Conserved Protein Domain Family
FapA

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pfam03961: FapA 
Flagellar Assembly Protein A
Members of this family include FapA (flagellar assembly protein A), found in Vibrio vulnificus. The synthesis of flagella allows bacteria to respond to chemotaxis by facilitating motility. Studies examining the role of FapA show that the loss or delocalization of FapA results in a complete failure of the flagellar biosynthesis and motility in response to glucose mediated chemotaxis. The polar localization of FapA is required for flagellar synthesis, and dephosphorylated EIIAGlc (Glucose-permease IIA component) inhibited the polar localization of FapA through direct interaction.
Statistics
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PSSM-Id: 335555
View PSSM: pfam03961
Aligned: 96 rows
Threshold Bit Score: 121.984
Threshold Setting Gi: 122677842
Created: 24-Mar-2017
Updated: 23-May-2017
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q1NU26        78 LLQRLKRDEPEPRV----------RL-------------------------D-----------------------FTVDY 99  delta proteobac...
Q7MSH2       100 FSLRLGEDFRELFL----------TL-------------------------Hkgsqi-------------tynavFLEEL 131 Wolinella succi...
Q0PC82        88 FTVKLRSNSNLTHLk--------aSI-------------------------Nltenfky---------ypnlkfdILQNI 125 Campylobacter j...
Q8RAV8         3 IILEISDDEMIVTLr--------kTL-------------------------Fsswgd-------------idiyeFLNIV 36  Caldanaerobacte...
Q24TB2       120 QDLLIWQDTKpqg-----------------------------------------------------------pywDQRKF 140 Desulfitobacter...
WP_061311493 135 iksrkevfeenkievifeevkahrelnvktdqnnmeayisviykpeikyglkdvedknylilnsckmeekdppyyTKEEI 214 Clostridium bot...
WP_011969178 157 ISVNISVDKMKGYI----------KVeykpayvyklrdkpmakdlilkamkVeedy---------------pkkyTLTEI 211 Clostridium bei...
BAF59995     111 KDLVLSAVKIIekk----------------------------------------------------------cpfDLAGI 132 Pelotomaculum t...
WP_012058639  69 VNITISEDKMKAYMtveyipkteyKI-------------------------KdrefyinlavstevllkeepeyfTVQEL 123 Clostridium bei...
WP_002849260 111 VVASIKEDSNVKYYpsf-------------------------------------------------------erdLINFI 135 Campylobacter f...
Q1NU26       100 DPAPHRRQV---------------IVDLARDR----------TRLAVKGRPPKDGIPGFIREKGryaaerr---arqhsg 151 delta proteobac...
Q7MSH2       132 FERVRAQKAimrvlfrqeakererIASLLKELqnlpfldkdyEILLAQSAGGGRCVEATLILHF---------------- 195 Wolinella succi...
Q0PC82       126 YKIMIKQKFlilrldknlfdkiddFILSIQKSpsi----keiELEIAKGVDKIEHKSDEIIYHRdvnee-------cfde 194 Campylobacter j...
Q8RAV8        37 ESELRKNGIivgidk----salisVYTQNKk-----------EAVIARGIPYKSGRDGYLEFIIkidkpri--lytetfs 99  Caldanaerobacte...
Q24TB2       141 LGDLQAHGIvfgvlp----gawynISMVQGKR----------EVVIAQGKPPTLPVAAQLVDLLtkketa-----leedq 201 Desulfitobacter...
WP_061311493 215 IEALKKMRIvygiik-----enleqCTKNNCI----------ELLIAKGKETINEEDESIEIKFttdnqelk-ltedktg 278 Clostridium bot...
WP_011969178 212 KEILRQNKItdgiiy----knlieACALGN-Ge---------EMLIAEGIGAIDDTPNEIKVLFdigekri--vnensne 275 Clostridium bei...
BAF59995     133 MREIAGKNIvygirh----deiraILDRPEDG----------LYVIARGDPPGESVDERVELKFaagreepkagavtgkd 198 Pelotomaculum t...
WP_012058639 124 YKKLKEKGIvfgike----eslelILK-GCSS----------EVLVAEGLEPVKDTPSEVKLFFtptqmvf--pepdsne 186 Clostridium bei...
WP_002849260 136 QKKLLKANIligirdy-imlreinKVTSILRIkeii--dkafTFVVVTGVDPVVAVDDNMIFYYksklkns---eknkdd 209 Campylobacter f...
Q1NU26       152 RMDHYTTGEFVETKAGEVLAlIDNTKIKGEPGIDIRGMVV---KPQTAPSYQIRLgEGVSKReKESGKLeLvSEFTGLVK 228 delta proteobac...
Q7MSH2       196 QEDPALQGRFPTIKEEMLLA-TFLKPQKGGAGRDCLGNYIppkEPSASAQNPLRI-DESIEErDEGNKInYyAKESGYLL 273 Wolinella succi...
Q0PC82       195 NINYDEGNYCKPIEKNELLF-EYIYRILGKEGRNLRGEILh-lNPIAFLDNPFIIkDESIYTeELEDRIkYfSANYGFLN 272 Campylobacter j...
Q8RAV8       100 EEDIFDMASIPFARKGDVIG-KLHKPIKGENGISVRGRII---NAPPVRDVEVKIlSDSIVFkEDEDKI-V-AIADIRPV 173 Caldanaerobacte...
Q24TB2       202 RIDHFA-SKLKLVNAGQALA-RKIPGVPGTPGRNVKGQEI---PSQKPRDFQFKLkKNVQLS-EDGLEV-L-ATVAGLPL 273 Desulfitobacter...
WP_061311493 279 NVDFKSIGSIESVKPGEVLA-VRKKGKEGQDGIDIKGIVK---KYKQGKKIILKPgQGTILRdED--TI-E-ATIKGKPC 350 Clostridium bot...
WP_011969178 276 KIDYRNVYSISSITEGQVLA-EIIPGKNGQDGKNICGEVL---KKKTVKSRPIKIgDGCKV---EGNSI-I-ATKTGRPS 346 Clostridium bei...
BAF59995     199 RIDFRDLVEIPSVEPGALLA-VKLPGAPGAPGKTVTGEII---PPRKPVVFELIAgKGAEVL-ADGSKV-Y-ARIGGRPV 271 Pelotomaculum t...
WP_012058639 187 KVDFKNLFRISNVNAGDKIA-EIIPEIPGKNGMNIFGKVI---EREYIRSLPIDAsKGCKI--EN-NHI-I-SLIDGKAH 257 Clostridium bei...
WP_002849260 210 KVNYSNRGFVQGVTEGEVII-EYIKPKTGIAGRNVKGDVIsvnEPKILIKEKINVsQNIDVKeDDDSIK-YiAKKNGYVN 287 Campylobacter f...
Q1NU26       229 TNyDGegnlryLAVE---QDLRLG-EVGLRSgGHVKgaq----------------------agGKG-SLQIEKaefrNVP 281 delta proteobac...
Q7MSH2       274 FEeYR------LSIT---QKIEIE-EVDIKTtGSLLggldaptsvvvkenhylkealgdgakiEAG-EVEIAG----NIG 338 Wolinella succi...
Q0PC82       273 KDhTG------YCIA---NNLKLS-QIGLKTtGSIKtntdeninleitnfdisddaiksgivnVQAsNIKVNG----NV- 337 Campylobacter j...
Q8RAV8       174 VH-KKdetdkfVYLFysiPVFFYKgSIPKNS-RLVT---------------------------FEG-DVIING----NVE 219 Caldanaerobacte...
Q24TB2       274 RM-DEl----sFGVE---PAYILNqDLDLSI-GSIE---------------------------FPG-DVFISG----DVH 312 Desulfitobacter...
WP_061311493 351 VK-SNi-----FYVY---QVHEVKgDVDIST-GNIT---------------------------FVG-DVVVKG----SVK 388 Clostridium bot...
WP_011969178 347 SK-NGi-----LSVN---SLYNIQ-DVDIKS-GNIF---------------------------FAG-GVHIKG----NVK 383 Clostridium bei...
BAF59995     272 AK-KLgnk-yvIDVD---PVLHKKgDVDISS-GNIR---------------------------FKG-DVVVHG----NVC 313 Pelotomaculum t...
WP_012058639 258 IA-NRs-----VSVN---PIYTVE-SVNMET-CNIK---------------------------FYG-DVEVYD----SVQ 294 Clostridium bei...
WP_002849260 288 EEkGT------YDIK---DELDIN-EVSFKTtGSIEtslesdvkinikekdilkdavgagmsiETT-SINVEG----NVA 352 Campylobacter f...
Q1NU26       282 PAFEARTEgDILVKelvQGIvHGATVTA-----EMVNQTAG-----------KYVAAtqGPLQINRSvQGATLYAPRvVL 345 delta proteobac...
Q7MSH2       339 SGSEIRAN-RVTIS---GQThQTSKIHAqsasiEAHKGWVEadevkvmrleaGIIRA--QKVHIEHA-HGGKVYAKE-IS 410 Wolinella succi...
Q0PC82       338 -GATKLYGkNISIK---GLThAKSEIFAqdifiTTHKGTLQadtvyiknlenGTIIA--KNVFVENC-MGGKIEAEN-IY 409 Campylobacter j...
Q8RAV8       220 KGNQIIASgNVQIL---GSV-YESVVEGgq-niIISGGIVD-----------SQLHA--GFLPGNIF-DKIELHAVNlIV 280 Caldanaerobacte...
Q24TB2       313 DGLHIFSEgKVEIR---GSS-SRAEIRAek-glTIYRNVLAg----------------kLVVGARYV------------- 358 Desulfitobacter...
WP_061311493 389 EGMKVEAGnSVEIK---KHV-ERAEIISks-nlNIDGNIINs-----------dIYGg-GEDTLK-------VMVLNkLE 444 Clostridium bot...
WP_011969178 384 EGMKVKSGnSLTIE---KNV-DISTIVAgg-eiNIKGSVIk----------sTVLTGq-VDMEKKMY--------LEkLN 439 Clostridium bei...
BAF59995     314 EGMTVQAAgRINIT---GMV-FGARIAAqg-niSVGQNVAG-----------SHIVAggNNIFFREV-NKI-------LA 369 Pelotomaculum t...
WP_012058639 295 DNMFVSAGgSLDVS---QNV-NMANVVTgg-eiTILGNTIN-----------SKILSgqVDIRKKEYsDV--------LT 350 Clostridium bei...
WP_002849260 353 KGAHIVAK-DVIIG---GQThAKSVIKAqtaeiSVHLGRLIcdeakidrlesGYVRA--KKVFINSV-IGGEIIANE-VH 424 Campylobacter f...
Q1NU26       346 GNQRVVATMLNTTVNAR-----------HCLVGHKlLLSGRNHLtlg-----------------sdkLREENP------- 390 delta proteobac...
Q7MSH2       411 IRFLHSNLQAFASEKIEi----------FEIMGEDnKFTLTPEAn---------------------pKIQSRL------- 452 Wolinella succi...
Q0PC82       410 ICNLLTDNTLYPRKNLIi---------------TNnIKFKNNIVvsp------------------lvSIENNS------- 449 Campylobacter j...
Q8RAV8       281 EKLSAIFLHIRELPTVMnnsrh----------lsekIKLIETLKe---------------------eLKTSST------- 322 Caldanaerobacte...
Q24TB2       359 VRSKLLHDLQALHDDLVa----------CLMITEDfINSPHGKDl----------------------kPGQCL------- 399 Desulfitobacter...
WP_061311493 445 KLKDILTELISAVEEIKrfnllgegkkdGEII--K-ILIENKFKtltki--------------ciaiMANINMcrsddee 507 Clostridium bot...
WP_011969178 440 EYKDIISKLVSAVEKLNess------nnSKKISEL-VKILIENRyksipklslniithsicedsdnnDLVSFI------- 505 Clostridium bei...
BAF59995     370 KLQAGFSELLKMVPALAehp------klKNVNAGQlVQLLIDRKypgi----------------pglISEMVR------- 420 Pelotomaculum t...
WP_012058639 351 EFKNI---LVSMIEYINglnlq--nferKDFVK---TLTEKNFGnfqkvalniis--lniknktkrsKLVDFI------- 413 Clostridium bei...
WP_002849260 425 IKRLFANSSITASTLVEi----------DELKGTNnRICIDSGEi---------------------lNYEGKL------- 466 Campylobacter f...
Q1NU26       391 KARQcAISGQDL-------FAGR--TRLLRELEDY---NKELTEINGR----INGLLMgHV-QDRVEARRPLDRDRIRRC 453 delta proteobac...
Q7MSH2       453 ATLLrSFEELSA-------ALKTkiKKFNEEAKEIkalRPLATKIKAM----IDLNRQeGVgTPAYLQEKLKSYINLLKY 521 Wolinella succi...
Q0PC82       450 DTECeNLKNLSL-------KIK---SKLDDTISKMqnyYDYLIKNQIK----IIKLQKtKN-PSAIEMKFSNLYHDIIKK 514 Campylobacter j...
Q8RAV8       323 EISMiRSS-----------------NVLQNLLEDL---KSLVKTLNNIldydIIGLIK-----------HLNSLKEIYEK 371 Caldanaerobacte...
Q24TB2       400 KLII-ERRFPGL-------PKQA--SDLEKFLLST---KDELIQQDLV----ISVRSAkRF-LGGLGPLDSQALPLLGRV 461 Desulfitobacter...
WP_061311493 508 DELV-GIIRKKLiglgpvhIKNY--RELEQIVNLI---EEKIKMCKEG----LSLPVNvNI-SYCQDSKIKSTGDIYITG 576 Clostridium bot...
WP_011969178 506 RSKM-MGLNLSK-------IESI--DDLRNLEELI---NNEIEMLEDN----MIISADiYI-GYCQDSLIKSTGNIIITD 567 Clostridium bei...
BAF59995     421 LSSQnSFILPRE-------MVHLl-EKIEKNLLGL-----NLMKVKTV-------------------------------- 455 Pelotomaculum t...
WP_012058639 414 KGKIlGLN-ILE-------IKSI--YDLKTLLNIL---DNEIDYYDKN----IIVPLDiRI-GYCQECEIKSTGNIIIGG 475 Clostridium bei...
WP_002849260 467 EEYSkTMSKLKT-------DILVipRELESKKNIIdsnRESVNSIKRR----IEELRStGKaPPMSFLNKLKDFQALVYE 535 Campylobacter f...
Q1NU26       454 LAAMVSLDAELMACGV-EEEEDIRRR----------ITTTLLd-IELENPLPVLrqlNEKKRLNR-ElESRQ-------- 512 delta proteobac...
Q7MSH2       522 TQAHKEEIEKLQGERH-ALSEEILSLqapt--lasyIWSKNGwkGYNEVRFKLLlppKDLFIAPK-TsIHHGllrldehq 597 Wolinella succi...
Q0PC82       515 YNHLSISYKKLVKLKY-QIDAKLNFLn----------------eMVYNVKIYIk-------------------------a 552 Campylobacter j...
Q8RAV8       372 ILFISRILTEEHENKGhILAKWVHDSkiya---mkdVIITSEa-GCYNTKISTNgsvSINGKVRM-StIEFKknifikea 446 Caldanaerobacte...
Q24TB2       462 SQAFEQIIGNITLDVPeKLECQVDYVqgali-ecagHFSCRKg-TYNSIIQAAGdvrIEGVCRGG-RiISGGnvvikelg 538 Desulfitobacter...
WP_061311493 577 KGEYISKLTSNNNVYF-TKDDSVARGghiiakneirCKEVGSe-AGVITKLQIL---QKGDIYVDvA-YQNTifiigdre 650 Clostridium bot...
WP_011969178 568 KGQYVSNLTALNDIIF-LRDDSVARGgvisargniklgivgspsgvttrlevlqggiitakiaysntvfcfggriktldv 646 Clostridium bei...
BAF59995     456 -EEFGSFLSEIGQVRQ-IIDGMAGDKasi-----tfSYSENSt-IEASGDVSVSgggCINTVIRA-GgNVRVkgv--frg 524 Pelotomaculum t...
WP_012058639 476 KGEYTSKLTAMKDIIF-TRSDSVARGgvlsagqnisLGVVGSr-AYIPTTLMVP---QYGRITAA-KaYANTvfcfgrtk 549 Clostridium bei...
WP_002849260 536 YNSMLKDLNGKKAALN-DLKEELKSMqs---------------mVFKAKIINKDrwkELNEIKFR-LiEPKKditystre 598 Campylobacter f...
Q1NU26       513 ENL 515 delta proteobacterium MLMS-1
Q7MSH2       598 QSI 600 Wolinella succinogenes
Q0PC82       553 ENI 555 Campylobacter jejuni
Q8RAV8       447 GSL 449 Caldanaerobacter subterraneus subsp. tengcongensis
Q24TB2       539 GSG 541 Desulfitobacterium hafniense Y51
WP_061311493 651 yll 653 Clostridium botulinum
WP_011969178 647 ssk 649 Clostridium beijerinckii
BAF59995     525 GEI 527 Pelotomaculum thermopropionicum SI
WP_012058639 550 VTL 552 Clostridium beijerinckii
WP_002849260 599 NEL 601 Campylobacter fetus
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