Conserved Protein Domain Family
FapA

?
pfam03961: FapA 
Flagellar Assembly Protein A
Members of this family include FapA (flagellar assembly protein A), found in Vibrio vulnificus. The synthesis of flagella allows bacteria to respond to chemotaxis by facilitating motility. Studies examining the role of FapA show that the loss or delocalization of FapA results in a complete failure of the flagellar biosynthesis and motility in response to glucose mediated chemotaxis. The polar localization of FapA is required for flagellar synthesis, and dephosphorylated EIIAGlc (Glucose-permease IIA component) inhibited the polar localization of FapA through direct interaction.
Statistics
?
PSSM-Id: 377177
View PSSM: pfam03961
Aligned: 96 rows
Threshold Bit Score: 123.14
Threshold Setting Gi: 122677842
Created: 6-May-2019
Updated: 18-Jul-2019
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
jgi:Dred_1859      87 IKVQLSPDRMSAFL----------EIKneclksyelidcppstnlvlqarqtkqrifreTKDTIINLLNQNHIsfgidl- 155 Desulfotom...
Q7MSH2            100 FSLRLGEDFRELFL----------TLHkgsqi----------------------tynavFLEELFERVRAQKAimrvlfr 147 Wolinella ...
tigr:CFF8240_0806 111 VVASIKEDSNVKYYpsf---------------------------------------erdLINFIQKKLLKANIligirdy 151 Campylobac...
Q0PC82             88 FTVKLRSNSNLTHLk--------aSINltenfky------------------ypnlkfdILQNIYKIMIKQKFlilrldk 141 Campylobac...
Q4HT23            121 IAIKILQNIYKKML----------KLKfligi-----------------------rifnFKKDLLNLLAKHKAsai---- 163 Campylobac...
CAL84314          181 Ik---------------------yGLKdvedknylilns---------ckmeekdppyyTEEEIIEALKKMGIvygiik- 229 Clostridiu...
jgi:Cbei_1855     157 ISVNISVDKMKGYIkveykpayvyKLRdkpmakdlilka---------mkveedypkkyTLTEIKEILRQNKItdgiiy- 226 Clostridiu...
jgi:Cbei_2425      69 VNITISEDKMKAYMtveyipkteyKIKdrefyinlavst---------evllkeepeyfTVQELYKKLKEKGIvfgike- 138 Clostridiu...
Q8RAV8              3 IILEISDDEMIVTLr--------kTLFsswgd----------------------idiyeFLNIVESELRKNGIivgidk- 51  Caldanaero...
BAF60877          125 YLIDQEPHAHLYLK----------TLQkeel------------------------ksplDVKQLMEMLFKENVvvgvdl- 169 Pelotomacu...
jgi:Dred_1859     156 ---qaledIITQQLEG----------LLLVAQGLAPGETIDDDVELLFE--------HKIDsdlsnaldTIDFKEMHSIP 214 Desulfotom...
Q7MSH2            148 qeakererIASLLKELqnlpfldkdyEILLAQSAGGGRCVEATLILHF---------------------QEDPALQGRFP 206 Wolinella ...
tigr:CFF8240_0806 152 -imlreinKVTSILRIkeii--dkafTFVVVTGVDPVVAVDDNMIFYYKsklknsekNKDD--------KVNYSNRGFVQ 220 Campylobac...
Q0PC82            142 nlfdkiddFILSIQKSpsi----keiELEIAKGVDKIEHKSDEIIYHRDvnee------------cfdeNINYDEGNYCK 205 Campylobac...
Q4HT23            164 ------kqVV----------------SITIAKGVEPTNSQDEALILCYK--------EKAKn------yTLDEQRANIIV 207 Campylobac...
CAL84314          230 ---enleqCTK-NNCI----------ELLIAKGKETINEEDESIEIKFTtdnqelklTEDKt------gNVDFKSIGSIE 289 Clostridiu...
jgi:Cbei_1855     227 ---knlieACALGNGE----------EMLIAEGIGAIDDTPNEIKVLFDigek-rivNENSn------eKIDYRNVYSIS 286 Clostridiu...
jgi:Cbei_2425     139 ---eslelILK-GCSS----------EVLVAEGLEPVKDTPSEVKLFFTptqm-vfpEPDSn------eKVDFKNLFRIS 197 Clostridiu...
Q8RAV8             52 ---salisVYTQNKk-----------EAVIARGIPYKSGRDGYLEFIIKidkprilyTETFs-------EEDIFDMASIP 110 Caldanaero...
BAF60877          170 ---sevvkVMDKPGKV----------RVTIARGEPPEPSVDEKVEIFFPqendfapvIKEDg-------RVDYYNIKNII 229 Pelotomacu...
jgi:Dred_1859     215 SVNAGETLAQKIIGKEGTPGTTVTNQIY---KAREAKRITLL--AGPGVEIV-DNGLRA-I-ANIEGLPRVQ-KSHnn-w 284 Desulfotom...
Q7MSH2            207 TIKEEMLLATFLKPQKGGAGRDCLGNYIppkEPSASAQNPLR--I-DESIEErDEGNKInYyAKESGYLLFEeYR----- 278 Wolinella ...
tigr:CFF8240_0806 221 GVTEGEVIIEYIKPKTGIAGRNVKGDVIsvnEPKILIKEKIN--VSQNIDVKeDDDSIK-YiAKKNGYVNEEkGT----- 292 Campylobac...
Q0PC82            206 PIEKNELLFEYIYRILGKEGRNLRGEILh-lNPIAFLDNPFI--IKDESIYTeELEDRIkYfSANYGFLNKDhTG----- 277 Campylobac...
Q4HT23            208 -VDENEIVLKHIKAKVGAEGKDLNLHNL---EVLEPKENKINfsCSNAFKSEeKENIVE-YiALKKGFVVEN-ANN---- 277 Campylobac...
CAL84314          290 SVKPGEVLAVRKKGKEGQDGIDIKGIVK---KYKQGKKIILK--PGQGTIL--RDEDTI-E-ASIKGKPCVK-SNI---- 355 Clostridiu...
jgi:Cbei_1855     287 SITEGQVLAEIIPGKNGQDGKNICGEVL---KKKTVKSRPIK--IGDGCKV--EG-NSI-I-ATKTGRPSSK-NGI---- 351 Clostridiu...
jgi:Cbei_2425     198 NVNAGDKIAEIIPEIPGKNGMNIFGKVI---EREYIRSLPID--ASKGCKI--EN-NHI-I-SLIDGKAHIA-NRS---- 262 Clostridiu...
Q8RAV8            111 FARKGDVIGKLHKPIKGENGISVRGRII---NAPPVRDVEVK--ILSDSIVFkEDEDKI-V-AIADIRPVVH-KKDetdk 182 Caldanaero...
BAF60877          230 CVEEGALLAQKHPGVMGRPGRNVCGEVV---LSPPPRNVILR--AGKGAVLS-EDGSKV-V-ACKSGRPVLQ-RLGri-y 299 Pelotomacu...
jgi:Dred_1859     285 tISVD---PVLNLSgDVDVKT-GNIR---------------------------FKG-NVNIMGSVETDMNVSASGNITIS 332 Desulfotom...
Q7MSH2            279 -LSIT---QKIEIE-EVDIKTtGSLLggldaptsvvvkenhylkealgdgakiEAG-EVEIAGNIGSGSEIRAN-RVTIS 351 Wolinella ...
tigr:CFF8240_0806 293 -YDIK---DELDIN-EVSFKTtGSIEtslesdvkinikekdilkdavgagmsiETT-SINVEGNVAKGAHIVAK-DVIIG 365 Campylobac...
Q0PC82            278 -YCIA---NNLKLS-QIGLKTtGSIKtntdeninleitnfdisddaiksgivnVQAsNIKVNGNV--GATKLYGKNISIK 350 Campylobac...
Q4HT23            278 -YDIA---NELEFG-AVDFKSiGNINasldknvkinikf-asdmqdavnsgvgIECeELNIIGSVAGNTNLKAT-RLKIE 350 Campylobac...
CAL84314          356 -FYVY---QVHEVKgDVDIST-GNIT---------------------------FVG-DVVVQGSVKEGMKVEAGNSVEIK 402 Clostridiu...
jgi:Cbei_1855     352 -LSVN---SLYNIQ-DVDIKS-GNIF---------------------------FAG-GVHIKGNVKEGMKVKSGNSLTIE 397 Clostridiu...
jgi:Cbei_2425     263 -VSVN---PIYTVE-SVNMET-CNIK---------------------------FYG-DVEVYDSVQDNMFVSAGGSLDVS 308 Clostridiu...
Q8RAV8            183 fVYLFysiPVFFYKgSIPKNS-RLVT---------------------------FEG-DVIINGNVEKGNQIIASGNVQIL 233 Caldanaero...
BAF60877          300 lISVE---DVLVHNgDVGIET-GNIL---------------------------FNGsLVIVRGNVRESMTVGTTGIIEVD 348 Pelotomacu...
jgi:Dred_1859     333 NIV-TRCKITAgg-nvTIKGNIVNseiis--ggfiVICNA-IKPLLSELLkTLEDLLISANLMLEKLPTNNKILFGNILM 407 Desulfotom...
Q7MSH2            352 GQThQTSKIHAqsasiEAHKGWVEadevkvmrleaGIIRA--QKVHIEHA-HGGKVYAKE-ISIRFLHSNLQAFASEKIE 427 Wolinella ...
tigr:CFF8240_0806 366 GQThAKSVIKAqtaeiSVHLGRLIcdeakidrlesGYVRA--KKVFINSV-IGGEIIANE-VHIKRLFANSSITASTLVE 441 Campylobac...
Q0PC82            351 GLThAKSEIFAqdifiTTHKGTLQadtvyiknlenGTIIA--KNVFVENC-MGGKIEAEN-IYICNLLTDNTLYPRKNLI 426 Campylobac...
Q4HT23            351 GAThSKAKIYAkngyiKTHRGVAS-----------------GENISVDLL-EGGSIKAKE-VRVKKSL--GGIIEADKIY 409 Campylobac...
CAL84314          403 KHV-ERAEIISks-nlNIDGNIIN-----------SDIYGgGEDTLKVMVlNK--------LEKLKDILTELISAVEEIK 461 Clostridiu...
jgi:Cbei_1855     398 KNV-DISTIVAgg-eiNIKGSVIK-----------STVLTgQVDMEKKMYlEK--------LNEYKDIISKLVSAVEKLN 456 Clostridiu...
jgi:Cbei_2425     309 QNV-NMANVVTgg-eiTILGNTIN-----------SKILSgQVDIRKKEYsDV--------LTEFKNI---LVSMIEYIN 364 Clostridiu...
Q8RAV8            234 GSV-YESVVEGgq-niIISGGIVD-----------SQLHA--GFLPGNIF-DKIELHAVNLIVEKLSAIFLHIRELPTVM 297 Caldanaero...
BAF60877          349 GIV-SGARVAAyd-rvHIEGNAIN-----------SIVNAgLSREFLKEV------------LACIASLEKDIKKIINVM 403 Pelotomacu...
jgi:Dred_1859     408 lliek-kftnfGTIIDKV-SKKLKEVDl-kLLGTy--------------gTLLEKALVNLtGINILNFKSSLeyQALLTD 470 Desulfotom...
Q7MSH2            428 i----------FEIMGEDnKFTLTPEAn---------------------pKIQSRLATLLrSFEELSAALKTkiKKFNEE 476 Wolinella ...
tigr:CFF8240_0806 442 i----------DELKGTNnRICIDSGEi---------------------lNYEGKLEEYSkTMSKLKTDILVipRELESK 490 Campylobac...
Q0PC82            427 i---------------TNnIKFKNNIVvspLV------------------SIENNSDTECeNLKNLSLKIK---SKLDDT 470 Campylobac...
Q4HT23            410 i----------EALVTNNtCTFFENIIverFEGD------------------NNKFFAKVkTLD-KNYDEEF--KNIDDE 458 Campylobac...
CAL84314          462 rfnllgegkkdGEIIK---ILIENKFKtltKICIaimaninmcrsddeedELVGIIRKKLiGLG-PVHIKNY--RELEQI 535 Clostridiu...
jgi:Cbei_1855     457 essnn--skkiSELVK---ILIENRYKsipKLSLniithsi--cedsdnnDLVSFIRSKMmGLN-LSKIESI--DDLRNL 526 Clostridiu...
jgi:Cbei_2425     365 glnlq--nferKDFVK---TLTEKNFGnfqKVALniislni--knktkrsKLVDFIKGKIlGLN-ILEIKSI--YDLKTL 434 Clostridiu...
Q8RAV8            298 nnsrh----------lsekIKLIETLKe---------------------eLKTSSTEISMiRSS----------NVLQNL 336 Caldanaero...
BAF60877          404 slpafqsavrkAGISYGYlLKLMIEKKlvsLPAIl--------------eNLDNLFKTLFlGVP----------EELEKV 459 Pelotomacu...
jgi:Dred_1859     471 LNNFyyyIESQVTSRSEihi-kvaLNSVIKsSG-DVIVTGGCFNTHILAEGSVhidgIVRGGIIQAHDDIFIqQIGSEMG 548 Desulfotom...
Q7MSH2            477 AKEIkalRPLATKIKAM-------IDLNRQeGVgTPAYLQEKLKSYINLLKYT----QAHKEEIEKLQGERH-ALSEEIL 544 Wolinella ...
tigr:CFF8240_0806 491 KNIIdsnRESVNSIKRR-------IEELRStGKaPPMSFLNKLKDFQALVYEY----NSMLKDLNGKKAALN-DLKEELK 558 Campylobac...
Q0PC82            471 ISKMqnyYDYLIKNQIK-------IIKLQKtKN-PSAIEMKFSNLYHDIIKKY----NHLSISYKKLVKLKY-QIDAKLN 537 Campylobac...
Q4HT23            459 LFAL---HNKIHTLKQSlsvgktaIDTLDA--------------QIQKLKESG----QKIPDKFTKMLQDYA-KLNEELQ 516 Campylobac...
CAL84314          536 VNLI---EEKIKMCKEG-------LSLPVNvNI-SYCQDSKIKSTGDIYITGK----GEYISKLTSNNNVYF-TKDDSVA 599 Clostridiu...
jgi:Cbei_1855     527 EELI---NNEIEMLEDN-------MIISADiYI-GYCQDSLIKSTGNIIITDK----GQYVSNLTALNDIIF-LRDDSVA 590 Clostridiu...
jgi:Cbei_2425     435 LNIL---DNEIDYYDKN-------IIVPLDiRI-GYCQECEIKSTGNIIIGGK----GEYTSKLTAMKDIIF-TRSDSVA 498 Clostridiu...
Q8RAV8            337 LEDL---KSLVKTLNNIld---ydIIGLIK-----------HLNSLKEIYEKI----LFISRILTEEHENKGhILAKWVH 395 Caldanaero...
BAF60877          460 FIACrrlLADPYQFISK----------------------------------------ENLCWILQSIKLAED-YFKSRKT 498 Pelotomacu...
jgi:Dred_1859     549 TKsvvig-skdkKIKINQ--AFDGVTIKIG---NMSRIIDRTmKNIVvll--dedGYL 598 Desulfotomaculum reducens MI-1
Q7MSH2            545 SLqapt--lasyIWSKNGwkGYNEVRFKLLlppKDLFIAPKTsIHHGllrldehqQSI 600 Wolinella succinogenes
tigr:CFF8240_0806 559 SMqs---------------mVFKAKIINKDrwkELNEIKFRLiEPKKditystreNEL 601 Campylobacter fetus subsp. fetus...
Q0PC82            538 FLn----------------eMVYNVKIYIk------------------------aENI 555 Campylobacter jejuni
Q4HT23            517 KS-----------LKIQKe-LLDK-KAHLN---EELLKLQDA-LLKAtfi--nrgGKW 555 Campylobacter upsaliensis RM3195
CAL84314          600 RGghiiakneirCKEVGSe-AGVITKLQIL---QKGDIYVDVaYQNTifiigdreYLL 653 Clostridium botulinum A str. ATC...
jgi:Cbei_1855     591 RGgvisargnikLGIVGSp-SGVTTRLEVL---QGGIITAKIaYSNTvfcfggriKTL 644 Clostridium beijerinckii NCIMB 8052
jgi:Cbei_2425     499 RGgvlsagqnisLGVVGSr-AYIPTTLMVP---QYGRITAAKaYANTvfcfgrtkVTL 552 Clostridium beijerinckii NCIMB 8052
Q8RAV8            396 DSkiya---mkdVIITSEa-GCYNTKISTNgsvSINGKVRMStIEFKknifikeaGSL 449 Caldanaerobacter subterraneus su...
BAF60877          499 KKanl-----eiGGAINCh-IRATGDVTIRgkgCFNTVINAEgNVRIngv--frgGEI 548 Pelotomaculum thermopropionicum SI
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap