Conserved Protein Domain Family
Scramblase

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pfam03803: Scramblase 
Scramblase
Scramblase is palmitoylated and contains a potential protein kinase C phosphorylation site. Scramblase exhibits Ca2+-activated phospholipid scrambling activity in vitro. There are also possible SH3 and WW binding motifs. Scramblase is involved in the redistribution of phospholipids after cell activation or injury.
Statistics
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PSSM-Id: 252175
View PSSM: pfam03803
Aligned: 10 rows
Threshold Bit Score: 278.084
Threshold Setting Gi: 74625919
Created: 26-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352904    59 NSNSGIIKVHDPIATTILNE-PTVIIERQIEFMNVFLGFEQANRYAIMDVNGNKIASMMERdf-siTKAIMRQFYRLHRP 136
gi 296452876  62 SAAPFLPLPGVPSGLEFLVQiDQILIHQKAERVETFLGWETCNRYELRSGAGQPLGQAAEE-----SNCCARLCCGARRP 136
gi 14548191   86 MPAP-QPPLNCPPGLEYLSQiDQILIHQQIELLEVLTGFETNNKYEIKNSFGQRVYFAAED-----TDCCTRNCCGPSRP 159
gi 212276457 100 MPGP-TPMANCPPGLEYLVQlDNIHVLQHFEPLEMMTCFETNNRYDIKNNSDQMVYIVTED-----TDDFTRNAYRTLRP 173
gi 74871934   42 MSIPVG-MPNCPQGLEYLTAlDQLLVSQKIEKLELLTGFETKNRFKVKNSLGQNVYFAYEE-----SDCCTRNMLGRSRP 115
gi 74959514   51 MPMP-PAIQGVPTGLEYLTYlDTIMVHQIKELIEIVTDWETKNKYVLKNANGEQCYYAFEE-----SGCCERQCCGPQRG 124
gi 75023813   48 MTGFNNLPAH--NVLDMISRtNSMMVVQALEPLEIATGIETPNQYVVHDMYCRPIMNCMER-----SNGFARQMQGSHRS 120
gi 74965259   74 MTGFVQLVAN--NILSAIAHtNSVMVVQCIKPLEIFTGFETPNRYVVHDMYCRPLLYCMER-----SNIFARQYEGNDRN 146
gi 75206027  150 MSGLLKPKTSDEAKIATLLArSNLLVTRDIEWANLVLGFEQENRYIVVDVCYPEAPVGSIRe---qSNLLARQLLRTRRP 226
gi 74625919   58 ISSTGAIPLNSPAA--PLLSqDVLIVERQLEMMNVFLGYEQANRYVILNQQGQHLGYIAEQgassiLSSLSRQFFHTHRA 135
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352904   137 FLVDVFDNWGNVIMTIKRPFSFINshiKtiippSAYVDNGSDSthyhDGKEGTTVGETIQNWHLWRRRYELFQKDGvEG- 215
gi 296452876 137 LRVRLADPGDREVLRLLRPLHCGCs--C-----CPCGLQEMEV----QAPPGTTIGHVLQTWHPFLPKFSIQDADR-QTv 204
gi 14548191  160 FTLRIIDNMGQEVITLERPLRCSS---Cc----CPCCLQEIEI----QAPPGVPIGYVIQTWHPCLPKFTIQNEKR-EDv 227
gi 212276457 174 FVLRVTDCMGREIMTMQRPFRCTC---Ccf--cCPSARQELEV----QCPPGVTIGFVAEHWNLCRAVYSIQNEKK-ENv 243
gi 74871934  116 FEMKILDNFQNEVLHLYRPFKCDIl--Cc----FPSCMNAVEV----SAPPGQVIGSVEQVCTFMRPKFNIKNTCG-DTv 184
gi 74959514  125 FVMHIVDNFKREVLTIKREFKCCGggcCgclacIGCCQQECII----ETPSMGVLGIIRQRCGCMSSNYDIMDGDG-NVi 199
gi 75023813  121 FAMMCTDLFGAHVMQCHRDQPWGS---------FTDHLTTQFL--------GQNIGIMSRTHG--DVNFHLLGAGS-NQs 180
gi 74965259  147 FGMQIMDTHGAQVMTCFRGRPCCS---------TDDFLSTQFL--------DQQIGMMKK--ECCNPNFELVGSGC-NQp 206
gi 75206027  227 FVASITDALGNELFRVRRPFW------------WLTSSIYAEI-------DGEEIGVVHRRWHLWRRIYDLYLGN--NQf 285
gi 74625919  136 FKADVMDSNGQLVLQLNRPFSWIN-----------SRLQIHSId--ySKFSSTLVGEVLQKWHLWRRRYELFLAKR---- 198
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352904   216 -STFDQFGKIDaPFLSFDFPVTDADG-KIMASVDRNWVGLGREMFTDTGVYVVRFDSqrcfdniy-----------ptem 282
gi 296452876 205 lRVVGPCWTCG-CGTDTNFEVKTRDEsRSVGRISKQWGGLVREALTDADDFGLQFPL----------------------- 260
gi 14548191  228 lKISGPCVVCS-CCGDVDFEIKSLDEqCVVGKISKHWTGILREAFTDADNFGIQFPL----------------------- 283
gi 212276457 244 mRVRGPCSTYG-CGSDSVFEVKSLDGiSNIGSIIRKWNGLLS-AMADADHFDIHFPL----------------------- 298
gi 74871934  185 lQIEGPVCPCK-CFSDTNFKVLSANN-EEIGKISKQWSGLGRELFTDADYFSVTFPL----------------------- 239
gi 74959514  200 fQIDGPCCCMLcGCQDKEFPIKTANNgTVVGAITKKWGGCFREAFTDADTFAVNFPG----------------------- 256
gi 75023813  181 lLIRSPLFAAS--GGTRSFPVMTYNG-MRVGEIVRLYPGYMQEMYSDADTYIVHFPM----------------------- 234
gi 74965259  207 lLIQSP--GCAgCGGTQKFPVMTFNG-VLVGEIVRLYPGFMQEMFTDADTYIVHFPM----------------------- 260
gi 75206027  286 aVVENPGF------WNWTFTVKDADG-EVLAQIDRDWRGFGFEIFTDAGQYVIRFGKadaaaktgpa-------tlveel 351
gi 74625919  199 -SMFEQFAKIDeRVLSWEFLLRN-EQdRILGSVSRNFMGLPREFFTDTGNYVLRFTStsaangsvnenqllqaahgiand 276
                        250       260
                 ....*....|....*....|....*...
gi 1352904   283 lssqVLTLDQRAVLLANAVSIDFDYFSR 310
gi 296452876 261 ----DLDVRVKAVLLGATFLIDYMFFEK 284
gi 14548191  284 ----DLDVKMKAVMIGACFLIDFMFFES 307
gi 212276457 299 ----DLDVKMKAMIFGACFLIDFMYFER 322
gi 74871934  240 ----NLDVRMKALIFAALFLIDAVYYEQ 263
gi 74959514  257 ----DLDVKLKGVLIGATFLIDFMEFEQ 280
gi 75023813  235 ----DLPPILKLLLISSVFLIDFTFFEN 258
gi 74965259  261 ----DMPPILKLLLVTSVFLIDFTYFED 284
gi 75206027  352 evkrPLTLSERAVVLTLAISLDNDYFSR 379
gi 74625919  277 vcarDMSLEERAVMLGSAVTIDFDYFSR 304
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