508 294 KNIKrkfdvldpehddrDLYSQFDEEtgkG----AFRLKRLRGYETVQ------TSGgtddkydeyvVIAMHDG------ 357 Botrytis cinerea T4
EHK48006 294 DRFRrkfdvddadrdeeDLYTHRGDTg--G----YFQFNRIRAYETAQ----ETELDhptky-edeiILSINEK------ 356 Trichoderma atrovir...
EGR52726 295 DRFRrkfdvddpshdddDLYTHKADTg--G----YFQFNRIRAYETAQ----ETELDhptky-edeiILAVNDD------ 357 Trichoderma reesei ...
GAA21825 245 ILEN-------------ELEKGMDEMdddShegkIYKFKRIRDYDMKQvaekPMTE-----------LAIRLNDkd---- 296 Saccharomyces cerev...
6GMH_V   400 Gd-----GVYYNELETRVRLSKRRAKagv----------qsgTNALLVVKHRDMNEKELEAQEARKAQlenHEPEEEEEE 464 human
CCF55803 302 ------gVAYYKPLRTRIELRRRRVNdvikp------lvtehNIDQLNISLRNPTTSEVNTRDRLRMKfdpINFVPVDEE 369 Kazachstania africa...
EDO16459 314 ------kAVYYKPIRSKIELRSRRVNdvirp------lvrehNLDQINISLRNPTTQESNLRDKLRTKfdpIDFPYVDED 381 Vanderwaltozyma pol...
CCE81444 349 KgdrkrkAAYYYPVTGKIDLKKHRAStnaein----rfirdsAYDIVNYKLREPNTNEMRRMDTIRSEfdpMEYEGEEEV 424 Millerozyma farinos...
EPY53462 307 ----knnKALYTPIYARSTLKRRHVRapv----------npdTIDGIELTLREPNREESVQLKRARYDsfaMGDVEALEK 372 Schizosaccharomyces...
Q9US06   312 ----eanQVLYTPIYARSTLKRRHVRapv----------sldAVDGIELSLRDLNDEESLQLKRARYDtfgLGNIKDLEE 377 Schizosaccharomyces...
CCD51508 358 TdglhqkAAHYYPVVQRSSIRPQRTKniqkmrhn-isgeeeeVLDMVDLSIVDPGAETKQVMEGFKTWpygENHE---DD 433 Botrytis cinerea T4
EHK48006 357 DtdasqkAVFYYPIMQRSTIRPQRTRniartnyglaeddepqVVDQLDLTVDEPTEEMRAAMKMYARHpmgWEQD----- 431 Trichoderma atrovir...
EGR52726 358 TtypkqkAVYYYPIMQKSTIRPQRTKniartnygladddeaqVVDQLDLTVEDPTEEMRGAMKMYAEHplgWDQEEGAEE 437 Trichoderma reesei ...
GAA21825 297 ------gIAYYKPLRSKIELRRRRVNdiikp------lvkehDIDQLNVTLRNPSTKEANIRDKLRMKfdpINFATVDEE 364 Saccharomyces cerev...
6GMH_V   465 EMETEEkeaggsDEEqEKGSSSEKEGSEDEHSGSESEREEGDRDEA---SDKSGSGEDESS 522 human
CCF55803 370 EEEKEE------ESR----EDDMSKEKHDDNEQHKHEDLDSTQNQI---TGKADSKEDEVE 417 Kazachstania africana CBS 2517
EDO16459 382 EDENEK------GVE----SSQQPGEQHDSDGEESLPLSAQSHDSL---PLSAQEHGSQGI 429 Vanderwaltozyma polyspora DSM 70294
CCE81444 425 AETNET------QPN------EEEQEKKDQDNGSSINNDQENNGET---KPEDDSSLKNQE 470 Millerozyma farinosa CBS 7064
EPY53462 373 EEQEIA------EEQ-AGEENELNEIEEQHQDENPLPNPSENPQPL---PTEESGQLSTKN 423 Schizosaccharomyces cryophilus OY26
Q9US06   378 EEEKLR------SVE-GSLNEELSEEEKPAESREQLESAEQTNGVK---PETQAQNMSASE 428 Schizosaccharomyces pombe 972h-
CCD51508 434 AERDAA------EVE-------------DALSEADAEGEDDDLNSPvrpSLGGKTIASRVQ 475 Botrytis cinerea T4
EHK48006 432 -----E------EDE-LHQGVERSIEEGDVDADGDAEGEDADRNGA---SSPAEKYHERSP 477 Trichoderma atroviride IMI 206040
EGR52726 438 HEHEQE------HEH-EHEHIEQSIEDADVDAD----GEEAERNGA---SSPGGQ--ERSP 482 Trichoderma reesei QM6a
GAA21825 365 DDEDEE------QPE----DVKKESEGDSKTEGSEQEGENEKDEEI---KQEKENEQDEEN 412 Saccharomyces cerevisiae Kyokai no. 7
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