5FJ8,1GO3,4QIW,3H0G,3AYH,2Y0S,2C35,5X4Z,4C2M


Conserved Protein Domain Family
SHS2_Rpb7-N

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pfam03876: SHS2_Rpb7-N 
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SHS2 domain found in N-terminus of Rpb7p/Rpc25p/MJ0397
Rpb7 bind to Rpb4 to form a heterodimer. This complex is thought to interact with the nascent RNA strand during RNA polymerase II elongation. This family includes the homologs from RNA polymerase I and III. In RNA polymerase I, Rpa43 is at least one of the subunits contacted by the transcription factor TIF-IA. The N-terminus of Rpb7p/Rpc25p/MJ0397 has a SHS2 domain that is involved in protein-protein interaction.
Statistics
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Aligned: 140 rows
Threshold Bit Score: 34.0096
Threshold Setting Gi: 74800653
Created: 6-May-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5FJ8_G            9 DLVRIPPDQFH--R-DTISAITHQLNNKFANKIIPNV-GLCITIYDLLT----------------VEE------------ 56  Saccharomyce...
jgi:OSTLU_25861  22 FTVALHPSALA----DPLAGA-RAVLDAMKMRHVDALgGVLMAYDDEALcgarrrerdddgdddgDDEtstsesddaead 96  Ostreococcus...
EDO80068         11 LRLAVLPHGLS----DMIKAS-KAHLNQYLFNLLPTTqSLLLGYKDIEL----------------IGE------------ 57  Giardia lamb...
Q7PV20           33 EILSLRPRDCE----HIVKGV-KRCVTDKIGRYHAKLnGIVLGYAKIRV----------------DNAl----------- 80  Anopheles ga...
Q16XZ3           35 NLVSVLPKYLG----DICEGV-KACLTQKIGKYDRTVdGIILAFKNTKI----------------LSPl----------- 82  yellow fever...
EAX90593         11 VTVDIPVWRMG----GLKDAT-KLILLNKLLTYDDTLeGVILGIKNTNP----------------ESPy----------- 58  Trichomonas ...
Q29JY4           34 MHLSMGPYGMA----SFKHALHELLIRTKVGIYDANLsAIVLGIKKIKV----------------LGQt----------- 82  Drosophila p...
Q75M02           10 LNVLISPSQLSpqGlLLRKAVIVRLLEDIANRKASKDhGYYIAVSELKA----------------ISE------------ 61  Japanese rice
Q8LE42            9 WDVTIPAEDMDt-GlMLQRAIVIRLLEAFSKEKATKDlGYLITPTILEN----------------IGE------------ 59  thale cress
A6QRA1            9 WNVMIPAENMDakGlMLKRAILVELLEAFASKKATKElGYYVAVTTLDK----------------IGE------------ 60  thale cress
5FJ8_G           57 --------GQLK-PGDGSSYINVTFRAVVF 77  Saccharomyces cerevisiae S288C
jgi:OSTLU_25861  97 dddgrggfGRVL-HASGHVDVRVRARCEVF 125 Ostreococcus lucimarinus CCE9901
EDO80068         58 --------TAALtYHSSHVHFTARCTLLLF 79  Giardia lamblia ATCC 50803
Q7PV20           81 --------SALR-LDSPYLHVRTTIDYYVF 101 Anopheles gambiae str. PEST
Q16XZ3           83 --------SAIR-PNSVRIHVKVSSNFYVF 103 yellow fever mosquito
EAX90593         59 --------SKFY-ADTPAIHQTIEGDFLVF 79  Trichomonas vaginalis G3
Q29JY4           83 --------AALR-ADDPSLHLLINADFYVF 103 Drosophila pseudoobscura
Q75M02           62 --------GKVR-ELTGDVLFPVTFTCItq 82  Japanese rice
Q8LE42           60 --------GKIK-EQTGEIQFPVVFNGICF 80  thale cress
A6QRA1           61 --------GKIR-EHTGEVLFPVMFSGMTF 81  thale cress
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